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120 results on '"Hoffman, Brenda J."'

1. Effect of endoscopic submucosal dissection on histologic diagnosis in Barrett’s esophagus visible neoplasia

Author

Yang, Dennis, King, William, Aihara, Hiroyuki, Karasik, Michael S., Ngamruengphong, Saowanee, Aadam, Abdul Aziz, Othman, Mohamed O., Sharma, Neil, Grimm, Ian S., Rostom, Alaa, Elmunzer, B. Joseph, Jawaid, Salmaan A., Perbtani, Yaseen B., Hoffman, Brenda J., Akki, Ashwin S., Schlachterman, Alexander, Coman, Roxana M., Wang, Andrew Y., and Draganov, Peter V.

Published
2022
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2. Endoscopic Submucosal Dissection in North America: A Large Prospective Multicenter Study

Author

Draganov, Peter V., Aihara, Hiroyuki, Karasik, Michael S., Ngamruengphong, Saowanee, Aadam, Abdul Aziz, Othman, Mohamed O., Sharma, Neil, Grimm, Ian S., Rostom, Alaa, Elmunzer, B. Joseph, Jawaid, Salmaan A., Westerveld, Donevan, Perbtani, Yaseen B., Hoffman, Brenda J., Schlachterman, Alexander, Siegel, Amanda, Coman, Roxana M., Wang, Andrew Y., and Yang, Dennis

Published
2021
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3. Late Recurrence of Barrett’s Esophagus After Complete Eradication of Intestinal Metaplasia is Rare: Final Report From Ablation in Intestinal Metaplasia Containing Dysplasia Trial

Author

Sampliner, Richard E., Fleischer, David E., Sharma, Virender K., Eisen, Glenn M., Fennerty, M. Brian, Hunter, John G., Bronner, Mary P., Goldblum, John R., Bennett, Ana E., Mashimo, Hiroshi, Rothstein, Richard I., Gordon, Stuart R., Edmundowicz, Steven A., Muthusamy, V. Raman, Chang, Kenneth J., Kimmey, Michael B., Spechler, Stuart J., Siddiqui, Ali A., Souza, Rhonda F., Infantolino, Anthony, Dumot, John A., Falk, Gary W., Jobe, Blair A., Hawes, Robert H., Hoffman, Brenda J., Sharma, Prateek, Chak, Amitabh, Cotton, Cary C., Wolf, W. Asher, Overholt, Bergein F., Li, Nan, Lightdale, Charles J., Wolfsen, Herbert C., Pasricha, Sarina, Wang, Kenneth K., and Shaheen, Nicholas J.

Published
2017
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6. Durability of Radiofrequency Ablation in Barrett's Esophagus With Dysplasia

Author

Shaheen, Nicholas J., Overholt, Bergein F., Sampliner, Richard E., Wolfsen, Herbert C., Wang, Kenneth K., Fleischer, David E., Sharma, Virender K., Eisen, Glenn M., Fennerty, M. Brian, Hunter, John G., Bronner, Mary P., Goldblum, John R., Bennett, Ana E., Mashimo, Hiroshi, Rothstein, Richard I., Gordon, Stuart R., Edmundowicz, Steven A., Madanick, Ryan D., Peery, Anne F., Muthusamy, V. Raman, Chang, Kenneth J., Kimmey, Michael B., Spechler, Stuart J., Siddiqui, Ali A., Souza, Rhonda F., Infantolino, Anthony, Dumot, John A., Falk, Gary W., Galanko, Joseph A., Jobe, Blair A., Hawes, Robert H., Hoffman, Brenda J., Sharma, Prateek, Chak, Amitabh, and Lightdale, Charles J.

Published
2011
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12. Radiofrequency Ablation in Barrettʼs Esophagus with Dysplasia

Author

Shaheen, Nicholas J., Sharma, Prateek, Overholt, Bergein F., Wolfsen, Herbert C., Sampliner, Richard E., Wang, Kenneth K., Galanko, Joseph A., Bronner, Mary P., Goldblum, John R., Bennett, Ana E., Jobe, Blair A., Eisen, Glenn M., Fennerty, Brian M., Hunter, John G., Fleischer, David E., Sharma, Virender K., Hawes, Robert H., Hoffman, Brenda J., Rothstein, Richard I., Gordon, Stuart R., Mashimo, Hiroshi, Chang, Kenneth J., Muthusamy, Raman V., Edmundowicz, Steven A., Spechler, Stuart J., Siddiqui, Ali A., Souza, Rhonda F., Infantolino, Anthony, Falk, Gary W., Kimmey, Michael B., Madanick, Ryan D., Chak, Amitabh, and Lightdale, Charles J.

Published
2009
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23. EUS-guided fine needle aspiration of the liver: Indications, yield, and safety based on an international survey of 167 cases

Author

tenBerge, Jorgen, Hoffman, Brenda J., Hawes, Robert H., van Enckevort, Conny, Giovannini, Marc, Erickson, Richard A., Catalano, Marc F., Fogel, Roberto, Mallery, Shawn, Faigel, Douglas O., Ferrari, Angelo P., Waxman, Irving, Palazzo, Larent, Ben-Menachem, Tamir, Jowell, Paul S., McGrath, Kevin M., Kowalski, Thomas E., Nguyen, Cuong C., Wassef, Wahid Y., Yamao, Keiji, Chak, Amitabh, Greenwald, Bruce D., Woodward, Timothy A., Vilmann, Peter, Sabbagh, Luis, and Wallace, Michael B.

Published
2002
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38. Modeling rectal cancer to advance neoadjuvant precision therapy.

Author

Janakiraman, Harinarayanan, Zhu, Yun, Becker, Scott A., Wang, Cindy, Cross, Ashley, Curl, Emily, Lewin, David, Hoffman, Brenda J., Warren, Graham W., Hill, Elizabeth G., Timmers, Cynthia, Findlay, Victoria J., and Camp, Ernest R.

Subjects
RECTAL cancer, COLON cancer, CANCER patient care, ANIMAL models in research, PATIENT selection, INVESTIGATIONAL therapies
Abstract

Progress in rectal cancer therapy has been hindered by the lack of effective disease‐specific preclinical models that account for the unique molecular profile and biology of rectal cancer. Thus, we developed complementary patient‐derived xenograft (PDX) and subsequent in vitro tumor organoid (PDTO) platforms established from preneoadjuvant therapy rectal cancer specimens to advance personalized care for rectal cancer patients. Multiple endoscopic samples were obtained from 26 Stages 2 and 3 rectal cancer patients prior to receiving 5FU/RT and implanted subcutaneously into NSG mice to generate 15 subcutaneous PDXs. Second passaged xenografts demonstrated 100% correlation with the corresponding human cancer histology with maintained mutational profiles. Individual rectal cancer PDXs reproduced the 5FU/RT response observed in the corresponding human cancers. Similarly, rectal cancer PDTOs reproduced significant heterogeneity in cellular morphology and architecture. PDTO in vitro 5FU/RT treatment response replicated the clinical 5FU/RT neoadjuvant therapy pathologic response observed in the corresponding patient tumors (p < 0.05). The addition of cetuximab to the 5FU/RT regiment was significantly more sensitive in the rectal cancer PDX and PDTOs with wild‐type KRAS compared to mutated KRAS (p < 0.05). Considering the close relationship between the patient's cancer and the corresponding PDX/PDTO, rectal cancer patient‐derived research platforms represent powerful translational research resources as population‐based tools for biomarker discovery and experimental therapy testing. In addition, our findings suggest that cetuximab may enhance RT effectiveness by improved patient selection based on mutational profile in addition to KRAS or by developing a protocol using PDTOs to identify sensitive patients. What's new? Rectal cancer has largely been omitted in prior colorectal cancer (CRC) patient‐derived xenograft (PDX) and tumor organoid (PDTO) investigations, due to the vast majority of rectal cancers being radiated prior to surgery. Here, the authors established novel complementary PDX and subsequent PDTO platforms from pre‐neoadjuvant therapy rectal cancers. Furthermore, they demonstrated that cetuximab can selectively potentiate radiation based on KRAS mutational status and identified further mutations that may impact cetuximab sensitivity. Their results also indicated that rectal cancer PDTOs may serve as a clinical tool to identify 5FU/RT‐resistant cancer and assist clinicians with tailoring appropriate personalized therapy for the patient. [ABSTRACT FROM AUTHOR]

Published
2020
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43. Response.

Author

King, William, Gorrepati, V. Subhash, Draganov, Peter, Aihara, Hiroyuki, Karasik, Michael, Ngamruengphong, Saowanee, Aadam, Abdul Aziz, Othman, Mohamed O., Sharma, Neil, Grimm, Ian S., Rostom, Alaa, Elmunzer, B. Joseph, Hoffman, Brenda J., and Yang, Dennis

Published
2023
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47. Endoscopic ultrasound for thoracic malignancy: a review.

Author

Savoy, Alan D., Ravenel, James G., Hoffman, Brenda J., and Wallace, Michael B.

Subjects
CANCER treatment, CANCER patients, CANCER prognosis, MEDICAL imaging systems
Abstract

Accurate cancer staging is critical in providing the most appropriate therapy for patients with lung cancer. The decision to attempt a curative surgery or avoid an unnecessary surgery is dependent on accurate staging. In the case of non-small-cell lung cancer (NSCLC), the most important parameters for optimal treatment and prognosis are the presence of cancer spread to the lymph nodes within the mediastinum and to distant organs. Endoscopic ultrasound (EUS) has become an important tool for the assessment of mediastinal lymph nodes and in some cases, distant organ metastases, because of its minimally invasive access to these sites through a transesophageal, transgastric, or transduodenal approach. The capability of performing fine needle aspiration (FNA) has greatly improved the accuracy and acceptability of EUS for lung cancer staging. This review will outline the basic principals of EUS-guided lung cancer staging and EUS-FNA techniques and outline the indications and contraindications to EUS staging of thoracic malignancy. [Copyright &y& Elsevier]

Published
2005
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50. Endoscopic Retrograde Cholangiopancreatography in Pregnancy.

Author

Jamidar, Priya A., Beck, Gregory J., Hoffman, Brenda J., Lehman, Glen A., Hawes, Robert H., Agrawal, Rad M., Ashok, Puducheri S., Ravi, T. Jan, Cunningham, John T., Troiano, Frank, Sherman, Stuart, and Brodmerkel Jr., George T.

Subjects
PREGNANCY, FETAL death, CONCEPTION, REPRODUCTION, PREGNANCY complications
Abstract

Background: Pancreaticobiliary disease in pregnancy is relatively uncommon. The frequency of choledocholithiasis in pregnancy requiring intervention has been reported to be as tow as one in 1200 deliveries. Traditionally, intervention in these patients has been surgical. Although surgery has an overall low morbidity and mortality for the expectant mother, it carries with it a 4- to 6-wk recovery period and a possibly increased risk of fetal wastage. Published information regarding the role and safety of ERCP in pregnancy is limited. This series of 23 pregnant patients undergoing ERCP was collected from six different medical centers. Methods: Twenty-three pregnant patients with symptomatic pancreaticobiliary disease underwent a total of 29 ERCPs (three patients had diagnostic ERCP, and 20 had therapeutic ERCP). Fifteen, eight, and six procedures were performed in the first, second, and third trimesters, respectively. The only ERCP complication was pancreatitis in one patient. There was one spontaneous abortion (3 months after ERCP) and one neonatal death; however, casual relationship to ERCP was not apparent. Conclusion: Diagnostic and therapeutic ERCP appears reasonably safe and effective in pregnancy. Cautious and selective use of this procedure offers a viable alternative to surgery or observation in patients with emergent pancreaticobiliary problems. [ABSTRACT FROM AUTHOR]

Published
1995

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