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11. General Discussion

Author

Clarkson, R. S., Hodges, S. D., Cairns, A. J. G., Leach, T., and Mariathasan, J. W. E.

Published
1994

18. The neural basis of effective memory therapy in a patient with limbic encephalitis

Author

Berry, E., Hampshire, A., Rowe, J., Hodges, S., Kapur, N., Watson, P., Browne, G., Smyth, G., Wood, K., and Owen, A.M.

Subjects
Encephalitis -- Care and treatment, Encephalitis -- Research, Amnesia -- Care and treatment, Amnesia -- Research, Magnetic resonance imaging -- Usage, Magnetic resonance imaging -- Research, Images, Photographic -- Usage, Images, Photographic -- Research, Photographs -- Usage, Photographs -- Research, Health, Psychology and mental health
Published
2009

33. Autoimmune chronic active hepatitis in a family

Author

Hodges, S., Lobo-Yeo, A., Donaldson, P., Tanner, M.S., and Vergani, D.

Subjects
Genetic disorders -- Physiological aspects, Autoimmune diseases -- Genetic aspects, Chronic active hepatitis -- Physiological aspects, Health
Abstract

In autoimmune diseases, the body's immune system mistakenly identifies a tissue type or secretory product as being a foreign substance, and produces antibodies against those parts of itself that it identifies as such. Insulin-dependent diabetes mellitus and celiac disease are two well studied forms of autoimmune disease; recent evidence suggests that at least one variant of chronic active hepatitis (an inflammatory condition affecting the liver) may have an autoimmune component. Close relatives of patients with chronic active hepatitis are reported to have a higher incidence of autoimmune disorders, suggesting a strong genetic basis; no compelling evidence has been reported to date documenting increased intrafamily incidence of this condition. A family is described in which five of seven siblings developed autoimmune conditions including multiple instances of chronic active hepatitis. Three sisters developed chronic active hepatitis, one sister yielded blood test results that indicated a degree of autoimmunity (asymptomatic at that point), and another sister developed celiac and thyroid autoimmune conditions. Two brothers were healthy and had no signs of autoimmunity of any sort. Biochemical analysis of the immune system background (determination of HLA type) of each sibling in the family indicated that, in association with the female sex, the DR3 histocompatibility antigen seemed to be more important than the B8 antigen in conferring susceptibility to autoimmune hepatitis. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

34. Reversible valproate hepatotoxicity due to mutations in mitochondrial DNA polymerase V (POLG1)

Author

McFarland, R., Hudson, G., Taylor, R.W., Green, S.H., Hodges, S., McKieman, P.J., Chinnery, P.F., and Ramesh, V.

Subjects
Divalproex -- Dosage and administration, Divalproex -- Complications and side effects, Divalproex -- Case studies, Valproic acid -- Dosage and administration, Valproic acid -- Complications and side effects, Valproic acid -- Case studies, Liver failure -- Development and progression, Liver failure -- Genetic aspects, Liver failure -- Case studies, Mitochondrial DNA -- Genetic aspects, Mitochondrial DNA -- Case studies
Published
2008

48. Decomposition, nitrogen and carbon mineralization from food and cover crop residues in the central plateau of Haiti.

Author

Lynch, M., Mulvaney, M., Hodges, S., Thompson, T., and Thomason, W.

Subjects
BIODEGRADATION, MINERALIZATION, CROP residues, FOOD crops, COVER crops, NO-tillage, NUTRIENT cycles
Abstract

Cover crops are a major focus of conservation agriculture efforts because they can provide soil cover and increase nutrient availability after their mineralization in cropping systems. To evaluate the effect of residue type and placement on rate of decomposition and carbon (C) and nitrogen (N) mineralization, residues from two food crops, maize ( Zea mays L.) and common bean ( Phaseolus vulgaris L.), and two promising cover crops, sunn hemp ( Crotalaria juncea L.) and sorghum sudangrass ( Sorghum bicolor [L.] Moench x S. bicolor var. Sudanese [Piper] Stapf) were used in a litterbag study in the Central Plateau region of Haiti from May to September, 2013. Residues were placed in litterbags at a rate equivalent to 3.25 Mg residue ha either on the soil surface or buried at 15 cm to represent a tilled and no-tillage system, respectively. Initial C:N ratios were: maize > common bean > sorghum sudangrass > sunn hemp. Highest residue mass loss rates and C and N mineralization generally occurred in the reverse order. Overall, surface-placed residues decomposed more slowly with 40 and 17 % of initial residue mass of surface and buried residues, respectively, remaining at 112 days. Carbon and N mineralization was higher when residues were buried. Net N mineralization of buried residues was 0.12, 0.07, 0.06, and 0.03 g N g residue for sunn hemp, sorghum sudangrass, maize, and common bean, respectively over 112 days. To achieve the goal of increasing nutrient supply while maintaining year-round cover, a combination of grass and legume cover crops may be required with benefits increasing over multiple seasons. [ABSTRACT FROM AUTHOR]

Published
2016
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