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The phenomenon of drug craving among adolescents with substance use disorders has been largely overlooked by addiction researchers. This study was designed to: (1) assess craving among adolescents with polysubstance use disorders (SUDs); and (2) examine the association between personality traits and craving among adolescents with SUDs. Craving was found to be amultidimensional phenomenon that demonstrated some degree of consistency across substances (in this case, marijuana and alcohol). Selected personality traits were associated with distinct components of craving; for example, adolescent substance users who obtained high sensation-seeking scores tended to crave the excitement associated with drug use. Adolescents who obtained high anxious-neuroticism scores tended to crave the experience of distress relief associated with drug use [ABSTRACT FROM AUTHOR]

Structural flexibility of molecule-based systems is key to realizing the novel functionalities. Tuning the structure in the atomic scale enables us to manipulate the quantum state in the molecule-based system. Here we present the reversible Hamiltonian manipulation in a single-molecule quantum dot consisting of an iron phthalocyanine molecule attached to an Au electrode and a scanning tunnelling microscope tip. We precisely controlled the position of Fe2+ ion in the molecular cage by using the tip, and tuned the Kondo coupling between the molecular spins and the Au electrode. Then, we realized the crossover between the strong-coupling Kondo regime and the weak-coupling regime governed by spin-orbit interaction in the molecule. The results open an avenue to simulate low-energy quantum many-body physics and quantum phase transition through the molecular flexibility. [ABSTRACT FROM AUTHOR]