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How is it possible to survive as a woman senior leader in the gendered managerial academy? In this autoethnographical article, I illustrate the lived reality, insecurity, and struggle of academic leadership. Drawing from three vignettes, I discuss decision‐making processes, blatant sexist aggressions, and the problematic negation of affect and personal life. Their critical contribution is to expose the consequences of gendered managerialism in the neo‐liberal academy and the false promise of 'leadership', in which women continue to experience gender challenges, sexism, and the risk of burnout in their everyday experiences. However, I also show how it is possible to counter the detrimental effects of gendered managerialism through four forms of resistance: resistance through embodied affective authenticity; resistance through solidarities, and social relations with others; resistance through feminist activism; and resistance by stepping back. [ABSTRACT FROM AUTHOR]

This reflective article addresses the role and power of accounting in creating, perpetuating and, potentially overcoming, inequalities. Such inequalities may be based on personal characteristics, including gender, or relate to the global effects of neo‐liberalism and broader structural inequalities resulting in colonialism, slavery, and repression. The article illustrates how accounting operates in society, its power and effects, particularly the role of accounting as a calculative practice and as a profession in creating and perpetuating inequalities. However, accounting can also subvert or overcome inequalities, when positioned with critical and emancipatory intent. Three areas of going beyond accounting's current confines are discussed where it is proposed that accounting research and practice can contribute to an enhanced understanding of intersectional perspectives and systemic inequalities, and, importantly, ways of overcoming them. These are: going beyond disciplinary orientation to embrace feminist interdisciplinarity; going beyond borders to embrace reflexive intersubjectivity and contextualized knowledge; and going beyond stasis towards academic activism. [ABSTRACT FROM AUTHOR]

Drawing from a study of women on boards in Egypt, in this methodological article we propose and illustrate four parts of a multidimensional feminist hermeneutic process for Interpretative Phenomenological Analysis (IPA) as a method of uncovering hidden stories of marginalised voices and unrecognised contexts. Underpinned by Heidegger’s hermeneutic phenomenology, our novel four-stage approach includes visual images as an alternative mode of data (re)presentation within the hermeneutic circle of interpretation. We show how IPA enables (re)imagining new possibilities of doing and writing feminist research and promotes an in-depth knowledge of the lived experience of women, as well as the systemic issues that concern them. Our contribution highlights our IPA process and outcomes, as a form of feminist praxis that prioritises the recognition of marginalisation and Otherness, embraces an ethic of care towards research participants and researchers, and provides a transformative, emancipatory opportunity for reciprocal learning, awareness and knowing of experience. [ABSTRACT FROM AUTHOR]

INTRODUCTION: MODEL‐AD (Model Organism Development and Evaluation for Late‐Onset Alzheimer's Disease) is creating and distributing novel mouse models with humanized, clinically relevant genetic risk factors to capture the trajectory and progression of late‐onset Alzheimer's disease (LOAD) more accurately. METHODS: We created the LOAD2 model by combining apolipoprotein E4 (APOE4), Trem2*R47H, and humanized amyloid‐beta (Aβ). Mice were subjected to a control diet or a high‐fat/high‐sugar diet (LOAD2+HFD). We assessed disease‐relevant outcome measures in plasma and brain including neuroinflammation, Aβ, neurodegeneration, neuroimaging, and multi‐omics. RESULTS: By 18 months, LOAD2+HFD mice exhibited sex‐specific neuron loss, elevated insoluble brain Aβ42, increased plasma neurofilament light chain (NfL), and altered gene/protein expression related to lipid metabolism and synaptic function. Imaging showed reductions in brain volume and neurovascular uncoupling. Deficits in acquiring touchscreen‐based cognitive tasks were observed. DISCUSSION: The comprehensive characterization of LOAD2+HFD mice reveals that this model is important for preclinical studies seeking to understand disease trajectory and progression of LOAD prior to or independent of amyloid plaques and tau tangles. Highlights: By 18 months, unlike control mice (e.g., LOAD2 mice fed a control diet, CD), LOAD2+HFD mice presented subtle but significant loss of neurons in the cortex, elevated levels of insoluble Ab42 in the brain, and increased plasma neurofilament light chain (NfL).Transcriptomics and proteomics showed changes in gene/proteins relating to a variety of disease‐relevant processes including lipid metabolism and synaptic function.In vivo imaging revealed an age‐dependent reduction in brain region volume (MRI) and neurovascular uncoupling (PET/CT).LOAD2+HFD mice also demonstrated deficits in acquisition of touchscreen‐based cognitive tasks. [ABSTRACT FROM AUTHOR]

This article addresses feminist solidarity between a daughter and a mother in academia. We are respectively a PhD student and aspirant early career academic, and a senior academic, both identifying as feminists and engaging in forms of activism to improve gender equality. We take an autoethnographical approach, drawing from vignettes and conversational dialogues, focusing on feminist perspectives, activism, our contested identities, fears and hopes. We reflect on the challenges of living feminist lives whilst working in gendered university institutions and highlight strategies to enact feminism whilst trying to progress and maintain an academic career at different positions on the career spectrum. Our contribution is to highlight differential experiences and understandings of academic activism between daughter and mother, early-career academics and senior leaders, in order to enhance mutual understanding and action on feminist solidarity and praxis in the academy. [ABSTRACT FROM AUTHOR]

Background: Early skin-to-skin care (SSC) has been shown to improve outcomes after preterm birth, including improved clinical stability and establishment of breastfeeding. Recent evidence suggests the most unstable infants get the most benefit, yet these infants are not consistently offered opportunities for SSC because of safety concerns and discomfort of the care team. Purpose: To identify barriers and implement a multidimensional approach to increase SSC within the first 72 hours of life among infants born less than 28 weeks' gestation and less than 1,000 g in a Level IV university-based regional intensive care nursery. Methods: Using Institute of Healthcare Improvement quality improvement methodology, a multidisciplinary team identified barriers to SSC and developed targeted interventions, including a unit-specific protocol; widespread parent, staff, and provider education; and an infant readiness checklist. The primary outcome was the rate of SSC within 72 hours. The balancing measure was the rate of severe intraventricular hemorrhage (IVH). Data were collected from monthly chart review and analyzed with statistical process control charts. The aim was to increase SSC within 72 hours of birth from 7 percent to greater than 80 percent within 12 months for infants born less than 28 weeks' gestation or less than 1,000 g. Results: Between June 2017 and December 2019, there were 52 extremely preterm infants included in the project (15 preintervention and 37 postintervention). The rate of SSC within the first 72 hours increased from 7 to 84 percent. There has been no increase in any or severe IVH during the project period despite the increased rate of SSC. Implications for Practice: Implementation of multidimensional, multidisciplinary interventions for reducing barriers to early SSC in extremely preterm infants resulted in rapid adoption of SSC in the first 72 hours of life without increasing severe IVH in this high-risk population. [ABSTRACT FROM AUTHOR]

In order to deliver public value, the UK government sought to build relationships and connect 'the public' with public servants (including back-office workers), but with what effect? Drawing on interviews with public service accountants, the authors found that how these accountants conceptualized 'the public'--as society or people--shaped whether public value was considered as a monetary or moral concept. Accountants who regarded the public as people spoke of an improper level of involvement and struggled to maintain their professionalism. [ABSTRACT FROM AUTHOR]

Purpose – The purpose of this paper is to explore the potential of the metaphor of capital, and to chart the development of the multiple capitals concept in the International < IR > Framework and consider how it might develop and be used. In doing so, the paper discusses the implications of the contributions to this special issue in the further development of the capitals concept. Design/methodology/approach – The authors draw on documents of the International Integrated Reporting Council (IIRC) and review the literature on capitals to consider the formation of the metaphor of multiple capitals. This is reflected upon while recognising the varied involvement of the authors with the IIRC capitals conception. The challenges of conceiving a multiple capitals framework are critiqued with reference to empirical and theoretical contributions drawn from recognition of planetary boundaries, gendered capitals, power and intersection of capitals and important practical and conceptual insights raised by papers in this special issue. Findings – The authors find that the agenda of the IIRC is a shift from a “financial capital market system” to an “inclusive capital market system” through recognition of multiple capitals and integrated reporting and thinking. It is emphasised that their vision is not intended as a call for the measurement of these various capitals in monetary terms alone. Through insights from research on planetary boundaries and gendered capitals, the authors critique the potential communsurability of capitals and make visible potential tensions between them. Some of the challenges and opportunities when reporting on multiple capitals are recognised. These include: use of the capitals terminology; analysing connectivity between the capitals; the extent to which value created (and depleted) by each capital should be monetised and highlight possibilities for future research. Practical implications – Reflecting on the vision of the IIRC, the authors use the critical potential of the metaphor to highlight the IIRC’s vision and understand the role of multiple capitals and potential tensions between them. The authors provide normative insights into the need for engagement on the philosophies of integrated thinking and symbolism of capital and multiple capitals as the way forward. Originality/value – It is through discussions around multiple capitals – what is in, what is out, how capital is valued – that metaphors will be (re)created. By considering the notion of capital in < IR > and critiquing this with reference to research insights, the authors seek to open up debate on the framing of multiple capitals. [ABSTRACT FROM AUTHOR]

The ubiquitin-proteasome pathway (UPP) of protein degradation has many roles in synaptic plasticity that underlies memory. Work on both invertebrate and vertebrate model systems has shown that the UPP regulates numerous substrates critical for synaptic plasticity. Initial research took a global view of ubiquitin-protein degradation in neurons. Subsequently, the idea of local protein degradation was proposed a decade ago. In this review, we focus on the functions of the UPP in long-term synaptic plasticity and discuss the accumulated evidence in support of the idea that the components of the UPP often have disparate local roles in different neuronal compartments rather than a single cell-wide function. [ABSTRACT FROM AUTHOR]

This article examines the way in which identity workspaces function to facilitate and stimulate transitions at mid-career. We explore our collective experience as a cohort of a mid-career management academics participating in a 2-year fellowship program, which acted as an identity workspace in which mid-career identity work took place. Using insights from our narratives, interviews, and experiences, we demonstrate how the fellowship provided rites of passage, experimentation, and social defenses, and we analyze our identity work, in relation to mid-career development, disciplinary orientation, and relationships with existing institutions. We conceptualize the identity workspace as a liminal zone in which to experiment with provisional selves, finding that identity workspaces function through alterity as well as identity, and at a communal as well as individual level. The article draws out the challenges for the academic community to facilitate mid-career identity work experienced in this identity workspace within existing institutions. [ABSTRACT FROM PUBLISHER]

Proteolysis by the ubiquitin-proteasome pathway appears to have a complex role in synaptic plasticity, but its various functions remain to be elucidated. Using late phase long-term potentiation (L-LTP) in the hippocampus of the mouse as a model for long-term synaptic plasticity, we previously showed that inhibition of the proteasome enhances induction but blocks maintenance of L-LTP. In this study, we investigated the possible mechanisms by which proteasome inhibition has opposite effects on L-LTP induction and maintenance. Our results show that inhibiting phosphatidyl inositol-3 kinase or blocking the interaction between eukaryotic initiation factors 4E (eIF4E) and 4G (eIF4G) reduces the enhancement of L-LTP induction brought about by proteasome inhibition suggesting interplay between proteolysis and the signaling pathway mediated by mammalian target of rapamycin (mTOR). Also, proteasome inhibition leads to accumulation of translational activators in the mTOR pathway such as eIF4E and eukaryotic elongation factor 1A (eEF1A) early during L-LTP causing increased induction. Furthermore, inhibition of the proteasome causes a buildup of translational repressors, such as polyadenylate-binding protein interacting protein 2 (Paip2) and eukaryotic initiation factor 4E-binding protein 2 (4E-BP2), during late stages of L-LTP contributing to the blockade of L-LTP maintenance. Thus, the proteasome plays a critical role in regulating protein synthesis during L-LTP by tightly controlling translation. Our results provide novel mechanistic insights into the interplay between protein degradation and protein synthesis in long-term synaptic plasticity. [ABSTRACT FROM AUTHOR]

Purpose – The aim of this paper is to critically evaluate sexuality and sexual symbolism within the organisational culture of an accounting firm to explore how it is implicated in processes of gendering identities of employees within the firm. Design/methodology/approach – The paper uses a reflexive autoethnographical approach, including short vignettes, to analyse the inter-relationships between gender, sexuality and power. Findings – By exploring the symbolic role of artefacts, images, language, behaviours and buildings in creating and maintaining gendered relations, male sexual cultures and female sexual countercultures, the paper finds that sexual symbolism in this accounting firm entwines gendered power and domination, practice and resistance, in complex cultural codes and behaviours. It draws out implications for organisations and accounting research. Originality/value – The paper extends current conceptualisation of gendered constructs in accounting to include sexuality; applies organisational and feminist theory to autoethnographical experience in accounting; and contributes a seldom-seen insight into the organisational symbolism and culture of a small accounting firm, rather than the oft-seen focus on large firms. [ABSTRACT FROM AUTHOR]

This article explores the professional identity formation of professionals and its relationship with their embodied physical image, with a particular focus on women in accounting and law. It examines the role of the professional services firm in defining a professional body image, socialization processes that contribute to the definition of the professional body, the role of the client in defining professionalism, the legitimation of certain types of embodied identities and the importance of the body in defining gendered perceptions of the self. The article draws on Bourdieu's concepts of capital to explore how physical capital is implicated in processes of socialization, subordination and control. By examining the development of professional embodiment of women in accounting and law, and drawing on interviews with contemporary practitioners, the article argues that notions of physical capital remain highly gendered in professional services firms, with implications for equality and diversity in the professions. [ABSTRACT FROM AUTHOR]

Purpose – The purpose of this paper is to explore a number of tensions arising in the presentation of autoethnographical research. Design/methodology/approach – The paper provides a reflexive autoethnographical account of undertaking and publically presenting autoethnographical research. Findings – The paper problematises the extent and form of disclosure; the voice and representation of the researcher; the difficulties in dealing with sensitive subjects; conflicts between public and private domains; questions of validity; the extent and form of theorisation of autoethnographical narratives; and emotion and performativity in presenting autoethnographical research. Originality/value – The paper provides an analysis of the potential of autoethnography, while exploring the presentational and performative context of academia. [ABSTRACT FROM AUTHOR]

Purpose – The purpose of this paper is to investigate the possibilities and problems for collaboration in the area of corporate social responsibility (CSR) and sustainability. The paper explores the nature and concept of collaboration and its forms, and critically evaluates the potential contribution a collaborative approach between agencies might offer to these agendas. Design/methodology/approach – The paper explores different forms of research on collaboration, together with a UK Government report on collaboration, to evaluate how the issue is addressed in theory and practice. Findings – Sustainable development creates extensive challenges for a wide range of agencies, including governments, non-governmental organizations, businesses and civil society. It is unlikely, however, that solutions will be found in any one quarter. Collaboration between agencies in some form would seem a logical step in supporting measures towards a more responsible and environmentally sustainable global economy. Originality/value – The paper offers new insights into developing a research and praxis agenda for collaborative possibilities towards the advancement of CSR and sustainability. [ABSTRACT FROM AUTHOR]

Purpose – The purpose of this paper is to explore the effects of undertaking research on both participants and researcher. Design/methodology/approach – Taking an auto/ethnographic approach, the paper provides a reflexive account of the impact of research on identity construction, especially in relation to the specific areas of the accounting profession and motherhood. Findings – There are potential therapeutic effects of undertaking and participating in research. Originality/value – The paper provides an analysis of a little considered area in qualitative research, namely the effects of the research on those involved. [ABSTRACT FROM AUTHOR]

Purpose – The purpose of this paper is to explore the effects of undertaking research on both participants and researcher. Design/methodology/approach – Taking an auto/ethnographic approach, the paper provides a reflexive account of the impact of research on identity construction, especially in relation to the specific areas of the accounting profession and motherhood. Findings – There are potential therapeutic effects of undertaking and participating in research. Originality/value – The paper provides an analysis of a little considered area in qualitative research, namely the effects of the research on those involved. [ABSTRACT FROM AUTHOR]

Maintenance of long-term synaptic plasticity requires gene expression mediated by cAMP-responsive element binding protein (CREB). Gene expression driven by CREB can commence only if the inhibition by a transcriptional repressor activating transcription factor 4 (ATF4; also known as CREB2) is relieved. Previous research showed that the removal of ATF4 occurs through ubiquitin-proteasome-mediated proteolysis. Using chemically induced hippocampal long-term potentiation (cLTP) as a model system, we investigate the mechanisms that control ATF4 degradation. We observed that ATF4 phosphorylated at serine-219 increases upon induction of cLTP and decreases about 30 min thereafter. Proteasome inhibitor β-lactone prevents the decrease in ATF4. We found that the phosphorylation of ATF4 is mediated by cAMP-dependent protein kinase. Our initial experiments towards the identification of the ligase that mediates ubiquitination of ATF4 revealed a possible role for β-transducin repeat containing protein (β-TrCP). Regulation of ATF4 degradation is likely to be a mechanism for determining the threshold for gene expression underlying maintenance of long-term synaptic plasticity and by extension, long-term memory. [ABSTRACT FROM AUTHOR]