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IntroductionThe aim of this study was to examine the psychometric properties of a Norwegian translation of the Sensation Seeking Scale for Children (SSSC), designed for children between 7 and 12 years of age.MethodsA sample of 393 children (7–10 years old) were recruited to participate in the study. The SSSC was administered through interviews with each child, wherein their responses to the SSSC questionnaire were recorded on a tablet.ResultsAnalysis of internal consistency reliability did not show acceptable reliability for all subscales, and confirmatory factor analysis (CFA) showed that the Thrill Seeking and Behavioral Intensity subscales were associated and somewhat overlapping, while Behavioral Inhibition appeared as a single factor. A further explanatory factor analysis (EFA) revealed a two-factor solution. CFA of the two-factor solution resulted in the removal of some items in both factors due to low factor loadings. The final factors resulting from this analysis were Thrill and Intensity Seeking (13 items) and Behavioral Inhibition (7 items). The results also show that boys scored higher than girls on Thrill and Intensity Seeking while girls scored higher than boys on Behavioral Inhibition. Furthermore, age was positively associated with both subscales, meaning that older children tended to score higher.DiscussionThe results in this study suggest that measures of children’s sensation seeking might be sensitive to cultural contexts and that, at least in a Norwegian population, a two-factor solution of the SSSC is recommended.

The objective of this study was to examine the psychometric properties of the Adolescent Motor Competence Questionnaire (AMCQ) for Norwegian adolescents. To this end, a sample of 349 Norwegian-speaking adolescents (13–16 years old) were recruited and completed the AMCQ. Initial results showed that confirmatory factor analysis (CFA) did not indicate statistical support for previous statistical models reported in the literature. Further analysis indicated factorial validity for a novel three-factor model identified through exploratory factor analysis, encompassing measures of fine motor skill (α = 0.65), gross motor skill (α = 0.74), and activities of daily living (ADL; α = 0.79) with acceptable internal consistency coefficients. Subsequent analysis indicated indices of measurement invariance in the study sample, as males rated their competence higher compared to females in 19 of the 27 items, and better model fit was obtained for the female adolescents. Strong invariance was tenable, and no factor mean differences were found across older and younger adolescents or across BMI scores. Overall results thus suggested that the AMCQ has acceptable psychometric properties and can be confidently used in further work with perceived motor competence in Norwegian 13–16 years-old adolescents.

Although assessing motor competence is vital to advancing current understandings of motor development and its significance in various fields, no consensus exists on how the construct should be operationalised and measured. Existing approaches to assessing motor competence in children typically involve applying qualitative and/or quantitative scoring procedures in which children’s performance is evaluated according to certain levels of assessment-specific task performance dependent upon predefined sets of instructions and procedures. Building upon ecological dynamics as a framework, different levels of motor competence can be identified in children’s attempts to coordinate their degrees of freedom while trying to complete the interactive task and environmental constraints. Given the dynamic, nonlinear features of that coordinating process, assessments need to consider the inherit structure of inter- and intra-individual variability in patterns of movement. Against that background, we investigated 7–10-year-old children’s (n = 58) whole-body joint kinematics as they freely explored a balance beam in a virtual reality playground. Specifically, we used exploratory cluster analysis to examine the discriminatory capability of utilising joint-specific sample entropy as a window into individual differences in movement coordination that emerged from children’s exploration of the constraints embedded in the virtual task. Among the results, three clusters of children with distinct profiles of movement variability emerged, all of which showed heterogeneous levels of repeatability in joint movements in combination with the level of spatiotemporal exploration on the balance beam that could not be explained by between-cluster differences in age and gender distributions. Those findings suggest that entropy from whole-body movements can be used to cluster children into distinct groups with different profiles regarding the structure of movement variability, which can inform new understandings and the development of gross motor competence assessments for children.

BackgroundResearch indicates that risky play benefits children’s risk assessment and risk management skills and offers several positive health effects such as resilience, social skills, physical activity, well-being, and involvement. There are also indications that the lack of risky play and autonomy increases the likelihood of anxiety. Despite its well-documented importance, and the willingness of children to engage in risky play, this type of play is increasingly restricted. Assessing long-term effects of risky play has been problematic because of ethical issues with conducting studies designed to allow or encourage children to take physical risks with the potential of injury. ObjectiveThe Virtual Risk Management project aims to examine children’s development of risk management skills through risky play. To accomplish this, the project aims to use and validate newly developed and ethically appropriate data collection tools such as virtual reality, eye tracking, and motion capturing, and to provide insight into how children assess and handle risk situations and how children’s past risky play experiences are associated with their risk management. MethodsWe will recruit 500 children aged 7-10 years and their parents from primary schools in Norway. Children’s risk management will be measured through data concerning their risk assessment, risk willingness, and risk handling when completing a number of tasks in 3 categories of virtual reality scenarios: street crossing, river crossing, and playing on playground equipment. The children will move around physically in a large space while conducting the tasks and wear 17 motion-capturing sensors that will measure their movements to analyze motor skills. We will also collect data on children’s perceived motor competence and their sensation-seeking personality. To obtain data on children’s risk experiences, parents will complete questionnaires on their parental style and risk tolerance, as well as information about the child’s practical risk experience. ResultsFour schools have been recruited to participate in data collection. The recruitment of children and parents for this study started in December 2022, and as of April 2023, a total of 433 parents have consented for their children to participate. ConclusionsThe Virtual Risk Management project will increase our understanding of how children’s characteristics, upbringing, and previous experiences influence their learning and ability to handle challenges. Through development and use of cutting-edge technology and previously developed measures to describe aspects of the children’s past experiences, this project addresses crucial topics related to children’s health and development. Such knowledge may guide pedagogical questions and the development of educational, injury prevention, and other health-related interventions, and reveal essential areas for focus in future studies. It may also impact how risk is addressed in crucial societal institutions such as the family, early childhood education, and schools. International Registered Report Identifier (IRRID)DERR1-10.2196/45857

This study examines constituent year effect (CYE) and race performance among junior alpine skiers in the World Championships. In various junior age cohorts competing together, variation in skiing performance can be expected not only due to practice load and experience but also due to inter-individual differences in physical and psychological maturation. Within a one-year cohort, this effect has been referred to as the birth month effect or the relative age effect (RAE). In cohorts with multiple age bands, the effect is termed the constituent year effect (CYE). The CYE works in principle as the RAE but can function as a magnifying lens of the development within a larger multi-year cohort. The results of the current study indicate that CYEs are present among junior alpine skier performance in the junior World Championships. The magnitude of the constituent year effect is greater in speed events (i.e., downhill and super-G) than in technical events (i.e., slalom and giant slalom), and greater among male skiers compared to female skiers. The findings are discussed in relation to previous research on relative age effects more generally and within the sport context specifically.

Sammendrag Artikkelen tar for seg å nyansere vår forståelse av det nordamerikanske rustbeltet gjennom ett case-studie av en nylig oppstartet kinesisk eid og drevet bilrutefabrikk i det gamle industrielle hjertelandet av USA. Fabrikken befinner seg i Moraine, Ohio, og artikkelen baserer seg på to kapitler i undertegnedes masteroppgave. Jeg belyser først tilstedeværelse av fabrikken i Moraine gjennom å undersøke den partikulære historien til stedet, fremveksten av prekære arbeidsrelasjoner og den nyere trenden av kinesiske investeringer til USA. Deretter utforsker jeg rollen til arbeidskraft på denne fabrikken gjennom å studere en mislykket kampanje for å fagorganisere arbeiderne. Jeg argumenterer så for at denne kampanjen synliggjør ulike forventninger til industriarbeid som deler de amerikanske arbeiderne mellom generasjoner. Videre argumenterer jeg for at dette eksempelet peker mot en ny og potensielt vedvarende industrirealitet preget av mindre demokrati på arbeidsplassen, lavere lønninger og dårligere jobbsikkerhet for industriarbeiderne.

In physical education (PE), both assessment practices and choice of teaching content indicate that pupil-related factors such as motor competence and physical fitness potentially influence pupils' academic achievement in PE. However, neither of these factors are explicitly expressed as assessment criteria in the Norwegian PE-curriculum. Hence, the aim of the current study was to investigate potential differences in motor competence and physical fitness between pupils with different academic achievements in PE. Forty-five boys and 31 girls (N = 76) from grades 8 to 10 in the lower secondary school participated in this study. In addition to collecting pupils' final grade in PE, as a proxy for academic achievement, they were assessed on the Test of Motor Competence (placing bricks, building bricks, heal-to-toe-walking, and walking/running in slopes) and four task items from the Test of Physical fitness (standing broad jump, pushing medicine ball, running 20 m as fast as possible, and reduced Cooper test). In the main analysis, the total score for motor competence and physical fitness, as well as their respective task items, were compared between pupils with different grades (i.e., 3 or 4, 5, 6). A one-way ANOVA revealed neither significant difference between pupils with different grades in overall motor competence (total score) nor the respective task items for fine motor assessment or the gross motor task heal-to-toe-walking. However, there was a large difference between pupils with different grades in performance of the gross motor task walking/running in slopes, where pupils receiving a grade of 6 and 5 completed the task significantly faster compared to their peers with a grade of 3 or 4. Furthermore, a one-way ANOVA indicated moderate-to-large differences between pupils with different grades in the total score of physical fitness and performance in three of the four respective task items (i.e., standing broad jump, running 20 m as fast as possible, and reduced Cooper test). Pupils with a grade of 6 had a significantly greater total score of physical fitness and jumped longer compared to pupils with a grade of 5 and 3 or 4. Additionally, pupils with a grade of 6 ran significantly faster as opposed to pupils with a grade of 3 or 4. Performance on the reduced Cooper test was significantly different between all groups of grades, with the distance covered being progressively increased from pupils receiving a grade of 3 or 4 to 6, respectively. These results indicate that physical fitness levels and one component of motor competence may influence pupils' academic achievement in PE. Since neither certain levels of gross motor competence nor physical fitness are explicitly stated as assessment criteria in the Norwegian PE curriculum, these findings may indicate a lack of alignment between PE-teachers' assessment practice and the curriculum's intentions. It is argued that PE-teachers should be aware of how these individual constraints may influence pupils' academic achievement in PE so that all pupils are given equal opportunities to meet the described learning outcomes.

Individual differences in tempo and timing of biological maturity, especially in adolescents, has been argued as a potential underlying cause of relative age effects observed in Physical education (PE). Indeed, differences in maturation could influence pupils`achievement in PE where motor behavior and physical activity are central tenets. However, the timing of biological maturity has not previously been investigated in the context of academic achievement in PE. Therefore, the current study`s aim was to investigate the association between timing of biological maturity and relative age on adolescents`academic achievement in PE. The data material consists of two samples from lower secondary schools (13–16 years old). Sample 1 (45 boys and 31 girls) was used to compare differences in anthropometrics and indicators of biological maturity between pupils with different grades (i.e., 3/4, 5, 6), while in sample 2 (114 boys and 127 girls) differences in mean grade were compared between birth quartiles. Pupils`final grade in PE were collected for both samples as a proxy for academic achievement. A one-way analysis of variance indicated a moderate-to-large association between timing of biological maturity, through age at peak height velocity, and academic achievement in PE, where later maturing pupils received a higher grade compared to earlier maturing pupils. Results from a factorial analysis of variance indicated an interaction effect between gender and birth quartile on academic achievement in PE. Post hoc analysis revealed that relatively younger boys received significantly lower grades as opposed to their relatively older peers. This effect was not present for girls. Collectively, these results indicate that developmental differences are associated with academic achievement in PE. Hence, PE teachers should be aware of these individual constraints in their teaching and assessment practice to accommodate fair and equal opportunities for achievement in the subject.

The relative age effect (RAE) is a statistical bias observed across sport contexts and consists of a systematic skewness in birth date distribution within an annual-age cohort. In soccer, January 1st is the common cut-off date when categorizing players in competitions according to their chronological age, which potentially disadvantages those within the cohort who were born later in the year. Thus, relatively older soccer players in their cohort can be favored in talent identification, selection, and development. The aim of the current study was to investigate the variations in RAE in male and female international youth world-cup tournaments (U17 and U20) in the period from 1997-2019 and in international senior world-cup-tournaments from 2006-2019. A total of 20,401 soccer players participating in 47 different tournaments were analyzed. The birthdate distributions were categorized into four quartiles (January-March, Q1; April-June, Q2; July-September, Q3; October-December, Q4) and compared to a uniform distribution using Chi-square analysis with Cramer's V (Vc) as a measure of effect size. Based on the existing data concerning RAE in elite junior and senior soccer, it was hypothesized that: (I) the RAE is present in youth soccer world cup tournaments but is stronger in male players than in female players; (II) the younger the soccer players, the stronger the RAE; and (III) the RAE in world cup soccer tournaments has strengthened over time. All these hypotheses were supported by the data; novel findings included that the effect has now entered women's soccer, and in men's soccer it persists into senior world cup tournaments. Thus, a strong RAE bias occurs in selection among elite soccer players competing in international world cup tournaments.

Performance of bimanual motor actions requires coordinated and integrated bilateral communication, but in some bimanual tasks, neural interactions and crosstalk might cause bilateral interference. The level of interference probably depends on the proportions of bilateral interneurons connecting homologous areas of the motor cortex in the two hemispheres. The neuromuscular system for proximal muscles has a higher number of bilateral interneurons connecting homologous areas of the motor cortex compared to distal muscles. Based on the differences in neurophysiological organization for proximal vs. distal effectors in the upper extremities, the purpose of the present experiment was to evaluate how the level of bilateral interference depends on whether the bilateral interference task is performed with homologous or non-homologous effectors as the primary task. Fourteen participants first performed a unilateral primary motor task with the dominant arm with (1) proximal and (2) distal controlled joysticks. Performance in the unilateral condition with the dominant arm was compared to the same effector’s performance when two different bilateral interference tasks were performed simultaneously with the non-dominant arm. The two different bilateral interference tasks were subdivided into (1) homologous and (2) non-homologous effectors. The results showed a significant decrease in performance for both proximal and distal controlled joysticks, and this effect was independent of whether the bilateral interference tasks were introduced with homologous or non-homologous effectors. The overall performance decrease as a result of bilateral interference was larger for proximal compared to distal controlled joysticks. Furthermore, a proximal bilateral interference caused a larger performance decrement independent of whether the primary motor task was controlled by a proximal or distal joystick. A novel finding was that the distal joystick performance equally interfered with either homologous (distal bilateral interference) or non-homologous (proximal bilateral interference) interference tasks performed simultaneously. The results indicate that the proximal–distal distinction is an important organismic constraint on motor control and for understanding bilateral communication and interference in general and, in particular, how bilateral interference caused by homologous vs. non-homologous effectors impacts motor performance for proximal and distal effectors. The results seem to map neuroanatomical and neurophysiological differences for these effectors.

Stocking of hatchery produced fish is widely used to supplement wild fish populations. Here, the authors show that supplementary stocking can unintentionally favour introgressed individuals with domestic genotypes and compromise the fitness of a wild population of Atlantic salmon.

The developmental pathways of athletes with a physical disability into world-class parasport are much less researched and understood compared to able-bodied athletes’ participation histories. The purpose of this study was to investigate the developmental pathways of para-athletes toward elite performance. Data from eight athletes with physical disabilities ranked among the top performers in Paralympics, World Championships, and/or European Championships were gathered. Thematic analysis of retrospective semi-structured interviews led to the identification of four themes. The findings showed the importance of early childhood sport-related encounters in a family environment followed by sampling of various organized and coach-led sports throughout the childhood period. The youth sport period was highly heterogenous, albeit with important transitions towards elite-level practice environments, competition, coaching, equipment adaptability and the first intentions of becoming an elite-level athlete. Throughout, significant contributions are attributed towards parents, friends, coaches, athletes, and others, towards fostering a sustained motivational climate focused on improvement and further progress. These findings could provide useful information to tailor developmental models towards elite-level performance in parasport.

Individual soccer performance is notoriously difficult to measure due to the many contributing sub-variables and the variety of contexts within which skills must be utilised. Furthermore, performance differs across rather specialised playing positions. In research, soccer performance is often measured using combinations of, or even single, sub-variables. All too often these variables have not been validated against actual performance. Another approach is the use of proxies. In sports research, the age of athletes when winning championship medals has been used as a proxy for determining their age of peak performance. In soccer, studies have used the average age of players in top European leagues or in the Champions League to determine the age of individual peak performance. Such approaches have methodological shortcomings and may underestimate the peak. We explore the use of a new proxy, the age at nomination for major individual awards, to determine the average age at peak individual soccer performance. A total of 1,981 players nominated for major awards from 1956 to 2019 were included, and a subset of 653 retired players was extracted, thus including players’ complete careers. Players’ average ages at nomination, at their first nomination, and at their last ever nomination were calculated, and differences across playing positions were calculated together with changes over time in the average age at peak. Based on our proxy, the age of individual peak soccer performance occurs around 27–28 years, varying across playing positions from 26 to 31 years. A player’s first peak, on average, seems to coincide with known peaks of physiological variables; their last-ever peak occurs long after physiological performance has started to decline, indicating that the decline can be compensated for by other variables. The peak age is higher than previously reported for soccer; however, it is similar to those in other team ball sports. The average age at peak performance has increased over time, especially in the last decade. Our approach of using proxies for unearthing information about hidden features of otherwise immeasurable complex performance appears to be viable, and such proxies may be used to validate sub-variables that measure complex behaviour.

We describe an Underwater Hyperspectral Imager (UHI) deployed on an instrument-carrying platform consisting of two interconnected mini-ROVs (Remotely Operated Vehicle) for the mapping and monitoring of Arctic macroalgal habitats in Kongsfjorden (Svalbard) during the Polar Night. The mini-ROV-UHI system is easy to transport, assemble and deploy from shore, even under the dark, icy and cold conditions of the Arctic Polar Night. The system can be operated by two persons, keeping the operational costs low. In vivo hyperspectral reflectance of collected specimens of brown, red and green macroalgae was measured with a spectrometer in the lab to provide a spectral library for supervised pigment group classification based on UHI photomosaics. The in situ UHI-photomosaics provided detailed information of the areal coverage of the seafloor substrate (16%), as well as brown (51% habitat cover), red (18%), and green (14%) macroalgae, with spatial resolution in the range of cm and spectral resolution of 2 nm. The collected specimens from the mapped area were also used for species identification and health state evaluation. This innovative UHI sampling method provides significant information about macroalgal distribution and physiology, and due to its flexibility in terms of deployment, it is applicable to a variety of environments.

Bimanual performance depends on effective and modular bilateral communication between the two bodysides. Bilateral neural interactions between the bodysides could cause bimanual interference, and the neuromuscular system for proximal and distal muscles is differently organized, where proximal muscles have more bilateral interneurons at both cortical and spinal level compared to distal muscles. These differences might increase the potential for bimanual interference between proximal arm muscles, because of greater proportions of bilateral interneurons to proximal muscles. The purpose of the present experiment was to evaluate potential differences in bimanual interference between proximal versus distal effectors in the upper extremities. 14 participants first performed a unilateral primary motor task with dominant arm with (1) a proximal and (2) distal controlled joysticks (condition A). Performance in condition A, was compared with the same effector’s performance when a bimanual interference task was performed simultaneously with the non-dominant arm (condition B). The results showed a significant bimanual interference for both the proximal and distal controlled joysticks. Most interestingly, the bimanual interference was larger for the proximal joystick compared to the distal controlled joystick. The increase in spatial accuracy error was higher for the proximal controlled joystick, compared with the distal controlled joystick. These results indicate that the proximal-distal distinction is an important organismic constraint on motor control, and especially for bilateral communication. There seem to be an undesired bilateral interference for both proximal and distal muscles. The interference is higher in the case of proximal effectors compared distal effectors, and the results seem to map the neuroanatomical and neurophysiological differences for these effectors.

A well-known hypothesis amongst educators and the general public is that matching instructional method with an individual’s modality-specific learning style improves learning. Several critical reports in the past decade, however, have shown that the psychometric properties of the inventories applied to establish modality-specific learning styles have been poorly validated. Furthermore, theoretical development has challenged the theoretical basis for the modality-specific learning style model. Thus, the aim of the current study was to examine the psychometric properties and relationship between, two modality-specific learning style inventories: the Barsch Learning Style Inventory (BLSI) and the Learning Style Survey (LSS). University students (n = 242) completed the two inventories, and their responses were subjected to confirmatory and exploratory factor analysis, as well as analysis of inter-item agreement (internal consistency). The results failed to support the expected three-factor measurement model and thus indicated questionable reliability and factorial validity of the two inventories. Analysis of inter-correlations between factors from the two inventories resulted in a one-factor solution explaining up to 40% of the variance, which is discussed as emerging through an overall multimodal learning style.

It is often argued within sports circles that the age span of around 6–12 years is a golden age for motor skill learning, and this period is often described as sensitive, or even critical, for learning such skills. Consequently, skill development programmes target this age span for teaching technical and coordinative skills. In the scientific literature, however, the term golden age is scarcely seen, and few studies have even attempted to test this hypothesis. When comparing motor learning between children and adults, studies have typically found little difference or differences favoring adults. Studies that have reported precocious learning within the golden age seem not to have controlled all relevant variables. Typically, the different age groups have not started from similar baselines and have tested tasks that have not been scaled according to physical differences between individuals belonging to the various groups. The present study tested 10-year-olds, 18-year-olds, and 40-year-olds on dart throwing with their non-dominant hands. They each completed 200 throws over 2 days, with 1 day in between. All participants performed at similar levels at the pre-test, and the task was scaled according to each participant’s individual size. No difference was found between the groups after practice in terms of change in absolute error, or with respect to the slopes of their learning curves. The 10-year-olds’ learning curves were more variable compared with the other groups. Thus, the present study found no evidence that the 10-year-olds belonged to a golden age for motor learning, and we would argue that previous findings of differences might well be artefacts due to lack of control of relevant variables.

While research on the effects of 'birth month' is usually referred to as relative age effects, the study of the effects of 'birth year' is described as the constituent year effect (CYE). In the present study we examined the impact of the CYE on participation in the Junior World Championship in alpine skiing. Based on previous research, we expected to find increasing numbers of participants the older the age-group, and that the CYE would be stronger in the speed events compared to the technical ones. The sample in the present study consisted of 1188 male skiers and 859 female skiers within the age range of 17 to 21 years at the time of competition. The results show that the number of male participants increased with increasing age, which can be described as a CYE. For female skiers, a CYE was found, but it dissipated two years earlier than for male skiers. The CYE varied with event and was more pronounced the higher the speed of the event. The findings thus suggest that a constituent year effect exists among skiers participating in the FIS Junior World Ski Championship in the alpine skiing championships, and that the effect varies with gender and event, rather unrelated to age. Thus, it seems that the effect may not be a relative age effect, but instead a relative development effect.

Abstract: Objective: The aim of our study is to evaluate seven flow rate regulators (FRR) to assess the reliability of these devices compared to standard perfuser with roller clamp. Study design: Each FRR was tested with 5% dextrose and 0.9% sodium chloride combined with three different theoretical flow rates (30, 80 and 250ml/h). Accuracy was compared with the theoretical value. Repeatability of flow rate was assessed thanks to variance break-up. Results: Each FFR exhibits at least one combination “flow rate–solution” significantly different of the theoretical flow rate. Exadrop® was the least successful of the FFR according to the accuracy. This FFR had for each combination a flow rate different of the theoretical (mean error: −24.0ml/h). Tutodrop® was the most successful of the FFR according to the accuracy with five combinations comparable to the theoretical value (mean error: −1.2ml/h). The standard perfuser with roller clamp, used without FRR, reported two combinations comparable to the theoretical value and showed lowest rates for repeatability. Conclusion: Our study exhibits the poor performances of the FRR studied: according to expected flow regulation, the reported results demonstrate the lack of accuracy. Their only one value added compare to the roller clamp is to improve the repeatability of the flow rate. [Copyright &y& Elsevier]

Administering various combinations of acetaminophen, ketoprofen, nefopam and ketamine, though sometimes discussed, is expected to provide superior pain relief and reduce opioid analgesic-related side effects. However, some studies have indicated that multimodal analgesia has limited efficacy. We studied the stability of various binary combinations of these four drugs.~Background and Objective~Objective~The drugs were studied at 25 degrees C. Binary mixtures of acetaminophen, ketoprofen, nefopam and ketamine were produced. Each drug concentration was assessed using a specific high-performance liquid chromatographic technique. Measurements were carried out at T0, +1, +2, +4, +6 and +24 h. A 5% loss of initial concentration was considered to be significant. The changes with time of the concentrations were analysed using linear regression analysis. A P value of less than 0.05 was significant.~Patients and Methods~Methods~The four drugs tested in the binary mixtures were stable, showing neither loss of concentration nor degradation products (P > or = 0.05).~Results~Results~Physicochemical negative interaction is not likely to account for the limited clinical efficacy sometimes reported with binary combinations of these drugs. Coadministration of binary mixtures of acetaminophen, nefopam, ketoprofen and ketamine from the same bottle or infusion bag using the same venous line is demonstrated to be feasible.~Conclusion~Conclusions [ABSTRACT FROM AUTHOR]

Abstract: We have previously shown that functional components of the NF-κB signaling pathway are up-regulated and sequestered in the cytoplasm of human papillomavirus 16 (HPV16)-transformed cell lines leading to a reduced activity of NF-κB. In this study, we examined the expression of the NF-κB precursors p100 and p105 in keratinocytes transformed or not by HPV16. Western immunoblotting experiments demonstrated high levels of p100 and p105 proteins not only in HPV16+ cervical carcinoma-derived keratinocytes but also in keratinocytes stably transfected by HPV16 E6 or E7 oncogenes. Moreover, p100 and p105 proteins were predominantly cytoplasmic and nuclear in keratinocytes expressing E7 and E6, respectively. A predominantly cytoplasmic localization of E7 protein was also detected in all keratinocytes expressing E7. Our results suggest that HPV16 E6 and E7 proteins modulate the expression and the subcellular localization of p100 and p105 NF-κB precursors. [Copyright &y& Elsevier]

Entrainment is a ubiquitous property not only of interacting non-linear dynamical systems but also of human movements. In the study reported here, two premises of entrainment theory were investigated in a tapping task conducted in both interpersonal (i.e. between individuals) and intrapersonal (i.e. between effectors) conditions. Hypothesis 1 was that interacting oscillatory systems should demonstrate synchronisation, which was predicted to emerge as in-phase tapping behaviour in both inter- and intrapersonal conditions. Support for Hypothesis 1 was observed in the in-phase synchronisation of tapping in both individual bimanual trials and uni-manual and bimanual tapping in dyads. By contrast, Hypothesis 2 was that the oscillatory system with the faster initial rate would decelerate, whereas the one with the slower initial rate would accelerate, as manifest in increased self-paced tapping rates amongst participants with initially slower rates and decreased rates amongst ones who initially tapped at faster rates. However, that pattern predicted in Hypothesis 2 was not observed; on the contrary, all participants increased their tapping rates in interpersonal conditions, which occurred significantly amongst participants with the lowest preferred tapping rates. Such an outcome indicates a novel aspect of synchronised movement in humans that warrants further investigation.

Appropriate levels of motor competence are an integrated part of individuals’ health-related fitness, and physical education is proposed as an important context for developing a broad range of motor skills. The aim of the current study was to apply meta-analyses to assess the effectiveness of curriculum-based physical education on the development of the overall motor competence of children and adolescents. Studies were located by searching seven databases and included according to predefined criteria. Random effects models using the standardized effect size (Hedges’ g) were used to aggregate results, including an examination of heterogeneity and inconsistency. The meta-analysis included 20 studies, and a total of 38 effect sizes were calculated. A statistically significant improvement in motor competence following curriculum-based physical education compared to active control groups was observed in children and adolescents (g = −0.69, 95% CI −0.91 to −0.46, n = 23). Participants’ ages, total time for physical education intervention, and type of motor competence assessment did not appear to be statistically significant moderators of effect size. Physical education with various curricula can, therefore, increase overall motor competence in children and adolescents.

Acute exercise influences human cognition, and evidence suggests that learning can be improved. According to the cognitive−energetic approach towards exercise cognition, exercise represents a stressor that elevates physiological arousal, which, in turn, increases the availability of mental resources. However, the degree of arousal is hypothesized to have optimal and suboptimal states, and moderate intensity exercise is thus considered to be favorable compared to low intensity and vigorous exercise. The current evidence for such a moderating effect of exercise intensity on motor learning, however, appears somewhat mixed. Therefore, the purpose of this study was to explore the effect of aerobic exercise conducted with different exercise intensities on immediate practice, transfer, and 24-h retention of a motor skill. To this end, young adults (n = 40, mean (SD) age: 23.80 (1.98) years) were randomized to exercise at either 50% or 75% of age-predicted maximal heart rate according to the Karvonen formulae. Immediately after exercising, participants practiced a high-precision golf putting task in a blocked design. Retention and transfer of skill were assessed after 24 h. Results indicated that both groups demonstrated motor learning, retention, and transfer at a similar level. Further works are thus needed to establish the specific relationship between exercise and learning and establish the factors that have an influence.

Many medical, psychiatric and neurological conditions have been characterized by a high prevalence of left-handedness or mixed-handedness. Several studies have indicated an elevated frequency of left-handedness in children with Developmental Coordination Disorder (DCD). However, there have been few studies explicitly exploring this relationship. The assumption is that the prevalence of left-handedness in individuals with DCD is higher compared with the prevalence in the general population and resembles the prevalence described in children with other developmental disorders. Computerized searches were conducted in PubMed, PsycInfo and CINAHL databases. Thirty-eight studies were identified and included in the present review, containing handedness distributions across 1071 persons with DCD and 1,045 controls. The distribution of DCD participants across handedness-categories was proved to be significantly different from that of the control group, with 14.7 and 8.1% left-handers, respectively. The prevalence of left-handedness within the DCD-group is lower than that reported for ASD, and larger than in dyslexia. The elevated levels of left-handedness within the different developmental disorders supports the notion of an association between the different diagnoses. However, the present results are not sufficient to conclude anything about a common cause or underlying factor via the male hormone testosterone. The present results could act as a starting point for testing the hypothesis of such a common factor, as one of the requirements is an elevated prevalence of left-handedness, and without such considerable doubt would be cast upon the hypothesis.

The impact on learning outcome of tailoring instruction and teaching toward modality-specific learning style preferences has been researched and debated for decades. Several topical reviews have concluded that there is no evidence to support the meshing hypothesis and that it represents a persistent neuromyth in education. The concept, however, is still utilized in educational practice and favored by many academics. This mini-review presents literature, which has applied explicit and rigorous methodological criteria, in relation to the meshing hypothesis. In order to demonstrate evidence for the meshing hypothesis, studies had to screen participants for their preferred learning style, assign participants to matched or non-matched conditions, and then provide the same test to assess learning for all participants, as well as presenting statistical crossover-interaction effects. Across studies that have applied these methodological criteria, the overall effect sizes were very low and non-significant, indicating that there is still no replicable statistical evidence for enhanced learning outcome by aligning instruction to modality-specific learning styles.

Previous studies have shown faster tapping speed and better tapping symmetry in drummers, compared with nondrummers. The present study investigated the effect on tapping frequency of mechanically constraining the joints of the arm on unimanual and bimanual drumming speed across drummers and nondrummers. Skilled drummers were compared with nondrummers on mean maximum tapping frequency under different conditions in which the joints of the arms were mechanically constrained. One condition, the free condition, allowed use of all three joints (shoulder, elbow, and wrist), and served as control. In the other two, joints were mechanically constrained in such a way that participants were allowed use of only the shoulder (proximal) or only the wrist (distal), respectively. Participants performed a rapid tapping task with drumsticks on a drum pad as fast as possible for 15 s. All conditions were performed both bimanually, unimanually with the left hand, and unimanually with the right hand. Drummers produced significantly higher mean tapping frequencies compared with nondrummers in the free bimanual, distal bimanual, and distal unimanual left conditions. No differences were observed in the proximal condition. The results suggest that the drummers acquire refined upper limb joint coordination patterns, especially in the more distal joints of the arm, compared with nondrummers.

The Relative Age Effect (RAE) can be described as the advantage of being born early after a certain cut-off date within a group of selection. The effect has been found across a wide range of sports and is particularly evident in pre-elite sports and team sports with a high selection pressure. At the absolute top level in team elite sports, the advantage of being relatively older has been reported to disappear, and even reverse, so that the relatively younger athletes are advantaged. In order to further examine such a reversal of the RAE, we investigated the performance of the overall top 50 skiers each year in the alpine World Cup, over a period of 20 years, among men (N = 234) and women (N = 235). The data indicated that the relatively younger male athletes at the absolute top level had accumulated, on average, more World Cup points compared to the relatively older skiers. No such effect was observed among the female skiers. This finding suggest the existence of a reversed relative age effect in male elite alpine skiing.

Tests or test batteries used for assessing motor skills, either in research studies or in clinical settings, apply a variety of procedures for scoring performances, including everything from one to ten attempts, of which the best is scored or an average is computed. The rationale behind scoring procedures is rarely stated, and it seems that the number of attempts allowed is decided without much qualification from research. It is uncertain whether procedures fairly capture an individual’s skill level. Thus, the validity of the tests may be compromised. The present study tested 24 young female soccer players on the juggling of a soccer ball. They were given 10 attempts, and trials were scored according to nine different procedures including the ‘best of’ or ‘mean of’ either one, two, three, five, or ten attempts. Individual raw scores differed widely across trials, but no general effect of trials was found. The mean (SD) percentage difference between the lowest and highest scores was 27.7(9.9)%, with 17 players (71%) demonstrating a significant change from lowest to highest score. Correlations between raw scores were low across trials, while they were generally higher across scoring procedures. The first trial was significantly different from the remaining both as a raw score and as scoring procedure. The mean percentage difference between best-of-two and best-of-ten scores was 95%, with 50 % of the players demonstrating a significant difference between the two scoring procedures. No significant differences were found across mean-of-rule scorings. Best-of-rule and mean-of-rule scorings were significantly different except for the best-of-two vs. mean-of-two. The mean difference between highest and lowest rank across players was 6.7 (3.6), with individual rankings within the group varying 33% on average across procedures. One player moved from 3rd to 23rd place because of procedural differences. Therefore, it is concluded that scoring procedures affect results and may have an impact on test outcomes. This may present consequences for decision-making from test results, such as diagnosing and selection of intervention groups. We hope that our results would inspire further research into the scoring procedures of the vast amount of tests and tasks in common use.

The aim of this study was to investigate differences in the physical (locomotor activities) and physiological (Banister’s training impulse) in-season training load between starters and substitutes in a well-trained junior soccer team. Physical performance variables from the Polar Team Pro system were collected and analyzed from a sample of junior soccer players (N = 18; age = 15.7 ± 0.5 years; stature, 177.9 ± 4.6 cm; body mass, 67.1 ± 5.5 kg). The study analyzed a total of 10 matches and 38 training sessions during the 2018 season with linear mixed models. The players from the starting line-ups demonstrated significantly higher average weekly physical load compared to the non-starters with respect to all variables: distance (total, running, high-speed running, and sprint) [F (1, 573) ≥ 66, p < 0.001, eta = 0.10], number of accelerations and sprints [F (1, 573) ≥ 66, p < 0.001, eta = 0.10], as well as Banister’s training impulse (TRIMP) [F (1, 569) = 10, p < 0.001, eta = 0.02]. Evidence from this study indicates that a large amount of weekly accumulated high-speed running and sprint distances is related to match playing time. Therefore, weekly fitness-related adaptations in running at high speeds seem to favor the starters in a soccer team.

Acute exercise has an influence on human cognition, and both theoretical approaches and previous investigations suggest that the learning process can be facilitated. A distinction has been made however, between the predominately positive effects on task speed compared to both the negative and null effects on aspects of task accuracy. The aim of this study was to investigate the effect of moderate-intensity aerobic exercise conducted before each practice trial (3 × week) for a period of four weeks, on speed and accuracy components in a novel keyboard typing task. To this end, young adults (n = 26) where randomized to a non-exercise resting group (control) or an exercise group (ergometer cycling at 65% of age-predicted maximal heart rate). Immediately after exercise or resting, participants practiced keyboard typing through specialized online software for a total of 2 h across the study period. All participants improved their speed and accuracy in the keyboard typing task. At 7-day retention, no differences were found between groups. Thus, the degree of improvement on both speed and accuracy task components was not significantly different between the exercise and control group. Further studies are warranted to establish the specific relationship between aerobic exercise and task components in motor learning and retention.

A well-known hypothesis in education and amongst the general public is that matching instructional method with an individual’s modality-specific learning style improves learning and cognitive performance. Several critical reviews in the past decade, however, have shown that the hypothesis has not been properly evaluated with appropriate methodology. Furthermore, the association between learning style and other cognitive abilities such as working memory has not been examined. Thus, the aim of the current study was to examine the association between modality-specific learning style, immediate recall, and working memory performance. University students with visual or auditory learning styles were randomly assigned to one of two instructional methods and then given a multiple-choice recall test. In addition, the participants completed working memory tasks with visual or auditory presentation. The results failed to support the matching hypothesis or any association between modality-specific learning style and working memory.

In this article, the psychometric properties of a new test battery aimed at quantifying motor competence across the life span are explored. The battery was designed to be quantitative, simple to administer, applicable for large-group testing, and reliably to monitor life span motor development. A total of 638 participants between 5 and 83 years of age completed assessment of four different motor tasks (two fine and two gross motor tasks), enabling us to investigate its feasibility, internal consistency, construct validity, and test–retest reliability. Feasibility : Overall pattern of results suggest that the test battery for motor competence presented here is applicable for the age-span studied (5-83). Important consideration in this regard is that the same tasks are applied for all ages. A u -shaped curve between age and total test score indicate the adequate sensitivity of the test battery for the age range examined. Internal consistency : All individual test item scores correlated positively with the total test score with correlations ranging from .48 to .64. Correlations between scores on individual test items were moderate to high (.31-.69). The Cronbach’s alpha value for the standardized items was .79. Construct validity : Pearson correlation coefficient between total score Test of Motor Competence (TMC) and Movement Assessment Battery for Children (MABC) were .47 for 7- to 8-years-old children ( n = 70) and .45 for 15- to 16-years-old ( n = 101). Test-retest reliability : Intraclass correlation coefficients (ICCs) between test and retest scores ranged from .75 to .94, and test–retest coefficient for the total score was .87.

This study examined the effects and specificity of structured and unstructured activities played at the playground Primo Sport 0246 in Northern Italy on motor skill competence in five years old children. The playground was specifically designed to promote gross motor skills in preschool children; in this study 71 children from local kindergartens came to the park once a week for ten consecutive weeks and were exposed to 30 minutes of free play and 30 minutes of structured activities. Before and after the ten visits, each child completed nine tests to assess levels of motor skills, three for fine-motor skills and six for gross-motor skills. As control, motor skills were also assessed on 39 children from different kindergartens who did not come to the park. The results show that the experimental group who practiced gross-motor activities in the playground for 1 hour a week for 10 weeks improved significantly in 4 out of the 6 gross motor tasks and in none of the fine motor tasks. The data indicate that limited transfer occurred between tasks referring to different domains of motor competences while suggesting cross feeding for improvement of gross-motor skills between different exercises when domains related to physical fitness and strength of specific muscle groups are involved. These results are relevant to the issue of condition(s) appropriate for maintaining and developing motor skills in this age group as well as for the planning, organization and implementation of play and physical activities in kindergartens.

Impaired postural control has been associated with poor reading skills, as well as with lower performance on measures of attention and motor control variables that frequently co-occur with reading difficulties. Measures of balance and motor control have been incorporated into several screening batteries for developmental dyslexia, but it is unclear whether the relationship between such skills and reading manifests as a behavioural continuum across the range of abilities or is restricted to groups of individuals with specific disorder phenotypes. Here were obtained measures of postural control alongside measures of reading, attention and general cognitive skills in a large sample of young adults (n = 100). Postural control was assessed using centre of pressure (CoP) measurements, obtained over 5 different task conditions. Our results indicate an absence of strong statistical relationships between balance measures with either reading, cognitive or attention measures across the sample as a whole.

The present study investigated the relationship between individual differences in timing movements at the level of milliseconds and performance on selected cognitive and fine motor skills. For this purpose, young adult participants (N = 100) performed a repetitive movement task paced by an auditory metronome at different rates. Psychometric measures included the digit-span and symbol search subtasks from the Wechsler battery as well as the Raven SPM. Fine motor skills were assessed with the Purdue Pegboard test. Motor timing performance was significantly related (mean r = .3) to cognitive measures, and explained both unique and shared variance with information-processing speed of Raven's scores. No significant relations were found between motor timing measures and fine motor skills. These results show that individual differences in cognitive and motor timing performance is to some extent dependent upon shared processing not associated with individual differences in manual dexterity.

Analyses of haematological and biochemical constituents were carried out on the Norwegian subspecies of free-ranging red deer (Cervus elaphus atlanticus). All animals were captured from January to March by using a mixture of xylazine and tiletamin-zolazepam. Immobilisation was performed with plastic projectile syringes fired from a dart gun. Fourteen haematological parameters were analysed. There were no differences in the values between hinds and stags and between adults and calves (P > 0.01). Of the 22 biochemical compounds investigated there was a significant difference (P < 0.01) between calves and adults for lactate dehydrogenase (LD), globulin, beta globulin, gamma globulin, and the minerals Na, K, Mg, Zn, Ca, and P. Differences (P < 0.01) between hinds and stags were found in cholesterol, gamma glutamyl transferase (GGT), alpha-1 globulin, alpha-2 globulin and Cu. The blood values determined in this study can be used as reference values for this red deer subspecies immobilised with a mixture of xylazine-tiletamin-zolazepam for health control and diagnosis of diseases. Abstract in Norwegian /Sammendrag: Hematologiske og biokjemiske parametere er analysert på norsk frittlevende hjort (Cervus elaphus atlanticus). Hjorten ble immobilisert i tidsrommet januar til mars ved hjelp av et spesialgevær ladet med plast kanyler som inneholdt en blanding av xylazin og tiletamin-zolazepam. Det var ingen forskjeller i de14 undersøkte hematologiske verdiene mellom hinder, kalver og bukker (P>0,01). Av de 22 biokjemiske parametrene som ble undersøkt var det en signifikant forskjell mellom kalver og voksne (P

Abstract Background In order to determine whether human prostate can be productively infected by HIV-1 strains with different tropism, and thus represent a potential source of HIV in semen, an organotypic culture of prostate from men undergoing prostatic adenomectomy for benign prostate hypertrophy (BPH) was developed. The presence of potential HIV target cells in prostate tissues was investigated using immunohistochemistry. The infection of prostate explants following exposures with HIV-1 R5, R5X4 and X4 strains was analyzed through the measure of RT activity in culture supernatants, the quantification of HIV DNA in the explants and the detection of HIV RNA+ cells in situ. Results The overall prostate characteristics were retained for 21/2 weeks in culture. Numerous potential HIV-1 target cells were detected in the prostate stroma. Whilst HIV-1 R5SF162 strain consistently productively infected prostatic T lymphocytes and macrophages, the prototypic X4IIIB strain and a primary R5X4 strain showed less efficient replication in this organ. Conclusion The BPH prostate is a site of HIV-1 R5 replication that could contribute virus to semen. A limited spreading of HIV-1 X4 and R5X4 in this organ could participate to the preferential sexual transmission of HIV-1 R5 strains.

Abstract: Tacrolimus (TRL) is an immunosuppressive drug characterized by a narrow therapeutic index, low bioavailability, and pharmacokinetic variability. Intravenous (IV) TRL may be needed whenever the oral route is unavailable. The small amount of infusion formulation (5 mg/mL) results in a large dilution and need for careful technical management of the infusion. This study addressed the feasibility to provide sublingual (SL) as an alternative to IV. TRL for transplanted patients. In a substudy, we performed a retrospective analysis of 17 lung and heart transplant patients using SL TRL. It included therapeutic drug monitoring and 4 area under curve (AUC) measurements. Patients received SL TRL on a dose-to-dose basis from the oral formulation. The mean age of the subjects (14 male, 3 female) was 35.3 ± 15.6 years; 146 trough (C0) samples were collected during the SL period (15.8 ± 20.6 days) showing a conformity level of 90.4%. Mean dose, C0, and AUC of SL tacrolimus were 0.116 ± 0.096 mg/kg, 12.9 ± 5 ng/mL, and 230 ± 74 ng·h/mL, respectively, with an average 1 hour time to peak concentration. Acute rejection episodes, renal toxicity, and drug interactions were not observed. This study supported the convenience of short-term SL TRL administration, even in unconscious patients. Further investigations are needed to validate the dose range of the SL route. [Copyright &y& Elsevier]