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Multilevel semicontinuous data occur frequently in medical, environmental, insurance and financial studies. Such data are often measured with covariates at different levels; however, these data have traditionally been modelled with covariate-independent random effects. Ignoring dependence of cluster-specific random effects and cluster-specific covariates in these traditional approaches may lead to ecological fallacy and result in misleading results. In this paper, we propose Tweedie compound Poisson model with covariate-dependent random effects to analyze multilevel semicontinuous data where covariates at different levels are incorporated at relevant levels. The estimation of our models has been developed based on the orthodox best linear unbiased predictor of random effect. Explicit expressions of random effects predictors facilitate computation and interpretation of our models. Our approach is illustrated through the analysis of the basic symptoms inventory study data where 409 adolescents from 269 families were observed at varying number of times from 1 to 17 times. The performance of the proposed methodology was also examined through the simulation studies. [ABSTRACT FROM AUTHOR]

The effects of the covariates are examined by considering the non-stationary correlation structure. The analysis has shown the effective working of the finite sample estimation performance of the generalized quasi-likelihood (GQL) technique, irrelevant of the underlying true correlation structure.

Generalized linear mixed models have played an important role in the analysis of longitudinal data; however, traditional approaches have limited flexibility in accommodating skewness and complex correlation structures. In addition, the existing estimation approaches generally rely heavily on the specifications of random effects distributions; therefore, the corresponding inferences are sometimes sensitive to the choice of random effect distributions under certain circumstance. In this paper, we incorporate serially dependent distribution-free random effects into Tweedie generalized linear models to accommodate a wide range of skewness and covariance structures for discrete and continuous longitudinal data. An optimal estimation of our model has been developed using the orthodox best linear unbiased predictors of random effects. Our approach unifies population-averaged and subject-specific inferences. Our method is illustrated through the analyses of patient-controlled analgesia data and Framingham cholesterol data. [ABSTRACT FROM AUTHOR]

Paired data have been widely collected in the efficiency studies of a new method against an established method in environmental, ecological and medical studies. For example, in comparative fishing studies, ability of catching target species (fish catch) or reducing the catch of non-target species (fish bycatch) is usually investigated through a paired design. These paired fish catches by weight are generally skewed and continuous, but with a significant portion of exact zeros (no catch). Such zero-inflated continuous data are traditionally handled by two-part models where the zero and positive components are handled separately; however, this separation generally destroys paired structure, and thus may result in substantial difficulty in characterizing the relative efficiency between two methods. To overcome this problem, we consider compound Poisson mixed model for paired data with which the zero and non-zero components are characterized in an integral way. In our approach, the clustering effects by pair are captured by incorporating relevant random effects. Our model is estimated using orthodox best linear unbiased predictor approach. Unlike two-part models, our approach unifies inferences of zero and positive components. Our method is illustrated with analyses of winter flounder bycatch data and ultrasound safety data. [ABSTRACT FROM PUBLISHER]

Longitudinal count data with excessive zeros frequently occur in social, biological, medical, and health research. To model such data, zero-inflated Poisson (ZIP) models are commonly used, after separating zero and positive responses. As longitudinal count responses are likely to be serially correlated, such separation may destroy the underlying serial correlation structure. To overcome this problem recently observationand parameter-driven modelling approaches have been proposed. In the observationdriven model, the response at a specific time point is modelled through the responses at previous time points after incorporating serial correlation. One limitation of the observation-driven model is that it fails to accommodate the presence of any possible over-dispersion, which frequently occurs in the count responses. This limitation is overcome in a parameter-driven model, where the serial correlation is captured through the latent process using random effects. We compare the results obtained by the two models. A quasi-likelihood approach has been developed to estimate the model parameters. The methodology is illustrated with analysis of two real life datasets. To examine model performance the models are also compared through a simulation study. [ABSTRACT FROM AUTHOR]

Clustered multinomial data with random cluster sizes commonly appear in health, environmental and ecological studies. Traditional approaches for analyzing clustered multinomial data contemplate two assumptions. One of these assumptions is that cluster sizes are fixed, whereas the other demands cluster sizes to be positive. Randomness of the cluster sizes may be the determinant of the within-cluster correlation and between-cluster variation. We propose a baseline-category mixed model for clustered multinomial data with random cluster sizes based on Poisson mixed models. Our orthodox best linear unbiased predictor approach to this model depends only on the moment structure of unobserved distribution-free random effects. Our approach also consolidates the marginal and conditional modeling interpretations. Unlike the traditional methods, our approach can accommodate both random and zero cluster sizes. Two real-life multinomial data examples, crime data and food contamination data, are used to manifest our proposed methodology. [ABSTRACT FROM PUBLISHER]

In medical and health studies, heterogeneities in clustered count data have been traditionally modeled by positive random effects in Poisson mixed models; however, excessive zeros often occur in clustered medical and health count data. In this paper, we consider a three-level random effects zero-inflated Poisson model for health-care utilization data where data are clustered by both subjects and families. To accommodate zero and positive components in the count response compatibly, we model the subject level random effects by a compound Poisson distribution. Our model displays a variance components decomposition which clearly reflects the hierarchical structure of clustered data. A quasi-likelihood approach has been developed in the estimation of our model. We illustrate the method with analysis of the health-care utilization data. The performance of our method is also evaluated through simulation studies. Copyright © 2009 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]