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12. Perceptions of NIV During Exercise in NIV-Naïve Patients With COPD

Author

Dennis, Clancy J, primary, Menadue, Collette, additional, Schneeberger, Tessa, additional, Leitl, Daniela, additional, Schoenheit-Kenn, Ursula, additional, Harmer, Alison R, additional, Barnes, David J, additional, Koczulla, Andreas R, additional, Kenn, Klaus, additional, and Alison, Jennifer A, additional

Published
2022
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14. Bilevel Noninvasive Ventilation During Exercise Reduces Dynamic Hyperinflation and Improves Cycle Endurance Time in Severe to Very Severe COPD

Author

Dennis, Clancy J., primary, Menadue, Collette, additional, Schneeberger, Tessa, additional, Leitl, Daniela, additional, Schoenheit-Kenn, Ursula, additional, Hoyos, Camilla M., additional, Harmer, Alison R., additional, Barnes, David J., additional, Koczulla, Andreas R., additional, Kenn, Klaus, additional, and Alison, Jennifer A., additional

Published
2021
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16. Knowledge, skills and barriers to evidence-based practice and the impact of a flipped classroom training program for physical therapists: An observational study.

Author

Harrison, Leora, Wong, David, Traeger, Adrian C., Harmer, Alison R., Jennings, Matthew, and Moseley, Anne M.

Subjects
NATIONAL competency-based educational tests, TEACHING methods, PROFESSIONS, EVALUATION of human services programs, SCIENTIFIC observation, CONFIDENCE intervals, PHYSICAL therapy, PROFESSIONAL employee training, EVIDENCE-based medicine, CLINICAL medicine research, PRE-tests & post-tests, PROFESSIONAL competence, RESEARCH funding, DESCRIPTIVE statistics, PHYSICAL therapy research, EDUCATIONAL outcomes
Abstract

To evaluate the knowledge, skills and barriers to evidence-based practice and the impact of evidence-based practice training for physical therapy clinicians. Physical therapists from a health district in Sydney, Australia were invited to participate. The primary outcome was the Assessing Competency in Evidence-based Medicine scale (range 0–15; 15 is high knowledge and skill) to quantify knowledge and skills. The secondary outcomes were the four subscales of the BARRIERS scale (range 1–4; 4 is high barrier) to quantify barriers. Outcomes were collected at baseline and post an evidence-based practice training program (flipped classroom approach that addressed the core competencies for teaching evidence-based practice) of 3 months duration. Registration: Australian and New Zealand Clinical Trial Register (ACTRN12619000038190). 104 participants completed baseline data and 94 completed post-training data. The mean score for the Assessing Competency in Evidence-based Medicine scale for knowledge and skills at baseline was 9.5 (standard deviation 1.6). The mean BARRIERS subscale scores at baseline were: Healthcare Provider 1.9 (0.5); Research 2.2 (0.5); Setting 2.6 (0.5); and Presentation 2.6 (0.5). On average, training increased the Assessing Competency in Evidence-based Medicine scale score by 0.1 points (95% confidence interval −0.2 to 0.5) and reduced barriers by −0.1 (−0.2 to 0.0; Setting subscale) to −0.2 (−0.3 to −0.1; Healthcare Provider subscale). Physical therapists have knowledge and skill in evidence-based practice that is comparable to other allied health professionals, medical students and medical doctors, and encountered barriers to using high-quality clinical research to guide practice. Training did not change knowledge and skills but did reduce barriers. [ABSTRACT FROM AUTHOR]

Published
2022
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19. Additional file 1 of Clinical risk factors associated with radiographic osteoarthritis progression among people with knee pain: a longitudinal study

Author

Simic, Milena, Harmer, Alison R., Agaliotis, Maria, Nairn, Lillias, Bridgett, Lisa, March, Lyn, Votrubec, Milana, Edmonds, John, Woodward, Mark, Day, Richard, and Fransen, Marlene

Abstract

Additional file 1: Post-hoc univariate analyses of the factors independently associated with radiographic osteoarthritis progression at two years: number (%) of people using NSAIDs and people not meeting physical activity guidelines, respectively. P values for association between independent variables and primary outcomes using Pearson χ2.

Published
2021
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20. Perceptions of Noninvasive Ventilation During Exercise in Noninvasive Ventilation-Naïve Patients With COPD.

Author

Dennis, Clancy J., Menadue, Collette, Schneeberger, Tessa, Leitl, Daniela, Schoenheit-Kenn, Ursula, Harmer, Alison R., Barnes, David J., Koczulla, Andreas R., Kenn, Klaus, and Alison, Jennifer A.

Subjects
OBSTRUCTIVE lung disease diagnosis, STATISTICS, NASAL cannula, CONTINUOUS positive airway pressure, HUMAN comfort, SENSORY perception, INTERVIEWING, ARTIFICIAL respiration, RANDOMIZED controlled trials, EXERCISE, PULMONARY function tests, SCALE analysis (Psychology), DESCRIPTIVE statistics, STATISTICAL sampling, DATA analysis
Abstract

BACKGROUND: The perceptions of using noninvasive ventilation (NIV) during exercise in patients with COPD who are naïve to NIV is unknown. The present study aimed to examine the perceptions of using NIV during exercise in people with COPD and to determine the relationship between patient perceptions with both baseline patient characteristics and exercise outcomes. METHODS: During a trial examining the effect of NIV during exercise on dynamic hyperinflation in people with COPD who were naïve to NIV, participants completed a 5-point Likert scale questionnaire (scored strongly disagree -2 to strongly agree +2) before and after using NIV during exercise and a semi-structured interview after using NIV during exercise. RESULTS: Eighteen participants, mean age (SD) 69 (7) y, FEV1/FVC 0.44 (0.08), FEV1 39 (7)% predicted, completed the study. Prior to exercise with NIV, participants were neutral about NIV, (mean [SD]) (0.67[0.84]). After exercise with NIV, participants felt that NIV made breathing easier (1.00 [0.77]) and that it helped exercise (1.06 [0.64]). There were moderate correlations between feeling that NIV was comfortable or effective and a change in exercise endurance time (q = - 0.588, P = .02), isotime inspiratory capacity (q = 0.488, P = .03), and measures of resting hyperinflation (q = 0.603, \P = .02). Interviews revealed that despite feeling comfortable using NIV during exercise, NIV might be too complicated for patients to manage outside a supervised environment. CONCLUSIONS: Individuals with COPD, naïve to NIV, and using NIV during exercise for the first time reported a positive effect of NIV on breathlessness and exercise performance. Participants' perceived benefit of NIV correlated moderately with increased endurance time and resting hyperinflation and with a reduction in dynamic hyperinflation during exercise, suggesting that patient reports could also aid selection of those who will benefit from NIV during exercise. [ABSTRACT FROM AUTHOR]

Published
2022
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24. 559-P: Signs of Early Change in Peripheral Axons in People with Early-Onset Type 2 Diabetes Mellitus

Author

GU, YU, primary, HARMER, ALISON R., additional, DENNIS, SARAH M., additional, LI, TIFFANY, additional, TIMMINS, HANNAH C., additional, TIEN LOH, PATRICIA CHIN, additional, GARG, NIDHI, additional, DHARMADASA, THANUJA, additional, WONG, JENCIA, additional, GAULD, AMANDA, additional, MUNOZ, PHILLIP A., additional, and PARK, SUSANNA B., additional

Published
2020
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33. Tables – Supplemental material for Prevalence and determinants of physical activity and sedentary behaviour before and up to 12 months after total knee replacement: a longitudinal cohort study

Author

Hodges, Alison, Harmer, Alison R, Dennis, Sarah, Lillias Nairn, March, Lyn, Crawford, Ross, Parker, David, and Fransen, Marlene

Subjects
FOS: Clinical medicine, 110604 Sports Medicine, FOS: Health sciences, humanities, 110904 Neurology and Neuromuscular Diseases, 110314 Orthopaedics
Abstract

Supplemental material, Tables for Prevalence and determinants of physical activity and sedentary behaviour before and up to 12 months after total knee replacement: a longitudinal cohort study by Alison Hodges, Alison R Harmer, Sarah Dennis, Lillias Nairn, Lyn March, Ross Crawford, David Parker and Marlene Fransen in Clinical Rehabilitation

Published
2018
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34. The effect of non-invasive ventilation (NIV) during exercise on inspiratory capacity (IC) and endurance time (Tlim) in patients with severe COPD

Author

Dennis, Clancy, primary, Menadue, Collette, additional, Schneeberger, Tessa, additional, Leitl, Daniela, additional, Glöckl, Rainer, additional, Harmer, Alison R, additional, Schönheit-Kenn, Ursula, additional, Koczulla, Andreas Rembert, additional, Barnes, David, additional, Kenn, Klaus, additional, and Alison, Jennifer A, additional

Published
2019
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43. Prevalence and determinants of fatigue following total knee replacement : A longitudinal cohort study

Author

Hodges, Alison, Harmer, Alison R., Dennis, Sarah, Nairn, Lillias, March, Lyn, Crosbie, Jack, Crawford, Ross, Parker, David, and Fransen, Marlene

Abstract

Objective To evaluate the prevalence and determinants of clinically important fatigue before and up to 12 months after total knee replacement (TKR) surgery. Methods This study was a secondary analysis of a prospective cohort study conducted among 422 patients (ages 45–74 years) undergoing primary TKR for osteoarthritis (OA) who participated in the Maximum Recovery After Knee Replacement randomized clinical trial. Assessments were carried out before, and at 6 weeks, 6 months, and 12 months after surgery. Self-reported fatigue was assessed on a 10-cm visual analog scale. Patients also completed a number of questionnaires evaluating knee pain, activity limitations, psychological well-being, comorbidity, and physical activity. Linear regression analyses were conducted to explore 6- and 12-month cross-sectional and longitudinal associations with self-reported fatigue. Results Clinically important fatigue (≥6.7 of 10) was reported by 145 patients (34%) before surgery, decreasing to 14%, 12%, and 8% at 6 weeks, 6 months, and 12 months after surgery, respectively. In multivariate analyses, muscle strength was strongly associated with fatigue at 6 months, and knee pain, activity limitations, number of comorbidities, and lack of energy were strongly associated with fatigue at both 6 and 12 months after TKR surgery. Female sex, number of comorbidities, depression, and fatigue were all early predictors of fatigue 12 months after TKR. Conclusion Among patients undergoing TKR for OA, clinically important fatigue is considerably prevalent both before and for at least 6 months after surgery. Identifying and addressing early predictors of ongoing fatigue has the potential to improve the quality of life following TKR surgery.

Published
2016

47. Validity of arterialised-venous PCO2, pH and bicarbonate in obesity hypoventilation syndrome

Author

Hollier, Carly A., Maxwell, Lyndal J., Harmer, Alison R., Menadue, Collette, Piper, Amanda J., Black, Deborah A., Willson, Grant N., and Alison, Jennifer A.

Subjects
Validation, Obesity, Obesity hypoventilation syndrome, Blood gas, Arterialised-venous
Abstract

This prospective study investigated the validity of arterialised-venous blood gases (AVBG) for estimating arterial carbon dioxide (PCO2 ), pH and bicarbonate (HCO3 −) in people with obesity hypoventilation syndrome (OHS). AVBGs were obtained from an upper limb vein, after heating the skin at 42–46 ◦C. Arterial blood gas (ABG) and AVBG samples were taken simultaneously and compared using Bland Altman analysis. Between-group differences were assessed with independent t-tests or Mann–Whitney U tests. Forty-two viable paired samples were analysed, including 27 paired samples from 15 OHS participants, and 15 paired samples from 16 controls. AVBG–ABG agreement was not different between groups, or between dorsal hand, forearm and antecubital AVBG sampling sites, and was clinically acceptable for PCO2 : mean difference (MD) 0.4 mmHg (0.9%), limits of agreement (LOA) −2.7–3.6 mmHg (±6.6%); pH: MD −0.008 (−0.1%), LOA −0.023–0.008 (±0.2%); and HCO3 −: MD −0.3 mmol L−1 (−1.0%), LOA −1.8–1.2 mmol L−1 (±5.3%). AVBG provides valid measures of PCO2 , pH, and HCO3 − in OHS.

Published
2013

50. Neuromuscular Fatigue in Individuals with and without Type 2 Diabetes

Author

Senefeld, Jonathon, primary, Harmer, Alison R., additional, Pereira, Hugo, additional, Yoon, Tejin, additional, Schlinder-DeLap, Bonnie, additional, Deering, Rita, additional, Buzzard, Anna, additional, Harkins, April, additional, Danduran, Mike, additional, Magill, Steven, additional, Kidambi, Srividya, additional, and Hunter, Sandra K., additional

Published
2014
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