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2. Chapter The Fight for Social Justice – Lalage Bown: A Lifetime’s Mission

Author

Hamilton, Robert

Subjects
Access, Adult Education, Decolonisation, Universities, Women’s Literacy, thema EDItEUR::J Society and Social Sciences::JN Education
Abstract

This chapter examines the life and legacy of the remarkable and inspiring Emeritus Professor Lalage Bown, OBE, who died in 2021, aged 94. The author locates Lalage’s commitment to adult education to a post-war Second World War period, when many believed that the kind of injustices suffered under colonial rule had to end. It is demonstrated that she was a globalist who believed that all humanity was interconnected, and that education could promote transformative change across and within national boundaries. An eminent women’s literacy advocate, who devoted her life’s work to improving education for the disadvantaged, especially women, Lalage sought to bring university opportunities to the widest possible sections of society. She was immersed in a tradition which regarded adult education as a catalyst for significant social change, and this chapter highlights how she developed new inclusive, post-colonial approaches to education, including the reform of university curricula across many countries in Africa and Europe.

Published
2023
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3. Patterns of Electrocardiographic Abnormalities in Children with Hypertrophic Cardiomyopathy

Author

Marshall, Mayme, Malik, Aneeq, Shah, Maully, Fish, Frank A., Etheridge, Susan P., Aziz, Peter F., Russell, Mark W., Tisma, Svjetlana, Pflaumer, Andreas, Sreeram, Narayanswami, Kubus, Peter, Law, Ian H., Kantoch, Michal J., Kertesz, Naomi J., Strieper, Margaret, Erickson, Christopher C., Moore, Jeremy P., Nakano, Stephanie J., Singh, Harinder R., Chang, Philip, Cohen, Mitchell, Fournier, Anne, Ilina, Maria V., Zimmermann, Frank, Horndasch, Michaela, Li, Walter, Batra, Anjan S., Liberman, Leonardo, Hamilton, Robert, Janson, Christopher M., Sanatani, Shubhayan, Zeltser, Ilana, McDaniel, George, Blaufox, Andrew D., Garnreiter, Jason M., and Balaji, Seshadri

Published
2024
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7. Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

Author

Wang, Anqi, Shen, Jiayi, Rodriguez, Alex A., Saunders, Edward J., Chen, Fei, Janivara, Rohini, Darst, Burcu F., Sheng, Xin, Xu, Yili, Chou, Alisha J., Benlloch, Sara, Dadaev, Tokhir, Brook, Mark N., Plym, Anna, Sahimi, Ali, Hoffman, Thomas J., Takahashi, Atushi, Matsuda, Koichi, Momozawa, Yukihide, Fujita, Masashi, Laisk, Triin, Figuerêdo, Jéssica, Muir, Kenneth, Ito, Shuji, Liu, Xiaoxi, Uchio, Yuji, Kubo, Michiaki, Kamatani, Yoichiro, Lophatananon, Artitaya, Wan, Peggy, Andrews, Caroline, Lori, Adriana, Choudhury, Parichoy P., Schleutker, Johanna, Tammela, Teuvo L. J., Sipeky, Csilla, Auvinen, Anssi, Giles, Graham G., Southey, Melissa C., MacInnis, Robert J., Cybulski, Cezary, Wokolorczyk, Dominika, Lubinski, Jan, Rentsch, Christopher T., Cho, Kelly, Mcmahon, Benjamin H., Neal, David E., Donovan, Jenny L., Hamdy, Freddie C., Martin, Richard M., Nordestgaard, Borge G., Nielsen, Sune F., Weischer, Maren, Bojesen, Stig E., Røder, Andreas, Stroomberg, Hein V., Batra, Jyotsna, Chambers, Suzanne, Horvath, Lisa, Clements, Judith A., Tilly, Wayne, Risbridger, Gail P., Gronberg, Henrik, Aly, Markus, Szulkin, Robert, Eklund, Martin, Nordstrom, Tobias, Pashayan, Nora, Dunning, Alison M., Ghoussaini, Maya, Travis, Ruth C., Key, Tim J., Riboli, Elio, Park, Jong Y., Sellers, Thomas A., Lin, Hui-Yi, Albanes, Demetrius, Weinstein, Stephanie, Cook, Michael B., Mucci, Lorelei A., Giovannucci, Edward, Lindstrom, Sara, Kraft, Peter, Hunter, David J., Penney, Kathryn L., Turman, Constance, Tangen, Catherine M., Goodman, Phyllis J., Thompson, Jr., Ian M., Hamilton, Robert J., Fleshner, Neil E., Finelli, Antonio, Parent, Marie-Élise, Stanford, Janet L., Ostrander, Elaine A., Koutros, Stella, Beane Freeman, Laura E., Stampfer, Meir, Wolk, Alicja, Håkansson, Niclas, Andriole, Gerald L., Hoover, Robert N., Machiela, Mitchell J., Sørensen, Karina Dalsgaard, Borre, Michael, Blot, William J., Zheng, Wei, Yeboah, Edward D., Mensah, James E., Lu, Yong-Jie, Zhang, Hong-Wei, Feng, Ninghan, Mao, Xueying, Wu, Yudong, Zhao, Shan-Chao, Sun, Zan, Thibodeau, Stephen N., McDonnell, Shannon K., Schaid, Daniel J., West, Catharine M. L., Barnett, Gill, Maier, Christiane, Schnoeller, Thomas, Luedeke, Manuel, Kibel, Adam S., Drake, Bettina F., Cussenot, Olivier, Cancel-Tassin, Geraldine, Menegaux, Florence, Truong, Thérèse, Koudou, Yves Akoli, John, Esther M., Grindedal, Eli Marie, Maehle, Lovise, Khaw, Kay-Tee, Ingles, Sue A., Stern, Mariana C., Vega, Ana, Gómez-Caamaño, Antonio, Fachal, Laura, Rosenstein, Barry S., Kerns, Sarah L., Ostrer, Harry, Teixeira, Manuel R., Paulo, Paula, Brandão, Andreia, Watya, Stephen, Lubwama, Alexander, Bensen, Jeannette T., Butler, Ebonee N., Mohler, James L., Taylor, Jack A., Kogevinas, Manolis, Dierssen-Sotos, Trinidad, Castaño-Vinyals, Gemma, Cannon-Albright, Lisa, Teerlink, Craig C., Huff, Chad D., Pilie, Patrick, Yu, Yao, Bohlender, Ryan J., Gu, Jian, Strom, Sara S., Multigner, Luc, Blanchet, Pascal, Brureau, Laurent, Kaneva, Radka, Slavov, Chavdar, Mitev, Vanio, Leach, Robin J., Brenner, Hermann, Chen, Xuechen, Holleczek, Bernd, Schöttker, Ben, Klein, Eric A., Hsing, Ann W., Kittles, Rick A., Murphy, Adam B., Logothetis, Christopher J., Kim, Jeri, Neuhausen, Susan L., Steele, Linda, Ding, Yuan Chun, Isaacs, William B., Nemesure, Barbara, Hennis, Anselm J. M., Carpten, John, Pandha, Hardev, Michael, Agnieszka, De Ruyck, Kim, De Meerleer, Gert, Ost, Piet, Xu, Jianfeng, Razack, Azad, Lim, Jasmine, Teo, Soo-Hwang, Newcomb, Lisa F., Lin, Daniel W., Fowke, Jay H., Neslund-Dudas, Christine M., Rybicki, Benjamin A., Gamulin, Marija, Lessel, Davor, Kulis, Tomislav, Usmani, Nawaid, Abraham, Aswin, Singhal, Sandeep, Parliament, Matthew, Claessens, Frank, Joniau, Steven, Van den Broeck, Thomas, Gago-Dominguez, Manuela, Castelao, Jose Esteban, Martinez, Maria Elena, Larkin, Samantha, Townsend, Paul A., Aukim-Hastie, Claire, Bush, William S., Aldrich, Melinda C., Crawford, Dana C., Srivastava, Shiv, Cullen, Jennifer, Petrovics, Gyorgy, Casey, Graham, Wang, Ying, Tettey, Yao, Lachance, Joseph, Tang, Wei, Biritwum, Richard B., Adjei, Andrew A., Tay, Evelyn, Truelove, Ann, Niwa, Shelley, Yamoah, Kosj, Govindasami, Koveela, Chokkalingam, Anand P., Keaton, Jacob M., Hellwege, Jacklyn N., Clark, Peter E., Jalloh, Mohamed, Gueye, Serigne M., Niang, Lamine, Ogunbiyi, Olufemi, Shittu, Olayiwola, Amodu, Olukemi, Adebiyi, Akindele O., Aisuodionoe-Shadrach, Oseremen I., Ajibola, Hafees O., Jamda, Mustapha A., Oluwole, Olabode P., Nwegbu, Maxwell, Adusei, Ben, Mante, Sunny, Darkwa-Abrahams, Afua, Diop, Halimatou, Gundell, Susan M., Roobol, Monique J., Jenster, Guido, van Schaik, Ron H. N., Hu, Jennifer J., Sanderson, Maureen, Kachuri, Linda, Varma, Rohit, McKean-Cowdin, Roberta, Torres, Mina, Preuss, Michael H., Loos, Ruth J. F., Zawistowski, Matthew, Zöllner, Sebastian, Lu, Zeyun, Van Den Eeden, Stephen K., Easton, Douglas F., Ambs, Stefan, Edwards, Todd L., Mägi, Reedik, Rebbeck, Timothy R., Fritsche, Lars, Chanock, Stephen J., Berndt, Sonja I., Wiklund, Fredrik, Nakagawa, Hidewaki, Witte, John S., Gaziano, J. Michael, Justice, Amy C., Mancuso, Nick, Terao, Chikashi, Eeles, Rosalind A., Kote-Jarai, Zsofia, Madduri, Ravi K., Conti, David V., and Haiman, Christopher A.

Published
2023
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10. Impact of Fontan Fenestration on Adverse Cardiovascular Outcomes: A Multicentre Study

Author

Dib, Nabil, Samuel, Michelle, Levesque, Sylvie, Zaidi, Ali, Cohen, Sarah, Opotowsky, Alexander R., Mongeon, François-Pierre, Mondésert, Blandine, Kay, Joseph, Ibrahim, Reda, Hamilton, Robert M., Fournier, Anne, Jameson, Susan M., Dore, Annie, Cook, Stephen C., Cohen, Scott, Chaix, Marie-A., Broberg, Craig S., Aboulhosn, Jamil, Poirier, Nancy, and Khairy, Paul

Published
2024
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11. Graph Convolutional Neural Networks for Histologic Classification of Pancreatic Cancer

Author

Wu, Weiyi, Liu, Xiaoying, Hamilton, Robert B., Suriawinata, Arief A., and Hassanpour, Saeed

Subjects
Medical imaging equipment -- Evaluation, Neural networks -- Evaluation, Social networks, Pancreatic cancer, Neural network, Health
Abstract

* Context.--Pancreatic ductal adenocarcinoma has some of the worst prognostic outcomes among various cancer types. Detection of histologic patterns of pancreatic tumors is essential to predict prognosis and decide the treatment for patients. This histologic classification can have a large degree of variability even among expert pathologists. Objective.--To detect aggressive adenocarcinoma and less aggressive pancreatic tumors from nonneoplasm cases using a graph convolutional network-based deep learning model. Design.--Our model uses a convolutional neural network to extract detailed information from every small region in a whole slide image. Then, we use a graph architecture to aggregate the extracted features from these regions and their positional information to capture the whole slide-level structure and make the final prediction. Results.--We evaluated our model on an independent test set and achieved an F1 score of 0.85 for detecting neoplastic cells and ductal adenocarcinoma, significantly outperforming other baseline methods. Conclusions.--If validated in prospective studies, this approach has a great potential to assist pathologists in identifying adenocarcinoma and other types of pancreatic tumors in clinical settings. doi: 10.5858/arpa.2022-0035-OA, Pancreatic ductal adenocarcinoma (PDAC) is an aggressive type of cancer derived from the epithelial cells that make up the ducts of the pancreas. PDAC ranks firmly first among all cancer [...]

Published
2023
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15. Prognostic Factor Risk Groups for Clinical Stage I Seminoma: An Individual Patient Data Analysis by the European Association of Urology Testicular Cancer Guidelines Panel and Guidelines Office

Author

Boormans, Joost L., Sylvester, Richard, Anson-Cartwright, Lynn, Glicksman, Rachel M., Hamilton, Robert J., Hahn, Ezra, Daugaard, Gedske, Lauritsen, Jakob, Wagner, Thomas, Avuzzi, Barbara, Nicolai, Nicola, del Muro, Xavier García, Aparicio, Jorge, Stalder, Odile, Rothermundt, Christian, Fischer, Stefanie, and Laguna, M. Pilar

Published
2024
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19. Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis

Author

Landi, Maria Teresa, Stevens, Victoria, Wang, Ying, Albanes, Demetrios, Caporaso, Neil, Brennan, Paul, Amos, Christopher I., Shete, Sanjay, Hung, Rayjean J., Bickeböller, Heike, Risch, Angela, Houlston, Richard, Lam, Stephen, Tardon, Adonina, Chen, Chu, Bojesen, Stig E., Johansson, Mattias, Wichmann, H-Erich, Christiani, David, Rennert, Gadi, Arnold, Susanne, Field, John K., Le Marchand, Loic, Melander, Olle, Brunnström, Hans, Liu, Geoffrey, Andrew, Angeline, Kiemeney, Lambertus A., Shen, Hongbing, Zienolddiny, Shan, Grankvist, Kjell, Johansson, Mikael, Teare, M. Dawn, Hong, Yun-Chul, Yuan, Jian-Min, Lazarus, Philip, Schabath, Matthew B., Aldrich, Melinda C., Eeles, Rosalind A., Haiman, Christopher A., Kote-Jarai, Zsofia, Schumacher, Fredrick R., Benlloch, Sara, Al Olama, Ali Amin, Muir, Kenneth R., Berndt, Sonja I., Conti, David V., Wiklund, Fredrik, Chanock, Stephen, Tangen, Catherine M., Batra, Jyotsna, Clements, Judith A., Grönberg, Henrik, Pashayan, Nora, Schleutker, Johanna, Albanes, Demetrius, Weinstein, Stephanie J., Wolk, Alicja, West, Catharine M.L., Mucci, Lorelei A., Cancel-Tassin, Géraldine, Koutros, Stella, Sørensen, Karina Dalsgaard, Grindedal, Eli Marie, Neal, David E., Hamdy, Freddie C., Donovan, Jenny L., Travis, Ruth C., Hamilton, Robert J., Ingles, Sue Ann, Rosenstein, Barry S., Lu, Yong-Jie, Giles, Graham G., MacInnis, Robert J., Kibel, Adam S., Vega, Ana, Kogevinas, Manolis, Penney, Kathryn L., Park, Jong Y., Stanfrod, Janet L., Cybulski, Cezary, Nordestgaard, Børge G., Nielsen, Sune F., Brenner, Hermann, Maier, Christiane, Logothetis, Christopher J., John, Esther M., Teixeira, Manuel R., Neuhausen, Susan L., De Ruyck, Kim, Razack, Azad, Newcomb, Lisa F., Lessel, Davor, Kaneva, Radka, Usmani, Nawaid, Claessens, Frank, Townsend, Paul A., Castelao, Jose Esteban, Roobol, Monique J., Menegaux, Florence, Khaw, Kay-Tee, Cannon-Albright, Lisa, Pandha, Hardev, Thibodeau, Stephen N., Hunter, David J., Kraft, Peter, Blot, William J., Riboli, Elio, Yarmolinsky, James, Robinson, Jamie W., Mariosa, Daniela, Karhunen, Ville, Huang, Jian, Dimou, Niki, Murphy, Neil, Burrows, Kimberley, Bouras, Emmanouil, Smith-Byrne, Karl, Lewis, Sarah J., Galesloot, Tessel E., Vermeulen, Sita, Martin, Paul, Hou, Lifang, Newcomb, Polly A., White, Emily, Wu, Anna H., Le Marchand, Loïc, Phipps, Amanda I., Buchanan, Daniel D., Zhao, Sizheng Steven, Gill, Dipender, Chanock, Stephen J., Purdue, Mark P., Davey Smith, George, Herzig, Karl-Heinz, Järvelin, Marjo-Riitta, Amos, Chris I., Dehghan, Abbas, Gunter, Marc J., Tsilidis, Kostas K., and Martin, Richard M.

Published
2024
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23. Identification and in-silico characterization of splice-site variants from a large cardiogenetic national registry

Author

Rayani, Kaveh, Davies, Brianna, Cheung, Matthew, Comber, Drake, Roberts, Jason D., Tadros, Rafik, Green, Martin S., Healey, Jeffrey S., Simpson, Christopher S., Sanatani, Shubhayan, Steinberg, Christian, MacIntyre, Ciorsti, Angaran, Paul, Duff, Henry, Hamilton, Robert, Arbour, Laura, Leather, Richard, Seifer, Colette, Fournier, Anne, Atallah, Joseph, Kimber, Shane, Makanjee, Bhavanesh, Alqarawi, Wael, Cadrin-Tourigny, Julia, Joza, Jacqueline, Gardner, Martin, Talajic, Mario, Bagnall, Richard D., Krahn, Andrew D., and Laksman, Zachary W. M.

Published
2023
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24. Real-world utilization and outcomes of docetaxel among older men with metastatic prostate cancer: a retrospective population-based cohort study in Canada

Author

Shayegan, Bobby, Wallis, Christopher J. D., Hamilton, Robert J., Morgan, Scott C., Cagiannos, Ilinas, Basappa, Naveen S., Ferrario, Cristiano., Gotto, Geoffrey T., Fernandes, Ricardo, Roy, Soumyajit, Noonan, Krista L., Niazi, Tamim, Hotte, Sebastien J., Saad, Fred, Hew, Huong, Park-Wyllie, Laura, Chan, Katherine F. Y., and Malone, Shawn

Published
2023
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28. Development, multi-institutional external validation, and algorithmic audit of an artificial intelligence-based Side-specific Extra-Prostatic Extension Risk Assessment tool (SEPERA) for patients undergoing radical prostatectomy: a retrospective cohort study

Author

Kwong, Jethro C C, Khondker, Adree, Meng, Eric, Taylor, Nicholas, Kuk, Cynthia, Perlis, Nathan, Kulkarni, Girish S, Hamilton, Robert J, Fleshner, Neil E, Finelli, Antonio, van der Kwast, Theodorus H, Ali, Amna, Jamal, Munir, Papanikolaou, Frank, Short, Thomas, Srigley, John R, Colinet, Valentin, Peltier, Alexandre, Diamand, Romain, Lefebvre, Yolene, Mandoorah, Qusay, Sanchez-Salas, Rafael, Macek, Petr, Cathelineau, Xavier, Eklund, Martin, Johnson, Alistair E W, Feifer, Andrew, and Zlotta, Alexandre R

Published
2023
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29. The use of 2-D speckle tracking echocardiography in differentiating healthy adolescent athletes with right ventricular outflow tract dilation from patients with arrhythmogenic cardiomyopathy

Author

Dorobantu, Dan M., Riding, Nathan, McClean, Gavin, de la Garza, María-Sanz, Abuli-Lluch, Marc, Sharma, Chetanya, Duarte, Nuno, Adamuz, Maria Carmen, Watt, Victoria, Hamilton, Robert M., Ryding, Diane, Perry, Dave, McNally, Steve, Stuart, A. Graham, Sitges, Marta, Oxborough, David L., Wilson, Mathew, Friedberg, Mark K., Williams, Craig A., and Pieles, Guido E.

Published
2023
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32. The Burden of Uncontrolled Cardiovascular Risk Factors in Men With Prostate Cancer: A RADICAL-PC Analysis

Author

Klimis, Harry, Pinthus, Jehonathan H., Aghel, Nazanin, Duceppe, Emmanuelle, Fradet, Vincent, Brown, Ian, Siemens, D. Robert, Shayegan, Bobby, Klotz, Laurence, Luke, Patrick P., Niazi, Tamim, Lavallee, Luke T., Mousavi, Negareh, Hamilton, Robert J., Chin, Joseph L., Gopaul, Darin, Violette, Philippe D., Davis, Margot K., Hanna, Nawar, Sabbagh, Robert, Ben Zadok, Osnat Itzhaki, Hajjar, Ludhmila Abrahão, Kann, Ariel Galapo, Mian, Rajibul, Rangarajan, Sumathy, Huei Ng, Kelvin Kuan, Iakobishvili, Zaza, Selvanayagam, Joseph B., Avezum, Alvaro, and Leong, Darryl P.

Published
2023
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33. Minimally invasive retroperitoneal lymph node dissection for men with testis cancer: a retrospective cohort study of safety and feasibility

Author

Fankhauser, Christian D., Afferi, Luca, Stroup, Sean P., Rocco, Nicholas R., Olson, Kathleen, Bagrodia, Aditya, Baky, Fady, Cazzaniga, Walter, Mayer, Erik, Nicol, David, Islamoglu, Ekrem, de Vergie, Stephane, Saoud, Ragheed, Eggener, Scott E., Nazzani, Sebastiano, Nicolai, Nicola, Hugar, Lee, Sexton, Wade J., Matei, Deliu-Victor, De Cobelli, Ottavio, Cheaib, Joseph, Pierorazio, Phillip M., Porter, James, Hermanns, Thomas, Hamilton, Robert J., Hiester, Andreas, Albers, Peter, Clarke, Noel, and Mattei, Agostino

Published
2022
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34. Extended Results and Independent Validation of a Phase 2 Trial of Metastasis-Directed Therapy for Molecularly Defined Oligometastatic Prostate Cancer

Author

Glicksman, Rachel M., Ramotar, Matthew, Metser, Ur, Chung, Peter W., Liu, Zhihui, Vines, Douglass, Finelli, Antonio, Hamilton, Robert, Fleshner, Neil E., Perlis, Nathan, Zlotta, Alexandre R., Bayley, Andrew, Helou, Joelle, Raman, Srinivas, Kulkarni, Girish, Catton, Charles, Lam, Tony, Chan, Rosanna, Warde, Padraig, Gospodarowicz, Mary, Jaffray, David A., and Berlin, Alejandro

Published
2022
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37. Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score

Author

Huynh-Le, Minh-Phuong, Karunamuni, Roshan, Fan, Chun Chieh, Asona, Lui, Thompson, Wesley K., Martinez, Maria Elena, Eeles, Rosalind A., Kote-Jarai, Zsofia, Muir, Kenneth R., Lophatananon, Artitaya, Schleutker, Johanna, Pashayan, Nora, Batra, Jyotsna, Grönberg, Henrik, Neal, David E., Nordestgaard, Børge G., Tangen, Catherine M., MacInnis, Robert J., Wolk, Alicja, Albanes, Demetrius, Haiman, Christopher A., Travis, Ruth C., Blot, William J., Stanford, Janet L., Mucci, Lorelei A., West, Catharine M. L., Nielsen, Sune F., Kibel, Adam S., Cussenot, Olivier, Berndt, Sonja I., Koutros, Stella, Sørensen, Karina Dalsgaard, Cybulski, Cezary, Grindedal, Eli Marie, Menegaux, Florence, Park, Jong Y., Ingles, Sue A., Maier, Christiane, Hamilton, Robert J., Rosenstein, Barry S., Lu, Yong-Jie, Watya, Stephen, Vega, Ana, Kogevinas, Manolis, Wiklund, Fredrik, Penney, Kathryn L., Huff, Chad D., Teixeira, Manuel R., Multigner, Luc, Leach, Robin J., Brenner, Hermann, John, Esther M., Kaneva, Radka, Logothetis, Christopher J., Neuhausen, Susan L., De Ruyck, Kim, Ost, Piet, Razack, Azad, Newcomb, Lisa F., Fowke, Jay H., Gamulin, Marija, Abraham, Aswin, Claessens, Frank, Castelao, Jose Esteban, Townsend, Paul A., Crawford, Dana C., Petrovics, Gyorgy, van Schaik, Ron H. N., Parent, Marie-Élise, Hu, Jennifer J., Zheng, Wei, Mills, Ian G., Andreassen, Ole A., Dale, Anders M., and Seibert, Tyler M.

Published
2022
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39. Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts

Author

Teng, Allen C. T., Gu, Liyang, Di Paola, Michelle, Lakin, Robert, Williams, Zachary J., Au, Aaron, Chen, Wenliang, Callaghan, Neal I., Zadeh, Farigol Hakem, Zhou, Yu-Qing, Fatah, Meena, Chatterjee, Diptendu, Jourdan, L. Jane, Liu, Jack, Simmons, Craig A., Kislinger, Thomas, Yip, Christopher M., Backx, Peter H., Gourdie, Robert G., Hamilton, Robert M., and Gramolini, Anthony O.

Published
2022
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41. Return of Results Policies for Genomic Research: Current Practices and the Hearts in Rhythm Organization (HiRO) Approach

Author

Comber, Drake A., Davies, Brianna, Roberts, Jason D., Tadros, Rafik, Green, Martin S., Healey, Jeffrey S., Simpson, Christopher S., Sanatani, Shubhayan, Steinberg, Christian, MacIntyre, Ciorsti, Angaran, Paul, Duff, Henry, Hamilton, Robert, Arbour, Laura, Leather, Richard, Seifer, Colette, Fournier, Anne, Atallah, Joseph, Kimber, Shane, Makanjee, Bhavanesh, Alqarawi, Wael, Cadrin-Tourigny, Julia, Joza, Jacqueline, Gibbs, Karen, Robb, Laura, Zahavich, Laura, Gardner, Martin, Talajic, Mario, Virani, Alice, Krahn, Andrew D., Lehman, Anna, and Laksman, Zachary W.M.

Published
2022
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43. Brugada Syndrome

Author

Krahn, Andrew D., Behr, Elijah R., Hamilton, Robert, Probst, Vincent, Laksman, Zachary, and Han, Hui-Chen

Published
2022
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44. Primary retroperitoneal lymph node dissection for metastatic non‐seminomatous germ cell tumours: outcomes and adjuvant chemotherapy.

Author

Mousa, Ahmad, Anson‐Cartwright, Lynn, Atenafu, Eshetu G., Jewett, Michael A.S., Bedard, Philippe, Jiang, Di Maria, Glicksman, Rachel, Chung, Peter, Warde, Padraig, O'Malley, Martin, Prendeville, Susan, and Hamilton, Robert J.

Subjects
LYMPHADENECTOMY, ADJUVANT chemotherapy, TUMOR classification, GERM cells, TESTICULAR cancer
Abstract

Objectives: To compare the outcomes and treatment burden of primary retroperitoneal lymph node dissection (pRPLND) alone versus pRPLND + adjuvant chemotherapy (AC) in patients with pathological stage II (PSII) non‐seminomatous germ cell tumours (NSGCT). Patients and Methods: Retrospective review of the Princess Margaret Cancer Center eTestes cancer database identified patients with PSII NSGCT after pRPLND between 1995 and 2020. The primary outcome was relapse‐free survival (RFS). Secondary outcomes included disease‐specific survival (DSS), burden of relapse treatment, and factors associated with relapse. Results: A total of 109 PSII patients were included in the study. There were 96 patients treated with pRPLND alone and 13 treated with pRPLND + AC. The median follow‐up was 61 months. The 5‐year RFS was 72% for the pRPLND‐only group vs 92% for the pRPLND + AC group (hazard ratio [HR] 4.372, 95% confidence interval [CI] 0.59–32.36; P = 0.11). Within the pRPLND‐only group the 5‐year RFS differed by pN stage (pN1 = 94% vs pN2/N3 = 67%, P = 0.03). Despite a higher relapse rate within the pRPLND‐only group, the DSS was similar at 5 years (98% pRPLND only vs 100% pRPLND + AC, P = 0.48). Only 24 (25%) of the patients in the pRPLND‐only group required any subsequent chemotherapy. Despite achieving similar survival, the cumulative post‐RPLND treatment burden was less for the pRPLND‐only group than the pRPLND+AC group overall (average 1.23 vs 2.46 cycles of chemotherapy per patient in group). Conclusion: The majority of patients with PSII NSGCT treated with pRPLND alone do not experience a recurrence or require chemotherapy. Despite a lower relapse risk when AC is given, no difference in survival was seen but higher chemotherapy burden was entertained. AC may constitute overtreatment for most patients with PSII NSGCT treated with pRPLND. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Screening asthmatics for atopic status using the ALergy EXplorer (ALEX2) macroarray.

Author

Hamilton, Robert G., Holbreich, Mark, Bronzert, Charles, Anderson, Rebecca L., Schoettler, Nathan, and Ober, Carole

Subjects
*RURAL children, *ASTHMATICS, *AGRICULTURE, *IMMUNOGLOBULIN E, *MEDICAL screening
Abstract

Background: Screening asthma patients for atopy facilitates management. Since 2010, the core biomarker for screening asthma subjects for atopic status has been the qualitative Phadiatop. multi-aeroallergen screen. A more quantitative macroarray, the Allergy Explorer (ALEX2), shows promise as an alternative. Objective: The study's goal was to examine the pros and cons of the use of ALEX2 in the screening of asthma patients for atopic status. Methods: We evaluated the atopic (IgE-sensitization) status in asthmatic Amish and Hutterite farm children using the ImmunoCAP and ALEX2 assays in Phadiatop equivocal and positive subjects. Results: All 42 asthmatic children were analyzed by Phadiatop and total serum IgE. Of these, 22 had a negative Phadiatop (<0.1 kUa/L) and total IgE <100 kU/L which defined them as non-atopic and they were excluded from ALEX2 testing. Of six children with equivocal Phadiatops (0.1–0.2 kUa/L-Group 1) and three children with a negative Phadiatop but total IgE >100 kUa/L (group 3), 44% (n = 4) had detectable IgE antibody by ALEX2 to mite, tree pollen, and other allergens not detected by Phadiatop, but confirmed by allergen-specific ImmunoCAP testing. In 11 Phadiatop positive subjects (>0.2 kUa/L–group 2), all but one were positive by ALEX2. IgE antibody specific for mold and rabbit aeroallergens matched their agricultural and pet exposure history. Three children were positive for IgE antibody to allergens in the profilin, nsLTP, or PR-10 cross-reactive protein families. Conclusion: Judicious use of ALEX2's enhanced specificity data not provided by the Phadiatop can aid in the interpretation of sensitization patterns and planning management of atopic asthmatics, but sensitization relevance must be confirmed by the patient's clinical history. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Aboriginal Title, Self-Government, and Indigenous Jurisdiction in Canadian Law.

Author

Beaton, Ryan, Hamilton, Robert, and Nichols, Joshua

Subjects
Conflict of laws -- Interpretation and construction -- Evaluation, Canadian native peoples -- Laws, regulations and rules, Tribal jurisdiction -- Laws, regulations and rules, Common law -- Evaluation, Tribal sovereignty -- Laws, regulations and rules, Government regulation, Canada. Constitution Act 1982 (Can. Const. s. 35)
Abstract

0. Introduction This article considers inherent Indigenous jurisdiction in the Canadian constitution in light of recent developments in Aboriginal law. Particular attention is paid to the doctrine of Aboriginal title [...]

Published
2022

48. Reconciliation and the Straitjacket: A Comparative Analysis of the Secession Reference and R v. Sparrow.

Author

Hamilton, Robert and Nichols, Joshua

Subjects
Native Americans -- Treaties, Canadian native peoples -- Laws, regulations and rules, Constitutional law -- Interpretation and construction, Reference by Governor in Council Concerning Certain Questions Relating to Secession of Quebec from Canada, In re ((1998) 2 S.C.R. 217 (Can.)), R. v. Sparrow ((1990) 1 S.C.R. 1075 (Can.)), Government regulation, Canada. Constitution Act 1982 (Can. Const. pt. 2, s. 35)
Abstract

CONTENTS Reconciliation and the Straitjacket: A Comparative Analysis of the Secession Reference and R v Sparrow Robert Hamilton & Joshua Nichols Introduction 209 I. The Cases 214 A. R v [...], IN THE 1990s the Supreme Court of Canada delivered two opinions that have had important consequences for the country&apos;s constitutional order. In R v Sparrow the Court sought to define the content of section 35 of the Constitution Act, 1982. In Reference re Secession of Quebec it was asked to assess the legality of a unilateral provincial secession from the federation. While the two cases seem distinct, and the Court treated them as categorically so, the relationship between the cases is far more open-textured than initially assumed. In both cases, the Supreme Court confronted situations where the explicit provisions of the Constitution did not offer them a clear path forward, in both the Court opted to use unwritten principles to avoid constitutional deadlock, and in both sub-state peoples challenged the constitutional order and their place in it, in the process challenging inherited notions of federalism, constitutionalism, and the nation-state. The resemblance between these cases is of pivotal importance to the future of Canada. With Indigenous peoples increasingly framing their constitutional demands in the language of self-determination, the limitations of the doctrine of Aboriginal rights, thirty years since Sparrow was decided, are beginning to show. This essay argues that the Court&apos;s presuppositions about the place of Indigenous peoples and the Quebecois in the constitutional order led it to develop distinct constitutional doctrine in the response to the demands of each, in Sparrow developing a constitution unevenly supported by uncomplimentary pillars of colonialism and constitutionalism, while relying on the pillars of legality and legitimacy in the Secession Reference. This essay explores the basis for, and consequences of, these distinct doctrinal approaches. Once the similarities and differences of these cases are seen clearly, they provide a judicially navigable route between colonialism and constitutionalism. In short, they provide a route to real and meaningful reconciliation. DURANT LES ANNEES 1990 la Cour supreme du Canada a rendu deux avis qui ont eu des repercussions importantes sur l&apos;ordre constitutionnel du pays. Dans l&apos;affaire R c Sparrow, la Cour supreme a cherche a definir le contenu de l&apos;article 35 de la Loi constitutionnelle de 1982. Dans le Renvoi relatif a la secession du Quebec, on lui a demande d&apos;evaluer la legalite d&apos;une secession provinciale unilaterale de la federation. Bien que les deux affaires semblent etre bien distinctes et que la Cour les ait traitees categoriquement ainsi, la relation entre ces deux affaires est beaucoup plus vague et complexe qu&apos;on ne le pensait au depart. Dans les deux cas, la Cour supreme a ete confrontee a des situations ou les dispositions explicites de la Constitution ne lui proposaient pas de voie claire a suivre. Dans les deux cas, la Cour a choisi d&apos;utiliser des principes non-ecrits pour eviter une impasse constitutionnelle, et dans les deux cas, les peuples infranationaux ont conteste l&apos;ordre constitutionnel et leur place au sein de celui-ci, remettant ainsi en question les notions heritees du federalisme, du constitutionnalisme et de l&apos;Etat-nation. La similitude entre ces affaires est d&apos;une importance capitale pour l&apos;avenir du Canada. Etant donne que les peuples autochtones formulent de plus en plus leurs demandes constitutionnelles en utilisant un langage axe sur l&apos;autodetermination, les limites de la doctrine des droits autochtones, commencent a faire leur apparition, trente ans apres l&apos;affaire Sparrow. Cet essai soutient que les presuppositions de la Cour concernant la place des peuples autochtones et des Quebecois dans l&apos;ordre constitutionnel l&apos;ont amenee a developper une doctrine constitutionnelle differente dans leur reponse aux deux demandes. Dans l&apos;affaire Sparrow, il est question du developpement d&apos;une constitution soutenue inegalement par les piliers, peu flatteurs, du colonialisme et du constitutionnalisme, tandis qu&apos;elle s&apos;appuie sur les piliers de la legalite et de la legitimite, dans le Renvoi relatif a la secession du Quebec. Cet essai explore les fondements et les consequences de ces approches doctrinales differentes. Une fois les ressemblances et les differences de ces affaires clairement pergues, elles paveront le chemin d&apos;un point de vue judiciaire afin de pouvoir mieux naviguer entre le colonialisme et le constitutionnalisme. En bref, elles pavent la voie de fagon a parvenir a une reconciliation veritable et significative.

Published
2021

49. THE UNITED NATIONS DECLARATION ON THE RIGHTS OF INDIGENOUS PEOPLES AND THE DIVISION OF POWERS: CONSIDERING FEDERAL AND PROVINCIAL AUTHORITY IN IMPLEMENTATION.

Author

Hamilton, Robert

Subjects
United Nations. General Assembly, United Nations, Indigenous peoples, United Nations Declaration on the Rights of Indigenous Peoples
Abstract

The United Nations Declaration on the Rights of Indigenous Peoples (1) (UNDRIP or the Declaration) was adopted by the General Assembly of the United Nations (UN) on 13 September 2007. [...]

Published
2021

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