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30 results on '"Haas, Kirsten"'

2. Ethical and coordinative challenges in setting up a national cohort study during the COVID-19 pandemic in Germany

Author

Tilch, Katharina, Hopff, Sina M., Appel, Katharina, Kraus, Monika, Lorenz-Depiereux, Bettina, Pilgram, Lisa, Anton, Gabi, Berger, Sarah, Geisler, Ramsia, Haas, Kirsten, Illig, Thomas, Krefting, Dagmar, Lorbeer, Roberto, Mitrov, Lazar, Muenchhoff, Maximilian, Nauck, Matthias, Pley, Christina, Reese, Jens-Peter, Rieg, Siegbert, Scherer, Margarete, Stecher, Melanie, Stellbrink, Christoph, Valentin, Heike, Winter, Christof, Witzenrath, Martin, and Vehreschild, J. Janne

Published
2023
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5. Burden of intracerebral haemorrhage in Europe: forecasting incidence and mortality between 2019 and 2050

Author

Veltkamp, Roland, Harvey, Kirsten H., Korompoki, Eleni, D’Anna, Lucio, Halse, Omid, Harvey, Emily R., Hügen, Klemens, Malzahn, Uwe, Ullmann, Sabine, Schuhmann, Carolin, Todd, Gabriele Putz, Brinz, Hannes, Fiessler, Cornelia, Heuschmann, Peter U., Haas, Kirsten, Rücker, Viktoria, Enzinger, Christian, Ropele, Stefan, Pinter, Daniela, Haidegger, Melanie, Gattringer, Thomas, Fandler-Höfler, Simon, Wolfe, Charles D.A., Wang, Yanzhong, Wafa, Hatem A., Montaner, Joan, Palà, Elena, Penalba, Anna, Vallverdu, Marcel Lamana, Pilco, Daisy Guaman, Debette, Stéphanie, Sibon, Igor, Renou, Pauline, Lachaize, Morgane, Milan, Léa, Heyvang, Nathalie, Ledure, Sylvain, Michel, Pascale, Conhoc, Johanna, Donnadieu, Léa, Hyves, Kelly, Caso, Valeria, Mosconi, Maria Giulia, Graziani, Mara, Cancelloni, Virginia, Marchini, Laura, Koehler, Bianca Emanuela, Nielsen, Peter Brønnum, Larsen, Torben Bjerregaard, Lip, Gregory Y.H., Horstmann, Solveigh, Purrucker, Jan, Ringleb, Peter, Haffa, Mariam, Klein, Sabrina, Taylor, Lenka, Hoppe-Tichy, Torsten, Haefeli, Walter E., Seidling, Hanna M., Burhenne, Jürgen, Foerster, Kathrin I., Wurmbach, Viktoria, Marquart, Claudia, Lane, Deirdre A., Ivany, Elena, Lotto, Robyn, Marshall, Iain, Xie, Wanqing, and Johnson, Catherine O.

Published
2024
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6. Effect of the addition of a mental health specialist for evaluation of undiagnosed patients in centres for rare diseases (ZSE-DUO): a prospective, controlled trial with a two-phase cohort design

Author

Akkaya, Federica, Babka, Christine, Bannert, Lisa, Bärsch-Michelmann, Anja, Böhm, Leonie, Brinkmann, Folke, Bullinger, Monika, Cario, Holger, de Greck, Moritz, Debatin, Klaus-Michael, Dillmann-Jehn, Katrin, Eymann, Jutta, Frisch, Julia, Glode, Anja, Gödecke, Vega, Grasemann, Corinna, Grauer, Eva, Haas, Astrid, Haisch, Lea, Isabell, Heinrich, Held, Melissa, Hennermann, Julia, Herpertz, Stephan, Herrmann-Werner, Anne, Hett, Julian, Heuschmann, Peter, Hilbig, Bettina, Holthöfer, Laura, Imhof, Christiane, Junne, Florian, Kassubek, Jan, Koschitzki, Kevin-Thomas, Krassort, Heike, Kropff, Birgit, Kuhn, Julia, Latzko, Philipp, Loew, Thomas, Ludolph, Albert C., Meyer, Torsten, Meyer dos Santos, Isabell, Mohnike, Klaus, Monninger, Martina, Mücke, Martin, Müller, Susanne, Musacchio, Thomas, Nießen, Margret, Nöhre, Mariel, Ott, Stephan, Petermann-Meyer, Andrea, Pfeifer-Duck, Christina, Piduhn, Lea-Sophie, Rampp, Carina, Rieß, Olaf, Schaubert, Kristina, Schmidt, Annika, Schneider, Simone, Schoels, Ludger, Schwalba, Martina, Selig, Udo, Sroka, Alexandra, Steinbüchel, Toni, Stösser, Sebastian, Suchant, Steffi, Ungethüm, Kathrin, Vogel, Matthias, Volk, Daniela, Vollmuth, Christoph, Volnov, Solange, Wagner, Thomas O.F., Walter, Sabrina, Warrings, Bodo, Zajt, Kamil, Zenker, Karola, Zhang, David, Zipfel, Stephan, Hebestreit, Helge, Lapstich, Anne-Marie, Brandstetter, Lilly, Krauth, Christian, Deckert, Jürgen, Haas, Kirsten, Pfister, Lisa, Witt, Stefanie, Schippers, Christopher, Dieris-Hirche, Jan, Maisch, Tim, Tüscher, Oliver, Bârlescu, Lavinia Aurelia, Berger, Alexandra, Berneburg, Mark, Britz, Vanessa, Deibele, Anna, Graeßner, Holm, Gündel, Harald, Heuft, Gereon, Lücke, Thomas, Mundlos, Christine, Quitmann, Julia Hannah, Rutsch, Frank, Schubert, Katharina, Schulz, Jörg B., Schweiger, Susann, Zeidler, Cornelia, Zeltner, Lena Margarete, de Zwaan, Martina, Bârlescu, Lavinia, Quitmann, Julia, Schulz, Jörg Bernhard, and Zeltner, Lena

Published
2023
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7. Dual guidance structure for evaluation of patients with unclear diagnosis in centers for rare diseases (ZSE-DUO): study protocol for a controlled multi-center cohort study

Author

Hebestreit, Helge, Zeidler, Cornelia, Schippers, Christopher, de Zwaan, Martina, Deckert, Jürgen, Heuschmann, Peter, Krauth, Christian, Bullinger, Monika, Berger, Alexandra, Berneburg, Mark, Brandstetter, Lilly, Deibele, Anna, Dieris-Hirche, Jan, Graessner, Holm, Gündel, Harald, Herpertz, Stephan, Heuft, Gereon, Lapstich, Anne-Marie, Lücke, Thomas, Maisch, Tim, Mundlos, Christine, Petermann-Meyer, Andrea, Müller, Susanne, Ott, Stephan, Pfister, Lisa, Quitmann, Julia, Romanos, Marcel, Rutsch, Frank, Schaubert, Kristina, Schubert, Katharina, Schulz, Jörg B., Schweiger, Susann, Tüscher, Oliver, Ungethüm, Kathrin, Wagner, Thomas O. F., and Haas, Kirsten

Published
2022
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10. Development of evidence-based quality indicators for deep brain stimulation in patients with Parkinson's disease and first year experience of implementation of a nation-wide registry

Author

Haas, Kirsten, Stangl, Stephanie, Steigerwald, Frank, Matthies, Cordula, Gruber, Doreen, Kühn, Andrea A., Krauss, Joachim K., Sixel-Döring, Friederike, von Eckardstein, Kajetan, Deuschl, Günther, Classen, Joseph, Winkler, Dirk, Voges, Jürgen, Galazky, Imke, Oertel, Wolfgang, Ceballos-Baumann, Andres O., Lange, Max, Gharabaghi, Alireza, Weiss, Daniel T., Volkmann, Jens, and Heuschmann, Peter U.

Published
2019
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11. Development and proof-of-concept of a multicenter, patient-centered cancer registry for breast cancer patients with metastatic disease—the “Breast cancer care for patients with metastatic disease” (BRE-4-MED) registry

Author

Stangl, Stephanie, Haas, Kirsten, Eichner, Felizitas A., Grau, Anna, Selig, Udo, Ludwig, Timo, Fehm, Tanja, Stüber, Tanja, Rashid, Asarnusch, Kerscher, Alexander, Bargou, Ralf, Hermann, Silke, Arndt, Volker, Meyer, Martin, Wildner, Manfred, Faller, Hermann, Schrauder, Michael G., Weigel, Michael, Schlembach, Ulrich, Heuschmann, Peter U., and Wöckel, Achim

Published
2020
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13. Systematic review with meta‐analysis: Stress‐management interventions for patients with irritable bowel syndrome.

Author

Horn, Anna, Stangl, Stephanie, Parisi, Sandra, Bauer, Nina, Roll, Julia, Löffler, Claudia, Gágyor, Ildikó, Haas, Kirsten, Heuschmann, Peter U., Langhorst, Jost, and Keil, Thomas

Subjects
IRRITABLE colon treatment, META-analysis, CONFIDENCE intervals, IRRITABLE colon, SYSTEMATIC reviews, MENTAL health, STRESS management, QUALITY of life, RESEARCH funding, SYMPTOMS, ADULTS
Abstract

Irritable bowel syndrome (IBS) is a common chronic gastrointestinal disorder of unknown pathological origin that is associated with psychological distress and reduced health‐related quality of life (HRQoL). We investigated the effects of stress‐management for adults with IBS on typical symptoms, HRQoL and mental health. With predefined criteria (patients: adults with IBS; intervention: stress‐management; control: care as usual or waitlist; outcome: patient‐relevant; study‐type: controlled trials), we registered the study with PROSPERO (168030) and searched the main medical databases. Two researchers independently reviewed the publications and assessed the risk of bias using the Scottish Intercollegiate Guidelines Network checklist. We performed meta‐analysis with homogeneous trials of acceptable quality. After screening 6656 publications, ten suitable randomized trials of acceptable (n = 5) or low methodological quality (n = 5) involving 587 patients were identified. Our meta‐analysis showed no effect of stress‐management on IBS severity 1–2 months after the intervention (Hedges' g = −0.23, 95%‐CI = −0.84 to −0.38, I2 = 86.1%), and after 3–12 months (Hedges' g = −0.77, 95%‐CI = −1.77 to −0.23, I2 = 93.3%). One trial found a short‐term reduction of symptoms, and one trial found symptom relief in the long‐term (at 6 months). One of two studies that examined HRQoL found an improvement (after 2 months). One of two studies that examined depression and anxiety found a reduction of these symptoms (after 3 weeks). Stress‐management may be beneficial for patients with IBS regarding the short‐term reduction of bowel and mental health symptoms, whereas long‐term benefits are unclear. Good quality RCTs with more than 6 months follow‐up are needed. [ABSTRACT FROM AUTHOR]

Published
2023
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15. Coagulation Testing in Intracerebral Hemorrhage Related to Non-vitamin K Antagonist Oral Anticoagulants

Author

Purrucker, Jan C., Rizos, Timolaos, Haas, Kirsten, Wolf, Marcel, Khan, Shujah, Heuschmann, Peter U., Veltkamp, Roland, Buchner, H., Ertl, M., Haarmeier, T., Hobohm, C., Jüttler, E., Neumann-Haefelin, T., Hennerici, M. G., Kleinschnitz, C., Köhrmann, M., Palm, F., Reinhard, M., Röther, J., Schellinger, P., Schmid, E., Seidel, G., Poli, S., Steiner, T., Tanislav, C., Thomalla, G., Veltkamp, R., Wartenberg, K., and on behalf of the RASUNOA investigators

Published
2017
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23. Versorgung von Parkinson-Patienten in Deutschland.

Author

Stangl, Stephanie, Haas, Kirsten, Eggers, Carsten, Reese, Jens-Peter, Tönges, Lars, and Volkmann, Jens

Abstract

In Germany various concepts for treating patients with Parkinson's disease (PD) are available, e.g. oral medication with levodopa or deep brain stimulation (DBS), depending on the stage and severity of symptoms and also multidisciplinary management up to intersectoral treatment approaches (e.g. complex PD treatment and integrative care concepts). Nevertheless, in the treatment of patients with PD a comprehensive provision of services and a nationwide standardized collation of treatment quality are so far lacking. This is particularly true for technically complicated procedures, which necessitate a high standard of expertise by the treating physician. Some of these challenges could be overcome by expanding digital approaches (e.g. teleneurological consultation and wearables) and by introducing quality assurance initiatives (e.g. comprehensive registries and certification programs). [ABSTRACT FROM AUTHOR]

Published
2020
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24. Role of B cells in chronic graft‐versus‐host disease after allogeneic stem cell transplantation in children and adolescents.

Author

Wiegering, Verena, Keupp, Anne, Frietsch, Marieke, Fiessler, Cornelia, Haas, Kirsten, Haubitz, Imme, Beyersdorf, Niklas, Wölfl, Matthias, Schlegel, Paul‐Gerhardt, and Eyrich, Matthias

Subjects
B cells, STEM cell transplantation, GRAFT versus host disease, CHRONIC diseases, TALL-1 (Protein)
Abstract

Importantly, B-cell values in children after resolution of cGvHD were not different from the non-cGvHD control group, which is strikingly different from adult cGvHD-patients, in which B-cell numbers remain depressed at least for two years after alloSCT (Glauzy I et al i , [4]). This indicates that bone marrow B-lymphopoiesis is less affected by cGvHD in children, which is in accordance with observations that children exhibit more bone marrow B-cell precursors after chemotherapy and alloSCT (Bras I et al i , [2]) and more signal joint kappa-deleting recombination excision circles (sjKRECs) (Nakatani I et al i , [8]) in the regenerative phase compared to adults. We extend these findings by showing that the distribution of bone marrow B-cell subsets as well as absolute peripheral B-cell counts exhibit no major alterations neither before nor during cGvHD. In summary, our analysis of T- and B-cell reconstitution reveals a preserved naïve CD4 SP + sp T-cell regeneration and a more robust B-cell regeneration during and after cGvHD in children compared to what is known from adult cGvHD patients. [Extracted from the article]

Published
2019
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28. Mutual requirement of CDK4 and Myc in malignant transformation: evidence for cyclin D1/CDK4 and p16INK4A as upstream regulators of Myc.

Author

Haas, Kirsten, Staller, Peter, Geisen, Christoph, Bartek, Jiri, Eilers, Martin, and Möröy, Tarik

Subjects
*CELL cycle, *CYCLINS, *ONCOGENES, *RAS oncogenes, *FIBROBLASTS
Abstract

We demonstrate in this paper that CDK4 which is a G1 phase specific cell cycle regulator and catalytic subunit of D-type cyclins has oncogenic activity similar to D-type cyclins themselves and is able to provoke focus formation when cotransfected with activated Ha-ras into primary rat embryo fibroblasts. Surprisingly, using two different mutants we show that CDK4's ability to bind to p16INK4a and not its kinase activity is important for its transforming potential. In addition, p16INK4a but not a mutant form that is found in human tumours can completely abrogate focus formation by CDK4 suggesting that CDK4 can malignantly transform cells by sequestering p16INK4a or other CKIs. We demonstrate that both cyclin D1 and CDK4 functionally depend on active Myc to exert their potential as oncogenes and vice versa that the transforming ability of Myc requires functional cyclin D/CDK complexes. Moreover, we find that p16INK4a and the Rb related protein p107 which releases Myc after phosphorylation by cyclin D1/CDK4 efficiently block Myc's activity as a transcriptional transactivator and as an oncogene. We conclude that both p16INK4a and cyclin D/CDK4 complexes are upstream regulators of Myc and directly govern Myc function in transcriptional transactivation and transformation via the pocket protein p107. [ABSTRACT FROM AUTHOR]

Published
1997
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