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Catchments show a wide range of response behaviour, even if they are adjacent. For many purposes it is necessary to characterise and classify them, e.g. for regionalisation, prediction in ungauged catchments, model parameterisation. In this study, we investigate hydrological similarity of catchments with respect to their response behaviour. We analyse more than 8200 event runoff coefficients (ERCs) and flow duration curves of 53 gauged catchments in Rhineland-Palatinate, Germany, for the period from 1993 to 2008, covering a huge variability of weather and runoff conditions. The spatio-temporal variability of event-runoff coefficients and flow duration curves are assumed to represent how different catchments "transform" rainfall into runoff. From the runoff coefficients and flow duration curves we derive 12 signature indices describing various aspects of catchment response behaviour to characterise each catchment. Hydrological similarity of catchments is defined by high similarities of their indices. We identify, analyse and describe hydrologically similar catchments by cluster analysis using Self-Organizing Maps (SOM). As a result of the cluster analysis we get five clusters of similarly behaving catchments where each cluster represents one differentiated class of catchments. As catchment response behaviour is supposed to be dependent on its physiographic and climatic characteristics, we compare groups of catchments clustered by response behaviour with clusters of catchments based on catchment properties. Results show an overlap of 67% between these two pools of clustered catchments which can be improved using the topologic correctness of SOMs.

In this study two approaches are presented to identify Dominant Runoff Processes (DRP) with respect to regionalization. The approaches are a simplification of an existing method to determine DRP by means of an extensive field campaign. The first approach combines the permeability of the substratum, land-use and slope of the basin in a GIS-based analysis. The second approach makes use of discriminant analysis of the physiographic characteristics of the basin and links it to the GIS analysis. The results of the developed approaches are maps, which identify dominant runoff processes and represent a spatial distribution of the hydrological behaviour of the soil during prolonged rainfall events. The approaches have been developed in a micro-scale basin (Germany). An additional meso-scale basin was introduced in which the two approaches were applied for quality control. The thus generated maps for the micro-scale basin were compared with an existing DRP map, which was derived with the existing method. The first approach showed a resemblance of 79% when compared to this map, whereas the second approach showed only a resemblance of 51%. The generated maps for the meso-scale basin were compared to DRP that were determined point wise according to the existing method. The first approach showed in this case a resemblance of 81%, whereas the second approach showed a resemblance of 68%. Therefore, the first approach is preferred to the second approach when accuracy, data input and calculation time are concerned.

In this study two approaches are used to predict winter storm flow coefficients in meso-scale basins (10 km² to 1000 km²) with a view to regionalization. The winter storm flow coefficient corresponds to the ratio between direct discharge and rainfall. It is basin specific and supposed to give an integrated response to rainfall. The two approaches, which used the permeability of the substratum and dominating runoff generation processes as basin attributes are compared. The study area is the Rhineland Palatinate and the Grand Duchy of Luxembourg and the study focuses on the Nahe basin and its 16 sub-basins (Rhineland Palatinate). For the comparison, three statistical models were derived by means of regression analysis. The models used the winter storm flow coefficient as the dependent variable; the independent variables were the permeability of the substratum, preliminary derived dominating runoff generation processes and a combination of both. It is demonstrated that the permeability and the preliminary derived processes carry different layers of information. Cross-validation and statistical tests were used to determine and evaluate model differences. The cross-validation resulted in a best model performance for the model that used both parameters, followed by the model that used the dominant runoff generation processes. From the statistical tests it was concluded that the models come from different populations, carrying different information layers. Analysis of the residuals of the models indicated that the permeability and runoff generation processes did provide complementary information. Simple linear models appeared to perform well in describing the winter storm flow coefficient at the meso-scale when a combination of the permeability of the substratum and dominating runoff generation processes served as independent parameters.

Hypogammaglobulinemia is a common symptom in different immunodeficiencies. It is, however, not usually associated with Epstein–Barr virus (EBV) infections. The X-linked lymphoproliferative disease (XLP) on the other hand shows immunological changes in response to the EBV. Here we report three previously healthy boys, all of which developed persistent hypogammaglobulinemia following severe acute infectious mononucleosis. All three patients revealed T-cell abnormalities including inverted CD4/CD8 and increased CD8+ T-cell numbers. The number of IFN-γ-producing T cells were markedly increased in the two patients studied so far. In addition, patient 2 showed mainly T cells, instead of B cells, to be infected with the EBV. Apart from an uncle of patient 3, who died of malignant lymphoma, family history was unremarkable in all cases. All three patients exhibited mutations in the SH2D1A gene, establishing the diagnosis of XLP. Protein expression was found on immunoblot analysis in one patient with a missense mutation. Development of persistent hypogammaglobulinemia after severe primary EBV infection seems to be a specific diagnostic sign for XLP even in males with unremarkable family history. [ABSTRACT FROM AUTHOR]