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Your search keyword '"Graff‐Guerrero, Ariel"' showing total 495 results
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495 results on '"Graff‐Guerrero, Ariel"'

1. Neurophysiological and other features of working memory in older adults at risk for dementia

Author

Patterson, Rachel A., Brooks, Heather, Mirjalili, Mina, Rashidi-Ranjbar, Neda, Zomorrodi, Reza, Blumberger, Daniel M., Fischer, Corinne E., Flint, Alastair J., Graff-Guerrero, Ariel, Herrmann, Nathan, Kennedy, James L., Kumar, Sanjeev, Lanctôt, Krista L., Mah, Linda, Mulsant, Benoit H., Pollock, Bruce G., Voineskos, Aristotle N., Wang, Wei, and Rajji, Tarek K.

Published
2024
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7. Variability and magnitude of brain glutamate levels in schizophrenia: a meta and mega-analysis

Author

Merritt, Kate, McCutcheon, Robert A., Aleman, André, Ashley, Sarah, Beck, Katherine, Block, Wolfgang, Bloemen, Oswald J. N., Borgan, Faith, Boules, Christiana, Bustillo, Juan R., Capizzano, Aristides A., Coughlin, Jennifer M., David, Anthony, de la Fuente-Sandoval, Camilo, Demjaha, Arsime, Dempster, Kara, Do, Kim Q., Du, Fei, Falkai, Peter, Galińska-Skok, Beata, Gallinat, Jürgen, Gasparovic, Charles, Ginestet, Cedric E., Goto, Naoki, Graff-Guerrero, Ariel, Ho, Beng-Choon, Howes, Oliver, Jauhar, Sameer, Jeon, Peter, Kato, Tadafumi, Kaufmann, Charles A., Kegeles, Lawrence S., Keshavan, Matcheri S., Kim, Sang-Young, King, Bridget, Kunugi, Hiroshi, Lauriello, J., León-Ortiz, Pablo, Liemburg, Edith, Mcilwain, Meghan E., Modinos, Gemma, Mouchlianitis, Elias, Nakamura, Jun, Nenadic, Igor, Öngür, Dost, Ota, Miho, Palaniyappan, Lena, Pantelis, Christos, Patel, Tulsi, Plitman, Eric, Posporelis, Sotirios, Purdon, Scot E., Reichenbach, Jürgen R., Renshaw, Perry F., Reyes-Madrigal, Francisco, Russell, Bruce R., Sawa, Akira, Schaefer, Martin, Shungu, Dikoma C., Smesny, Stefan, Stanley, Jeffrey A., Stone, James, Szulc, Agata, Taylor, Reggie, Thakkar, Katharine N., Théberge, Jean, Tibbo, Philip G., van Amelsvoort, Thérèse, Walecki, Jerzy, Williamson, Peter C., Wood, Stephen J., Xin, Lijing, Yamasue, Hidenori, McGuire, Philip, and Egerton, Alice

Published
2023
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17. Evaluation of the Glymphatic System in Schizophrenia Spectrum Disorder Using Proton Magnetic Resonance Spectroscopy Measurement of Brain Macromolecule and Diffusion Tensor Image Analysis Along the Perivascular Space Index.

Author

Abdolizadeh, Ali, Torres-Carmona, Edgardo, Kambari, Yasaman, Amaev, Aron, Song, Jianmeng, Ueno, Fumihiko, Koizumi, Teruki, Nakajima, Shinichiro, Agarwal, Sri Mahavir, Luca, Vincenzo De, Gerretsen, Philip, and Graff-Guerrero, Ariel

Abstract

Background and Hypothesis The glymphatic system (GS), a brain waste clearance pathway, is disrupted in various neurodegenerative and vascular diseases. As schizophrenia shares clinical characteristics with these conditions, we hypothesized GS disruptions in patients with schizophrenia spectrum disorder (SCZ-SD), reflected in increased brain macromolecule (MM) and decreased diffusion-tensor-image-analysis along the perivascular space (DTI-ALPS) index. Study Design Forty-seven healthy controls (HCs) and 103 patients with SCZ-SD were studied. Data included 135 proton magnetic resonance spectroscopy (1H-MRS) sets, 96 DTI sets, with 79 participants contributing both. MM levels were quantified in the dorsal-anterior cingulate cortex (dACC), dorsolateral prefrontal cortex, and dorsal caudate (point resolved spectroscopy, echo-time = 35ms). Diffusivities in the projection and association fibers near the lateral ventricle were measured to calculate DTI-ALPS indices. General linear models were performed, adjusting for age, sex, and smoking. Correlation analyses examined relationships with age, illness duration, and symptoms severity. Study Results MM levels were not different between patients and HCs. However, left, right, and bilateral DTI-ALPS indices were lower in patients compared with HCs (P  < .001). In HCs, age was positively correlated with dACC MM and negatively correlated with left, right, and bilateral DTI-ALPS indices (P  < .001). In patients, illness duration was positively correlated with dACC MM and negatively correlated with the right DTI-ALPS index (P  < .05). In the entire population, dACC MM and DTI-ALPS indices showed an inverse correlation (P  < .01). Conclusions Our results suggest potential disruptions in the GS of patients with SCZ-SD. Improving brain's waste clearance may offer a potential therapeutic approach for patients with SCZ-SD. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Investigating structural subdivisions of the anterior cingulate cortex in schizophrenia, with implications for treatment resistance and glutamatergic levels

Author

Ochi, Ryo, Plitman, Eric, Patel, Raihaan, Tarumi, Ryosuke, Iwata, Yusuke, Tsugawa, Sakiko, Kim, Julia, Honda, Shiori, Noda, Yoshihiro, Uchida, Hiroyuki, Devenyi, Gabriel A., Mimura, Masaru, Graff-Guerrero, Ariel, Chakravarty, M. Mallar, and Nakajima, Shinichiro

Subjects
Anterior cingulate cortex -- Structure -- Health aspects, Schizophrenia -- Physiological aspects -- Care and treatment, Glutamate -- Physiological aspects, Health, Psychology and mental health
Abstract

Background: Abnormalities in the anterior cingulate cortex (ACC) are thought to play an important role in the pathophysiology of schizophrenia. Given regional variations in ACC structure, the present study aimed to examine ACC structural subdivisions and their relationships to treatment resistance and glutamatergic levels in schizophrenia. Methods: This study included 100 patients with schizophrenia and 52 healthy controls from 2 cohorts. We applied non-negative matrix factorization to identify accurate and stable spatial components of ACC structure. Between groups, we compared ACC structural indices in each spatial component based on treatment resistance or response and tested relationships with ACC glutamate + glutamine levels. Results: We detected reductions in cortical thickness and increases in mean diffusivity in the spatial components on the surface of the cingulate sulcus, especially in patients with treatment-resistant and clozapine-resistant schizophrenia. Notably, mean diffusivity in these components was higher in patients who did not respond to clozapine compared to those who did. Furthermore, these ACC structural alterations were related to elevated ACC glutamate + glutamine levels but not related to symptomatology or antipsychotic dose. Limitations: Sample sizes, cross-sectional findings and mixed antipsychotic status were limitations of this study. Conclusion: This study identified reproducible abnormalities in ACC structures in patients with treatment-resistant and clozapine-resistant schizophrenia. Given that these spatial components play a role in inhibitory control, the present study strengthens the notion that glutamate- related disinhibition is a common biological feature of treatment resistance in schizophrenia., Introduction Current antipsychotics fail to alleviate clinical symptoms in approximately one-third of patients with schizophrenia. (1) This subtype is termed treatment-resistant schizophrenia, which is formally defined as having an inadequate [...]

Published
2022
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25. White matter microstructural organizations in patients with severe treatment-resistant schizophrenia: A diffusion tensor imaging study

Author

Ochi, Ryo, Noda, Yoshihiro, Tsuchimoto, Shohei, Tarumi, Ryosuke, Honda, Shiori, Matsushita, Karin, Tsugawa, Sakiko, Plitman, Eric, Masuda, Fumi, Ogyu, Kamiyu, Wada, Masataka, Miyazaki, Takahiro, Fujii, Shinya, Chakravarty, M. Mallar, Graff-Guerrero, Ariel, Uchida, Hiroyuki, Mimura, Masaru, and Nakajima, Shinichiro

Published
2020
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30. Levels of glutamatergic neurometabolites in patients with severe treatment-resistant schizophrenia: a proton magnetic resonance spectroscopy study

Author

Tarumi, Ryosuke, Tsugawa, Sakiko, Noda, Yoshihiro, Plitman, Eric, Honda, Shiori, Matsushita, Karin, Chavez, Sofia, Sawada, Kyosuke, Wada, Masataka, Matsui, Mie, Fujii, Shinya, Miyazaki, Takahiro, Chakravarty, M. Mallar, Uchida, Hiroyuki, Remington, Gary, Graff-Guerrero, Ariel, Mimura, Masaru, and Nakajima, Shinichiro

Published
2020
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37. Metformin for early comorbid glucose dysregulation and schizophrenia spectrum disorders: a pilot double-blind randomized clinical trial

Author

Agarwal, Sri Mahavir, Panda, Roshni, Costa-Dookhan, Kenya A., MacKenzie, Nicole E., Treen, Quinn Casuccio, Caravaggio, Fernando, Hashim, Eyesha, Leung, General, Kirpalani, Anish, Matheson, Kelly, Chintoh, Araba F., Kramer, Caroline K., Voineskos, Aristotle N., Graff-Guerrero, Ariel, Remington, Gary J., and Hahn, Margaret K.

Published
2021
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38. Neurocognitive correlates of metabolic dysregulation in individuals with mood disorders: a systematic review and meta-analysis.

Author

Maksyutynska, Kateryna, Stogios, Nicolette, Prasad, Femin, Gill, Jashan, Hamza, Zaineb, De, Riddhita, Smith, Emily, Horta, Angelina, Goldstein, Benjamin I., Korczak, Daphne, Graff-Guerrero, Ariel, Hahn, Margaret K., and Agarwal, Sri Mahavir

Subjects
METABOLIC disorders, SELF-evaluation, BODY mass index, EXECUTIVE function, COGNITIVE processing speed, AFFECTIVE disorders, META-analysis, QUANTITATIVE research, SYSTEMATIC reviews, INSULIN resistance, TYPE 2 diabetes, COGNITION disorders, MEMORY, OBESITY, MENTAL depression, COGNITION
Abstract

Individuals with mood disorders are predisposed to metabolic dysfunction, while those with metabolic dysregulation such as diabetes and obesity experience more severe depressive symptoms. Both metabolic dysfunction and mood disorders are independently associated with cognitive deficits. Therefore, given their close association, this study aimed to explore the association between metabolic dysfunction in individuals with mood disorders in relation to cognitive outcomes. A comprehensive search comprised of these three domains was carried out; a random-effects meta-analysis pooling mean cognitive outcomes was conducted (PROSPERO ID: CRD42022295765). Sixty-three studies were included in this review; 26 were synthesized in a quantitative meta-analysis. Comorbid metabolic dysregulation was associated with significantly lower global cognition among individuals with mood disorders. These trends were significant within each mood disorder subgroup, including major depressive disorder, bipolar disorder, and self-report depression/depressive symptoms. Type 2 diabetes was associated with the lowest cognitive performance in individuals with mood disorders, followed by peripheral insulin resistance, body mass index ⩾25 kg/m2, and metabolic syndrome. Significant reduction in scores was also observed among individual cognitive domains (in descending order) of working memory, attention, executive function, processing speed, verbal memory, and visual memory. These findings demonstrate the detrimental effects of comorbid metabolic dysfunction in individuals with mood disorders. Further research is required to understand the underlying mechanisms connecting mood disorders, metabolism, and cognition. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Associations Between Structural Covariance Network and Antipsychotic Treatment Response in Schizophrenia.

Author

Tsugawa, Sakiko, Honda, Shiori, Noda, Yoshihiro, Wannan, Cassandra, Zalesky, Andrew, Tarumi, Ryosuke, Iwata, Yusuke, Ogyu, Kamiyu, Plitman, Eric, Ueno, Fumihiko, Mimura, Masaru, Uchida, Hiroyuki, Chakravarty, Mallar, Graff-Guerrero, Ariel, and Nakajima, Shinichiro

Subjects
DRUG therapy for schizophrenia, RESEARCH funding, ANTIPSYCHOTIC agents, MAGNETIC resonance imaging, CHI-squared test, RESEARCH, ONE-way analysis of variance, CEREBRAL cortical thinning, DISEASE progression
Abstract

Background and Hypothesis Schizophrenia is associated with widespread cortical thinning and abnormality in the structural covariance network, which may reflect connectome alterations due to treatment effect or disease progression. Notably, patients with treatment-resistant schizophrenia (TRS) have stronger and more widespread cortical thinning, but it remains unclear whether structural covariance is associated with treatment response in schizophrenia. Study Design We organized a multicenter magnetic resonance imaging study to assess structural covariance in a large population of TRS and non-TRS, who had been resistant and responsive to non-clozapine antipsychotics, respectively. Whole-brain structural covariance for cortical thickness was assessed in 102 patients with TRS, 77 patients with non-TRS, and 79 healthy controls (HC). Network-based statistics were used to examine the difference in structural covariance networks among the 3 groups. Moreover, the relationship between altered individual differentiated structural covariance and clinico-demographics was also explored. Study Results Patients with non-TRS exhibited greater structural covariance compared with HC, mainly in the fronto-temporal and fronto-occipital regions, while there were no significant differences in structural covariance between TRS and non-TRS or HC. Higher individual differentiated structural covariance was associated with lower general scores of the Positive and Negative Syndrome Scale in the non-TRS group, but not in the TRS group. Conclusions These findings suggest that reconfiguration of brain networks via coordinated cortical thinning is related to treatment response in schizophrenia. Further longitudinal studies are warranted to confirm if greater structural covariance could serve as a marker for treatment response in this disease. [ABSTRACT FROM AUTHOR]

Published
2024
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48. OASIS: The Obesity Awareness and Insight Scale

Author

Gerretsen, Philip, Kim, Julia, Shah, Parita, Quilty, Lena, Balakumar, Thushanthi, Caravaggio, Fernando, Plitman, Eric, Chung, Jun Ku, Iwata, Yusuke, Pollock, Bruce G., Dash, Satya, Sockalingam, Sanjeev, and Graff-Guerrero, Ariel

Published
2018
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