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Your search keyword '"Godeke, G-J"' showing total 9 results
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9 results on '"Godeke, G-J"'

4. Serological Evidence of MERS-CoV Antibodies in Dromedary Camels (Camelus dromedaries) in Laikipia County, Kenya

Author

Deem, SL, Fevre, Eric, Kinnaird, M, Browne, AS, Muloi, D, Godeke, G-J, Koopmans, M, Reusken, CB, and Virology

Subjects
medicine.medical_specialty, Veterinary medicine, Middle East respiratory syndrome coronavirus, Science, viruses, medicine.disease_cause, Virus, SDG 3 - Good Health and Well-being, RA0421, Epidemiology, medicine, Seroprevalence, QR355, Multidisciplinary, biology, business.industry, virus diseases, Seroepidemiologic Studies, Herd, biology.protein, Medicine, Livestock, Antibody, business, Research Article
Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) is a recently identified virus causing severe viral respiratory illness in people. Little is known about the reservoir in the Horn of Africa. In Kenya, where no human MERS cases have been reported, our survey of 335 dromedary camels, representing nine herds in Laikipia County, showed a high seroprevalence (46.9%) to MERS-CoV antibodies. Between herd differences were present (14.3%- 82.9%), but was not related to management type or herd isolation. Further research should focus on identifying similarity between MERS-CoV viral isolates in Kenya and clinical isolates from the Middle East and elsewhere.

Published
2015

5. Specific serology for emerging human coronaviruses by protein microarray

Author

Reusken, C, Mou, H, Godeke, G J, van der Hoek, L, Meyer, B, Müller, M A, Haagmans, B, de Sousa, R, Schuurman, Nancy, Dittmer, U, Rottier, P, Osterhaus, A, Drosten, C, Bosch, B J, Koopmans, M, Dep Infectieziekten Immunologie, LS Virologie, Bedrijfsvoering, Dep Infectieziekten Immunologie, LS Virologie, Bedrijfsvoering, Amsterdam institute for Infection and Immunity, Medical Microbiology and Infection Prevention, Medical Informatics, Virology, and Medical Oncology

Subjects
Male, Epidemiology, Protein subunit, viruses, Medizin, Protein Array Analysis, Sequence Homology, Biology, medicine.disease_cause, Serology, 03 medical and health sciences, Antigen, Virology, medicine, Humans, skin and connective tissue diseases, 030304 developmental biology, Coronavirus, 0303 health sciences, Sequence Homology, Amino Acid, 030306 microbiology, fungi, Public Health, Environmental and Occupational Health, virus diseases, Human coronavirus, 3. Good health, body regions, Amino Acid, Protein microarray, biology.protein, Female, Antibody, Coronavirus Infections
Abstract

We present a serological assay for the specific detection of IgM and IgG antibodies against the emerging human coronavirus hCoV-EMC and the SARS-CoV based on protein microarray technology. The assay uses the S1 receptor-binding subunit of the spike protein of hCoV-EMC and SARS-CoV as antigens. The assay has been validated extensively using putative cross-reacting sera of patient cohorts exposed to the four common hCoVs and sera from convalescent patients infected with hCoV-EMC or SARS-CoV.

Published
2013

6. Middle East respiratory syndrome coronavirus (MERS-CoV) RNA and neutralising antibodies in milk collected according to local customs from dromedary camels, Qatar, April 2014.

Author

Reusken, C. B., Farag, E. A., Jonges, M., Godeke, G. J., El-Sayed, A. M., Pas, S. D., Raj, V. S., Mohran, K. A., Moussa, H. A., Ghobashy, H., Alhajri, F., Ibrahim, A. K., Bosch, B. J., Pasha, S. K., Al-Romaihi, H. E., Al-Thani, M., Al-Marri, S. A., AlHajri, M. M., Haagmans, B. L., and Koopmans, M. P.

Published
2014
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8. Assembly of HCV E1 and E2 glycoproteins into coronavirus VLPs.

Author

Jourdan, N., Godeke, G.-J., Penaud, M., Mottola, G., Sorrentino, A., Rottier, P. J. M., and Bonatti, S.

Subjects
*HEPATITIS C virus, *GLYCOPROTEINS, *PROTEINS, *CORONAVIRUSES, *HEPATITIS, *LABORATORY mice
Abstract

Hepatitis C virus (HCV) is believed to assemble by budding into membranes of the early secretory pathway, consistent with the membrane location where the viral envelope glycoproteins E1 and E2 accumulate when expressed. Coronavirus assembly also takes place at pre-Golgi membranes. Here, we generated coronavirus-like particles carrying in their envelope chimeric HCV glycoproteins composed of the ectodomains of E1 and E2, each fused to the transmembrane plus endodomain of the mouse hepatitis coronavirus spike glycoprotein. The chimeric particle system will enable structural and functional studies of the HCV glycoproteins. [ABSTRACT FROM AUTHOR]

Published
2006
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