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Your search keyword '"Girish G. Babu"' showing total 2 results
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1. The Diabetic Heart: Too Sweet for Its Own Good?

Author

Hannah J. Whittington, Girish G. Babu, Mihaela M. Mocanu, Derek M. Yellon, and Derek J. Hausenloy

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Diabetes mellitus is a major risk factor for ischemic heart disease (IHD). Patients with diabetes and IHD experience worse clinical outcomes, suggesting that the diabetic heart may be more susceptible to ischemia-reperfusion injury (IRI). In contrast, the animal data suggests that the diabetic heart may be either more, equally, or even less susceptible to IRI. The conflicting animal data may be due to the choice of diabetic and/or IRI animal model. Ischemic conditioning, a phenomenon in which the heart is protected against IRI by one or more brief nonlethal periods of ischemia and reperfusion, may provide a novel cardioprotective strategy for the diabetic heart. Whether the diabetic heart is amenable to ischemic conditioning remains to be determined using relevant animal models of IRI and/or diabetes. In this paper, we review the limitations of the current experimental models used to investigate IRI and cardioprotection in the diabetic heart.

Published
2012
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2. Ventricular Arrhythmia Burden in Patients With Heart Failure and Cardiac Resynchronization Devices: The Importance of Renal Function

Author

Edward Rowland, Oliver R. Segal, Sanjeev Kumar, Holly Daw, Fakhar Khan, Matthew Webber, Aerakondal Gopalamurugan, Anthony Chow, Girish G. Babu, Martin Lowe, Syed Ahsan, Dominic P. Rogers, Pier D. Lambiase, and Rui Providência

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Cardiac resynchronization therapy, Renal function, Retrospective cohort study, 030204 cardiovascular system & hematology, Implantable cardioverter-defibrillator, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), Internal medicine, Heart failure, Cohort, cardiovascular system, medicine, Cardiology, cardiovascular diseases, 030212 general & internal medicine, Risk factor, Cardiology and Cardiovascular Medicine, business, Kidney disease
Abstract

Background Chronic kidney disease (CKD) is a risk factor for arrhythmias in patients with heart failure (HF). However, the effects of CKD on ventricular arrhythmia burden in patients with cardiac resynchronization therapy and defibrillator (CRT-D) devices in a primary prevention setting are unknown. Objective To determine whether baseline CKD is associated with increased risk of ventricular arrhythmia (VA) in patients implanted with primary prevention CRT-D devices. Methods and Results In this retrospective study, 199 consecutive primary prevention CRT-D recipients (2005-2010) were stratified by estimated glomerular filtration rate (eGFR) levels prior to device implantation with 106 (53.2%) ≥CKD III (eGFR III as the only predictor of sustained VA in this group (adjusted HR 2.92, CI = 1.39–6.1, p = 0.004). Conclusion Baseline CKD is a strong independent risk factor for ventricular arrhythmia in primary prevention CRT-D recipients. Further understanding of the underlying arrhythmogenic mechanisms relating to CKD may be of interest to allow appropriate correction and prevention. Device programming in this cohort may need to reflect this increased risk. This article is protected by copyright. All rights reserved

Published
2016
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