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OBJECTIVE: To assess the comparison of isometric exercises and active range of motion in neck pain of female sewing machine operators. STUDY DESIGN: A Randomized controlled trial. PLACE AND DURATION: At Physiotherapy Department of The University of Faisalabad from 1st March till 30th August 2017. METHODOLOGY: Data was collected from all the female sewing machine operators that were currently working over there. Patients were divided into two groups i.e. control group and treatment group. Stretching exercises given to both groups. Control group received Active range of motion exercises and Treatment group received isometric exercises for four weeks at alternate days. Data was gathered from thirty workers using Northwick Park neck pain Questionnaire, Numeric rating scale for pain and goniometer for ranges by getting signed consent form earlier. RESULTS: By comparing outcomes of Isomeric exercises and Active range of motion exercises, Isometric exercises were more effective as compared to Active range of motion exercises in improving pain, percentage disability and ranges of motion as p Value <0.05 at the end of treatment session. CONCLUSION: Isometric exercises were more effective than active range of motion exercises of neck related to sewing machine operators as compared to active range of motion exercises. [ABSTRACT FROM AUTHOR]