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Interpersonal Distance (IPD) is defined as the physical distance that individuals maintain between themselves and others during social interactions. While literature has extensively focused on this everyday social behavior, how IPD changes throughout the lifespan remains an open question. In this study, 864 participants, aged 3–89 years, performed the Stop Distance Paradigm in their real-life environments, and we measured the distance they kept from both familiar and unfamiliar others during social interactions. We found that IPD not only differs based on the identity of the other person (familiar versus unfamiliar) but critically declines as a function of age, following two distinct non-linear trends for familiar and unfamiliar others. Moreover, behavioral variability also undergoes a lifetime development, with IPD becoming more stable as age increases. Overall, the present study suggests that IPD is a complex and acquired behavior that changes throughout the lifespan and varies according to individual and situational variables. [ABSTRACT FROM AUTHOR]

People naturally seek an interpersonal distance that feels comfortable, striking a balance between not being too close or too far from others until reaching a state of equilibrium. Previous studies on interpersonal distance preferences among autistic individuals have yielded inconsistent results. Some show a preference for greater distance, while others indicate a preference for shorter distances, or reveal higher variance in preferences among autistic individuals. In a related vein, previous studies have also investigated the way autistics accurately judge distance, and these studies have received inconsistent results, with some showing superior spatial abilities and others indicating biases in distance estimations. However, the link between distance estimation and preference has never been examined. To address this gap, our study measured interpersonal distance preferences and estimations and tested the correlation between the two factors. The results indicate greater variance among autistic people in both the preference of distance and the ability to estimate distance accurately, suggesting that inconsistencies in previous studies originate from greater individual differences among autistics. Furthermore, only among autistic individuals were interpersonal distance preference and estimation bias associated in a manner that violated equilibrium. Underestimation bias (judging others as closer than they are) was linked to a preference for closer proximity, while overestimation bias (judging others as further away) was associated with a preference for maintaining a greater distance. This connection suggests that biases in the estimation of interpersonal distance contribute to extreme preferences (being too close or too far away). Taken together, the findings suggest that biases in the estimation of interpersonal distance are associated with socially inappropriate distance preferences among autistics. [ABSTRACT FROM AUTHOR]

Although humans can recognize their body movements in point-light displays, self-recognition ability varies substantially across action types and participants. Are these variations primarily due to an awareness of visually distinct movement patterns, or to underlying factors related to motoric planning and/or individual differences? To address this question, we conducted a large-scale study in self-action recognition (N = 101). We motion captured whole-body movements of participants who performed 27 different actions across action goals and degree of motor planning. After a long delay period (~ 1 month), participants were tested in a self-recognition task: identifying their point-light action amongst three other point-light actors performing identical actions. We report a self-advantage effect from point-light actions, consistent with prior work in self-action recognition. Further, we found that self-recognition was modulated by the action complexity (associated with the degree of motor planning in performed actions) and individual differences linked to motor imagery and subclinical autism and schizotypy. Using dynamic time warping, we found sparse evidence in support of visual distinctiveness as a primary contributor to self-recognition, though speed distinctiveness negatively influenced self-recognition performance. Together, our results reveal that self-action recognition involves more than an awareness of visually distinct movements, with important implications for how the motor system may be involved. [ABSTRACT FROM AUTHOR]

Background and objective: Only few studies investigated social cognition in Becker muscular dystrophy (BMD). However, brain dystrophin deficiency could be a neural substrate for cognitive, emotional, and neuropsychological features in BMD. Methods: We compared interoceptive accuracy and interpersonal comfort distance in two brothers with BMD presenting with the same genetic deletion and a healthy control. When possible, we collected neuropsychological and psychopathological assessments. Results: Our BMD patients were significantly different in interoceptive accuracy, with patient 1 being extremely accurate and patient 2 being significantly less accurate than his brother but more accurate than the control. Interestingly, they presented opposite patterns of interpersonal distance. Patient 1 was comfortable with very short interpersonal distance (≤50 cm from the confederate/object) vs the control and patient 2. By contrast, patient 2 preferred larger distance vs the control and patient 1. Patient 1 also presented difficulties in social and emotional skills on the psychopathological assessment. Conclusions: We are aware this is a small sample; nonetheless, this is also the first description of such aspects in BMD and the first report ever of such divergent behavioral pattern. As impaired social cognition affects the quality of life and social relationship, further studies are needed for a closer understanding of involved mechanisms. [ABSTRACT FROM AUTHOR]

Why you should read this article: • To enhance your understanding of neurodivergence • To recognise the need to reframe behaviours that challenge as expressions of distress or unmet needs • To contribute towards revalidation as part of your 35 hours of CPD (UK readers) • To contribute towards your professional development and local registration renewal requirements (non-UK readers). People who are neurodivergent, including autistic people, may perceive the world differently from neurotypical people. At times, this can prompt them to demonstrate so-called ‘behaviour that challenges’, which may be better termed ‘distressed behaviour’. Distressed behaviour can occur for several reasons, from processing information to feeling unwell, tired or hungry. Some people with learning disabilities are autistic and this may increase the likelihood that they will demonstrate distressed behaviour. It is crucial that healthcare professionals who work with people with learning disabilities understand neurodivergence and are equipped to respond effectively to distressed behaviour in neurodivergent service users. This article supports these healthcare professionals to improve the quality of life of service users and those around them by understanding neurodivergence better and developing appropriate strategies for responding to distressed behaviour. [ABSTRACT FROM AUTHOR]

Background: Transcranial random noise stimulation (tRNS) is a form of noninvasive transcranial electrical stimulation that applies alternating current in various randomized frequencies to the cortex, thereby improving cognitive functioning in multiple domains. However, the precise mechanism of tRNS, as well as its impact on human electroencephalography (EEG), remains unclear. This is partly because most studies have used tRNS in conjunction with a cognitive task, making it difficult to tease apart whether the observed changes in EEG are a result of tRNS, the cognitive task, or their interaction. Methods: Forty-nine healthy individuals participated in this study and were randomly assigned to active tRNS (n = 24) and sham (n = 25) groups. tRNS was delivered for 20 minutes over Fp1/Fp2 and Oz. Resting-state EEG data were collected before and after either tRNS or sham stimulation. Results: Cluster-based permutation tests using FieldTrip revealed no frequency-specific effect of tRNS on resting-state EEG data across four frequency bands (theta, alpha, beta, gamma). Conclusions: These observations suggest that tRNS itself does not target or alter specific EEG frequencies. Rather, tRNS most likely interacts with the cognitive task/activity at hand to produce an observable difference in post-tRNS EEG. Positive tRNS-EEG findings from previous studies are also likely to have resulted from the interactive and cognitive activity-dependent nature of tRNS. [ABSTRACT FROM AUTHOR]

Background: Developmental Dyslexia (DD) is a brain-based developmental disorder causing severe reading difficulties. The extensive data on the neurobiology of DD have increased interest in brain-directed approaches, such as transcranial direct current stimulation (tDCS), which have been proposed for DD. While positive outcomes have been observed, results remain heterogeneous. Various methodological approaches have been employed to address this issue. However, no studies have compared the effects of different transcranial electrical stimulation techniques (e.g., tDCS and transcranial random noise stimulation, tRNS), on reading in children and adolescents with DD. Methods: The present within-subject, double-blind, and sham-controlled trial aims to investigate the effects of tDCS and hf-tRNS on reading in children and adolescents with DD. Participants will undergo three conditions with a one-week interval session: (A) single active tDCS session; (B) single active hf-tRNS session; and (C) single sham session (tDCS/hf-tRNS). Left anodal/right cathodal tDCS and bilateral tRNS will be applied over the temporo-parietal regions for 20 min each. Reading measures will be collected before and during each session. Safety and blinding parameters will be recordered. Discussion: We hypothesize that tRNS will demonstrate comparable effectiveness to tDCS in improving reading compared to sham conditions. Additionally, we anticipate that hf-tRNS will exhibit a similar safety profile to tDCS. This study will contribute novel insights into the effectiveness of hf-tRNS, expediting the validation of brain-based treatments for DD. [ABSTRACT FROM AUTHOR]

This perspective review aims to explore the potential neurobiological mechanisms involved in the application of transcranial Direct Current Stimulation (tDCS) for Down syndrome (DS), the leading cause of genetically-based intellectual disability. The neural mechanisms underlying tDCS interventions in genetic disorders, typically characterized by cognitive deficits, are grounded in the concept of brain plasticity. We initially present the neurobiological and functional effects elicited by tDCS applications in enhancing neuroplasticity and in regulating the excitatory/inhibitory balance, both associated with cognitive improvement in the general population. The review begins with evidence on tDCS applications in five neurogenetic disorders, including Rett, Prader-Willi, Phelan-McDermid, and Neurofibromatosis 1 syndromes, as well as DS. Available evidence supports tDCS as a potential intervention tool and underscores the importance of advancing neurobiological research into the mechanisms of tDCS action in these conditions. We then discuss the potential of tDCS as a promising non-invasive strategy to mitigate deficits in plasticity and promote fine-tuning of the excitatory/inhibitory balance in DS, exploring implications for cognitive treatment perspectives in this population. [ABSTRACT FROM AUTHOR]

In adolescence individuals enlarge their social relationships and peer groups acquire a strong importance for their identity. Moreover, adolescents can experiment negative relationships with peers, i.e., bullying/cyberbullying. The present study aims to investigate the relationship between the feeling of belonging to a specific group, social identification, the distance that adolescents maintain interacting with others, interpersonal distance, and bullying/cyberbullying behaviors. Adolescents (age range 10–15 years) completed online measures of group identification (social identification with classmates, friends and family), interpersonal distance, and bullying and cyberbullying (perpetration and victimization). Results showed that adolescents with low social identification with classmates and friends chose larger interpersonal distance. Additionally, low scores in social identification with classmates were associated with higher victimization in cyberbullying. In contrast, adolescents with low scores in social identification with family were more involved as bullies in bullying and as victims in cyberbullying. Male adolescents were more likely to be victimized in bullying than females. This study underlines how social identification with peers and family works as a buffer in interfacing strangers, adjusting the distance maintained with them, and as a protective factor against aggressive relationships in adolescence. This study provides new opportunities for psychologists in understanding the psychological dynamics that shape social interactions among adolescents. [ABSTRACT FROM AUTHOR]

Scleritis is an inflammation of the episcleral and scleral tissues, characterized by injection in both superficial and deep episcleral vessels. When only episcleral tissue is involved, it is referred to as episcleritis. Episcleritis is mainly idiopathic but may be secondary to an underlying rheumatologic disease. Despite being rare, drug-associated episcleritis and scleritis should also be included in the differential diagnosis. Tumor necrosis factor-alpha (TNF-α) inhibitors are generally well-tolerated, but etanercept, in particular, has the potential to cause paradoxical adverse reactions including ocular inflammations, such as uveitis, scleritis, and ocular myositis. Etanercept differs in its mechanism of action from other TNF-α inhibitors as it acts as a decoy receptor, and this may partly explain the more frequently reported etanercept-associated ocular inflammation. Etanercept may also be ineffective in preventing ocular inflammation. However, the dechallenge and rechallenge phenomena have proven there is a causative link between etanercept and new-onset ocular inflammation. We report a case of a 15-year-old boy with enthesitis-related arthritis and familial Mediterranean fever who presented with episcleritis and blepharitis while receiving etanercept treatment and subsequently showed dechallenge and rechallenge reactions. Therefore, physicians should also be aware that episcleritis should be considered a paradoxical adverse reaction to etanercept and can occur in pediatric patients. We also reviewed the English literature to provide an overview and evaluate intervention options. [ABSTRACT FROM AUTHOR]

Background: Chronic kidney disease affects 10% of the world population, and it is associated with progression to end-stage kidney disease and increased morbidity and mortality. The advent of multi-omics technologies has expanded our knowledge on the complexity of kidney diseases, revealing their frequent genetic etiology, particularly in children and young subjects. Genetic heterogeneity and drug screening require patient-derived disease models to establish a correct diagnosis and evaluate new potential treatments and outcomes. Summary: Patient-derived renal progenitors can be isolated from urine to set up proper disease modeling. This strategy allows to make diagnosis of genetic kidney disease in patients carrying unknown significance variants or uncover variants missed from peripheral blood analysis. Furthermore, urinary-derived tubuloids obtained from renal progenitors of patients appear to be potentially valuable for modeling kidney diseases to test ex vivo treatment efficacy or to develop new therapeutic approaches. Finally, renal progenitors derived from urine can provide insights into acute kidney injury and predict kidney function recovery and outcome. Key Messages: Renal progenitors derived from urine are a promising new noninvasive and easy-to-handle tool, which improves the rate of diagnosis and the therapeutic choice, paving the way toward a personalized healthcare. [ABSTRACT FROM AUTHOR]

Social interactions are often shaped by the space we prefer to maintain between us and others, that is, interpersonal distance. Being too distant or too close to a stranger can often be perceived as odd, and lead to atypical social interactions. This calibration of appropriate interpersonal distance thus constitutes an important social skill. Individuals with autism spectrum disorder (ASD, hereafter autism) often experience difficulties with this skill, and anecdotal accounts suggest atypical interpersonal distances in their social interactions. In the current study, we systematically measured interpersonal distance in individuals with autism using immersive virtual reality (IVR) to recreate a naturalistic interaction with a full body avatar of a similar age. Participants observed their own virtual body in first‐person perspective, and the other avatar in two tasks: in the first task, they approached the other avatar (active), in the second one they were approached by the other avatar (passive). Two groups of neurotypical and autistic adults, performed both tasks. Autistic adults showed greater interpersonal distance when compared to non‐autistic adults. Additionally, the difference between the passive and active conditions was smaller for non‐autistic compared to autistic adults. Across the full sample, greater interpersonal distance was associated with higher autism‐related traits. This study provides systematic evidence for greater interpersonal distance in autistic adults using a paradigm with high ecological validity and can be useful in informing the design of appropriate environmental adjustments for shared spaces. Lay Summary: Social interactions are often shaped by the space we prefer to maintain between us and others, that is, interpersonal distance. We used immersive virtual reality to measure interpersonal distance, where participants either approached or were approached by a virtual character. All participants preferred larger interpersonal distances when they were approached versus when they approached themselves. Autistic adults preferred a larger interpersonal distance compared to non‐autistic adults. These results can inform the design of appropriate environments (e.g., public spaces) for autistic individuals. [ABSTRACT FROM AUTHOR]

Previous research has highlighted the role of the excitation/inhibition (E/I) ratio for typical and atypical development, mental health, cognition, and learning. Other research has highlighted the benefits of high-frequency transcranial random noise stimulation (tRNS)—an excitatory form of neurostimulation—on learning. We examined the E/I as a potential mechanism and studied whether tRNS effect on learning depends on E/I as measured by the aperiodic exponent as its putative marker. In addition to manipulating E/I using tRNS, we also manipulated the level of learning (learning/overlearning) that has been shown to influence E/I. Participants (n = 102) received either sham stimulation or 20-minute tRNS over the dorsolateral prefrontal cortex (DLPFC) during a mathematical learning task. We showed that tRNS increased E/I, as reflected by the aperiodic exponent, and that lower E/I predicted greater benefit from tRNS specifically for the learning task. In contrast to previous magnetic resonance spectroscopy (MRS)-based E/I studies, we found no effect of the level of learning on E/I. A further analysis using a different data set suggest that both measures of E/I (EEG versus MRS) may reflect, at least partly, different biological mechanisms. Our results highlight the role of E/I as a marker for neurostimulation efficacy and learning. This mechanistic understanding provides better opportunities for augmented learning and personalized interventions. Previous work has suggested that the excitation/inhibition ratio (E/I) contributes to typical and atypical development, mental health, cognition and learning. This study reveals that the E/I ratio in the brain plays an important role in neurostimulation efficacy and is a possible marker for learning. [ABSTRACT FROM AUTHOR]

Introduction: Personal space (PS) is a safe area around an individual's body that affects spatial distance when socially interacting with others. Previous studies have shown that social interaction may modulate PS. However, these findings are often confounded by the effects of familiarization. Furthermore, whether the potential regulatory effects of social interaction on PS can be generalized from interacting confederates to strangers remains unclear. Methods: To answer these questions, we enrolled 115 participants in a carefully designed experiment. Results: We found that prosocial interaction in the form of a cooperative task effectively reduced PS, and this regulatory effect could be generalized from interacting confederates to non-interacting confederates. Discussion: These findings deepen our understanding of PS regulation and may be aid in the diagnosis and rehabilitation of dysfunctional social behaviors. [ABSTRACT FROM AUTHOR]

If you are stuck in a traffic jam, the more numerous the queuing cars are, the longer you expect to wait. Time and numerosity are stimulus dimensions often associated in the same percept and whose interaction can lead to misjudgements. At brain level it is unclear to which extent time and numerosity recruit same/different neural populations and how their perceptual integration leads to changes in these populations' responses. Here we used high-spatial-resolution functional magnetic resonance imaging with neural model-based analyses to investigate how the topographic representations of numerosity and time change when these dimensions are varied together on the same visual stimulus in a congruent (the more numerous the items, the longer the display time) or incongruent manner. Compared to baseline conditions, where only one dimension was changed at a time, the variation of both stimulus dimensions led to changes in neural population responses that became more sensitive either to the two features or to one of them. Magnitude integration led also to degradation of topographies and shifts in response preferences. These changes were more pronounced in the comparison between parietal and frontal maps. Our results while pointing to partially distinct representations of time and numerosity show a common neural response to magnitude integration. [ABSTRACT FROM AUTHOR]

Perception of peripersonal space (PPS) and interpersonal distance (IPD) has been shown to be modified by external factors such as perceived danger, the use of tools, and social factors. Especially in times of social distancing in the context of the COVID-19 pandemic, it is vital to study factors that modify PPS and IPD. The present work addresses the question of whether wearing a face mask as a protection tool and social interaction impact the perception of IPD. We tested estimated IPD in pictures at three distances: 50 cm, 90 cm, and 150 cm in both social interaction (shaking hands) and without interaction and when the two people in the pictures wore a face mask or not. Data from 60 subjects were analyzed in a linear mixed model (on both difference in distance estimation to the depicted distance and in absolute distance estimation) and in a 3 (distance: 50, 90, 150) × 2 (interaction: no interaction, shake hands), × 2 face mask (no mask, mask) rmANOVA on distance estimation difference. All analyses showed that at a distance of 50 and 90 cm, participants generally underestimated the IPD while at an IPD of 150 cm, participants overestimated the distance. This could be grounded in perceived danger and avoidance behavior at closer distances, while the wider distance between persons was not perceived as dangerous. Our findings at an IPD of 90 cm show that social interaction has the largest effect at the border of our PPS, while the face mask did not affect social interaction at either distance. In addition, the ANOVA results indicate that when no social interaction was displayed, participants felt less unsafe when depicted persons wore a face mask at distances of 90 and 150 cm. This shows that participants are on the one hand aware of the given safety measures and internalized them; on the other hand, that refraining from physical social interaction helps to get close to other persons. [ABSTRACT FROM AUTHOR]

Interpersonal distance regulation is an essential element of social communication. Its impairment in autism spectrum disorder (ASD) is widely acknowledged among practitioners, but only a handful of studies reported empirical research in real-life settings, focusing mainly on children. Interpersonal distance in adults with ASD and related autonomic functions received less attention. Here, we measured interpersonal distance along with heart rate variability (HRV) in adults with ASD, and tested the modulatory effects of eye-contact and attribution. Twenty-two adults diagnosed with ASD and 21 matched neurotypical controls participated in our study from October 2019 to February 2020. Our experimental design combined the modified version of the stop distance paradigm with HRV measurement controlling for eye contact between the experimenter and the participant to measure interpersonal distance. Still, we did not detect significant modulatory effect of eye contact and attribution. Our results showed a greater preferred distance in ASD. Moreover, we found lower baseline HRV and reduced HRV reactivity in ASD; however, these autonomic measurements could not predict preferred interpersonal distance. Our study highlights the importance of interpersonal space regulation in ASD: it might be considered that people with ASD need individually variable, presumably greater interpersonal distance. In addition, regardless of the distance they may have reduced autonomic regulatory capacity in social situations. Our results could help shape future experiments with sophisticated designs to grasp the complexity and underlying factors of distance regulation in typical and atypical populations. [ABSTRACT FROM AUTHOR]

Recent research has investigated whether the representation of space around the body, in terms of reach–action (imagining of reaching another person) and comfort–social (tolerance of the other's proximity) spaces, may reflect a shared sensorimotor basis. Some studies exploiting motor plasticity induced by tool use have not observed sensorimotor identity (i.e., the same mechanisms that underlie, based on sensory information, the representation of proximal space in terms of action possibilities, goal-directed motor actions, and anticipation of the sensorimotor consequences), whereas evidence to the contrary has also emerged. Since the data are not fully convergent, here we wondered whether or not the combination of motor plasticity induced by tool use and the processing of the role of social context might reflect a similar modulation in both spaces. To this end, we conducted a randomized control trial with three groups of participants (N = 62) in which reaching and comfort distances were measured in Pre- and Post-tool-use sessions. The tool-use sessions were conducted under different conditions: (i) in the presence of a social stimulus (determining the social context) (Tool plus Mannequin group); (ii) without any stimulus (Only Tool group); (iii) in the presence of a box (Tool plus Object group) as a control condition. Results showed an extension of comfort distance in the Post-tool session of the Tool plus Mannequin group compared with the other conditions. Conversely, the reaching distance was larger after tool use than at the Pre-tool-use session, independently of the experimental conditions. Our findings suggest that motor plasticity impacts reaching and comfort spaces to different degrees; while reaching space is markedly sensitive to motor plasticity, comfort space needs qualification of social context information. [ABSTRACT FROM AUTHOR]

Today we are experiencing a hybrid real-virtual society in which the interaction with virtual humans is normal and "quasi-social". Understanding the way we react to the interaction with virtual agents and the impact of emotions on social dynamics in the virtual world is fundamental. Therefore, in this study we investigated the implicit effect of emotional information by adopting a perceptual discrimination task. Specifically, we devised a task that explicitly required perceptual discrimination of a target while involving distance regulation in the presence of happy, neutral, or angry virtual agents. In two Immersive Virtual Reality experiments, participants were instructed to discriminate a target on the virtual agents' t-shirts, and they had to provide the response by stopping the virtual agents (or themselves) at the distance where they could identify the target. Thus, facial expressions were completely irrelevant to the perceptual task. The results showed that the perceptual discrimination implied a longer response time when t-shirts were worn by angry rather than happy or neutral virtual agents. This suggests that angry faces interfered with the explicit perceptual task people had to perform. From a theoretical standpoint, this anger-superiority effect could reflect an ancestral fear/avoidance mechanism that prompts automatic defensive reactions and bypasses other cognitive processes. [ABSTRACT FROM AUTHOR]

Working memory is a cognitive process that involves short-term active maintenance, flexible updating, and processing of goal- or task-relevant information. All frequency bands are involved in working memory. The activities of the theta and gamma frequency bands in the frontoparietal network are highly involved in working memory processes; theta oscillations play a role in the temporal organization of working memory items, and gamma oscillations influence the maintenance of information in working memory. Transcranial alternating current stimulation (tACS) results in frequency-specific modulation of endogenous oscillations and has shown promising results in cognitive neuroscience. The electrophysiological and behavioral changes induced by the modulation of endogenous gamma frequency in the prefrontal cortex using tACS have not been extensively studied in the context of working memory. Therefore, we aimed to investigate the effects of frontal gamma-tACS on working memory outcomes. We hypothesized that a 10-min gamma tACS administered over the frontal cortex would significantly improve working memory outcomes. Young healthy participants performed Luck–Vogel cognitive behavioral tasks with simultaneous pre- and post-intervention EEG recording (Sham versus 40 Hz tACS). Data from forty-one participants: sham (15 participants) and tACS (26 participants), were used for the statistical and behavioral analysis. The relative changes in behavioral outcomes and EEG due to the intervention were analyzed. The results show that tACS caused an increase in the power spectral density in the high beta and low gamma EEG bands and a decrease in left-right coherence. On the other hand, tACS had no significant effect on success rates and response times. Conclusion: 10 min of frontal 40 Hz tACS was not sufficient to produce detectable behavioral effects on working memory, whereas electrophysiological changes were evident. The limitations of the current stimulation protocol and future directions are discussed in detail in the following sections. [ABSTRACT FROM AUTHOR]

Past research on object constancy has tended to treat the viewer as a passive observer. Here we examine viewers' body and eye movements when they are asked to view photos of people in a gallery setting. Participants considered one individual in each photo, before indicating how socially connected they felt toward them and then moving to a spot in the gallery where they would be most comfortable when talking to them. Photographed individuals varied in their projected distance from the camera (near, far) and in their image resolution (sharp, slightly blurred). Results showed that participants looked more directly at near versus far individuals and at sharp versus blurred individuals. They also rated their social connection as stronger when the images were near versus far and sharp versus blurred. Where participants stood when making these ratings was strongly correlated with the projected distance of the images and with their ratings of social connection. These findings are discussed with regard to brain mechanisms for maintaining stability in our perceptions of geometric and social aspects of our world. They also highlight our inherent tendency to attribute qualities of our perceptual experiences to objects in that world. [ABSTRACT FROM AUTHOR]

Personal space (PS) is the space around the body that people prefer to maintain between themselves and unfamiliar others. Intrusion into personal space evokes discomfort and an urge to move away. Physiologic studies in nonhuman primates suggest that defensive responses to intruding stimuli involve the parietal cortex. We hypothesized that the spatial encoding of interpersonal distance is initially transformed from purely sensory to more egocentric mapping within human parietal cortex. This hypothesis was tested using 7 Tesla (7T) fMRI at high spatial resolution (1.1 mm isotropic), in seven subjects (four females, three males). In response to visual stimuli presented at a range of virtual distances, we found two categories of distance encoding in two corresponding radially-extending columns of activity within parietal cortex. One set of columns (P columns) responded selectively to moving and stationary face images presented at virtual distances that were nearer (but not farther) than each subject's behaviorally-defined personal space boundary. In most P columns, BOLD response amplitudes increased monotonically and nonlinearly with increasing virtual face proximity. In the remaining P columns, BOLD responses decreased with increasing proximity. A second set of parietal columns (D columns) responded selectively to disparity-based distance cues (near or far) in random dot stimuli, similar to disparity-selective columns described previously in occipital cortex. Critically, in parietal cortex, P columns were topographically interdigitated (nonoverlapping) with D columns. These results suggest that visual spatial information is transformed from visual to body-centered (or person-centered) dimensions in multiple local sites within human parietal cortex. [ABSTRACT FROM AUTHOR]

Children with attention deficit/hyperactivity disorder (ADHD) are commonly observed to have learning difficulties. This study examined how three neuropsychological constructs—executive dysfunction, delay aversion, and time perception—were associated with ADHD symptoms and early academic performance in preschoolers at risk of ADHD. One hundred and thirty-one preschoolers (70 boys, 53%) aged 4 to 6 (M = 5.31 years) were assessed on their ADHD-related behaviors, neuropsychological functioning, word reading, and math abilities at two time points one year apart. Factor analysis indicated that inhibitory and attentional control deficit, delay aversion, and time perception/working memory deficit were three dissociable factors. Among the three factors, inhibitory and attentional control measured at Time 1 was the strongest predictor of ADHD symptoms at both Time 1 and Time 2. Time perception was closely related to working memory, and they predicted word reading and numeration across time most strongly among other neuropsychological constructs. Our findings suggested that inhibitory and attentional control, delay aversion, and time perception are dissociable neuropsychological deficits underlying ADHD symptoms in preschoolers. Poor time perception may serve as a marker for the early identification of preschoolers with potential learning problems, and a possible target of intervention for ADHD. [ABSTRACT FROM AUTHOR]

Digital photography is deeply embedded in people's daily lives, as camera phones and digital compact cameras are widely used in social and cultural settings. People have an increased agency and choice over what they want to photograph, where and when; many people carry their smartphones everywhere and share their images instantly via social media platforms. Within the recent scholarship on everyday photography, however, little attention has been paid to the photographic practices of people with Autism Spectrum Disorder (ASD), one of many marginalized groups whose photography has not been explored. This article addresses this shortfall. Drawing on a qualitative, image-based investigation, the author turns to phenomenology to examine four young male ASD adults' unique ways of seeing and being-in-the-world as expressed through the use of their camera. Their involvement indicates that ASD people have the potential to have a powerful voice in how society conceives of what autism is and what it means to live with ASD. A case study discussion of key research findings presents examples of the pictures taken in the sphere of participants' everyday lives, revealing that the camera acts as an extension of experience and perception, a mediator and filter. Photography enables the four male ASD individuals' being-in-the-world and exposes the social life of this marginalized group. The article offers a significant contribution to the field of visual communication and sensory experience. [ABSTRACT FROM AUTHOR]

Background Changes in the regulation of interpersonal distance, or "personal space" (PS), have been repeatedly observed in schizophrenia and, in some studies, linked to negative symptoms. However, the neurobiological basis of these impairments is poorly understood. Methods Personal space measurements, functional connectivity of a brain network sensitive to intrusions into PS, and symptoms of social withdrawal and anhedonia were assessed, and associations among these outcomes measured, in 33 individuals with a psychotic disorder (primarily schizophrenia [SCZ]) and 36 control subjects (CON). Results Personal space size was significantly higher (P =.002) and PS permeability (reflecting the capacity to tolerate intrusions into PS) was significantly lower (P =.021) in the SCZ relative to the CON group, and both measures were significantly correlated with social anhedonia and withdrawal in the full sample (all P <.007). Moreover, functional connectivity between the PS and default mode (DM) networks was significantly correlated with the permeability, but not the size, of PS in the full sample and in the SCZ and CON groups separately, and with social withdrawal in the SCZ group. Lastly, the association between PS-DM network connectivity and social withdrawal in the SCZ group was fully mediated by PS permeability. Discussion Neural and behavioral aspects of PS regulation are linked to social motivation in both healthy individuals and those with psychotic disorders, suggesting that measurements of PS could serve as transdiagnostic markers of social functioning. [ABSTRACT FROM AUTHOR]

Background: Increased social distance is one of the manifestations of social impairment. Chronic low back pain (CLBP) is one of factors associated with increased social distance and social withdrawal. Exercise therapy is an effective means to social impairment. However, whether exercise could reduce social distance in patients with CLBP remains unknown. This study aimed to investigate the effect of exercise on social distance in middle-aged and elderly patients with CLBP. Methods: The longitudinal intervention recruited 29 middle-aged and elderly patients with CLBP from various communities in Yangpu District, Shanghai, China. The participants received exercise intervention for 8 weeks. The assessments were conducted before and after the intervention, including social distance, pain intensity, unpleasantness of pain, Roland-Morris Questionnaire (RMDQ), Self-Rating Anxiety Scale (SAS), and Self-Rating Depression Scale (SDS). Intention to treat analysis was performed. Results: After the 8-week exercise intervention, the social distance of patients with CLBP was shorter than that before intervention and showed significant difference (p < 0.05). The scores of pain intensity, unpleasantness of pain, RMDQ, SAS, and SDS also decreased and were significantly different between pre- and post-intervention (p < 0.05). In addition, the social distance, pain intensity, unpleasantness of pain, RMDQ, SAS, and SDS scores of the moderate CLBP group decreased more after the intervention compared with those of the mild CLBP group. Conclusion: The 8-week exercise intervention cannot only shorten the social distance in middle-aged and elderly patients with CLBP but also relieve pain, disability, and negative emotions. [ABSTRACT FROM AUTHOR]

This study aimed to evaluate the precision, accuracy, and reliability of the common measurement methods for collecting comfort and reachability distances. Four measurement methods were applied in the study: real-life measurement, virtual reality (VR) simulation, the media method, and the paper-and-pencil test. Forty participants were recruited, who were required to determine their comfort and reachability distances when approached by, or actively approaching, confederates under the four methods. The relative error magnitude and mean absolute difference were used to evaluate the precision and accuracy of the methods, respectively. Then, intraclass correlation coefficients were applied to evaluate the reliability of the methods. The ANOVA results showed that the confederate's gender, method, and pattern all had significant effects on the comfort and reachability distances. The distance obtained by the paper-and-pencil test was the smallest, while the distance measured by the media method was larger. The real-life measurement had high reliability, but its precision performance was worse than that of both the VR simulation and the active media method. The VR simulation had the best precision and reliability, while the measurement value tended to be overestimated. The media method in the passive pattern showed the worst precision, accuracy, and reliability performance among the four methods. The active media method performed well except for accuracy when collecting distance data. The paper-and-pencil test showed erroneous results regarding the precision and reliability performance. These findings provide scientific reference suggestions for the selection of measuring methods for collecting comfort and reachability distances. [ABSTRACT FROM AUTHOR]

This study extends the previous research in which it has been shown that a mixed reality (MR) system fosters social interaction behaviours (SIBs) in children with Autism Spectrum Condition (ASC). When comparing this system to a LEGO-based non-digital intervention, it has been observed that an MR system effectively mediates a face-to-face play session between a child with ASC and a child without ASC providing new specific advantageous properties (e.g. not being a passive tool, not needing to be guided by the therapist). Considering the newly collected multimodal data totaling to 72 children (36 trials of dyads, child with ASC/child without ASC), a first goal of the present study is to apply detailed statistical inference and machine learning techniques to extensively evaluate the overall effect of this MR system, when compared to the LEGO condition. This goal also includes the analysis of psychophysiological data and allows the context-driven triangulation of the multimodal data which is operationalized by (i) video-coding of SIBs, (ii) psychophysiological data, and (iii) system logs of user-system events. A second goal is to show how SIBs, taking place in these experiences, are influenced by the internal states of the users and the system. SIBs were measured by video-coding overt behaviours (Initiation, Response and Externalization) and with self-reports. Internal states were measured using a wearable device designed by the FuBIntLab (Full-Body Interaction Lab) to acquire: Electrocardiogram (ECG) and Electrodermal Activity (EDA) data. Affective sliders and State Trait Anxiety Scale questionnaires were used as self-reports. Repeated-measures design was chosen with two conditions, the MR environment and the traditional therapy LEGO. The results show that the MR system has a positive effect on SIBs when compared to the LEGO condition, with an added advantage of being more flexible. [ABSTRACT FROM AUTHOR]

Quantity estimation can be represented in either an analog or symbolic manner and recent evidence now suggests that analog and symbolic representation of quantities interact. Nonetheless, those two representational forms of quantities may be enhanced by convergent multisensory information. Here, we elucidate those interactions using high-density electroencephalography (EEG) and an audiovisual oddball paradigm. Participants were presented simultaneous audiovisual tokens in which the co-varying pitch of tones was combined with the embedded cardinality of dot patterns. Incongruencies were elicited independently from symbolic and non-symbolic modality within the audio-visual percept, violating the newly acquired rule that "the higher the pitch of the tone, the larger the cardinality of the figure." The effect of neural plasticity in symbolic and non-symbolic numerical representations of quantities was investigated through a cross-sectional design, comparing musicians to musically naïve controls. Individual's cortical activity was reconstructed and statistically modeled for a predefined time-window of the evoked response (130–170 ms). To summarize, we show that symbolic and non-symbolic processing of magnitudes is re-organized in cortical space, with professional musicians showing altered activity in motor and temporal areas. Thus, we argue that the symbolic representation of quantities is altered through musical training. [ABSTRACT FROM AUTHOR]

Background: To analyse demographic, clinical features, treatment and therapeutic outcomes of pediatric uveitis and scleritis patients.Subjects: The clinical records of pediatric uveitis and scleritis cases between January 2012 and December 2020 at a tertiary uveitis service center in Tianjin Medical University Eye Hospital (TMUEH) were reviewed.Results: In total, 209 patients (337 eyes) were included, 49.3% were male. The median onset age was 9.0 (IQR, 7.0-12.0) years. Chronic uveitis and scleritis accounted for 86.1%. Panuveitis (29.2%), anterior uveitis(29.2%), and intermediate uveitis (22.0%) were the most common presentations. The most common diagnoses were idiopathic (71.3%), JIA (8.1%), and infectious uveitis (4.8%). At baseline, 40.7% patients received oral corticosteroid therapy; during follow-up, corticosteroids (66.0%), disease-modifying antirheumatic drugs (61.2%), and biologic agents (35.4%) were the mainstay. Posterior synechia (26.1%) and cataracts (25.5%) were the most common complications. In acute cases, the median best corrected visual acuity (BCVA) was 0.99 (IQR, 0.5-1.0) at baseline and 0 (IQR, 0-0) at last follow-up; in chronic cases, the median BCVA improved from 1.09 (IQR, 0.5-2.0) to 0.27 (IQR, 0-0.5), with anterior chamber cell grade significantly declining. Ten eyes underwent cataract surgery during regular follow-up and achieved satisfactory long-term visual outcomes and decreased burden of immunosuppressants. The incidence of steroid-induced ocular hypertension was 41.0%, and children with frequent instillation of eyedrops were at high risk.Conclusions: Most cases were of chronic uveitis and scleritis requiring long-term systemic immunosuppressive therapies in pediatric uveitis and scleritis in China. Good management of complications is important for long-term prognosis. [ABSTRACT FROM AUTHOR]

Atypical development of numerical cognition (dyscalculia) may increase the onset of neuropsychiatric symptoms, especially when untreated, and it may have long-term detrimental social consequences. However, evidence-based treatments are still lacking. Despite plenty of studies investigating the effects of transcranial electrical stimulation (tES) on numerical cognition, a systematized synthesis of results is still lacking. In the present systematic review (PROSPERO ID: CRD42021271139), we found that the majority of reports (20 out of 26) showed the effectiveness of tES in improving both number (80%) and arithmetic (76%) processing. In particular, anodal tDCS (regardless of lateralization) over parietal regions, bilateral tDCS (regardless of polarity/lateralization) over frontal regions, and tRNS (regardless of brain regions) strongly enhance number processing. While bilateral tDCS and tRNS over parietal and frontal regions and left anodal tDCS over frontal regions consistently improve arithmetic skills. In addition, tACS seems to be more effective than tDCS at ameliorating arithmetic learning. Despite the variability of methods and paucity of clinical studies, tES seems to be a promising brain-based treatment to enhance numerical cognition. Recommendations for clinical translation, future directions, and limitations are outlined. [ABSTRACT FROM AUTHOR]

Autism spectrum disorder (ASD) is mainly described as a disorder of communication and socialization. However, motor abnormalities are also common in ASD. New technologies may offer quantitative and automatic metrics to measure movement difficulties. We sought to identify computational methods to automatize the assessment of motor impairments in ASD. We systematically searched for the terms 'autism', 'movement', 'automatic', 'computational' and 'engineering' in IEEE (Institute of Electrical and Electronics Engineers), Medline and Scopus databases and reviewed the literature from inception to 2018. We included all articles discussing: (1) automatic assessment/new technologies, (2) motor behaviours and (3) children with ASD. We excluded studies that included patient's or parent's reported outcomes as online questionnaires that focused on computational models of movement, but also eye tracking, facial emotion or sleep. In total, we found 53 relevant articles that explored static and kinetic equilibrium, like posture, walking, fine motor skills, motor synchrony and movements during social interaction that can be impaired in individuals with autism. Several devices were used to capture relevant motor information such as cameras, 3D cameras, motion capture systems, accelerometers. Interestingly, since 2012, the number of studies increased dramatically as technologies became less invasive, more precise and more affordable. Open-source software has enabled the extraction of relevant data. In a few cases, these technologies have been implemented in serious games, like "Pictogram Room", to measure the motor status and the progress of children with ASD. Movement computing opens new perspectives for patient assessment in ASD research, enabling precise characterizations in experimental and at-home settings, and a better understanding of the role of sensorimotor disturbances in the development of social cognition and ASD. These methods would likely enable researchers and clinicians to better distinguish ASD from other motors disorders while facilitating an improved monitoring of children's progress in more ecological settings (i.e. at home or school). [ABSTRACT FROM AUTHOR]

Two original studies explored relationships between visual attention of children with ASD (candidates for receiving a service dog) and their behaviors during their first interaction with a service dog. The first study consisted in video behavioural analyses of 16 children with ASD interacting with a service dog. During the interaction with a service dog, the time children with ASD spent looking towards social items vs objects was associated with how they interacted with the service dog. The second study was exploratory (i.e. 6 children), using the same behavioural approach but coupled with eye-tracking data. The more children with ASD looked at both their parent and the evaluator, as opposed to inanimate items, the more they interacted with the service dog. [ABSTRACT FROM AUTHOR]

Wearing face masks and maintaining social distancing of 1.5m are two common preventive measures against the spread of COVID-19. However, the interaction of these preventive measures in interpersonal space (IPS) perception remains unknown. This study evaluated the effects of wearing surgical masks, sex dyads, and approaching patterns on IPS judgment. Data were collected from participants from Mainland China (n =100) and Taiwan (n =100) through an online survey. Therefore, the regional differences were also examined. A smaller IPS was observed when participants faced confederates wearing surgical masks than in the no-mask condition. Female dyads tended to maintain a smaller IPS than did both male and mixed-sex dyads, and Taiwanese participants maintained a significantly larger IPS than did Mainland Chinese participants. No significant difference was observed between the active and passive pattern. Moreover, the interaction between region and mask had a significant influence on IPS perception. Among all test combinations, only the IPS perceived by Taiwanese participants facing confederates without surgical masks exceeded 1.5m. This study revealed that the wearing of surgical masks for health protection during the pandemic influences IPS perception in different regions. The current findings may provide useful information for social interaction and environmental design during the COVID-19 pandemic. [ABSTRACT FROM AUTHOR]

What exactly is meant by "self-advantage effect" in implicit recognition of one's hand? Comments on "No self-advantage in recognizing photographs of one's own hand" (Holmes, Spence, Rossetti Exp Brain Res., 2022). The title is deceptive even when considering the results of the meta-analysis, conducted by the authors: they conclude that "Overall, there is some evidence of a self-advantage effect for implicit tasks only, but this is complicated by an apparent bias for those effects to be published" (Pag.9). [Extracted from the article]

The space around the body crucially serves a variety of functions, first and foremost, preserving one's own safety and avoiding injury. Recent research has shown that emotional information, in particular threatening facial expressions, affects the regulation of peripersonal-reaching space (PPS, for action with objects) and interpersonal-comfort space (IPS, for social interaction). Here we explored if emotional facial expressions may similarly or differently affect both spaces in terms of psychophysiological reactions (cardiac inter-beat intervals: IBIs, i.e. inverse of heart rate; Skin Conductance Response amplitude: SCR amplitude) and spatial distance. Through Immersive Virtual Reality technology, participants determined reaching-distance (PPS) and comfort-distance (IPS) from virtual confederates exhibiting happy/angry/neutral facial expressions while being approached by them. During these interactions, spatial distance and psychophysiological reactions were recorded. Results revealed that when interacting with angry virtual confederates the distance increased similarly in both comfort-social and reaching-action spaces. Moreover, interacting with virtual confederates exhibiting angry rather than happy or neutral expressions provoked similar psychophysiological activations (SCR amplitude, IBIs) in both spaces. Regression analyses showed that psychophysiological activations, particularly SCR amplitude in response to virtual confederates approaching with angry expressions, were able to predict the increase of PPS and IPS. These findings suggest that self-protection functions could be the expression of a common defensive mechanism shared by social and action spaces. [ABSTRACT FROM AUTHOR]

Interpersonal space (IPS) is the area around the body that individuals maintain between themselves and others during social interactions. When others violate our IPS, feeling of discomfort rise up, urging us to move farther away and reinstate an appropriate interpersonal distance. Previous studies showed that when individuals are exposed to closeness of an unknown person (a confederate), the skin conductance response (SCR) increases. However, if the SCR is modulated according to participant's preferred IPS is still an open question. To test this hypothesis, we recorded the SCR in healthy participants when a confederate stood in front of them at various distances simulating either an approach or withdrawal movement (Experiment 1). Then, the comfort-distance task was adopted to measure IPS: participants stop the confederate, who moved either toward or away from them, when they felt comfortable with other's proximity (Experiment 2). We found higher SCR when the confederate stood closer to participants simulating an IPS intrusion, compared to when the confederate moved farther away. Crucially, we provide the first evidence that SCR, acting as a warning signal, contributes to interpersonal distance preference suggesting a functional link between behavioral components of IPS regulation and the underlying physiological processes. [ABSTRACT FROM AUTHOR]

Interpersonal distance (IPD) is a simple social regulation metric which is altered in autism. We performed a stop-distance paradigm to evaluate IPD regulation in autism spectrum disorder (ASD) and control groups in a real versus a virtual environment mimicking in detail the real one. We found a bimodal pattern of IPDs only in ASD. Both groups showed high IPD correlations between real and virtual environments, but the significantly larger slope in the control group suggests rescaling, which was absent in ASD. We argue that loss of nuances like non-verbal communication, such as perception of subtle body gestures in the virtual environment, lead to changed regulation of IPD in controls, whilst ASD participants show similar deficits in perceiving such subtle cues in both environments. [ABSTRACT FROM AUTHOR]

Call et al. (2013) described a method of assessing the function of social interactions that used time allocation as a dependent measure. The current study replicated the method described by Call et al. and evaluated several extensions aimed at increasing the feasibility and efficiency of the assessment and the utility of its results. Seven children diagnosed with Autism Spectrum Disorder (ASD) participated. Social interactions were concluded to be reinforcing for 5 participants and aversive for 2 partcipants. Time allocation data for all participants are presented as well as additional analyses related to patterns of switching toward or away from social contact and session duration. Implications of this study and its methodology as well as future directions in this line of research are discussed. [ABSTRACT FROM AUTHOR]

This study explores the interpersonal space (IPS) and peripersonal space (PPS) of Chinese people and evaluates the relationship between the two spaces for different directions and genders. Seventy-one participants were recruited for this study. Participants were required to determine their IPS in eight directions (0°, 45°, 90°, 135°, 180°, 225°, 270°, 315°) when approached by male or female confederates in the comfort distance task. Each participant was also asked to judge their PPS in five directions (0°, 45°, 90°, 270°, 315°) following the same procedure. Results showed that their IPS was significantly influenced by direction (p < 0.05), with the largest distance in the front (0°) and the closest distance in the rear (135°, 180°, 225°), indicating non-circular IPS among Chinese subjects. Moreover, the PPS on the right side (90°) was larger than in other directions (0°, 45°, 270°, 315°). Participants maintained larger IPS than PPS in the front, but the IPS was closer than PPS on the right and left sides. When facing a female confederate, larger IPS was preferred than PPS, whereas the opposite held true when facing a male confederate. Comparison of participants' arm length and PPS showed that the reachability distance was overestimated in the front but underestimated laterally. The findings of this study can be applied to environmental design, space utilization, and social interaction. [ABSTRACT FROM AUTHOR]

Pragmatic difficulties resulting in problems with reciprocal conversation are widely studied in individuals with autism spectrum disorder (ASD). There is some consensus on the conversation differences between individuals with autism compared to neurotypical groups and groups with other developmental delays. There is little information on whether conversation partners (neurotypical or with ASD) of individuals with ASD find these differences problematic. The results indicate that behaviors reported to be the most problematic were not necessarily behaviors commonly addressed in research. Further, some conversational capacities that have received less research focus were perceived as more problematic. Although conversation partners who had ASD themselves reported the frequency of behaviors similarly to the neurotypical group, they did not find the behaviors as problematic. [ABSTRACT FROM AUTHOR]

In healthy individuals, increasing cognitive load induces an asymmetric deployment of visuospatial attention, which favors the right visual space. To date, the neural mechanisms of this left/right attentional asymmetry are poorly understood. The aim of the present study was thus to investigate whether a left/right asymmetry under high cognitive load is due to a shift in the interhemispheric balance between the left and right posterior parietal cortices (PPCs), favoring the left PPC. To this end, healthy participants completed a visuospatial attention detection task under low and high cognitive load, whilst undergoing biparietal transcranial direct current stimulation (tDCS). Three different tDCS conditions were applied in a within-subjects design: sham, anodal left/cathodal right, and cathodal left/anodal right stimulation. The results revealed a left/right attentional asymmetry under high cognitive load in the sham condition. This asymmetry disappeared during cathodal left/anodal right tDCS, yet was not influenced by anodal left/cathodal right tDCS. There were no left/right asymmetries under low cognitive load in any of the conditions. Overall, these findings demonstrate that attentional asymmetries under high cognitive load can be modulated in a polarity-specific fashion by means of tDCS. They thus support the assumption that load-related asymmetries in visuospatial attention are influenced by interhemispheric balance mechanisms between the left and right PPCs. [ABSTRACT FROM AUTHOR]

Modeling in other organism species is one of the crucial stages in ascertaining the association between gene and psychiatric disorder. Testing Autism Spectrum Disorder (ASD) in mice is very popular but construct validity of the batteries is not available. We presented here the first factor analysis of a behavioral model of ASD-like in mice coupled with empirical validation. We defined fourteen measures aligning mouse-behavior measures with the criteria defined by DSM-5 for the diagnostic of ASD. Sixty-five mice belonging to a heterogeneous pool of genotypes were tested. Reliability coefficients vary from.68 to.81. The factor analysis resulted in a three- factor solution in line with DSM criteria: social behavior, stereotypy and narrowness of the field of interest. The empirical validation with mice sharing a haplo-insufficiency of the zinc-finger transcription factor TSHZ3/Tshz3 associated with ASD shows the discriminant power of the highly loaded items. [ABSTRACT FROM AUTHOR]