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306 results on '"Garnero, P"'

2. Satellitome analysis on the pale-breasted thrush Turdus leucomelas (Passeriformes; Turdidae) uncovers the putative co-evolution of sex chromosomes and satellite DNAs

Author

Souza, Guilherme Mota, Kretschmer, Rafael, Toma, Gustavo Akira, de Oliveira, Alan Moura, Deon, Geize Aparecida, Setti, Princia Grejo, Zeni dos Santos, Rodrigo, Goes, Caio Augusto Gomes, Del Valle Garnero, Analía, Gunski, Ricardo José, de Oliveira, Edivaldo Herculano Correa, Porto-Foresti, Fabio, Liehr, Thomas, Utsunomia, Ricardo, and de Bello Cioffi, Marcelo

Published
2024
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3. Evolution of bird sex chromosomes: a cytogenomic approach in Palaeognathae species

Author

Setti, Príncia Grejo, Deon, Geize Aparecida, Zeni dos Santos, Rodrigo, Goes, Caio Augusto Gomes, Garnero, Analía Del Valle, Gunski, Ricardo José, de Oliveira, Edivaldo Herculano Corrêa, Porto-Foresti, Fábio, de Freitas, Thales Renato Ochotorena, Silva, Fábio Augusto Oliveira, Liehr, Thomas, Utsunomia, Ricardo, Kretschmer, Rafael, and de Bello Cioffi, Marcelo

Published
2024
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13. The C-Terminal Intact Forms of Periostin (iPTN) Are Surrogate Markers for Osteolytic Lesions in Experimental Breast Cancer Bone Metastasis

Author

Gineyts, Evelyne, Bonnet, Nicolas, Bertholon, Cindy, Millet, Marjorie, Pagnon-Minot, Aurélie, Borel, Olivier, Geraci, Sandra, Bonnelye, Edith, Croset, Martine, Suhail, Ali, Truica, Cristina, Lamparella, Nicholas, Leitzel, Kim, Hartmann, Daniel, Chapurlat, Roland, Lipton, Allan, Garnero, Patrick, Ferrari, Serge, Clézardin, Philippe, and Rousseau, Jean-Charles

Published
2018
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17. Automatic Apnea Time Adjustments During Ventilation With Automode.

Author

Garnero, Ariel J. and Chatburn, Robert L.

Subjects
ARTIFICIAL respiration equipment, TIME, MECHANICAL ventilators, RESEARCH methodology, APNEA, SIMULATION methods in education, CONTINUING education units, RESPIRATORY measurements, AUTOMATION, DESCRIPTIVE statistics, WAVE analysis, ALGORITHMS
Abstract

BACKGROUND: Automode is a feature on Servo ventilators that automatically switches between mandatory and spontaneous breaths. Spontaneous breaths suppress mandatory breaths until apnea. The period from the last spontaneous breath to the first mandatory breath is automatically adjusted by a calculated apnea time limit based on a maximum apnea time setting, the mandatory breathing frequency setting, and the spontaneous breath count. The purpose of this study was to validate the apnea time algorithm by using simulated mechanical ventilation. METHODS: A Servo-u ventilator was connected to an ASL 5000 breathing simulator. Ventilator settings were the following: Automode (pressure control to pressure support), pressure control = 10 cm H2O; pressure support 5 = cm H2O; PEEP = 10 cm H2O; breathing frequency 5 10, 12, 15, 20 breaths/min; maximum apnea time = 7 and 12 s. Simulator settings were the following: resistance = 10 cm H2O/L/s; compliance = 35 mL/cm H2O; flow trigger model: frequency = 20 breaths/min, trigger flow = 10 L/min, trigger duration 5 800 ms. Flow waveforms were recorded, and the observed apnea time limit was compared with the calculated value. The outcome variable was error, defined as the difference between observed and calculated apnea times expressed as a percentage. RESULTS: The observed apnea time limit ranged from 3 to 12 s, depending on the mandatory frequency and the spontaneous breath count. The average error ranged from 22 to 0%. CONCLUSIONS: The measured apnea time for simulated ventilation settings was within 2% of calculated times. Automode allowed a spontaneous frequency lower than expected based on the mandatory frequency. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Bedside Assessment of Lung Recruitability: Making Sense of the Recruitment-to-Inflation Ratio.

Author

Chatburn, Robert L., Cutro, Ryan, Garnero, Ariel J., Babic, Sherry A., and Hatipoğlu, Umur

Subjects
LUNG volume measurements, LUNGS, POSITIVE end-expiratory pressure, AIRWAY (Anatomy), RESPIRATORY measurements, ADULT respiratory distress syndrome, ARTIFICIAL respiration, RESPIRATORY mechanics
Abstract

Determination of optimum PEEP levels remains an elusive goal. One factor is the recruitability of the lung, yet this is another difficult determination. Recently, a simple bedside technique, called the recruitment-to-inflation ratio, has been described and validated by comparison to the dual pressure-volume curve method. We describe the prior research and concepts of lung mechanics leading up to this metric and develop some background mathematics that help clinicians understand its meaning. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Proteogenomic reconstruction of organ-specific metabolic networks in an environmental sentinel species, the amphipod Gammarus fossarum.

Author

Koenig, Natacha, Baa-Puyoulet, Patrice, Lafont, Amélie, Lorenzo-Colina, Isis, Navratil, Vincent, Leprêtre, Maxime, Sugier, Kevin, Delorme, Nicolas, Garnero, Laura, Queau, Hervé, Gaillard, Jean-Charles, Kielbasa, Mélodie, Ayciriex, Sophie, Calevro, Federica, Chaumot, Arnaud, Charles, Hubert, Armengaud, Jean, Geffard, Olivier, and Degli Esposti, Davide

Abstract

Metabolic pathways are affected by the impacts of environmental contaminants underlying a large variability of toxic effects across different species. However, the systematic reconstruction of metabolic pathways remains limited in environmental sentinel species due to the lack of available genomic data in many taxa of animal diversity. In this study we used a multi-omics approach to reconstruct the most comprehensive map of metabolic pathways for a crustacean model in biomonitoring, the amphipod Gammarus fossarum in order to improve the knowledge of the metabolism of this sentinel species. We revisited the assembly of RNA-seq data by de novo approaches to reduce RNA contaminants and transcript redundancy. We also acquired extensive mass spectrometry shotgun proteomic data on several organs from a reference population of G. fossarum males and females to identify organ-specific metabolic profiles. The G. fossarum metabolic pathway reconstruction (available through the metabolic database GamfoCyc) was performed by adapting the genomic tool CycADS and we identified 377 pathways representing 7630 annotated enzymes, 2610 enzymatic reactions and the expression of 858 enzymes was experimentally validated by proteomics. To our knowledge, our analysis provides for the first time a systematic metabolic pathway reconstruction and the proteome profiles of these pathways at the organ level in this sentinel species. As an example, we show an elevated abundance in enzymes involved in ATP biosynthesis and fatty acid beta-oxidation indicative of the high-energy requirement of the gills, or the key anabolic and detoxification role of the hepatopancreatic caeca, as exemplified by the specific expression of the retinoid biosynthetic pathways and glutathione synthesis. In conclusion, the multi-omics data integration performed in this study provides new resources to investigate metabolic processes in crustacean amphipods and their role in mediating the effects of environmental contaminant exposures in sentinel species. This study provide the first evidence that it is possible to combine multiple omics data to exhaustively describe the metabolic network of a model species in ecotoxicology, Gammarus fossarum , for which a reference genome is not yet available. [Display omitted] • Metabolic pathway systematic reconstruction using transcriptomics of a sentinel freshwater amphipod, Gammarus fossarum. • Creation of an open-access molecular resource for G. fossarum metabolic network at http://arthropodacyc.cycadsys.org • Identification of organ-specific metabolic profiles using high resolution mass spectrometry proteomics [ABSTRACT FROM AUTHOR]

Published
2024
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42. Humanized anti-interleukin-6-receptor antibody (tocilizumab) monotherapy is more effective in slowing radiographic progression in patients with rheumatoid arthritis at high baseline risk for structural damage evaluated with levels of biomarkers, radiography, and BMI: data from the SAMURAI study

Author

Hashimoto, Jun, Garnero, Patrick, van der Heijde, Désirée, Miyasaka, Nobuyuki, Yamamoto, Kazuhiko, Kawai, Shinichi, Takeuchi, Tsutomu, Yoshikawa, Hideki, and Nishimoto, Norihiro

Published
2011
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