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12. Internet-Based Patient Education Prior to Colonoscopy: Prospective, Observational Study of a Single Center's Implementation, with Objective Assessment of Bowel Preparation Quality and Patient Satisfaction.

Author

Trasolini, Roberto, Nap-Hill, Estello, Suzuki, Matthew, Galorport, Cherry, Yonge, Jordan, Amar, Jack, Bressler, Brian, Ko, Hin Hin, Lam, Eric C S, Ramji, Alnoor, Rosenfeld, Gregory, Telford, Jennifer J, Whittaker, Scott, and Enns, Robert A

Published
2020
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16. Utility of Transient Elastography in Estimating Hepatic Iron Concentration in Comparison to Magnetic Resonance Imaging in Patients Who are Transfusion-Dependent: A Canadian Center Experience.

Author

Ou, George, Ko, Hin Hin, Tiwari, Pari, Sandhu, Navdeep, Galorport, Cherry, Lee, Terry, and Ezzat, Hatoon

Subjects
ELASTOGRAPHY, MAGNETIC resonance imaging, CHELATION therapy, IRON in the body, FERRITIN, STATISTICAL correlation
Abstract

Transfusion-dependent hereditary anemias such as β-thalassemia (β-thal), predispose patients to iron overload and its numerous clinical sequelae. Accurate assessment of overall iron status and prompt initiation of chelation therapy to prevent irreversible end-organ damage can be achieved using magnetic resonance imaging (MRI) to measure liver iron concentration (LIC) as a surrogate marker of total body iron; however, its access may be associated with long wait times and delay in treatment. We report an observational cohort study at a single tertiary care center assessing the theoretical role of transient elastography (TE), which measures liver stiffness, in estimating LIC compared to other established diagnostic measures. While regression analyses confirm a moderate correlation between LIC per R2 MRI and serum ferritin level (pooled estimate of correlation = 0.55), there was no significant correlation between TE reading and LIC based on R2 MRI (pooled estimate of correlation = −0.06), and only a weak correlation was observed with serum ferritin level (pooled estimate of correlation = 0.45). These results suggest TE may not be sensitive enough to detect subtle changes in the hepatic parenchymal stiffness associated with liver iron deposition. [ABSTRACT FROM AUTHOR]

Published
2017
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19. The effect of chewing gum on small-bowel transit time in capsule endoscopy: a prospective, randomized trial.

Author

Ou, George, Svarta, Sigrid, Chan, Calvin, Galorport, Cherry, Qian, Hong, and Enns, Robert

Abstract

Background: Approximately 1 in 6 capsule endoscopies (CEs) does not visualize the entire small bowel at completion of the examination because of limited battery life. Objective: To determine whether chewing gum can reduce the small-bowel transit time and increase CE completion rates. Design: Prospective, single-blind, randomized, controlled trial. Setting: A tertiary university-affiliated hospital. Patients: Consecutive patients 19 years of age and older undergoing outpatient small-bowel CE from October 2010 to July 2012 were assessed for eligibility. Those with previous gastric or small-bowel surgery or ileostomy, dysphagia prohibiting capsule ingestion, diabetes mellitus with evidence of end-organ damage, use of narcotics or prokinetics within 5 days before the procedure, clinical hyper-/hypothyroidism, and symptoms suggestive of acute bowel obstruction were excluded. Intervention: Gum chewing for at least 20 minutes every 2 hours starting at the time of capsule ingestion. Main Outcome Measurements: Small-bowel transit time, gastric transit time, and completion rate were measured. Results: Chewing gum did not have any significant effect on gastric transit time (rate ratio 1.06; 95% CI, 0.73-1.55; P = .75), small-bowel transit time (rate ratio 0.91; 95% CI, 0.62-1.35; P = .65), or completion rate (91.67% chewing gum vs 88.71% control, P = .58) of CE. Limitation: Single-center study involving relatively healthy subjects. Procedures were done on an outpatient basis so participants were not monitored for adherence to protocol. Conclusions: Chewing gum does not speed up capsule transit or increase completion rate of CE in patients without risk factors for incomplete studies. (Clinical trial registration number: NCT01241825.) [Copyright &y& Elsevier]

Published
2014
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21. Capsule Endoscopy for Obscure Gastrointestinal Bleeding in Patients with Comorbid Rheumatic Diseases.

Author

Shahidi, Neal, Ou, George, Tong, Jessica, Kwok, Ricky, Galorport, Cherry, Law, Joanna K., and Enns, Robert

Subjects
ENDOSCOPY, GASTROINTESTINAL diseases, HEMORRHAGE, COMORBIDITY, RHEUMATISM, ANTI-inflammatory agents, PATIENTS
Abstract

Background and Aim. We evaluated the association between patients with rheumatic diseases (RD) suffering from obscure gastrointestinal bleeding (OGIB) and positive capsule endoscopy (CE) findings. Methods. All CE procedures performed on patients with RD and OGIB were assessed from a large database at St. Paul's Hospital (Vancouver, BC, Canada) between December 2001 and April 2011. A positive finding on CE was defined as any pathology, including ulcers/erosions, vascular lesions, and mass lesions, perceived to be the source of bleeding. Results. Of the 1133 CEs performed, 41 (4%) complete CEs were for OGIB in patients with RD. Of these, 54% presented with overt bleeding. Mean age was 66 years. Positive findings were seen in 61% of patients. Ulcerations/erosions (36%) and vascular lesions (36%) were the most common findings. Significant differences between the RD versus non-RD populations included: inpatient status, nonsteroidal anti-inflammatory drug (NSAIDs) use, oral steroid use, and mean Charlson index score (all P = 0.008). Similar nonsignificant trends were seen between positive and negative CEs among the RDpopulation. Conclusions. The correlation between RD and positiveC Efindings is likely influenced by ongoing anti-inflammatory drug use, poorer health status, and a predisposition for angiodysplastic lesions. [ABSTRACT FROM AUTHOR]

Published
2014
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