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Your search keyword '"Göhl, Jonas"' showing total 18 results
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18 results on '"Göhl, Jonas"'

9. Reduction in Adhesive Small-Bowel Obstruction by Seprafilm® Adhesion Barrier After Intestinal Resection

Author

Fazio, Victor W., Cohen, Zane, Fleshman, James W., van Goor, Harry, Bauer, Joel J., Wolff, Bruce G., Corman, Marvin, Beart, Jr., Robert W., Wexner, Steven D., Becker, James M., Monson, John R. T., Kaufman, Howard S., Beck, David E., Bailey, H. Randolph, Ludwig, Kirk A., Stamos, Michael J., Darzi, Ara, Bleday, Ronald, Dorazio, Richard, Madoff, Robert D., Smith, Lee E., Gearhart, Susan, Lillemoe, Keith, and Göhl, Jonas

Published
2006
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11. Ist das akrolentiginöse Melanom (ALM) maligner als das superfiziell spreitende Melanom (SSM) in einer High-risk-Lokalisation?: Ein matched-pair-Vergleich zwischen je 113 ALM und SSM im Rahmen einer multizentrischen Studie

Author

Breuninger, Helmut, Köhler, Claus, Drepper, Hubert, Bastian, Boris, Bröcker, Eva-B., Göhl, Jonas, Groth, Wolfgang, Hermanek, Paul, Hohenberger, Werner, Lippold, Andrea, Kölmel, Klaus, Landthaler, Michael, Peters, Almut, and Tilgen, Wolfgang

Published
1994
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12. Perineal and vaginal wall reconstruction using a combined inferior gluteal and pudendal artery perforator flap: A case report.

Author

Schmidt, Volker J., Horch, Raymund E., Dragu, Adrian, Weber, Klaus, Göhl, Jonas, Mehlhorn, Grit, and Kneser, Ulrich

Subjects
PERINEUM surgery, VAGINAL surgery, PLASTIC surgery, BUTTOCKS, PUDENDAL nerve, SURGICAL flaps, WOUNDS & injuries
Abstract

Summary: Reliable perineal and posterior vaginal wall restoration following extensive abdominoperineal excision or pelvic exenteration is a reconstructive challenge, especially if the rectus abdominis is unavailable or insufficient for transpelvic transposition. In this short report, we present a novel combined perforator-based technique, in which an inferior gluteal perforator flap is used for perineal reconstruction whereas vaginal reconstruction is performed simultaneously by means of a pudendal artery perforator flap. This procedure circumvents functional muscle loss, permits a tension-free closure of difficult three-dimensional defects and offers a high degree of reconstructive flexibility, which allows a straightforward and independent reconstruction of two different anatomical units. [Copyright &y& Elsevier]

Published
2012
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16. Benefit of elective lymph node dissection in subgroups of melanoma patients. Results of a multicenter study of 3616 patients.

Author

Drepper, Hubert, Köhler, Claus O., Bastian, Boris, Breuninger, Helmut, Bröcker, Eva-B., Göhl, Jonas, Groth, Wolfgang, Hermanek, Paul, Hohenberger, Werner, Lippold, Andrea, Kölmel, Klaus, Landthaler, Michael, Peters, Almut, Tilgen, Wolfgang, Drepper, H, Köhler, C O, Bastian, B, Breuninger, H, Bröcker, E B, and Göhl, J

Published
1993
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18. Anti-TNF-refractory colitis after checkpoint inhibitor therapy: Possible role of CMV-mediated immunopathogenesis.

Author

Lankes, Katharina, Hundorfean, Gheorghe, Harrer, Thomas, Pommer, Ansgar J., Agaimy, Abbas, Angelovska, Irena, Tajmir-Riahi, Azadeh, Göhl, Jonas, Schuler, Gerold, Neurath, Markus F., Hohenberger, Werner, and Heinzerling, Lucie

Subjects
IMMUNOPATHOLOGY, ADVERSE health care events, IMMUNOSUPPRESSIVE agents, IMMUNOSUPPRESSION, AMYLASES
Abstract

Immune-related adverse events (irAEs) induced by checkpoint inhibitors are well known. Since fatal outcomes have been reported early detection and adequate management are crucial. In particular, colitis is frequently observed and can result in intestinal perforation. This is the first report of an autoimmune colitis that was treated according to algorithms but became resistant due to a CMV reactivation. The 32-y-old male patient with metastatic melanoma treated within an anti-PD-1/ipilimumab combination study developed severe immune-mediated colitis (CTCAE grade 3) with up to 18 watery stools per day starting 2 weeks after treatment initiation. After improving upon therapy with immunosuppressive treatment (high dose steroids and infliximab) combined with parenteral nutrition diarrhea again exacerbated. Additionally, the patient had asymptomatic grade 3 CTCAE amylase and lipase elevation. Colitis was monitored by weekly endoscopies and colon biopsies were analyzed histologically with CMV staining, multi-epitope ligand cartography (MELC) and qRT-PCR for inflammatory genes. In the course, CMV reactivation was detected in the colon and treated with antiviral medication in parallel to a reduction of corticosteroids. Subsequently, symptoms improved. The patient showed a complete response for 2 y now including regression of bone metastases. CMV reactivation under checkpoint inhibitor therapy in combination with immunosuppressive treatment for autoimmune side effects has to be considered in these patients and if present treated. Potentially, CMV reactivation is underdiagnosed. Treatment algorithms should include CMV diagnostics. [ABSTRACT FROM AUTHOR]

Published
2016
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