23 results on '"Firth, Mike A"'
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2. Epigenetic modulators link mitochondrial redox homeostasis to cardiac function in a sex-dependent manner
3. Identification of cell type-specific cell-penetrating peptides through in vivo phage display leveraged by next generation sequencing
4. An aptamer-mediated base editing platform for simultaneous knockin and multiple gene knockout for allogeneic CAR-T cells generation
5. A Type II-B Cas9 nuclease with minimized off-targets and reduced chromosomal translocations in vivo
6. Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing
7. Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing
8. Correction of a urea cycle defect after ex vivo gene editing of human hepatocytes
9. A Novel Screening Approach for the Dissection of Cellular Regulatory Networks of NF-κB Using Arrayed CRISPR gRNA Libraries
10. Delivering Robust Candidates to the Drug Pipeline through Computational Analysis of Arrayed CRISPR Screens
11. Universal toxin-based selection for precise genome engineering in human cells
12. Rapid target validation in a Cas9-inducible hiPSC derived kidney model
13. High-content phenotypic assay for proliferation of human iPSC-derived cardiomyocytes identifies L-type calcium channels as targets
14. CRISPR GUARD protects off-target sites from Cas9 nuclease activity using short guide RNAs
15. In vivo CRISPR editing with no detectable genome-wide off-target mutations
16. BE-FLARE: a fluorescent reporter of base editing activity reveals editing characteristics of APOBEC3A and APOBEC3B
17. Engineered Cas9 extracellular vesicles as a novel gene editing tool.
18. Systematic Evaluation of CRISPRa and CRISPRi Modalities Enables Development of a Multiplexed, Orthogonal Gene Activation and Repression System.
19. Orthologue chemical space and its influence on target prediction.
20. Targeted Metabolic Profiling of the Tg197 Mouse Model Reveals Itaconic Acid as a Marker of Rheumatoid Arthritis.
21. Systematic Explorationof Dual-Acting Modulators froma Combined Medicinal Chemistry and Biology Perspective.
22. An incremental, exploratory and transformational environment for lazy functional programming.
23. Goods and Services Tax reaches a difficult age.
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