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9 results on '"Firas, Jaber"'

1. Breaking constraint of mammalian axial formulae

Author

Hauswirth, Gabriel M., Garside, Victoria C., Wong, Lisa S. F., Bildsoe, Heidi, Manent, Jan, Chang, Yi-Cheng, Nefzger, Christian M., Firas, Jaber, Chen, Joseph, Rossello, Fernando J., Polo, Jose M., and McGlinn, Edwina

Published
2022
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2. TINC— A Method to Dissect Regulatory Complexes at Single-Locus Resolution— Reveals an Extensive Protein Complex at the Nanog Promoter

Author

Knaupp, Anja S., Mohenska, Monika, Larcombe, Michael R., Ford, Ethan, Lim, Sue Mei, Wong, Kayla, Chen, Joseph, Firas, Jaber, Huang, Cheng, Liu, Xiaodong, Nguyen, Trung, Sun, Yu B.Y., Holmes, Melissa L., Tripathi, Pratibha, Pflueger, Jahnvi, Rossello, Fernando J., Schröder, Jan, Davidson, Kathryn C., Nefzger, Christian M., Das, Partha P., Haigh, Jody J., Lister, Ryan, Schittenhelm, Ralf B., and Polo, Jose M.

Published
2020
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3. Reprogramming roadmap reveals route to human induced trophoblast stem cells

Author

Liu, Xiaodong, Ouyang, John F., Rossello, Fernando J., Tan, Jia Ping, Davidson, Kathryn C., Valdes, Daniela S., Schröder, Jan, Sun, Yu B. Y., Chen, Joseph, Knaupp, Anja S., Sun, Guizhi, Chy, Hun S., Huang, Ziyi, Pflueger, Jahnvi, Firas, Jaber, Tano, Vincent, Buckberry, Sam, Paynter, Jacob M., Larcombe, Michael R., Poppe, Daniel, Choo, Xin Yi, O’Brien, Carmel M., Pastor, William A., Chen, Di, Leichter, Anna L., Naeem, Haroon, Tripathi, Pratibha, Das, Partha P., Grubman, Alexandra, Powell, David R., Laslett, Andrew L., David, Laurent, Nilsson, Susan K., Clark, Amander T., Lister, Ryan, Nefzger, Christian M., Martelotto, Luciano G., Rackham, Owen J. L., and Polo, Jose M.

Published
2020
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8. New routes to prepare superabsorbent polymers free of acrylate cross-linker

Author

Firas Jaber, Rachid Salghi, Shehdeh Jodeh, Haythem A. Saadeh, Emad M. Hamed, Kamel Adwan, and Othman A. Hamed

Subjects
Allyl chloride, Acrylate, Aqueous solution, Diglycidyl ether, Materials science, Polymers and Plastics, General Chemical Engineering, Polyacrylic acid, Solution polymerization, chemistry.chemical_compound, chemistry, Superabsorbent polymer, Materials Chemistry, Organic chemistry, Nuclear chemistry, Acrylic acid
Abstract

In this study, new series of superabsorbent polymers, which were free of acrylate cross-linkers, were synthesized and their absorbent properties were evaluated. The new superabsorbent polymers showed high free swell and absorbency under loading. They were synthesized in a single-step process through a solution polymerization of partially neutralized acrylic acid in the presence of cross-linking agents allyl sucrose (AS) and epoxy allyl sucrose (EAS). Allyl sucrose was synthesized by reacting sucrose with allyl chloride in an alkaline medium. Allyl sucrose was then converted into EAS by oxidation with peracetic acid. The synthesis and absorbent properties of superabsorbent polymers (SAPs) cross-linked with commercially available non-sucrose-based epoxy cross-linking agents, e.g., glycerol diglycidyl ethers (GDGE), 1,4-butanediol diglycidyl ether (1,4-BDGE) and 1,4-cyclohexanedimethanol diglycidyl ether (1,4-CHDDMDGE) have been evaluated, as well. Absorbent properties of the prepared superabsorbent polymers were evaluated in saline solution and results showed high dependency of the absorbent properties on the cross-linking agent polarity and concentration. Superabsorbent polymers cross-linked with EAS and GDGE showed the highest absorbency under loading and indicated that they formed gels with high strength in the aqueous solution. Absorbent properties of the prepared SAPs showed reversible correlation with cross-linking agent concentration. The pH of the reaction mixture was optimized to achieve the highest free swell and absorbency under loading. The biodegradation properties of the superabsorbent polymers cross-linked with sucrose-based cross-linking agents were also evaluated and they showed degradation behavior under the influence of organisms Pseudomonas aeruginosa and Trichophyton rubrum.

Published
2015
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9. Cell Type of Origin Dictates the Route to Pluripotency.

Author

Nefzger, Christian M., Rossello, Fernando J., Joseph Chen, Xiaodong Liu, Knaupp, Anja S., Firas, Jaber, Paynter, Jacob M., Pflueger, Jahnvi, Buckberry, Sam, Sue Mei Lim, Williams, Brenda, Alaei, Sara, Faye-Chauhan, Keshav, Petretto, Enrico, Nilsson, Susan K., Lister, Ryan, Ramialison, Mirana, Powell, David R., Rackham, Owen J. L., and Polo, Jose M.

Abstract

Our current understanding of induced pluripotent stem cell (iPSC) generation has almost entirely been shaped by studies performed on reprogramming fibroblasts. However, whether the resulting model universally applies to the reprogramming process of other cell types is still largely unknown. By characterizing and profiling the reprogramming pathways of fibroblasts, neutrophils, and keratinocytes, we unveil that key events of the process, including loss of original cell identity, mesenchymal to epithelial transition, the extent of developmental reversion, and reactivation of the pluripotency network, are to a large degree cell-type specific. Thus, we reveal limitations for the use of fibroblasts as a universal model for the study of the reprogramming process and provide crucial insights about iPSC generation from alternative cell sources. [ABSTRACT FROM AUTHOR]

Published
2017
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