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Your search keyword '"Fernandez-Ruiz, Sonia"' showing total 6 results
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6 results on '"Fernandez-Ruiz, Sonia"'

1. Angiocrine polyamine production regulates adiposity

Author

Monelli, Erika, Villacampa, Pilar, Zabala-Letona, Amaia, Martinez-Romero, Anabel, Llena, Judith, Beiroa, Daniel, Gouveia, Leonor, Chivite, Iñigo, Zagmutt, Sebastián, Gama-Perez, Pau, Osorio-Conles, Oscar, Muixi, Laia, Martinez-Gonzalez, Ainara, Castillo, Sandra D., Martín-Martín, Natalia, Castel, Pau, Valcarcel-Jimenez, Lorea, Garcia-Gonzalez, Irene, Villena, Josep A., Fernandez-Ruiz, Sonia, Serra, Dolors, Herrero, Laura, Benedito, Rui, Garcia-Roves, Pablo, Vidal, Josep, Cohen, Paul, Nogueiras, Rubén, Claret, Marc, Carracedo, Arkaitz, and Graupera, Mariona

Published
2022
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2. PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer

Author

Zabala-Letona, Amaia, Arruabarrena-Aristorena, Amaia, Fernandez-Ruiz, Sonia, Viera, Cristina, Carlevaris, Onintza, Ercilla, Amaia, Mendizabal, Isabel, Martin, Teresa, Macchia, Alice, Camacho, Laura, Pujana-Vaquerizo, Mikel, Sanchez-Mosquera, Pilar, Torrano, Verónica, Martin-Martin, Natalia, Zuniga-Garcia, Patricia, Castillo-Martin, Mireia, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Unda, Miguel, Mato, Jose M., Berra, Edurne, Martinez-Chantar, Maria L., and Carracedo, Arkaitz

Published
2022
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3. Methodological aspects of the molecular and histological study of prostate cancer: Focus on PTEN

Author

Ugalde-Olano, Aitziber, Egia, Ainara, Fernández-Ruiz, Sonia, Loizaga-Iriarte, Ana, Zuñiga-García, Patricia, Garcia, Stephane, Royo, Félix, Lacasa-Viscasillas, Isabel, Castro, Erika, Cortazar, Ana R., Zabala-Letona, Amaia, Martín-Martín, Natalia, Arruabarrena-Aristorena, Amaia, Torrano-Moya, Verónica, Valcárcel-Jiménez, Lorea, Sánchez-Mosquera, Pilar, Caro-Maldonado, Alfredo, González-Tampan, Jorge, Cachi-Fuentes, Guido, Bilbao, Elena, Montero, Rocío, Fernández, Sara, Arrieta, Edurne, Zorroza, Kerman, Castillo-Martín, Mireia, Serra, Violeta, Salazar, Eider, Macías-Cámara, Nuria, Tabernero, Jose, Baselga, Jose, Cordón-Cardo, Carlos, Aransay, Ana M., Villar, Amaia Del, Iovanna, Juan L., Falcón-Pérez, Juan M., Unda, Miguel, Bilbao, Roberto, and Carracedo, Arkaitz

Published
2015
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4. mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.

Author

Zabala-Letona, Amaia, Arruabarrena-Aristorena, Amaia, Martín-Martín, Natalia, Fernandez-Ruiz, Sonia, Sutherland, James D., Clasquin, Michelle, Tomas-Cortazar, Julen, Jimenez, Jose, Torres, Ines, Quang, Phong, Ximenez-Embun, Pilar, Bago, Ruzica, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Torrano, Verónica, Cabrera, Diana, van Liempd, Sebastiaan M., and Cendon, Ylenia

Abstract

Activation of the PTEN-PI3K-mTORC1 pathway consolidates metabolic programs that sustain cancer cell growth and proliferation. Here we show that mechanistic target of rapamycin complex 1 (mTORC1) regulates polyamine dynamics, a metabolic route that is essential for oncogenicity. By using integrative metabolomics in a mouse model and human biopsies of prostate cancer, we identify alterations in tumours affecting the production of decarboxylated S-adenosylmethionine (dcSAM) and polyamine synthesis. Mechanistically, this metabolic rewiring stems from mTORC1-dependent regulation of S-adenosylmethionine decarboxylase 1 (AMD1) stability. This novel molecular regulation is validated in mouse and human cancer specimens. AMD1 is upregulated in human prostate cancer with activated mTORC1. Conversely, samples from a clinical trial with the mTORC1 inhibitor everolimus exhibit a predominant decrease in AMD1 immunoreactivity that is associated with a decrease in proliferation, in line with the requirement of dcSAM production for oncogenicity. These findings provide fundamental information about the complex regulatory landscape controlled by mTORC1 to integrate and translate growth signals into an oncogenic metabolic program. [ABSTRACT FROM AUTHOR]

Published
2017
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6. Corrigendum: mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.

Author

Zabala-Letona, Amaia, Arruabarrena-Aristorena, Amaia, Martín-Martín, Natalia, Fernandez-Ruiz, Sonia, Sutherland, James D., Clasquin, Michelle, Tomas-Cortazar, Julen, Jimenez, Jose, Torres, Ines, Quang, Phong, Ximenez-Embun, Pilar, Bago, Ruzica, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Torrano, Verónica, Cabrera, Diana, van Liempd, Sebastiaan M., and Cendon, Ylenia

Abstract

This corrects the article DOI: 10.1038/nature22964 [ABSTRACT FROM AUTHOR]

Published
2018
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