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1. Mineral resource base of the CIS countries of the Central Asian region: status, areas of interaction and development

Author

Chernykh A. I., Girfanov M. M., Istomin V. A., Fedorov D. T., Pashkov V. S., and Svatkov A. S.

Subjects
mineral resource base, non-ferrous metals, precious metals, republic of kazakhstan, kyrgyz republic, republic of tajikistan, republic of uzbekistan, russian federation, cis, central asian region, Geology, QE1-996.5
Abstract

The countries of the Central Asian region of the CIS – the Republic of Kazakhstan, the Kyrgyz Republic, the Republic of Tajikistan, the Republic of Uzbekistan – have a powerful mineral resource base (MRB) covering almost the entire spectrum of mineral raw materials: ferrous, non-ferrous, noble, rare metals and combustible minerals. The foundation of this wealth was laid during the existence of the Soviet Union, when the joint efforts of the union republics carried out a systematic geological study of their territory and created the mining industry and metallurgy. The article discusses the state of MRB and mining production of mineral raw materials in the region, primarily regarding “basic” non-ferrous (copper, lead, zinc, nickel) and precious (gold and silver) metals.

Published
2023
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2. Effect of HIF-1α inhibition with topotecan and postconditioning on cardiac and skeletal muscle biomarkers during severe hypoxia

Author

Fedorov D. A., Frolova M. Yu., and Kuleva N. V.

Subjects
hypoxia, myoglobin, troponin i, topotecan, hypoxia-inducible factor hif-1α, postconditioning, biomarkers for muscle damage, Microbiology, QR1-502, Physiology, QP1-981, Zoology, QL1-991
Abstract

The work used a model of severe hypobaric hypoxia (SH) – a three-hour session of rats staying at 180 mmHg (5% O2) and an attempt was made to evaluate the possibility of its use for muscle tissue by determining biomarkers of cardiac muscle and skeletal muscles damage in the blood plasma. To assess the effect of HIF1, we used the HIF-1α translation inhibitor, topotecan, which was administered intraperitoneally (5 mg/kg body weight) in a DMSO–0.09% NaCl mixture 10 min before hypoxia. For postconditioning (PostC), moderate hypobaric hypoxia was used [1]. A significant increase in the level of cardiac biomarker troponin I in the blood plasma of rats subjected to TH was shown, which indicated myocardial damage after SH. The blood level of the nonspecific muscle biomarker myoglobin did not change significantly after SH. However, when the HIF-1α inhibitor topotecan was used before SH, the amount of myoglobin in the blood plasma of rats one day after the SH session was significantly lower than in the absence of the inhibitor. Thus, it can be assumed that inhibition of the transcription factor HIF-1α before SH reduces skeletal muscle damage. Topotecan can be proposed as a means to reduce damage to injured muscles.

Published
2024
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3. Numerical simulation of deformations of a specimen of a composite helicopter blade as part of a resonant vibration set-up

Author

Fedorov D. and Shcherban K.

Subjects
Environmental sciences, GE1-350
Abstract

To determine the fatigue life of the tail rotor blade of a helicopter made of polymer composite materials (CM), a method of fatigue testing of the specimens of the blade with accompanied numerical modeling of the deformed state has been developed. The tests are carried out on a resonant vibration set-up, with simultaneous reproduction of a forcing harmonic transverse force and a constant longitudinal tensile force. The tests are carried out by a vibration loading mode equivalent in fatigue damage, which includes one level of variable load in the thrust plane and in the plane of rotation. The equivalent mode is formed based on the variable loading spectrum of the blade, which is obtained from the results of flight measurements of the loads on the tail rotor, as well as the repeatability of the expected operating conditions of the helicopter. The tests are accompanied by computational and experimental studies, which include finite element calculation of the stress state and modal analysis of the standard blade and the test specimen, as well as the strain measuring of the structure. According to the results of the research, the vibration loading modes are corrected.

Published
2023
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6. Production study of Fr, Ra and Ac radioactive ion beams at ISOLDE, CERN

Author

Jajčišinová, E., Dockx, K., Au, M., Bara, S., Cocolios, T. E., Chrysalidis, K., Farooq-Smith, G. J., Fedorov, D. V., Fedosseev, V. N., Flanagan, K. T., Heines, M., Houngbo, D., Johnson, J. D., Kellerbauer, A., Kraemer, S., Marsh, B. A., Popescu, L., Ramos, J. P., Rothe, S., Seliverstov, M. D., Sels, S., Stegemann, S., Stryjczyk, M., and Verelst, V.

Published
2024
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31. Measurement and microscopic description of odd–even staggering of charge radii of exotic copper isotopes

Author

de Groote, R. P., Billowes, J., Binnersley, C. L., Bissell, M. L., Cocolios, T. E., Day Goodacre, T., Farooq-Smith, G. J., Fedorov, D. V., Flanagan, K. T., Franchoo, S., Garcia Ruiz, R. F., Gins, W., Holt, J. D., Koszorús, Á., Lynch, K. M., Miyagi, T., Nazarewicz, W., Neyens, G., Reinhard, P.-G., Rothe, S., Stroke, H. H., Vernon, A. R., Wendt, K. D. A., Wilkins, S. G., Xu, Z. Y., and Yang, X. F.

Published
2020
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37. Characterization of the shape-staggering effect in mercury nuclei

Author

Marsh, B. A., Day Goodacre, T., Sels, S., Tsunoda, Y., Andel, B., Andreyev, A. N., Althubiti, N. A., Atanasov, D., Barzakh, A. E., Billowes, J., Blaum, K., Cocolios, T. E., Cubiss, J. G., Dobaczewski, J., Farooq-Smith, G. J., Fedorov, D. V., Fedosseev, V. N., Flanagan, K. T., Gaffney, L. P., Ghys, L., Huyse, M., Kreim, S., Lunney, D., Lynch, K. M., Manea, V., Martinez Palenzuela, Y., Molkanov, P. L., Otsuka, T., Pastore, A., Rosenbusch, M., Rossel, R. E., Rothe, S., Schweikhard, L., Seliverstov, M. D., Spagnoletti, P., Van Beveren, C., Van Duppen, P., Veinhard, M., Verstraelen, E., Welker, A., Wendt, K., Wienholtz, F., Wolf, R. N., Zadvornaya, A., and Zuber, K.

Published
2018
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42. Identification of Melittin-Like Proteins with a Molecular Weight of 67 kDa that Interact with Na+/K+-ATPase.

Author

Varfolomeeva, L. A., Klimanova, E. A., Sidorenko, S. V., Fedorov, D. A., and Lopina, O. D.

Subjects
PROTEOMICS, BEE venom, MOLECULAR chaperones, MOLECULAR weights, MELITTIN, PEPTIDES, AFFINITY chromatography
Abstract

Melittin, a peptide from bee venom, was found to be able to interact with many proteins, including calmodulin target proteins and ion-transporting P-type ATPases. It is assumed that melittin mimics a protein module involved in protein-protein interactions within cells. Previously, a Na+/K+-ATPase containing the α1 isoform of the catalytic subunit was found to co-precipitate with a protein with a molecular weight of about 70 kDa that interacts with antibodies against melittin by cross immunoprecipitation. In the presence of a specific Na+/K+-ATPase inhibitor (ouabain), the amount of protein with a molecular weight of 70 kDa interacting with Na+/K+-ATPase increases. In order to identify melittin-like protein from murine kidney homogenate, a fraction of melittin-like proteins with a molecular weight of approximately 70 kDa was obtained using affinity chromatography with immobilized antibodies specific to melittin. By mass spectrometry analysis, the obtained protein fraction was found to contain three molecular chaperones of Hsp70 superfamily: mitochondrial mtHsp70 (mortalin), Hsp73, Grp78 (BiP) of endoplasmic reticulum. These data suggest that chaperones from the HSP-70 superfamily contain a melittin-like module. [ABSTRACT FROM AUTHOR]

Published
2023
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