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1. Developments in anaplastic large-cell lymphoma: targeting the anaplastic lymphoma kinase

Author

Farina F, Stasia A, and Gambacorti-Passerini C

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Francesca Farina, Alessandra Stasia, Carlo Gambacorti-Passerini Department of Health Sciences, University of Milano Bicocca, Monza, Italy Abstract: Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase protein implicated in a variety of hematological malignancies and solid tumors. ALK contributes to the development of cancers in different cell lineages through a variety of genetic mechanisms: gene fusions, activating point mutations, and possibly gene amplification. Recent developments led to significant therapeutic advances, including efficient diagnostic tests and ALK-targeting agents. This review addresses some therapeutic considerations with regard to the use of ALK inhibitors in ALK-positive lymphomas where, in spite of the advanced stage of the disease, long-lasting responses could be obtained in a substantial portion of heavily pretreated patients. Data and mechanisms for the development of resistance to ALK inhibitors will also be presented and discussed. Keywords: ALK, lymphoma, tyrosine kinase, targeted therapy, crizotinib

Published
2014

4. The predictive value of clinical, radiographic, echocardiographic variables and cardiac biomarkers for assessing risk of the onset of heart failure or cardiac death in dogs with preclinical myxomatous mitral valve disease enrolled in the DELAY study

Author

Borgarelli, M., Ferasin, L., Lamb, K., Chiavegato, D., Bussadori, C., D'Agnolo, G., Migliorini, F., Poggi, M., Santilli, R.A., Guillot, E., Garelli-Paar, C., Toschi Corneliani, R., Farina, F., Zani, A., Dirven, M., Smets, P., Guglielmini, C., Oliveira, P., Di Marcello, M., Porciello, F., Crosara, S., Ciaramella, P., Piantedosi, D., Smith, S., Vannini, S., Dall’Aglio, E., Savarino, P., Quintavalla, C., Patteson, M., Silva, J., Locatelli, C., and Baron Toaldo, M.

Published
2021
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8. DELay of Appearance of sYmptoms of Canine Degenerative Mitral Valve Disease Treated with Spironolactone and Benazepril: the DELAY Study

Author

Borgarelli, M., Ferasin, L., Lamb, K., Bussadori, C., Chiavegato, D., D'Agnolo, G., Migliorini, F., Poggi, M., Santilli, R.A., Guillot, E., Garelli-Paar, C., Toschi Corneliani, R., Farina, F., Zani, A., Dirven, M., Smets, P., Guglielmini, C., Oliveira, P., Di Marcello, M., Porciello, F., Crosara, S., Ciaramella, P., Piantedosi, D., Smith, S., Vannini, S., Dall’Aglio, E., Savarino, P., Quintavalla, C., Patteson, M., Silva, J., Locatelli, C., and Baron Toaldo, M.

Published
2020
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22. Predictors of Anxiety towards Computers.

Author

Farina, F.

Abstract

Relationships between anxiety toward computers and variables trait anxiety, anxiety toward mathematics, perceived impact of computers on society, and experience in using computers were studied in a sample of 81 male and 81 female university students. All of these variables were found to influence anxiety toward computers, and a significant difference was also found by sex. (29 references) (Author/DB)

Published
1991

29. Fear of memory loss predicts increased memory failures and lower quality of life in older adults: preliminary findings from a fear-avoidance of memory loss (FAM) scale.

Author

Farina, F. R., Bennett, M., Griffith, J. W., and Lenaert, B.

Subjects
DEMENTIA, MEMORY, RESEARCH evaluation, AFFECT (Psychology), SELF-evaluation, RESEARCH methodology evaluation, RESEARCH methodology, MATHEMATICAL models, FEAR, PSYCHOLOGY, AVOIDANCE (Psychology), PSYCHOLOGICAL tests, CRONBACH'S alpha, QUALITY of life, MENTAL depression, INDEPENDENT living, FACTOR analysis, DESCRIPTIVE statistics, COGNITIVE testing, ANXIETY, PSYCHOLOGICAL resilience, OLD age
Abstract

Few studies have measured the impact of dementia-related fear on daily functioning, despite its clinical relevance. Our aim was to determine the relationship between fear-avoidance of memory loss, perceived memory failures and self-reported quality of life in a community based sample of older adults using a novel fear of memory loss (FAM) scale. Sixty-seven older adults (59–81 years) completed a 23-item self-report scale designed to capture multi-faceted components of fear of memory loss, known as the FAM scale. Perceived memory failures were measured using the Memory Failures Scale (MFS) and quality of life was assessed using the Older Person's Quality of Life scale (OPQOL-35). Participants also completed the Wechsler Memory Scale (WMS-IV) as a measure of objective memory performance and the Depression, Anxiety and Stress Scales (DASS) and the Geriatric Anxiety Inventory (GAI) as measures of general anxiety. The FAM scale demonstrated strong internal consistency (Cronbach's α =.82) and concurrent validity with the GAI (r =.47). Three latent factors were observed: (1) fear-avoidance, (2) problematic beliefs and (3) affective resilience. After adjusting for objective memory performance and general anxiety, higher fear-avoidance significantly predicted increased perceived memory failures (p =.014) and reduced quality of life (p =.033). Fear of memory loss predicts increased perceived memory failures and lower self-reported quality of life in a community sample of older adults. Based on these findings, we propose a preliminary fear-avoidance model that explains the development and maintenance of dementia-related functional disability in terms of psychological processes. [ABSTRACT FROM AUTHOR]

Published
2022
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36. Data Location, Transfer and Bookkeeping in CMS

Author

Delgado Peris, A., Fanfani, A., Farina, F., Verlato, M., Elmer, P., Tuura, L., Afaq, A., Guo, Y., Kosyakov, S., Lueking, L., Sekhri, V., Dolgert, A., Jones, C., Kuznetsov, V., Riley, D., Rehn, J., Metson, S., Feichtinger, D., Egeland, R., Toteva, Z., and Bockelman, B.

Published
2008
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38. BNT162b2 vaccine induces antibody release in saliva: a possible role for mucosal viral protection?

Author

Abbass Darwich, Chiara Pozzi, Giulia Fornasa, Michela Lizier, Elena Azzolini, Ilaria Spadoni, Francesco Carli, Antonio Voza, Antonio Desai, Carlo Ferrero, Luca Germagnoli, ICH COVID‐19 Task‐force, Alberto Mantovani, Maria Rescigno, Aghemo Alessio, Anfray Clement, Badalamenti Salvatore, Belgiovine Cristina, Bertocchi Alice, Bombace Sara, Brescia Paola, Calcaterra Francesca, Calvi Michela, Cancellara Assunta, Capucetti Arianna, Carenza Claudia, Carloni Sara, Carnevale Silvia, Cazzetta Valentina, Cecconi Maurizio, Ciccarelli Michele, Coianiz Nicolò, Darwich Abbass, Ana Lleo De Nalda, De Paoli Federica, Di Donato Rachele, Digifico Elisabeth, Durante Barbara, Farina Floriana Maria, Ferrari Valentina, Fornasa Giulia, Franzese Sara, Gil Gomez Antonio, Giugliano Silvia, Ana Rita Gomes, Lizier Michela, Lo Cascio Antonino, Melacarne Alessia, Mozzarelli Alessandro, My Ilaria, Oresta Bianca, Pasqualini Fabio, Pastò Anna, Pelamatti Erica, Perucchini Chiara, Pozzi Chiara, Rimoldi Valeria, Rimoldi Monica, Scarpa Alice, Selmi Carlo, Silvestri Alessandra, Sironi Marina, Spadoni Ilaria, Spano' Salvatore, Spata Gianmarco, Supino Domenico, Tentorio Paolo, Ummarino Aldo, Valentino Sonia, Voza Antonio, Zaghi Elisa, and Zanon Veronica

Subjects
BNT162b2, IgA, IgG, mucosal immunity, SARS‐CoV‐2, Medicine (General), R5-920, Genetics, QH426-470
Abstract

Abstract Vaccination against an airborne pathogen is very effective if it induces also the development of mucosal antibodies that can protect against infection. The mRNA‐based vaccine‐encoding SARS‐CoV‐2 full‐length spike protein (BNT162b2, Pfizer/BioNTech) protects also against infection despite being administered systemically. Here, we show that upon vaccination, cognate IgG molecules are also found in the saliva and are more abundant in SARS‐CoV‐2 previously exposed subjects, paralleling the development of plasma IgG. The antibodies titer declines at 3 months from vaccination. We identified a concentration of specific IgG in the plasma above which the relevant IgG can be detected in the saliva. Regarding IgA antibodies, we found only protease‐susceptible IgA1 antibodies in plasma while they were present at very low levels in the saliva over the course of vaccination of SARS‐CoV‐2‐naïve subjects. Thus, in response to BNT162b2 vaccine, plasma IgG can permeate into mucosal sites and participate in viral protection. It is not clear why IgA1 are detected in low amount, they may be proteolytically cleaved.

Published
2022
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39. A ‘Multiomic’ Approach of Saliva Metabolomics, Microbiota, and Serum Biomarkers to Assess the Need of Hospitalization in Coronavirus Disease 2019

Author

Chiara Pozzi, Riccardo Levi, Daniele Braga, Francesco Carli, Abbass Darwich, Ilaria Spadoni, Bianca Oresta, Carola Conca Dioguardi, Clelia Peano, Leonardo Ubaldi, Giovanni Angelotti, Barbara Bottazzi, Cecilia Garlanda, Antonio Desai, Antonio Voza, Elena Azzolini, Maurizio Cecconi, Alberto Mantovani, Giuseppe Penna, Riccardo Barbieri, Letterio S. Politi, Maria Rescigno, Aghemo Alessio, Anfray Clement, Badalamenti Salvatore, Belgiovine Cristina, Bertocchi Alice, Bombace Sara, Brescia Paola, Calcaterra Francesca, Calvi Michela, Cancellara Assunta, Capucetti Arianna, Carenza Claudia, Carloni Sara, Carnevale Silvia, Cazzetta Valentina, Cecconi Maurizio, Ciccarelli Michele, Coianiz Nicolò, Darwich Abbass, Lleo de Nalda Ana, De Paoli Federica, Di Donato Rachele, Digifico Elisabeth, Durante Barbara, FARINA Floriana Maria, Ferrari Valentina, Fornasa Giulia, Franzese Sara, Gil Gomez Antonio, Giugliano Silvia, Gomes Ana Rita, Lizier Michela, Lo Cascio Antonino, Melacarne Alessia, Mozzarelli Alessandro, My Ilaria, Oresta Bianca, Pasqualini Fabio, Pastò Anna, Pelamatti Erica, Perucchini Chiara, Pozzi Chiara, Rimoldi Valeria, Rimoldi Monica, Scarpa Alice, Selmi Carlo, Silvestri Alessandra, Sironi Marina, Spadoni Ilaria, Spano' Salvatore, Spata Gianmarco, Supino Domenico, Tentorio Paolo, Ummarino Aldo, Valentino Sonia, Voza Antonio, Zaghi Elisa, and Zanon Veronica

Subjects
Metabolome, Microbiota, CHI3L1, COVID-19, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Background and Aims: The SARS-CoV-2 pandemic has overwhelmed the treatment capacity of the health care systems during the highest viral diffusion rate. Patients reaching the emergency department had to be either hospitalized (inpatients) or discharged (outpatients). Still, the decision was taken based on the individual assessment of the actual clinical condition, without specific biomarkers to predict future improvement or deterioration, and discharged patients often returned to the hospital for aggravation of their condition. Here, we have developed a new combined approach of omics to identify factors that could distinguish coronavirus disease 19 (COVID-19) inpatients from outpatients. Methods: Saliva and blood samples were collected over the course of two observational cohort studies. By using machine learning approaches, we compared salivary metabolome of 50 COVID-19 patients with that of 270 healthy individuals having previously been exposed or not to SARS-CoV-2. We then correlated the salivary metabolites that allowed separating COVID-19 inpatients from outpatients with serum biomarkers and salivary microbiota taxa differentially represented in the two groups of patients. Results: We identified nine salivary metabolites that allowed assessing the need of hospitalization. When combined with serum biomarkers, just two salivary metabolites (myo-inositol and 2-pyrrolidineacetic acid) and one serum protein, chitinase 3-like-1 (CHI3L1), were sufficient to separate inpatients from outpatients completely and correlated with modulated microbiota taxa. In particular, we found Corynebacterium 1 to be overrepresented in inpatients, whereas Actinomycetaceae F0332, Candidatus Saccharimonas, and Haemophilus were all underrepresented in the hospitalized population. Conclusion: This is a proof of concept that a combined omic analysis can be used to stratify patients independently from COVID-19.

Published
2022
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44. Cardiac mesenchymal stromal cells are a source of adipocytes in arrhythmogenic cardiomyopathy.

Author

Sommariva, E., Brambilla, S., Carbucicchio, C., Gambini, E., Meraviglia, V., Russo, A. Dello, Farina, F. M., Casella, M., Catto, V., Pontone, G., Chiesa, M., Stadiotti, I., Cogliati, E., Paolin, A., Alami, N. Ouali, Preziuso, C., d'Amati, G., Colombo, G. I., Rossini, A., and Capogrossi, M. C.

Abstract

Aim Arrhythmogenic cardiomyopathy (ACM) is a genetic disorder mainly due to mutations in desmosomal genes, characterized by progressive ?bro-adipose replacement of the myocardium, arrhythmias, and sudden death. It is still unclear which cell type is responsible for fibro-adipose substitution and which molecular mechanisms lead to this structural change. Cardiac mesenchymal stromal cells (C-MSC) are the most abundant cells in the heart, with propensity to differentiate into several cell types, including adipocytes, and their role in ACM is unknown. The aim of the present study was to investigate whether C-MSC contributed to excess adipocytes in patients with ACM. Methods We found that, in ACM patients' explanted heart sections, cells actively differentiating into adipocytes are of mes- and results enchymal origin. Therefore, we isolated C-MSC from endomyocardial biopsies of ACM and from not affected by arrhythmogenic cardiomyopathy (NON-ACM) (control) patients. We found that both ACM and control C-MSC express desmosomal genes, with ACM C-MSC showing lower expression of plakophilin (PKP2) protein vs. controls. Arrhythmogenic cardiomyopathy C-MSC cultured in adipogenic medium accumulated more lipid droplets than controls. Accordingly, the expression of adipogenic genes was higher in ACM vs. NON-ACM C-MSC, while expression of cell cycle and anti-adipogenic genes was lower. Both lipid accumulation and transcription reprogramming were dependent on PKP2 deficiency. Conclusions Cardiac mesenchymal stromal cells contribute to the adipogenic substitution observed in ACM patients' hearts. More-over, C-MSC from ACM patients recapitulate the features of ACM adipogenesis, representing a novel, scalable, patient-specific in vitro tool for future mechanistic studies. [ABSTRACT FROM AUTHOR]

Published
2016
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