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Aggressive B-cell lymphoma encompasses Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL), and, as per the 2016 WHO classification, high-grade B-cell lymphoma (HGBL) not otherwise specified (NOS) and HGBL double/triple hit (DH/TH). However, the diagnostic distinction of HGBL from BL and DLBCL is difficult by means of histology/immunostaining in a substantial number of patients. This study aimed to improve subtyping by the identification of molecular features of aggressive B-cell lymphomas, with a specific focus on HGBL. To this end, we performed a comprehensive gene expression and mutational pattern analysis as well as the detection of B-cell clonality of 34 cases diagnosed with BL (n = 4), DLBCL (n = 16), HGBL DH (n = 8), and HGBL NOS (n = 6). Three distinct molecular subgroups were identified based on gene expression, primarily influenced by MYC expression/translocation and cell proliferation. In HGBL, compared to BL, there was an upregulation of PRKAR2B and TERT. HGBL DH exhibited elevated expression of GAMT and SMIM14, while HGBL NOS showed increased expression of MIR155HG and LZTS1. Our gene mutation analysis revealed MYC, ARID1A, BCL2, KMT2D, and PIM1 as the most affected genes in B-cell lymphoma, with BCL2 and CREBBP predominant in HGBL DH, and MYC and PIM1 in HGBL NOS. Clonality analysis of immunoglobulin heavy and light chain rearrangements did not show distinguishable V- or J-usage between the diagnostic subgroups.

Abstract Background A variant in the canine phosphodiesterase (PDE) 5A gene (PDE5A:E90K) is associated with decreased concentrations of circulating cyclic guanosine monophosphate (cGMP) and response to PDE5 inhibitor treatment. Pimobendan is a PDE inhibitor recommended for medical treatment of certain stages of myxomatous mitral valve disease (MMVD) in dogs. Hypothesis PDE5A:E90K polymorphism attenuates the inhibitory effect of pimobendan on in vitro platelet aggregation and increases basal platelet aggregation in Cavalier King Charles Spaniels (CKCS). Selected clinical variables (MMVD severity, sex, age, hematocrit, platelet count in platelet‐rich plasma [PRP], and echocardiographic left ventricular fractional shortening [LV FS]) will not show an association with results. Animals Fifty‐two privately owned CKCS with no or preclinical MMVD. Methods Using blood samples, we prospectively assessed PDE5A genotype using Sanger sequencing and adenosine diphosphate‐induced platelet aggregation response (area under the curve [AUC], maximal aggregation [MaxA], and velocity [Vel]) with and without pimobendan using light transmission aggregometry. Dogs also underwent echocardiography. Results Pimobendan inhibited platelet function as measured by AUC, MaxA, and Vel at a concentration of 10 μM (P

We explore the morphological features and star formation activities of [O ii ] emitters in the COSMOS UltraDeep field at z ∼ 1.5 using JWST NIRCam data from the COSMOS-Web survey and Subaru Hyper Suprime-Cam. We also report the discovery of large filamentary structures traced by [O ii ] emitters surrounding an extremely overdense core with a galaxy number density ∼11× higher than the field average. These structures span over 50 cMpc, underscoring their large scale in the cosmic web at this epoch. After matching the stellar-mass distributions, the core galaxies show a higher frequency of disturbances (50% ± 9%) than those in the outskirts (41% ± 9%) and the field (21% ± 5%), indicative of more frequent mergers and interactions in the innermost ≲1.′5 region. Additionally, we observe that specific star formation rates are elevated in denser environments. A Kolmogorov–Smirnov test comparing the distribution of specific star formation rates of core and field galaxies yields a p -value of 0.02, suggesting an enhancement of star formation activity driven by the dense environment. Our findings underscore the environmental impact on galaxy evolution during a pivotal cosmic epoch and set the stage for further investigation with the increasing larger data from upcoming surveys.

Purpose - Employing a qualified workforce is a crucial topic for organiza-tional success. Research on employer branding in family businesses has not come to a clear conclusion of which family business characteristics might be attractive for which potential employees. Aim(s) - This paper focuses on family businesses in the IT industry to analyze whether they might or might not profit from the communication of family involvement. Design/methodology/approach - To answer the research question, an online survey was conducted. The participants were divided into two groups, whereby one group was manipulated by the communication of the owner-ship. Findings - The results show that family businesses are associated with greater security but fewer development opportunities. In addition, certain personality traits of job applicants influence the perception of organizational attractiveness. However, the communication of ownership had no significant influence on employer attractiveness. Similarly, the varying importance of job security and development opportunities among applicants cannot be clearly explained by personality traits. Limitation of the Study - The final sample size was relatively small. In addi-tion, in reality the applicants would be provided with more and more detailed information about the company. The representativeness and generalizability of the survey must therefore be questioned. Practical implications – As the results show a positive correlation between perceived job security, opportunities for further development and attractive-ness, it might be valuable for family businesses to support and communicate job security and opportunities for further development for raising increased attractiveness. Originality/value - The attempt is made to give companies, especially family businesses, a better understanding of the effect of communicating the own-ership relationship on potential applicants.

We present new free-form and hybrid mass reconstructions of the galaxy cluster lens MACS J0416.1 |$-$| 2403 at |$z=0.396$| using the lens inversion method GRALE. The reconstructions use 237 spectroscopically confirmed multiple images from Bergamini et al. (2023) as the main input. Our primary model reconstructs images to a positional accuracy of 0.191 arcsec, thus representing one of the most precise reconstructions of this lens to date. Our models find broad agreement with previous reconstructions, and identify two |$\sim 10^{12}\, {\rm M}_{\odot }$| light-unaffiliated substructures. We focus on two highly magnified arcs: Spock and Mothra. Our model features a unique critical curve structure around the Spock arc with 2 crossings. This structure enables sufficient magnification across this arc to potentially explain the large number of transients as microlensing events of supergiant stars. Additionally, we develop a model of the millilens substructure expected to be magnifying Mothra, which may be a binary pair of supergiants with |$\mu \sim 6000$|⁠. This model accounts for flexibility in the millilens position while preserving the observed flux and minimizing image position displacements along the Mothra arc. We constrain the millilens mass and core radius to |$\lesssim 10^6 {\rm M}_{\odot }$| and |$\lesssim 17$|  pc, respectively, which would render it one of the smallest and most compact substructures constrained by lensing. If the millilens is dominated by wave dark matter, the axion mass is constrained to be |$\lesssim 3.0 \times 10^{-21}$|  eV. Further monitoring of this lens with JWST will uncover more transients, permitting tighter constraints on the structure surrounding these two arcs. [ABSTRACT FROM AUTHOR]

The current paradigm for the co-evolution of galaxies and their supermassive black holes postulates that dust-obscured active galactic nuclei (AGNs) represent a transitional phase towards a more luminous and unobscured state. However, our understanding of dusty AGNs and their host galaxies at early cosmic times is inadequate due to observational limitations. Here, we present JWST observations of CID-931, an X-ray-detected AGN at a spectroscopic redshift of |$z_{\rm spec}=4.91$|⁠. Multiband NIRCam imaging from the COSMOS-Web program reveals an unresolved red core, similar to JWST-discovered dusty AGNs. Strikingly, the red core is surrounded by at least eight massive star-forming clumps spread over |${1{^{\prime \prime}_{.}}6} \approx 10\,\,{\rm kpc}$|⁠ , each of which has a stellar mass of |$10^9$| – |$10^{10}\, M_{\odot }$| and a radius of |$\sim$| 0.1–1 kpc. The whole system amounts to |$10^{11}\, M_{\odot }$| in stellar mass, higher than typical star-forming galaxies at the same epoch. In this system, gas inflows and/or complex merger events may trigger clump formation and AGN activity, thus leading to the rapid formation of a massive galaxy hosting a supermassive black hole. Future follow-up observations will provide new insights into the evolution of the galaxy–black hole relationship during such transitional phases in the early universe. [ABSTRACT FROM AUTHOR]

Aggressive B-cell lymphoma encompasses Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL), and, as per the 2016 WHO classification, high-grade B-cell lymphoma (HGBL) not otherwise specified (NOS) and HGBL double/triple hit (DH/TH). However, the diagnostic distinction of HGBL from BL and DLBCL is difficult by means of histology/immunostaining in a substantial number of patients. This study aimed to improve subtyping by the identification of molecular features of aggressive B-cell lymphomas, with a specific focus on HGBL. To this end, we performed a comprehensive gene expression and mutational pattern analysis as well as the detection of B-cell clonality of 34 cases diagnosed with BL (n = 4), DLBCL (n = 16), HGBL DH (n = 8), and HGBL NOS (n = 6). Three distinct molecular subgroups were identified based on gene expression, primarily influenced by MYC expression/translocation and cell proliferation. In HGBL, compared to BL, there was an upregulation of PRKAR2B and TERT. HGBL DH exhibited elevated expression of GAMT and SMIM14, while HGBL NOS showed increased expression of MIR155HG and LZTS1. Our gene mutation analysis revealed MYC, ARID1A, BCL2, KMT2D, and PIM1 as the most affected genes in B-cell lymphoma, with BCL2 and CREBBP predominant in HGBL DH, and MYC and PIM1 in HGBL NOS. Clonality analysis of immunoglobulin heavy and light chain rearrangements did not show distinguishable V- or J-usage between the diagnostic subgroups. [ABSTRACT FROM AUTHOR]

The ability to determine galaxy properties such as masses, ages, and star formation rates robustly is critically limited by the ability to measure dust attenuation accurately. Dust reddening is often characterized by comparing observations to models of either nebular recombination lines or the UV continuum. Here, we use a new technique to measure dust reddening by exploiting the He ii λ 1640 and λ 4686 emission lines originating from the stellar winds of Wolf–Rayet stars. The intrinsic line ratio is determined by atomic physics, enabling an estimate of the stellar reddening similar to how the Balmer lines probe gas-emission reddening. The He ii line ratio is measured from UV and optical spectroscopy using the Space Telescope Imaging Spectrograph on board the Hubble Space Telescope for eight nearby galaxies hosting young massive star clusters. We compare our results to dust reddening values estimated from UV spectral slopes and from Balmer line ratios and find tentative evidence for systematic differences. The reddening derived from the He ii lines tends to be higher, whereas that from the UV continuum tends to be lower. A larger sample size is needed to confirm this trend. If confirmed, this may indicate an age sequence probing different stages of dust clearing. Broad He ii lines have also been detected in galaxies more distant than in our sample, providing the opportunity to estimate the dust reddening of the youngest stellar populations out to distances of ∼100 Mpc.

In the last decades, an increasing scientific interest has been growing in the elusive population of dark (i.e., lacking an optical/near-IR, hereafter NIR, counterpart) dusty star-forming galaxies (DSFGs). Although extremely promising for their likely contribution to the cosmic star formation rate density (SFRD) and for their possible role in the evolution of the first massive and passive galaxies around z ∼ 3, the difficulty in selecting statistically significant samples of dark DSFGs is limiting their scientific potentialities. This work presents the first panchromatic study of a sample of 263 radio-selected NIR-dark (RS-NIRdark) galaxies discovered in the COSMOS field following the procedure by Talia et al. These sources are selected as radio-bright galaxies ( S _3 GHz > 12.65 μ Jy) with no counterpart in the NIR-selected COSMOS2020 catalog ( Ks ≳ 25.5 mag). For these sources, we build a new photometric catalog including accurate photometry from the optical to the radio obtained with a new deblending pipeline (Photometry Extractor for Blended Objects, or PhoEBO ). We employ this catalog to estimate the photo- z s and the physical properties of the galaxies through an spectral energy distribution-fitting procedure performed with two different codes ( Magphys and Cigale ). Finally, we estimate the active galactic nucleus contamination in our sample by performing a series of complementary tests. The high values of the median extinction ( A _v ∼ 4) and star formation rate (SFR ∼ 500 M _⊙ yr ^−1 ) confirm the likely DSFG nature of the RS-NIRdark galaxies. The median photo- z ( z ∼ 3) and the presence of a significant tail of high- z candidates ( z > 4.5) suggest that these sources are important contributors to the cosmic SFRD and the evolutionary path of galaxies at high redshifts.

We present the results of a systematic study of the rest-frame optical morphology of quiescent galaxies at z ≥ 3 using the Near-Infrared Camera (NIRCam) on board the James Webb Space Telescope (JWST). Based on a sample selected by UVJ color or NUVUVJ color, we focus on 26 quiescent galaxies with $9.8\lt \mathrm{log}({M}_{\star }/{M}_{\odot })\lt 11.4$ at 2.8 < z _phot < 4.6 with publicly available JWST data. Their sizes are constrained by fitting the Sérsic profile to all available NIRCam images. We see a negative correlation between the observed wavelength and the size and derive their size at the rest frame 0.5 μ m using size measurements in multiple bands. Our quiescent galaxies show a significant correlation between the rest-frame 0.5 μ m size and the stellar mass at z ≥ 3. The analytical fit for them at $\mathrm{log}({M}_{\star }/{M}_{\odot })\gt 10.3$ implies that our size–stellar mass relations are below those at lower redshifts, with the amplitude of ∼0.6 kpc at M _⋆ = 5 × 10 ^10 M _⊙ . This value agrees with the extrapolation of the size evolution of quiescent galaxies at z < 3 in the literature, implying that the size of quiescent galaxies increases monotonically from z ∼ 3–5. Our sample mainly comprises galaxies with bulge-like structures according to their median Sérsic index and axis ratio of n ∼ 3–4 and q ∼ 0.6–0.8, respectively. On the other hand, there is a trend of increasing fraction of galaxies with low Sérsic index at higher redshift, suggesting 3 < z < 5 might be the epoch of onset of morphological transformation with a fraction of very notable disky quenched galaxies.

We report the discovery of 15 exceptionally luminous 10 ≲ z ≲ 14 candidate galaxies discovered in the first 0.28 deg ^2 of JWST/NIRCam imaging from the COSMOS-Web survey. These sources span rest-frame UV magnitudes of −20.5 > M _UV > −22, and thus constitute the most intrinsically luminous z ≳ 10 candidates identified by JWST to date. Selected via NIRCam imaging, deep ground-based observations corroborate their detection and help significantly constrain their photometric redshifts. We analyze their spectral energy distributions using multiple open-source codes and evaluate the probability of low-redshift solutions; we conclude that 12/15 (80%) are likely genuine z ≳ 10 sources and 3/15 (20%) likely low-redshift contaminants. Three of our z ∼ 12 candidates push the limits of early stellar mass assembly: they have estimated stellar masses ∼ 5 × 10 ^9 M _⊙ , implying an effective stellar baryon fraction of ϵ _⋆ ∼ 0.2−0.5, where ϵ _⋆ ≡ M _⋆ /( f _b M _halo ). The assembly of such stellar reservoirs is made possible due to rapid, burst-driven star formation on timescales < 100 Myr where the star formation rate may far outpace the growth of the underlying dark matter halos. This is supported by the similar volume densities inferred for M _⋆ ∼ 10 ^10 M _⊙ galaxies relative to M _⋆ ∼ 10 ^9 M _⊙ —both about 10 ^−6 Mpc ^−3 —implying they live in halos of comparable mass. At such high redshifts, the duty cycle for starbursts would be of order unity, which could cause the observed change in the shape of the UV luminosity function from a double power law to a Schechter function at z ≈ 8. Spectroscopic redshift confirmation and ensuing constraints of their masses will be critical to understand how, and if, such early massive galaxies push the limits of galaxy formation in the Lambda cold dark matter paradigm.

Entering the era of large-scale galaxy surveys, which will deliver unprecedented amounts of photometric and spectroscopic data, there is a growing need for more efficient, data-driven, and less model-dependent techniques to analyze the spectral energy distribution of galaxies. In this work, we demonstrate that by taking advantage of manifold learning approaches, we can estimate spectroscopic features of large samples of galaxies from their broadband photometry when spectroscopy is available only for a fraction of the sample. This will be done by applying the self-organizing map algorithm on broadband colors of galaxies and mapping partially available spectroscopic information into the trained maps. In this pilot study, we focus on estimating the 4000 Å break in a magnitude-limited sample of galaxies in the Cosmic Evolution Survey (COSMOS) field. We also examine this method to predict the H δ _A index given our available spectroscopic measurements. We use observed galaxy colors ( u,g,r,i,z,Y,J,H ), as well as spectroscopic measurements for a fraction of the sample from the LEGA-C and z COSMOS spectroscopic surveys to estimate this feature for our parent photometric sample. We recover the D4000 feature for galaxies that only have broadband colors with uncertainties about twice the uncertainty of the employed spectroscopic surveys. Using these measurements, we observe a positive correlation between D4000 and the stellar mass of the galaxies in our sample with weaker D4000 features for higher-redshift galaxies at fixed stellar masses. These can be explained by the downsizing scenario for the formation of galaxies and the decrease in their specific star formation rate as well as the aging of their stellar populations over this time period.

We present observations and analysis of the starburst PACS-819 at z = 1.45 ( M _* = 10 ^10.7 M _⊙ ), using high-resolution (0.″1; 0.8 kpc) Atacama Large Millimeter/submillimeter Array (ALMA) and multiwavelength JWST images from the COSMOS-Web program. Dissimilar to Hubble Space Telescope (HST) ACS images in the rest-frame UV, the redder NIRCam and MIRI images reveal a smooth central mass concentration and spiral-like features, atypical for such an intense starburst. Through dynamical modeling of the CO ( J = 5–4) emission with ALMA, PACS-819 is rotation dominated and thus consistent with having a disk-like nature. However, kinematic anomalies in CO and asymmetric features in the bluer JWST bands (e.g., F150W) support a more disturbed nature likely due to interactions. The JWST imaging further enables us to map the distribution of stellar mass and dust attenuation, thus clarifying the relationships between different structural components not discernible in the previous HST images. The CO ( J = 5–4) and far-infrared dust continuum emission are cospatial with a heavily obscured starbursting core (

We present the first results from the Web Epoch of Reionization Ly α Survey (WERLS), a spectroscopic survey of Ly α emission using Keck I/MOSFIRE and LRIS. WERLS targets bright ( J < 26) galaxy candidates with photometric redshifts of 5.5 ≲ z ≲ 8 selected from pre-JWST imaging embedded in the Epoch of Reionization (EoR) within three JWST deep fields: CEERS, PRIMER, and COSMOS-Web. Here, we report 11 z ∼ 7–8 Ly α emitters (LAEs; three secure and eight tentative candidates) detected in the first five nights of WERLS MOSFIRE data. We estimate our observed LAE yield is ∼13%, which is broadly consistent with expectations assuming some loss from redshift uncertainty, contamination from sky OH lines, and that the Universe is approximately half-ionized at this epoch, whereby observable Ly α emission is unlikely for galaxies embedded in a neutral intergalactic medium. Our targets are selected to be UV-bright, and span a range of absolute UV magnitudes with −23.1 < M _UV < −19.8. With two LAEs detected at z = 7.68, we also consider the possibility of an ionized bubble at this redshift. Future synergistic Keck+JWST efforts will provide a powerful tool for pinpointing beacons of reionization and mapping the large-scale distribution of mass relative to the ionization state of the Universe.

The recent discovery of a galaxy at z = 7.3 with undetected optical emission lines and a blue UV-to-optical continuum ratio in JWST spectroscopy is surprising and needs to be explained physically. Here, we explore two possibilities that could cause such a seemingly quiescent ∼5 × 10 ^8 M _⊙ galaxy in the early Universe: (i) stochastic variations in the star formation history (SFH) and (ii) the effect of spatially varying dust attenuation on the measured line and continuum emission properties. Both scenarios can play out at the same time to amplify the effect. A stochastic star formation model (similar to realistic SFHs from hydrodynamical simulations of similar-mass galaxies) can create such observed properties if star formation is fast-varying with a correlation time of

We report the identification of 15 galaxy candidates at z ≥ 9 using the initial COSMOS-Web JWST observations over 77 arcmin ^2 through four Near Infrared Camera filters (F115W, F150W, F277W, and F444W) with an overlap with the Mid-Infrared Imager (F770W) of 8.7 arcmin ^2 . We fit the sample using several publicly available spectral energy distribution (SED) fitting and photometric redshift codes and determine their redshifts between z = 9.3 and z = 10.9 (〈 z 〉 = 10.0), UV magnitudes between M _UV = −21.2 and −19.5 (with 〈 M _UV 〉 = −20.2), and rest-frame UV slopes (〈 β 〉 = −2.4). These galaxies are, on average, more luminous than most z ≥ 9 candidates discovered by JWST so far in the literature, while exhibiting similar blue colors in their rest-frame UV. The rest-frame UV slopes derived from SED fitting are blue ( β ∼ [−2.0, −2.7]) without reaching extremely blue values as reported in other recent studies at these redshifts. The blue color is consistent with models that suggest the underlying stellar population is not yet fully enriched in metals like similarly luminous galaxies in the lower-redshift Universe. The derived stellar masses with $\langle {\mathrm{log}}_{10}($ M _⋆ / M _⊙ )〉 ≈ 8–9 are not in tension with the standard Lambda cold dark matter (ΛCDM) model, and our measurement of the volume density of such UV-luminous galaxies aligns well with previously measured values presented in the literature at z ∼ 9–10. Our sample of galaxies, although compact, is significantly resolved.

Several large JWST blank field observing programs have not yet discovered the first galaxies expected to form at 15 ≤ z ≤ 20. This has motivated the search for more effective survey strategies that will be able to effectively probe this redshift range. Here, we explore the use of gravitationally lensed cluster fields, which have historically been the most effective discovery tool with the Hubble Space Telescope. In this paper, we analyze the effectiveness of the most massive galaxy clusters that provide the highest median magnification factor within a single JWST NIRCam module in uncovering this population. The results of exploiting these lensing clusters to break the z > 15 barrier are compared against the results from large-area, blank-field surveys such as JADES and CEERS in order to determine the most effective survey strategy for JWST. We report that the fields containing massive foreground galaxy clusters specifically chosen to occupy the largest fraction of a single NIRCam module with high magnification factors in the source plane while containing all multiple images in the image plane within a single module provide the highest probability of both probing the 15 ≤ z ≤ 20 regime as well as discovering the highest-redshift galaxy possible with JWST. We also find that using multiple massive clusters in exchange for shallower survey depths is a more time-efficient method of probing the z > 15 regime.

With their high angular resolutions of 30–100 mas, large fields of view, and complex optical systems, imagers on next-generation optical/near-infrared space observatories, such as the Near-Infrared Camera (NIRCam) on the James Webb Space Telescope, present new opportunities for science and also new challenges for empirical point-spread function (PSF) characterization. In this context, we introduce ShOpt , a new PSF fitting tool developed in Julia and designed to bridge the advanced features of PSFs in the full field of view (PIFF) with the computational efficiency of PSF Extractor (PSFEx). Along with ShOpt , we propose a suite of nonparametric statistics suitable for evaluating PSF fit quality in space-based imaging. Our study benchmarks ShOpt against the established PSF fitters PSFEx and PIFF using real and simulated COSMOS-Web Survey imaging. We assess their respective PSF model fidelity with our proposed diagnostic statistics and investigate their computational efficiencies, focusing on their processing speed relative to the complexity and size of the PSF models. We find that ShOpt can already achieve PSF model fidelity comparable to PSFEx and PIFF while maintaining competitive processing speeds, constructing PSF models for large NIRCam mosaics within minutes.

PurposeDevelopmental dyslexia in alphabetic languages (DD) is characterized by a phonological deficit. Since logographic scripts rely predominantly on visual and morphological processing, reading performance in DD can be assumed to be less impaired when reading logographic scripts.Methods40 German-speaking children (18 with DD, 22 not reading-impaired-group C; 9-11 years) received Chinese lessons. Eye movements (EM) were recorded during naming single alphabetic words, pictures (confrontational) and Chinese characters to be named in German and Chinese. The main outcome variables were: Articulation latency, numbers and durations of fixations. Quality of life (QoL) was assessed by questionnaires.ResultsWhile reading alphabetic words, articulation latencies and numbers of fixations were significantly higher for group DD than for group C (AL-DD = 1.13, AL-C = 0.84, p< .001; FN-DD = 3.50; FN-C = 2.00, p< .001). For naming pictures and Chinese characters in German and in Chinese, no significant group differences were found for any of the EM variables. The percentage of correct answers was high for German naming (DD = 86.67%, C = 95.24%; p = .015) and lower for Chinese naming in both groups, but significantly lower in group DD, especially for Chinese naming (DD = 56.67%, C: 83.77%; p = .003). QoL differed between groups from the children's perspective only at posttest. Parents of group DD perceived their children`s QoL to be lower compared with parents of group C at pre- and posttest.ConclusionsChildren with dyslexia performed as well as group C during naming Chinese characters in German and in Chinese regarding their EM variables, presumably because they processed Chinese characters by the visuo-spatial pathway with direct access to the semantic system. However, the significantly lower percentage of correct answers especially during Chinese naming showed that group DD had more difficulties naming Chinese characters than group C, which could be attributed to their phonological deficit, among other factors.Trial registrationGerman clinical trials register (DRKS00015697).

A large fraction of the accreting supermassive black hole population is shrouded by copious amounts of gas and dust, particularly in the distant ( z ≳ 1) universe. While much of the obscuration is attributed to a parsec-scale torus, there is a known contribution from the larger-scale host galaxy. Using JWST/NIRCam imaging from the COSMOS-Web survey, we probe the galaxy-wide dust distribution in X-ray selected active galactic nuclei (AGNs) up to z ∼ 2. Here, we focus on a sample of three AGNs with their host galaxies exhibiting prominent dust lanes, potentially due to their edge-on alignment. These represent 27% (3 out of 11 with early NIRCam data) of the heavily obscured ( N _H > 10 ^23 cm ^−2 ) AGN population. With limited signs of a central AGN in the optical and near-infrared, the NIRCam images are used to produce reddening maps E ( B − V ) of the host galaxies. We compare the mean central value of E ( B − V ) to the X-ray obscuring column density along the line of sight to the AGN ( N _H ∼ 10 ^23−23.5 cm ^−2 ). We find that the extinction due to the host galaxy is present (0.6 ≲ E ( B − V ) ≲ 0.9; 1.9 ≲ A _V ≲ 2.8) and significantly contributes to the X-ray obscuration at a level of N _H ∼ 10 ^22.5 cm ^−2 assuming an SMC gas-to-dust ratio that amounts to ≲30% of the total obscuring column density. These early results, including three additional cases from CEERS, demonstrate the ability to resolve such dust structures with JWST and separate the different circumnuclear and galaxy-scale obscuring structures.

Photometric redshifts are widely used in studies of dusty star-forming galaxies (DSFGs), but catastrophic photo-z failure can undermine all redshift-dependent results. Here we report the spectroscopic redshift confirmation of COSBO-7, a strongly lensed DSFG in the COSMOS-PRIMER field. Recently, a photometric redshift solution of z ≳ 7.0 was reported for COSBO-7 based on ten bands of James Webb Space Telescope (JWST) NIRCam and MIRI imaging data. This z value was favored by four independent spectral energy distribution (SED) fitting codes, and the result provided an appealing candidate for the most distant massive DSFG known to date. This photo-z solution was also supported by a single line detection in Atacama Large Millimeter Array (ALMA) Band 3 consistent with CO(7–6) at z = 7.46. However, our new ALMA observations robustly detect two lines in Band 6 identified as CO(7–6) and [CI](2–1) at zspec = 2.625, and thus the Band 3 line as CO(3–2). These three robust line detections decidedly place COSBO-7 at z = 2.625, refuting the photo-z solution. We derive physical parameters by fitting near-infrared(NIR)-to-millimeter(mm) photometry and lens modeling, revealing that COSBO-7 is a main sequence galaxy. We examine possible reasons for this photo-z failure and attribute it to (1) the likely underestimation of photometric uncertainties at 0.9 μm and 1.15 μm; and (2) the lack of photometry at wavelengths beyond 20 μm. Notably, we recover a bona fide zphot ∼ 2.3 by including the existing MIPS 24 μm photometry, demonstrating the critical importance of mid-infrared (MIR) data in bolstering photo-z measurements. This work highlights a common challenge in modeling the SEDs of DSFGs, and provides a cautionary tale regarding the reliability of photometric redshifts as well as pseudo-spectroscopic redshifts based on single line detection. [ABSTRACT FROM AUTHOR]

We present the results of a systematic search for candidate quiescent galaxies in the distant universe in 11 JWST fields with publicly available observations collected during the first 3 months of operations and covering an effective sky area of ∼145 arcmin ^2 . We homogeneously reduce the new JWST data and combine them with existing observations from the Hubble Space Telescope. We select a robust sample of ∼80 candidate quiescent and quenching galaxies at 3 < z < 5 using two methods: (1) based on their rest-frame UVJ colors, and (2) a novel quantitative approach based on Gaussian mixture modeling of the near-UV − U , U − V , and V − J rest-frame color space, which is more sensitive to recently quenched objects. We measure comoving number densities of massive ( M _⋆ ≥ 10 ^10.6 M _⊙ ) quiescent galaxies consistent with previous estimates relying on ground-based observations, after homogenizing the results in the literature with our mass and redshift intervals. However, we find significant field-to-field variations of the number densities up to a factor of 2–3, highlighting the effect of cosmic variance and suggesting the presence of overdensities of red quiescent galaxies at z > 3, as could be expected for highly clustered massive systems. Importantly, JWST enables the robust identification of quenching/quiescent galaxy candidates at lower masses and higher redshifts than before, challenging standard formation scenarios. All data products, including the literature compilation, are made publicly available.

Atacama Large Millimeter/submillimeter Array (ALMA) observations of the long-wavelength dust continuum are used to estimate the gas masses in a sample of 708 star-forming galaxies at z = 0.3−4.5. We determine the dependence of gas masses and star formation efficiencies (SFEs; SFR per unit gas mass) on redshift (z), M _* , and star formation rate (SFR) relative to the main sequence (MS). We find that 70% of the increase in SFRs of the MS is due to the increased gas masses at earlier epochs, while 30% is due to increased efficiency of star formation (SF). For galaxies above the MS this is reversed—with 70% of the increased SFR relative to the MS being due to elevated SFEs. Thus, the major evolution of star formation activity at early epochs is driven by increased gas masses, while the starburst activity taking galaxies above the MS is due to enhanced triggering of star formation (likely due to galactic merging). The interstellar gas peaks at z = 2 and dominates the stellar mass down to z = 1.2. Accretion rates needed to maintain continuity of the MS evolution reach >100 M _⊙ yr ^−1 at z > 2. The galactic gas contents are likely the driving determinant for both the rise in SF and AGN activity from z = 5 to their peak at z = 2 and subsequent fall at lower z . We suggest that for self-gravitating clouds with supersonic turbulence, cloud collisions and the filamentary structure of the clouds regulate the star formation activity.

The quasar SDSS 0956 + 5128 exhibits three distinct velocity components with large offsets in emission: the systemic velocity of [O ii ], [O iii ], and [Ne iii ] narrow lines have redshift z = 0.7142; the broad Mg ii line is shifted by −1200 km s ^−1 with respect to the narrow lines; the broad H α and H β lines are at −4100 km s ^−1 . We present new Hubble Space Telescope spectra of Ly α and C iv emission lines and high-resolution images of the quasar. The offsets of these lines are consistent with the velocity component of the Balmer emission, and the photometry in optical and near-infrared wavelengths does not show any signs of recent mergers in the host galaxy or irregularities in the location of the quasar. The data do not confirm predictions of the previous most likely hypotheses involving a special orientation and morphology of the quasar disk, such as in the recoiling black hole scenario, neither it is consistent with accretion disk winds. Instead, based on the cumulative evidence, we propose a new scenario, in which the broad-line region is in the state of outflow caused by a strong shock wave, with a supernova as a possible event for producing the shock ejecta.

Utilizing the James Webb Space Telescope Early Release NIRCam Observations, we perform a weak-lensing analysis of the massive galaxy cluster SMACS J0723.3–7327 ( z = 0.39). We investigate the spatial variation of the point-spread function (PSF) from the stars in the mosaic image. Our measurements show that the PSF for both modules has very small spatial and temporal variation with average complex ellipticity components of e _1 = 0.007 ± 0.001 and e _2 = 0.029 ± 0.001 in the observed north-up reference frame. We create PSF models through a principal component analysis of the stars and show that they properly account for the ellipticity of the PSF with residual shapes of e _1 = (0.3 ± 3.5) × 10 ^−4 and e _2 = (1.8 ± 4.0) × 10 ^−4 . We select background galaxies by their photometric redshift and measure galaxy shapes by model fitting. Our weak-lensing source catalog achieves ∼215 galaxies arcmin ^−2 . We map the convergence field of SMACSJ0723 and detect the cluster with a peak significance of 12.2 σ . The mass distribution is found to elongate in the east–west direction with an extension to the northeast edge of the field of view where a candidate substructure is found in the Chandra X-ray imaging. We fit the tangential shear with a Navarro–Frenk–White model and estimate the mass of the cluster to be M _500 = 7.9 ± 1.1 × 10 ^14 M _⊙ ( M _200 = 11.4 ± 1.5 × 10 ^14 M _⊙ ), which agrees with existing mass estimates. Combining the multiwavelength evidence from literature with our weak-lensing analysis, we hypothesize that SMACSJ0723 is observed near first pericenter passage and we identify candidate radio relics.

We present the survey design, implementation, and outlook for COSMOS-Web, a 255 hr treasury program conducted by the James Webb Space Telescope in its first cycle of observations. COSMOS-Web is a contiguous 0.54 deg ^2 NIRCam imaging survey in four filters (F115W, F150W, F277W, and F444W) that will reach 5 σ point-source depths ranging ∼27.5–28.2 mag. In parallel, we will obtain 0.19 deg ^2 of MIRI imaging in one filter (F770W) reaching 5 σ point-source depths of ∼25.3–26.0 mag. COSMOS-Web will build on the rich heritage of multiwavelength observations and data products available in the COSMOS field. The design of COSMOS-Web is motivated by three primary science goals: (1) to discover thousands of galaxies in the Epoch of Reionization (6 ≲ z ≲ 11) and map reionization’s spatial distribution, environments, and drivers on scales sufficiently large to mitigate cosmic variance, (2) to identify hundreds of rare quiescent galaxies at z > 4 and place constraints on the formation of the universe’s most-massive galaxies ( M _⋆ > 10 ^10 M _⊙ ), and (3) directly measure the evolution of the stellar-mass-to-halo-mass relation using weak gravitational lensing out to z ∼ 2.5 and measure its variance with galaxies’ star formation histories and morphologies. In addition, we anticipate COSMOS-Web’s legacy value to reach far beyond these scientific goals, touching many other areas of astrophysics, such as the identification of the first direct collapse black hole candidates, ultracool subdwarf stars in the Galactic halo, and possibly the identification of z > 10 pair-instability supernovae. In this paper we provide an overview of the survey’s key measurements, specifications, goals, and prospects for new discovery.

A growing number of far-infrared (FIR) bright sources completely invisible in deep extragalactic optical surveys hint at an elusive population of z > 4 dusty, star-forming galaxies. Cycle 1 JWST surveys are now detecting their rest-frame optical light, which provides key insight into their stellar properties and statistical constraints on the population as a whole. This work presents the JWST Near Infrared Camera (NIRCam) counterpart from the COSMOS-Web survey to an FIR SCUBA-2 and Atacama Large Millimeter/submillimeter Array (ALMA) source, AzTECC71, which was previously undetected at wavelengths shorter than 850 μ m. AzTECC71, among the reddest galaxies in COSMOS-Web with F277W − F444W ∼ 0.9, is undetected in NIRCam/F150W and F115W and fainter in F444W than other submillimeter galaxies identified in COSMOS-Web by 2–4 magnitudes. This is consistent with the system having both a lower stellar mass and higher redshift than the median dusty, star-forming galaxy. With deep ground- and space-based upper limits combined with detections in F277W, F444W, and the FIR including ALMA Band 6, we find a high probability (99%) that AzTECC71 is at z > 4 with ${z}_{\mathrm{phot}}={5.7}_{-0.7}^{+0.8}$ . This galaxy is massive ( $\mathrm{log}\,{M}_{* }/{M}_{\odot }\sim 10.7$ ) and infrared-luminous ( $\mathrm{log}\,{L}_{\mathrm{IR}}/{L}_{\odot }\sim 12.7$ ), comparable to other optically undetected but FIR-bright dusty, star-forming galaxies at z > 4. This population of luminous, infrared galaxies at z > 4 is largely unconstrained but comprises an important bridge between the most extreme dust-obscured galaxies and more typical high-redshift star-forming galaxies. If further FIR-selected galaxies that drop out of the F150W filter in COSMOS-Web have redshifts z > 4 like AzTECC71, then the volume density of such sources may be ∼3–10 × greater than previously estimated.

About 12 billion years ago, the Universe was first experiencing light again after the dark ages, and galaxies filled the environment with stars, metals, and dust. How efficient was this process? How fast did these primordial galaxies form stars and dust? We can answer these questions by tracing the star formation rate density (SFRD) back to its widely unknown high-redshift tail, traditionally observed in the near-infrared (NIR), optical, and UV bands. Thus, objects with a large amount of dust were missing. We aim to fill this knowledge gap by studying radio-selected NIR-dark (RS-NIRdark) sources, i.e., sources not having a counterpart at UV-to-NIR wavelengths. We widen the sample of Talia et al. from 197 to 272 objects in the Cosmic Evolution Survey (COSMOS) field, including also photometrically contaminated sources, which were previously excluded. Another important step forward consists in the visual inspection of each source in the bands from u * to MIPS 24 μ m. According to their “environment” in the different bands, we are able to highlight different cases of study and calibrate an appropriate photometric procedure for the objects affected by confusion issues. We estimate that the contribution of RS-NIRdark sources to the cosmic SFRD at 3 < z < 5 is ∼10%–25% of that based on UV-selected galaxies.

While space-borne optical and near-infrared facilities have succeeded in delivering a precise and spatially resolved picture of our Universe, their small survey area is known to underrepresent the true diversity of galaxy populations. Ground-based surveys have reached comparable depths but at lower spatial resolution, resulting in source confusion that hampers accurate photometry extractions. What once was limited to the infrared regime has now begun to challenge ground-based ultradeep surveys, affecting detection and photometry alike. Failing to address these challenges will mean forfeiting a representative view into the distant Universe. We introduce The Farmer : an automated, reproducible profile-fitting photometry package that pairs a library of smooth parametric models from The Tractor with a decision tree that determines the best-fit model in concert with neighboring sources. Photometry is measured by fitting the models on other bands leaving brightness free to vary. The resulting photometric measurements are naturally total, and no aperture corrections are required. Supporting diagnostics (e.g., χ ^2 ) enable measurement validation. As fitting models is relatively time intensive, The Farmer is built with high-performance computing routines. We benchmark The Farmer on a set of realistic COSMOS-like images and find accurate photometry, number counts, and galaxy shapes. The Farmer is already being utilized to produce catalogs for several large-area deep extragalactic surveys where it has been shown to tackle some of the most challenging optical and near-infrared data available, with the promise of extending to other ultradeep surveys expected in the near future. The Farmer is available to download from GitHub ( https://github.com/astroweaver/the_farmer ) and Zenodo ( https://doi.org/10.5281/zenodo.8205817 ).

We present a search for extremely red, dust-obscured, z > 7 galaxies with JWST/NIRCam+MIRI imaging over the first 20 arcmin ^2 of publicly available Cycle 1 data from the COSMOS-Web, CEERS, and PRIMER surveys. Based on their red color in F277W−F444W (∼2.5 mag) and detection in MIRI/F770W (∼25 mag), we identify two galaxies, COS-z8M1 and CEERS-z7M1, that have best-fit photometric redshifts of $z={8.4}_{-0.4}^{+0.3}$ and ${7.6}_{-0.1}^{+0.1}$ , respectively. We perform spectral energy distribution fitting with a variety of codes (including bagpipes , prospector , beagle , and cigale ) and find a >95% probability that these indeed lie at z > 7. Both sources are compact ( R _eff ≲ 200 pc) and highly obscured ( A _V ∼ 1.5–2.5) and, at our best-fit redshift estimates, likely have strong [O iii ]+H β emission contributing to their 4.4 μ m photometry. We estimate stellar masses of ∼10 ^10 M _⊙ for both sources; by virtue of detection in MIRI at 7.7 μ m, these measurements are robust to the inclusion of bright emission lines, for example, from an active galactic nucleus. We identify a marginal (2.9 σ ) Atacama Large Millimeter/submillimeter Array detection at 2 mm within 0.″5 of COS-z8M1, which, if real, would suggest a remarkably high IR luminosity of ∼10 ^12 L _⊙ . These two galaxies, if confirmed at z ∼ 8, would be extreme in their stellar and dust masses and may be representative of a substantial population of highly dust-obscured galaxies at cosmic dawn.

O presente artigo compara o conceito de liberdade nas obras de Friedrich Hayek e John Rawls. O objetivo deste artigo é analisar comparativamente tais conceitos, com vista no âmbito político jurídico, assim como as suas concepções de liberalismo. Partindo de elementos comuns, analisamos o conceito de liberdade em Hayek, conforme as obras O caminho da servidão (1945) e Constitution of Liberty (1960), e o conceito enunciado por Rawls, conforme as obras Uma teoria de justiça (1971) e Liberalismo Político (1993). Concluímos que, embora ambos estejam dentro da ampla tradição do liberalismo, divergem em pontos importantes, o que aproxima Rawls da democracia deliberativa e Hayek do libertarianismo.

We present the first spectroscopic ALMA follow-up for a pilot sample of nine radio-selected near-IR-dark galaxies in the COSMOS field. These sources were initially selected as radio-detected sources (S3 GHz > 12.65 μJy) without an optical or near-IR (NIR) counterpart in the COSMOS2015 catalog (Ks ≳ 24.7 mag), and just three of them were subsequently detected in the deeper COSMOS2020. Several studies highlighted that this selection could provide a population of highly dust-obscured, massive, and star-bursting galaxies. With these new ALMA observations, we assess the spectroscopic redshifts of this pilot sample of sources and improve the quality of the physical properties estimated through SED-fitting. Moreover, we measure the quantity of molecular gas inside these galaxies and forecast their potential evolutionary path, finding that the radio-selected NIR-dark galaxies might likely represent a population of high-z progenitors of the massive and passive galaxies that were discovered at z ∼ 3. Finally, we present some initial constraints on the kinematics of the interstellar medium within the analyzed galaxies, reporting a high fraction (∼55%) of double-peaked lines that can be interpreted as the signature of a rotating structure in our targets or as the presence of major mergers in our sample. The results we present here show the scientific potential of (sub)mm observations for this elusive population of galaxies and highlight the potential contribution of these sources to the evolution of the massive and passive galaxies at high z. [ABSTRACT FROM AUTHOR]

Aims. We provide an in-depth analysis of the COSMOS-Web ring, an Einstein ring at z ≈ 2 that we serendipitously discovered during the data reduction of the COSMOS-Web survey and that could be the most distant lens discovered to date. Methods. We extracted the visible and near-infrared photometry of the source and the lens from more than 25 bands. We combined these observations with far-infrared detections to study the dusty nature of the source and we derived the photometric redshifts and physical properties of both the lens and the source with three different spectral energy distribution (SED) fitting codes. Using JWST/NIRCam images, we also produced two lens models to (i) recover the total mass of the lens, (ii) derive the magnification of the system, (iii) reconstruct the morphology of the lensed source, and (iv) measure the slope of the total mass density profile of the lens. Results. We find the lens to be a very massive elliptical galaxy at z = 2.02 ± 0.02 with a total mass within the Einstein radius of Mtot(<θEin = (3.66 ± 0.36) × 1011M⊙ and a total stellar mass of M⋆ = 1.37−0.11+0.14 × 1011 M⊙. We also estimate it to be compact and quiescent with a specific star formation rate below 10−13 yr. Compared to stellar-to-halo mass relations from the literature, we find that the total mass of the lens within the Einstein radius is consistent with the presence of a dark matter (DM) halo of total mass Mh = 1.09−0.57+1.46 × 1013 M⊙. In addition, the background source is a M⋆ = (1.26 ± 0.17) × 1010M⊙ star-forming galaxy (SFR ≈ (78 ± 15) M⊙ yr) at z = 5.48 ± 0.06. The morphology reconstructed in the source plane shows two clear components with different colors. Dust attenuation values from SED fitting and nearby detections in the far infrared also suggest that the background source could be at least partially dust-obscured. Conclusions. We find the lens at z ≈ 2. Its total, stellar, and DM halo masses are consistent within the Einstein ring, so we do not need any unexpected changes in our description of the lens such as changing its initial mass function or including a non-negligible gas contribution. The most likely solution for the lensed source is at z ≈ 5.5. Its reconstructed morphology is complex and highly wavelength dependent, possibly because it is a merger or a main sequence galaxy with a heterogeneous dust distribution. [ABSTRACT FROM AUTHOR]

The morphology of galaxies is shaped by stellar activity, feedback, gas and dust properties, and interactions with surroundings, and can therefore provide insight into these processes. In this paper, we study the spatial offsets between stellar and interstellar medium emission in a sample of 54 main-sequence star-forming galaxies at z ∼ 4–6 observed with the Atacama Large Millimeter/submillimeter Array (ALMA), and drawn from the ALMA Large Program to INvestigate C+ at Early times (ALPINE). We find no significant spatial offset for the majority (∼70 per cent) of galaxies in the sample among any combination of [C  ii ], far-infrared continuum, optical, and ultraviolet emission. However, a fraction of the sample (∼30 per cent) shows offsets larger than the median by more than 3σ significance (compared to the uncertainty on the offsets), especially between [C  ii ] and ultraviolet emission. We find that these significant offsets are of the order of ∼0.5–0.7 arcsec, corresponding to ∼3.5–4.5 kiloparsecs. The offsets could be caused by a complex dust geometry, strong feedback from stars and active galactic nuclei, large-scale gas inflow and outflow, or a combination of these phenomena. However, our current analysis does not definitively constrain the origin. Future, higher resolution ALMA and JWST observations may help resolve the ambiguity. Regardless, since there exist at least some galaxies that display such large offsets, galaxy models and spectral energy distribution fitting codes cannot assume co-spatial emission in all main-sequence galaxies, and must take into account that the observed emission across wavelengths may be spatially segregated. [ABSTRACT FROM AUTHOR]

We report the identification of 64 new candidates of compact galaxies, potentially hosting faint quasars with bolometric luminosities of Lbol = 1043–1046 erg s−1, residing in the reionization epoch within the redshift range of 6 ≲ z ≲ 8. These candidates were selected by harnessing the rich multiband datasets provided by the emerging JWST-driven extragalactic surveys, focusing on COSMOS-Web, as well as JADES, UNCOVER, CEERS, and PRIMER. Our search strategy includes two stages: applying stringent photometric cuts to catalog-level data and detailed spectral energy distribution fitting. These techniques effectively isolate the quasar candidates while mitigating contamination from low-redshift interlopers, such as brown dwarfs and nearby galaxies. The selected candidates indicate physical traits compatible with low-luminosity active galactic nuclei, likely hosting ≈105–107M⊙ supermassive black holes (SMBHs) living in galaxies with stellar masses of ≈108–1010M⊙. The SMBHs selected in this study, on average, exhibit an elevated mass compared to their hosts, with the mass ratio distribution slightly higher than those of galaxies in the local Universe. As with other high-z studies, this is at least in part due to the selection method for these quasars. An extensive Monte Carlo analysis provides compelling evidence that heavy black hole seeds from the direct collapse scenario appear to be the preferred pathway to mature this specific subset of SMBHs by z ≈ 7. Notably, most of the selected candidates might have emerged from seeds with masses of ∼105M⊙, assuming a thin disk accretion with an average Eddington ratio of fEdd = 0.6 ± 0.3 and a radiative efficiency of ϵ = 0.2 ± 0.1. This work underscores the significance of further spectroscopic observations, as the quasar candidates presented here offer exceptional opportunities to delve into the nature of the earliest galaxies and SMBHs that formed during cosmic infancy. [ABSTRACT FROM AUTHOR]