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3. Leukocyte elastase and free collagenase activity in synovial effusions: Relation to numbers of polymorphonuclear leukocytes

Author

K. Fehr, G. Cohen, and F. J. Wagenhäuser

Subjects
medicine.medical_specialty, Neutrophils, Immunology, Leukocyte elastase, In Vitro Techniques, Leukocyte Count, chemistry.chemical_compound, Rheumatology, Rheumatic Diseases, Lactate dehydrogenase, Internal medicine, Synovial Fluid, Humans, Immunology and Allergy, Medicine, Synovial fluid, Collagenase activity, chemistry.chemical_classification, L-Lactate Dehydrogenase, Pancreatic Elastase, business.industry, Activator (genetics), Molecular biology, Microbial Collagenase, Enzyme, chemistry, Collagenase, Joint Diseases, business, medicine.drug
Abstract

In 310 freshly analysed synovial fluid (SF) samples from patients with rheumatic and non-rheumatic diseases, activities of leukocyte elastase, collagenase and activator for human leukocyte latent collagenase were determined. These activities were investigated in relation to the number of polymorphonuclear leukocytes (PMN) and the activity of lactate dehydrogenase (LDH). Special care was taken to avoid artificial leakage of enzymes from SF cells after aspiration. The activator of latent collagenase was found in 86% of the SF tested and did not correlate with PMN counts and LDH activity, suggesting that this activity is not of leukocytic origin.

Published
1983
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