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This study presents the current literature regarding the investigation of varnish contamination among the various types of lubricant contaminations. As the duration of use of lubricants increases, the lubricant deteriorates and may become contaminated. Varnish has been known to cause filter plugging, sticking of the hydraulic valves and fuel injection pumps, flow obstruction, clearance reduction, poor heating and cooling performance, and increased friction and wear in various lubrication systems. These problems may also result in mechanical system failures, performance degradation, and increased maintenance and repair costs. To improve the problems caused by varnish contamination, an adequate understanding of varnish is required. Therefore, in this review, the definitions and characteristics, generating machinery, generating mechanisms, causes, measurement methods, and prevention or removal methods of varnish are summarized. Most of the data presented herein are reports from manufacturers related to lubricants and machine maintenance that are included in published works. We expect that this summary will be helpful to those who are engaged in reducing or preventing varnish-related problems.

Purpose This study compared the pain-relieving effects of human milk, sucrose, and distilled water during examinations for retinopathy of prematurity. Methods Forty-five preterm infants were randomly assigned to receive a pacifier dipped in one of three solutions: human milk (n=14), 24% sucrose (n=15), or distilled water (n=16), 2 minutes before an eye examination. Their pain score, pulse rate, and oxygen saturation were measured at three time points: 5 minutes before the examination, 30 seconds after speculum introduction, and 2 minutes after the examination. Results The infants’ mean gestational age and weight at birth were 33.1±2.1 weeks and 1,842±470 g, respectively. There were no between-group differences in pain relief during the eye examination. The pain score significantly increased both during (p

BackgroundHyperthyroidism relapse in Graves disease after antithyroid drug (ATD) withdrawal is common; however, measuring the thyrotropin receptor antibody (TRAb) at ATD withdrawal in order to predict outcomes is controversial. This study compared measurement of thyroid stimulatory antibody (TSAb) and thyrotropin-binding inhibitory immunoglobulin (TBII) at ATD withdrawal to predict relapse.MethodsThis retrospective study enrolled patients with Graves disease who were treated with ATDs and whose serum thyroid-stimulating hormone levels were normal after receiving low-dose ATDs. ATD therapy was stopped irrespective of TRAb positivity after an additional 6 months of receiving the minimum dose of ATD therapy. Patients were followed using thyroid function tests and TSAb (TSAb group; n=35) or TBII (TBII group; n=39) every 3 to 6 months for 2 years after ATD withdrawal.ResultsTwenty-eight patients (38%) relapsed for a median follow-up of 21 months, and there were no differences in baseline clinical characteristics between groups. In the TSAb group, relapse was more common in patients with positive TSAb at ATD withdrawal (67%) than patients with negative TSAb (17%; P=0.007). Relapse-free survival was shorter in TSAb-positive patients. In the TBII group, there were no differences in the relapse rate and relapse-free survivals according to TBII positivity. For predicting Graves disease relapse, the sensitivity and specificity of TSAb were 63% and 83%, respectively, whereas those of TBII were 28% and 65%.ConclusionTSAb at ATD withdrawal can predict the relapse of Graves hyperthyroidism, but TBII cannot. Measuring TSAb at ATD withdrawal can assist with clinical decisions making for patients with Graves disease.

BackgroundObesity is associated with aggressive pathological features and poor clinical outcomes in breast and prostate cancers. In papillary thyroid carcinoma (PTC), these relationships remain still controversial. This study aimed to evaluate the associations between body mass index (BMI) and the clinical outcomes of patients with PTC.MethodsThis retrospective study included 1,189 patients who underwent total thyroidectomy for PTCs equal to or larger than 1 cm in size. Clinical outcomes were evaluated and compared based on the BMI quartiles.ResultsThere were no significant associations between BMI quartiles and primary tumor size, extrathyroidal invasion, cervical lymph node metastasis, or distant metastasis. However, an increase in mean age was associated with an increased BMI (P for trend

BackgroundThe prevalence of thyroid cancer has increased very rapidly in Korea. However, there is no published report focusing on thyroid cancer mortality in Korea. In this study, we aimed to evaluate standardized thyroid cancer mortality using data from Statistics Korea (the Statistical Office of Korea).MethodsPopulation and mortality data from 1985 to 2010 were obtained from Statistics Korea. Age-standardized rates of thyroid cancer mortality were calculated according to the standard population of Korea, as well as World Health Organization (WHO) standard population and International Cancer Survival Standard (ICSS) population weights.ResultsThe crude thyroid cancer mortality rate increased from 0.1 to 0.7 per 100,000 between 1985 and 2010. The pattern was the same for both sexes. The age-standardized mortality rate (ASMR) for thyroid cancer for Korean resident registration population increased from 0.19 to 0.67 between 1985 and 2000. However, it decreased slightly, from 0.67 to 0.55, between 2000 and 2010. When mortality was adjusted using the WHO standard population and ICSS population weights, the ASMR similarly increased until 2000, and then decreased between 2000 and 2010.ConclusionThyroid cancer mortality increased until 2000 in Korea. It started to decrease from 2000.

Cancer metastases to the thyroid or adrenal gland are uncommon. Furthermore, cases showing long-term survival after surgical resection of those metastatic tumors are rare. We report a case of pulmonary artery intimal sarcoma with metastases to the thyroid and adrenal glands sequentially that was successfully treated with sequential metastasectomies. A 62-year-old woman presented with a 4-week history of dyspnea on exertion and facial edema in November 1999. Echocardiography and chest computed tomography (CT) revealed an embolism-like mass in the pulmonary trunk. Pulmonary artery endarterectomy with pulmonary valve replacement was performed, and histopathology revealed pulmonary artery intimal sarcoma. A thyroid nodule was found by chest CT in November 2001 (2 years after initial surgery). During follow-up, this lesion showed no change, but we decided to obtain fine needle aspiration cytology (FNAC) in August 2004 (4.7 years after initial surgery). FNAC revealed atypical spindle cells suggestive of metastatic intimal sarcoma. She underwent total thyroidectomy. During follow-up, a right adrenal gland mass was detected by chest CT in March 2006 (6.3 years after initial surgery), and adrenalectomy was done, which also revealed metastatic sarcoma. She has been followed up without any evidence of recurrent disease until May 2012 (12.5 years after initial surgery).

BACKGROUND:Lateral cervical lymph node (LCLN) metastasis, or pathologic N1b disease, is an important risk factor in papillary thyroid carcinoma (PTC). However, many patients have favorable prognosis even with pathologic N1b patients in clinical practice. The study aims to identify high- and intermediate-risk groups based on initial pathologic characteristics in these patients. PATIENTS:This study included 518 classical PTC patients confirmed as pathologic N1b at initial surgery between 2001 and 2010. All patients underwent a single fixed activity (5.6 GBq) of radioactive I-131 remnant ablation. RESULTS:Patients with a primary tumor larger than 4 cm, gross extrathyroidal extension, metastatic LN larger than 3 cm, or greater than 10 metastatic LCLN were classified as high-risk group. These comprehensive pathologic criteria were retrieved from cox proportional hazard models. Twenty two percent of patients (n = 113) were classified as high-risk and 78% (n = 405) as intermediate-risk group. Successful ablation was identified in only 32% of the patients in the high-risk group and 61% in the intermediate-risk group (p < 0.001). The difference between the two risk groups was independent to gender. There was a significant difference in disease-free survival between the high- and intermediate- risk N1b groups during 5.1 years of median follow-up (84% vs. 59%, p < 0.001). Distant metastasis was more prevalent in the high-risk group (20%) than in the intermediate-risk group (4%, p < 0.001). CONCLUSIONS:The prognosis of PTC patients with LCLN metastasis varies depending on initial pathologic characteristics. We proposed the comprehensive pathologic criteria for sub-classification of N1b into high- and intermediate-risk groups and this sub-classification may permit personalized management of N1b PTC patients.

Pulmonary function test (PFT) is a useful tool for an objective assessment of respiratory function. Impaired pulmonary function is critical for the survival and quality of life in patients with pulmonary metastases of solid cancers including thyroid cancer. This study aimed to evaluate clinical factors associated with severely impaired pulmonary function by serial assessment with PFT in patients with pulmonary metastasis of differentiated thyroid cancer (DTC) who received radioactive iodine treatment (RAIT).This retrospective study enrolled 31 patients who underwent serial PFTs before and after RAIT for pulmonary metastasis of DTC. We evaluated the risk factors for severe impairment of pulmonary function.The median age of the patients was 44.1 years and 18 of them were female patients. Severe impairment of pulmonary function was observed in five patients (16%) after a median of three RAITs (cumulative I-131 activity = 20.4 GBq). These patients were older and more frequently had mild impairment of baseline pulmonary function, respiratory symptoms, or progressive disease compared with patients with stable pulmonary function. Neither cumulative dose nor number of RAIT was associated with decreased pulmonary function. Coexisting pulmonary diseases, presence of respiratory symptoms, and metastatic disease progression were significantly associated with severe decrease in forced vital capacity during follow-up (p =.047, p =.011, and p =.021, respectively).Pulmonary function was severely impaired during follow-up in some patients with pulmonary metastasis of DTC after a high-dose RAITs. Neither the number of RAIT nor the cumulative I-131 activity was associated with decreased pulmonary function. Serial PFT might be considered for some high-risk patients during follow-up.

Research has been conducted on levansucrase gene from Rahnella aquatilis. Molecular basis for the growth phase-dependent expression of this gene and the role of upstream region in genetic regulation have been investigated and discussed.

Measuring eco-innovation helps us understand the overall trends and raises awareness in society. Measuring eco-innovation at the national level and making comparisons across countries may allow us to benchmark performance and foster policy learning. This paper assesses two indices developed in two different regions: The ASEM Eco-Innovation Index (ASEI) by the ASEM SMEs Eco-Innovation Center, based in Republic of Korea; and the Eco-Innovation Scoreboard (Eco-IS) developed by the Eco-Innovation Observatory, based in the European Union. This paper aims to examine and compare the features of both and attempts to obtain insights on their strengths and weaknesses. Towards this aim, our paper assesses those scoreboards against four criteria stemming from innovation analysis: (1) relevance of areas and stakeholders covered; (2) ability to indicate changes; (3) directions towards common goals; and (4) ability to facilitate further changes. We conclude both are promising, despite data shortages, and have great potential to contribute towards the sustainable development goals (SDGs), particularly with regard to the SDGs on sustainable industrialization and sustainable consumption and production. In comparison, the ASEI covers more countries than the Eco-IS. However, the ASEI has limitations on measuring indicators due to limited data availability in Asian countries. The Eco-IS is closely linked with the regional and national policies for eco-innovation in Europe, while the ASEI's impact appears more limited, as of now. In conclusion, the research results give insights into key areas, goals and applications of eco-innovation indices, and can help upgrading eco-innovation indices. This research helps interpret the scores of two indices better and facilitate application of the scores in the multiple ways. It is expected that this research contributes to developing and modifying a global eco-innovation index and enhancing the ability of these indices to facilitate eco-innovation strategies at national levels and across relevant actors. [ABSTRACT FROM AUTHOR]

Background: Anaplastic thyroid carcinoma (ATC), the most aggressive type of thyroid cancer, has no effective therapy. Due to its dismal prognosis, it is vital to understand the genetic alterations of ATC and identify effective molecular targets. Targeted next-generation sequencing was performed to investigate the mutational profile of ATC using a massive parallel sequencing approach. Methods: DNA from formalin-fixed, paraffin-embedded archival samples of 11 ATCs and normal matched pairs were used. A total of 48 genetic alterations were identified by targeted exome sequencing. These alterations were validated by mass spectrometric genotyping and direct Sanger sequencing. Results: The most commonly mutated gene was BRAF, identified in 10 samples (91%), all showing the V600E point mutation. A KRAS point mutation was observed in the one sample (9%) without the BRAFV600E mutation. All 11 ATCs harbored BRAF or RAS mutations, reflecting the possibility that differentiated thyroid carcinomas progress to ATCs after the accumulation of mutations. A loss of function mutation of TP53 was observed in eight samples (73%), a PIK3CA mutation was observed in two samples (18%), and a frameshift mutation of PTEN was observed in one sample (9%). Twenty-eight novel mutated genes were found that had not previously been associated with ATC. Of these, loss of function mutations of NF2, KMT2D, and PKHD1 were repeatedly seen in three samples (27%), two samples (18%), and two samples (18%), respectively. Using direct Sanger sequencing, two samples (18%) were also found with a RASAL1 mutation. KMT2D and RASAL1 mutations were significantly associated with shorter ATC patient survival. Conclusions: This comprehensive analysis of ATCs using targeted massive parallel sequencing identified several novel mutations in ATCs, such as loss of function mutations of NF2 or KMT2D. Future studies are needed to confirm the role of these novel mutations as independent drivers of ATC development. [ABSTRACT FROM AUTHOR]

Background: Acute hypothyroidism induced by thyroid hormone withdrawal (THW) in patients with thyroid cancer after total thyroidectomy can affect mood and quality of life (QoL). While loss or dysregulation of thyroid hormone (TH) has these well-known behavioral consequences, the effects of TH alterations on brain function are notwell understood. Resting state functional connectivity (FC) measured by functionalmagnetic resonance imaging (fMRI) allows non-invasive evaluation of human brain function. This study therefore examined whether THW affects resting state FC and whether changes in FC correlate with themood or QoL of the patients with THWstatus. Methods: Twenty-one patients who had undergone total thyroidectomy for thyroid cancer were recruited. Resting state fMRI scanning of the brain, thyroid function tests, and administration of the 12-Item Short FormHealth Survey (SF-12) and the Patient Health Questionnaire-9 (PHQ-9) were performed before and after two weeks of THW. Regional homogeneity (ReHo), one of the measures of resting state FC, was calculated, and each voxel was compared between before and after THW in 19 patients. The ReHo values were extracted from the regions of interest showing within-group differences in ReHo values after THW, and correlations of ReHo values with thyrotropin (TSH) levels, total score of the PHQ-9, and composite scores of the SF-12 were statistically evaluated. Results: Higher ReHo was observed after THW in the brain cortical regions across primary motor and sensory, visual, and association cortices. Among the regions, the ReHo values in the bilateral pre- and postcentral gyri, bilateral middle occipito-temporal cortices, the left precuneus, and the left lingual gyrus showed positive correlations with serum TSH levels after THW. Higher ReHo values in the bilateral pre- and postcentral gyri, the left middle temporo-occipital cortices, and the left ligual gyrus correlated with the lower mental component summary score fromthe SF-12, while higher ReHo values in the bilateral pre- and postcentral gyri correlated with higher total scores in the PHQ-9. Conclusions: Local brain FC is increased in the acute hypothyroid state. Higher FC correlates with a poorer mental QoL and increased depression in the hypothyroid state. [ABSTRACT FROM AUTHOR]

Following the trend on focusing on a nation's economic-growth, side effects such as resource exhaustion, environmental pollution, and social injustice have begun to appear. As a solution, eco-innovation has received a great amount of attention from European countries and as a result, many efforts to analyze the development of eco-innovation quantitatively have been made. This study aims to evaluate the validity of an eco-innovation index developed to support the sustainable development goal. For this purpose, four factors of eco-innovation--capacity, supportive environment, activity, and performance--were applied to three categories of the Triple-Bottom-Line (TBL) concept in sustainability to compare the eco-innovation development level of 49 Asia-Europe Meeting countries. Factors for eco-innovation and TBL at the country level were organized in quartile and compared to see strength and weaknesses for each nation. In order to test if eco-innovation factors of a nation adequately reflect its sustainability, we used various comparisons of ANOVA. The results of this study are as follows: First, the one-way ANOVA tests present the scores for capacity, supportive environment, and performance as grouped into four quartiles in the same pattern as their economic, social, and environmental scores. The three-way ANOVA tests showed significance for the economic category. Scores for capacity, supportive environment, activity and performance were significant at a nation's economic level. Lastly, the MANOVA test revealed that TBL significantly explains four eco-innovation factors. In addition, the eco-innovation performance level of European nations and Asian nations were compared. The possibility that many nations still have room to be competitive in their eco-innovation efforts was identified. Nations with unbalanced eco-innovation growth are urged to implement new strategies to balance their growth. Therefore, this research contributes to extending research on eco-innovation. [ABSTRACT FROM AUTHOR]

Eco-innovation globally emerged as an effort to implement sustainable development. States and firms established and implemented policies and strategies for eco-innovation as one route to achieving sustainable development. Eco-innovation has been facilitated in developed countries, specifically OECD members and European countries, through action plans. Recently, eco-innovation policies have emerged in developing countries. Thus, this study analyzes eco-innovation policies in Asian countries. Policies related to eco-innovation in 17 Asian countries were investigated using policy instrument categories. National policies for eco-innovation were interpreted and compared with development stage classifications. The results indicate that there are similar and different policy approaches to eco-innovation in Asian countries. Given the balance between a technology push (supply side) and a market pull (demand side) in policy instruments for eco-innovation, 17 countries were identified by four categories: leaders, followers, loungers, and laggards. The results provide insight for designing national strategies for eco-innovation in Asia's developing countries. Therefore, this research contributes to facilitating and diffusing eco-innovation toward sustainability in Asia. [ABSTRACT FROM AUTHOR]

Photorhabdus temperata is an entomopathogenic enterobacterium; it is a nematode symbiont that possesses pathogenicity islands involved in insect virulence. Herein, we constructed a P. temperata M1021 cosmid library in Escherichia coli XL1-Blue MRF' and obtained 7.14 × 105 clones. However, only 1020 physiologically active clones were screened for insect virulence factors by injection of each E. coli cosmid clone into Galleria mellonella and Tenebrio molitor larvae. A single cosmid clone, PtC1015, was consequently selected due to its characteristic virulent properties, e.g., loss of body turgor followed by death of larvae when the clone was injected into the hemocoel. The sequence alignment against the available sequences in Swiss-Prot and NCBI databases, confirmed the presence of the mcf gene homolog in the genome of P. temperata M1021 showing 85% homology and 98% query coverage with the P. luminescens counterpart. Furthermore, a 2932 amino acid long Mcf protein revealed limited similarity with three protein domains. The N-terminus of the Mcf encompassed consensus sequence for a BH3 domain, the central region revealed similarity to toxin B, and the C-terminus of Mcf revealed similarity to the bacterial export domain of ApxIVA, an RTX-like toxin. In short, the Mcf toxin is likely to play a role in the elimination of insect pests, making it a promising model for use in the agricultural field. [ABSTRACT FROM AUTHOR]

Abstract  The production of dextran was optimized by a novel Leuconostoc citreum, which was isolated from Korean traditional fermented vegetable, Dongchimi. This strain was identified as Leuconostoc citreum S5 by a physiological analysis, API-kit analysis, 16-rDNA sequencing and RAPD-PCR. The type and production of dextrans were greatly affected by the sucrose concentration, food ingredients and fermentation time. In particular, the addition of skim milk and potato powder greatly increased the consistency of the culture broth after fermentation for 12 h at 30 °C, resulting in the maximum values after 72 h. The culture broth with the highest consistency, was obtained from the defined medium containing 20% sucrose, 1.5% skim milk and 0.5% potato powder, and it showed typical pseudoplastic behavior with a pH of 4.07, 1.12% titratable acidity, 472.5 Pa of the elasticity modulus (G′) and 85.0 Pa of viscosity modulus (G″). In addition, total dextran is composed of soluble dextran (33.2 g/L) and insoluble dextran (29.8 g/L). The conversion yield of sucrose was decreased by an increase, in the sucrose concentration in a defined medium, remaining sucrose and some of glucose and fructose. High-molecular weight dextran (2,000 kDa), as a minor fraction, was produced by increasing the sucrose. With the addition of food ingredients such as skim milk and potato powder, however, the conversion of sucrose is complete, showing only some fructose as a by-product. Low-molecular weight dextran (1,100 kDa) was only produced regardless of sucrose concentration. [ABSTRACT FROM AUTHOR]

The importance of Reducing Emissions from Deforestation and Forest Degradation (REDD+) has been elevated within the new climate framework outlined by the Paris Agreement, placing a significant emphasis on encouraging nations to adopt and promote REDD+ strategies. The success of REDD+ is highly dependent on financial resources that aid in addressing and mitigating the primary causes of deforestation and forest degradation. Furthermore, REDD+ projects utilize technology to counter challenges such as land-use changes for agriculture, infrastructure development, illegal logging, fuelwood collection, and forest fires. This study investigates the status of REDD+ projects, which are aimed at combating global deforestation and climate change, supported by the Climate Technology Center Network (CTCN) and the Green Climate Fund (GCF), both of which are critical mechanisms under the United Nations Framework Convention on Climate Change (UNFCCC). We examined these projects through the lenses of technology convergence and finance blending. The analysis revealed that the CTCN and GCF predominantly support projects leveraging technology for forest disaster management. In addition, the agricultural sector demonstrated the highest degree of technology convergence. The findings indicate that a strategic approach for securing private funding involves integrating mitigation and adaptation efforts in projects. Furthermore, partnerships can facilitate the blending of financial strategies to mitigate risks. The study highlights the potential of technology convergence in enhancing the feasibility of scaling up REDD+ projects by promoting stakeholder engagement and catalyzing the private capital influx.

Agriculture accounts for the largest share of anthropogenic methane emissions. Rice paddy fields emit a significant amount of methane gas worldwide. Changing paddy water management practices has an enormous potential to reduce greenhouse gases. The clean development mechanism (CDM) project uses a market mechanism to reduce methane through private participation. There are various risks associated with private investment in CDM projects, although carbon credits as an economic incentive assist in mitigating some of these risks. Farmer participation plays a key role in the success of paddy water management projects in rural areas; however, despite the significant potential to reduce global methane emissions, very few projects have been implemented. When designing a Sustainable Development Mechanism (SDM) system, it is crucial to understand why the market mechanism in the existing CDM projects has failed. This study identifies and categorizes the risks and barriers to paddy water management in CDM projects and analyzes risk management options in CDM projects in India, Indonesia, and Mozambique. The results of this study showed that aside from economic risks, barriers to the application of technology in the field pose critical risks. The lack of knowledge and implementation experiences in rural areas increases barriers to practice. This in turn causes risk of difficulties in technology transfer which can be alleviated by improving awareness and introducing new knowledge through education and training in rural project implementation. Additionally, we highlight the importance of international efforts to build governance between the private and public sectors and promote technology transfers through multi-stakeholder engagement. This study provides specific information to encourage methane reduction worldwide and vitalize rice paddy water management in carbon reduction projects.

This study evaluated the applicability of existing sediment yield and transport estimation models developed using data mining classification and prediction techniques and validated them. Field surveys were conducted by using an acoustic Doppler current profiler and laser in situ scattering and transmission at measuring points in the main stream of the Nakdong River located where the tributaries of the Geumho, Hwang, and Nam Rivers join. Surveys yielded estimations of water velocity, discharge, and suspended sediment concentrations were measured. In contrast with models based on the general watershed characteristics factors, some models based on hydraulic explanatory flow variables demonstrated an excellent predictability. This is because the selected submodels for validation, which provided excellent prediction results, were based on a large number of calibration data. It indicates that a sufficient number of reliable data is required in developing a sediment yield estimation model using data mining. For practical applications of data mining to extant sediment yield estimation models, comprehensive considerations are required, including the purpose and background of model development, and data range. Furthermore, the existing models should be periodically updated with the consideration of temporal and spatial lumping problems.

Photorhabdus temperata is an entomopathogenic enterobacterium; it is a nematode symbiont that possesses pathogenicity islands involved in insect virulence. Herein, we constructed a P. temperata M1021 cosmid library in Escherichia coli XL1-Blue MRF` and obtained 7.14 × 105 clones. However, only 1020 physiologically active clones were screened for insect virulence factors by injection of each E. coli cosmid clone into Galleria mellonella and Tenebrio molitor larvae. A single cosmid clone, PtC1015, was consequently selected due to its characteristic virulent properties, e.g., loss of body turgor followed by death of larvae when the clone was injected into the hemocoel. The sequence alignment against the available sequences in Swiss-Prot and NCBI databases, confirmed the presence of the mcf gene homolog in the genome of P. temperata M1021 showing 85% homology and 98% query coverage with the P. luminescens counterpart. Furthermore, a 2932 amino acid long Mcf protein revealed limited similarity with three protein domains. The N-terminus of the Mcf encompassed consensus sequence for a BH3 domain, the central region revealed similarity to toxin B, and the C-terminus of Mcf revealed similarity to the bacterial export domain of ApxIVA, an RTX-like toxin. In short, the Mcf toxin is likely to play a role in the elimination of insect pests, making it a promising model for use in the agricultural field.