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1. Pengaruh Ekstrak Bayam Merah (Amaranthus gangeticus) terhadap Morfologi Stratum Hipokampus Model Anak Mencit Pascasapih Induk yang Terpapar Timbal Selama Masa Kehamilan

Author

Viskasari Kalanjati, Made Pury Pratiwi, Noer Halimatus Syakdiyah, Etha Dini Widiasi, Mayang Rizki Anggraeni, Intan Anggun Pratiwi, and Raden Argarini

Subjects
Hippocampus, lead acetate, red spinach, Medicine
Abstract

Antioxidants in red spinach (Amaranthus gangeticus) extract are proposed to combat the toxicity of lead acetate in the central nervous system. The effect of red spinach extract to the morphology of post weaning mouse hippocampus model (Mus musculus) in pregnant mice that received oral lead acetate during pregnancy was analyzed. Twenty seven post-weaning mice offsprings were grouped into 3 groups: M0 (sodium carboxymethyl cellulose or CMC Na 0.5%), M1 (CMC Na 0.5%+lead acetate 1.16 mg/10 g of body weight/day) and M2 (CMC Na 0.5%+lead acetate 1.16 mg/10 g of body weight/day+red spinach extract 382.2 mg/10 g of body weight/day). Brains were histologically processed and stained with hematoxylin-eosin (HE). Width of stratum granulare (SG) of the dentate gyrus (GD) and each of stratum oriens-pyramidale (SOP) of CA1, CA2, CA3 from each mouse hippocampus were obtained and analyzed statistically using analysis of variance (ANOVA) and least significant difference (LSD) (p0.05). In conclusion, red spinach extract might dampen the adverse effects of oral lead acetate in post-weaning mouse hippocampus model from pregnant mice orally exposed to lead acetate during pregnancy.

Published
2014
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2. Markers of Renal Complications in Beta Thalassemia Patients with Iron Overload Receiving Chelation Agent Therapy: A Systematic Review

Author

Pradana Zaky Romadhon, Ami Ashariati, Siprianus Ugroseno Yudho Bintoro, Mochammad Thaha, Satriyo Dwi Suryantoro, Choirina Windradi, Bagus Aulia Mahdi, Dwiki Novendrianto, Krisnina Nurul Widiyastuti, Okla Sekar Martani, Etha Dini Widiasi, Esthiningrum Dewi Agustin, Emil Prabowo, Yasjudan Rastrama Putra, Harik Firman Thahadian, Imam Manggalya Adhikara, Dwita Dyah Adyarini, Kartika Prahasanti, Aditea Etnawati Putri, and Narazah Mohd Yusoff

Subjects
Hematology
Abstract

The emerging renal complications in beta-thalassemia patients have raised the global exchange of views. Despite better survival due to blood transfusion and iron chelation therapy, the previously unrecognized renal complication remain a burden of disease affecting this population -the primary concern on how iron overload and chelation therapy correlated with renal impairment is still controversial. Early detection and diagnosis is crucial in preventing further kidney damage. Therefore, a systematic review was performed to identify markers of kidney complications in beta thalassemia patients with iron overload receiving chelation therapy.Searches of PubMed, Scopus, Science Direct, and Web of Science were conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) to identify studies of literature reporting renal outcome in β-TM patients with iron overload and receiving chelation therapy. The eligible 17 studies were obtained.uNGAL/NGAL, uNAG/NAG, uKIM-1 are markers that can be used as predictor of renal tubular damage in early renal complications, while Cystatin C and uβ2MG showed further damage at the glomerular level.The renal complication in beta-thalassemia patients with iron overload receiving chelating agent therapy may progress to kidney disease. Early detection using accurate biological markers is a substantial issue that deserves further evaluation to determine prevention and management.

Published
2022
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