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Objective The Parkinson Anxiety Scale (PAS) was developed to measure the severity of anxiety symptoms in patients with Parkinson’s disease (PD), and it has not yet been adapted and validated in Portuguese. Thus, this study evaluated the reliability and validity of a translated and adapted version of the PAS for the Brazilian population of PD patients. Methods The Parkinson Anxiety Scale – Brazilian Version (PAS-BV) was completed by 55 patients with PD. The reliability (test-retest reliability, interrater reliability and internal consistency) and construct validity of the PAS-BV were assessed by comparing it with the Beck Anxiety Inventory (BAI), the Parkinson’s Disease Fatigue Scale (PFS) and the Unified Parkinson Disease Rating Scale (UPDRS) part III. Results Patients with PD had an average age of 64.51 ± 9.20 years and had PD for an average of 6.98 ± 5.02 years. The reliability of the PAS-BV was 0.83, and the intraclass correlation coefficient (ICC) (retest-test) was 0.88. The scale presented good convergent validity with the BAI (rs = 0.82, p < 0.05). It also presented good divergent validity with the PFS (rs = 0.24, p > 0.05) and the UPDRS part II (rs = -0.10, p > 0.05), part III (rs = -0.21, p > 0.05), and part IV (rs = 0.03, p > 0.05), as indicated by the absence of significant correlations. However, there was a significant correlation between the PAS-BV and part I of the UPDRS (rs = 0.67, p < 0.05). Conclusion The PAS-BV presents substantial reliability and validity for patients with PD without dementia.

O objetivo desse relato é apresentar os efeitos do treinamento resistido sobre os sintomas depressivos, parâmetros físicos e funcionais de um homem com Doença de Parkinson Um homem com DP, inicialmente apresentou diversos sintomas depressivos e motores. Além de diabetes mellitus tipo 2, hipertensão e baixa visão. Passou por anamnese inicial, avaliações físicas, funcionais e do estado depressivo. Após 20 semanas de intervenção, o paciente apresentou melhora em todas as avaliações as quais foi submetido. O protocolo de TR utilizado reduziu a gravidade dos sintomas depressivos e melhorou as capacidades físicas e funcionais do sujeito. ABSTRACT Resistance training reduced depressive symptoms and improved physical and functional parameters of a patient with Parkinson's disease The object this report is shows the effects of resistance training on depressive symptoms, and physical and functional parameters of a man with Parkinson's Disease. A man with PD initially had several depressive and motor symptoms, in addition to Type 2 Diabetes Mellitus, hypertension, and low vision. He underwent initial anamnesis, physical, functional, and depressive status assessments. After 20 weeks of intervention, the patient presented improvement in all the evaluations that were submitted. The RT protocol used reduces the severity of depressive symptoms and improves the physical and functional capabilities of the subject.

Background. Recent data have suggested that polymorphisms in the length of the polyalanine tract (polyA) of FOXE1 gene may act as a susceptibility factor for thyroid dysgenesis. The main purpose of this study was to investigate the influence of polyA of FOXE1 gene on the risk of thyroid dysgenesis. Method. A case-control study was conducted in a sample of 90 Brazilian patients with thyroid dysgenesis and 131 controls without family history of thyroid disease. Genomic DNA was isolated from peripheral blood samples and the genotype of each individual was determined by automated sequencing. Results. More than 90% of genotypes found in the group of patients with thyroid dysgenesis and in controls subjects were represented by sizes 14 and 16 polymorphisms in the following combinations: 14/14, 14/16, and 16/16. Genotypes 14/16 and 16/16 were more frequent in the control group, while genotype 14/14 was more frequent in the group of patients with thyroid dysgenesis. There was no difference between agenesis group and control group. Genotype 14/14 when compared to genotypes 14/16 and 16/16A showed an association with thyroid dysgenesis. Conclusion. PolyA of FOXE1 gene alters the risk of thyroid dysgenesis, which may explain in part the etiology of this disease.

ABSTRACT Objective: To assess the effects of resistance training on the anxiety symptoms and quality of life in patients with Parkinson's disease. Methods: Thirty-five elderly patients were randomly divided into two groups: 17 patients in the control group and 18 in the intervention group. All patients maintained standard pharmacological treatment for Parkinson's disease, but the intervention group participated in a 24-week resistance training program. The anxiety symptoms were assessed through the Beck's Anxiety Inventory, and quality of life by the Parkinson's Disease Questionnaire–39. Results: There was a significant reduction in anxiety level and increase in quality of life after 24 weeks of resistance training. Conclusion: The results of the present study indicate that resistance training is an effective intervention in the reduction of anxiety symptoms and improves the quality of life in elderly people with Parkinson's disease.

Introdução: compreender os efeitos dos exercícios resistidos sobre a qualidade de vida e autopercepção dos praticantes acerca dos benefícios são fatores fundamentais que podem garantir inclusive a aderência em programas de atividade física. Objetivo: O objetivo deste estudo foi avaliar de forma qualitativa os efeitos dos exercícios resistidos sobre a qualidade de vida em idosos. Foram incluídos 22 idosos (68,8 ± 9,0 anos) que praticavam de maneira exclusiva e regular os exercícios resistidos. Foram realizadas entrevistas que continham dez perguntas abertas baseado no Medical Outcomes Study 36 (questionário de fácil aplicabilidade e compreensão). Utilizamos o método análise de conteúdo e o conceito de representações sociais. A estruturação das falas foi dividida em categorias de sentido e significado: 1) Melhora na saúde 2) Diálogos inter-relacionais. Resultados: na categoria melhora da saúde foram identificadas três subcategorias: bem-estar, ausência de dores e força. A categoria diálogos inter-relacionais identificamos: cansaço, desânimo, irritação, medo, disposição, forma física e independência que traduzem a visão e percepção dos idosos quanto aos benefícios elucidados pela prática regular dos exercícios resistidos. Conclusão: em conclusão os exercícios resistidos melhoram a qualidade de vida de idosos, evidenciado através da análise qualitativa. ABSTRACT Resistant exercises improve the quality of life in elderly: qualitative study Aims: The aim of this study was to qualitatively evaluate the effects of resistance training on quality of life in elderly subjects. Methods: The study included 22 older adults (68.8 ± 9.0 years) who exclusively and regularly practiced resistance training (over six months). Interviews containing ten open questions based on the Medical Outcomes Study 36 (questionnaire of easy application and understanding) were conducted. The analysis of content method and the concept of social representations were used. The structuring of speeches was divided into categories of meaning and significance: 1) Improving health 2) Inter-relational dialogues. Results: In improving health category, three subcategories were identified: welfare, absence/reduction of pain and strength. Inter-relational dialogues category identified the following: tiredness, weariness, irritation, fear, willingness, fitness and independence, which represent the perception of the elderly about the benefits provided by the regular practice of these exercises. Conclusion: In conclusion, resistance training improves quality of life in the elderly, evidenced by qualitative analysis.

ABSTRACT Mutations of the GBA gene have been reported in patients with Parkinson's disease (PD) from a number of different countries, including Brazil. In order to confirm this pattern in a sample of PD patients from northern Brazil, we conducted a case-control study of the occurrence of the two most common mutations of the GBA gene (c.1226A>G; p.N370S and c.1448T>C; p.L444P) in a group of 81 PD patients and 81 control individuals, using PCR-RFLP, confirmed by the direct sequencing of the PCR products. In the patient group, three patients (3.7%) were heterozygous for the GBA c.1226A>G; p.N370S mutation, and three (3.7%) for GBA c.1448T>C; p.L444P Neither mutation was detected in the control group (p =0.0284). Patients with the c.1448T>C; p.L444P mutation showed a tendency to have an earlier disease onset, but a larger sample number is required to confirm this observation. Our results suggest an association between the GBA c.1226A>G; p.N370S and c.1448T>C; p.L444P mutations and the development of PD in the population of patients from the Northern Brazil.

ABSTRACT Osteoporosis is considered a common metabolic bone disease and its prevalence is increasing worldwide. In this context, physical activity has been used as a non-pharmacological tool for prevention and auxiliary treatment of this disease. The aim of this systematic review was to evaluate the effects of cycling and swimming practice on bone mineral density (BMD). This research was conducted in accordance with the recommendations outlined by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The studies were consulted in the period from 2004 to 2014, through major electronic databases: PubMed®, SciELO® and LILACS®. Ten studies evaluated the effects of cycling on BMD, and the results showed that nine studies have linked the practice of professional cycling with low levels of BMD. Another 18 studies have reported that swimming has no positive effects on bone mass. We conclude that cycling and swimming do not cause positive effects on BMD; thus, these are not the most suitable exercises for prevention and treatment of osteoporosis.