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1. Robust differences in antisaccade performance exist between COGS schizophrenia cases and controls regardless of recruitment strategies

Author

Radant, Allen D., Millard, Steven P., Braff, David L., Calkins, Monica E., Dobie, Dorcas J., Freedman, Robert, Green, Michael F., Greenwood, Tiffany A., Gur, Raquel E., Gur, Ruben C., Lazzeroni, Laura C., Light, Gregory A., Meichle, Sean P., Nuechterlein, Keith H., Olincy, Ann, Seidman, Larry J., Siever, Larry J., Silverman, Jeremy M., Stone, William S., Swerdlow, Neal R., Sugar, Catherine A., Tsuang, Ming T., Turetsky, Bruce I., and Tsuang, Debby W.

Published
2015
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2. Neurocognitive performance in family-based and case-control studies of schizophrenia

Author

Gur, Ruben C., Braff, David L., Calkins, Monica E., Dobie, Dorcas J., Freedman, Robert, Green, Michael F., Greenwood, Tiffany A., Lazzeroni, Laura C., Light, Gregory A., Nuechterlein, Keith H., Olincy, Ann, Radant, Allen D., Seidman, Larry J., Siever, Larry J., Silverman, Jeremy M., Sprock, Joyce, Stone, William S., Sugar, Catherine A., Swerdlow, Neal R., Tsuang, Debby W., Tsuang, Ming T., Turetsky, Bruce I., and Gur, Raquel E.

Published
2015
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3. Spatial and Temporal Mapping of De Novo Mutations in Schizophrenia to a Fetal Prefrontal Cortical Network

Author

Braff, David, Cadenhead, Kristin S., Calkins, Monica E., Dobie, Dorcas J., Freedman, Robert, Green, Michael, Greenwood, Tiffany, Gur, Raquel E., Gur, Ruben C., Lazzeroni, Laura, Light, Gregory, Nuechterlein, Keith, Olincy, Ann, Radant, Al, Ray, Amrita, Schork, Nik, Seidman, Larry J., Siever, Larry, Silverman, Jeremy, Stone, William S., Sugar, Catherine, Swerdlow, Neal, Tsuang, Debby, Tsuang, Ming, Turetsky, Bruce, Aduroja, Tolulope, Allen, Trina, Bradford, L. Diane, Devlin, Bernie, Edwards, Neil B., Ganguli, Rohan, Go, Rodney C.P., Kwentus, Joseph, Lahti, Adrienne C., Lyons, Paul, Mathos, Kim, May, Roberta, McLeod-Bryant, Steve, McEvoy, Joseph P., Montgomery-Barefield, Laura, Nimgaonkar, Vishwajit L., O’Jile, Judith, Santos, Al, Savage, Robert M., Swanson, Charles L., Jr., Wilson, William, Gulsuner, Suleyman, Walsh, Tom, Watts, Amanda C., Lee, Ming K., Thornton, Anne M., Casadei, Silvia, Rippey, Caitlin, Shahin, Hashem, Swerdlow, Neal R., Braff, David L., King, Mary-Claire, and McClellan, Jon M.

Published
2013
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4. Group and site differences on the California Verbal Learning Test in persons with schizophrenia and their first-degree relatives: Findings from the Consortium on the Genetics of Schizophrenia (COGS)

Author

Stone, William S., Giuliano, Anthony J., Tsuang, Ming T., Braff, David L., Cadenhead, Kristin S., Calkins, Monica E., Dobie, Dorcas J., Faraone, Stephen V., Freedman, Robert, Green, Michael F., Greenwood, Tiffany A., Gur, Raquel E., Gur, Ruben C., Light, Gregory A., Mintz, Jim, Nuechterlein, Keith H., Olincy, Ann, Radant, Allen D., Roe, Andrea H., Schork, Nicholas J., Siever, Larry J., Silverman, Jeremy M., Swerdlow, Neal R., Thomas, Alison R., Tsuang, Debby W., Turetsky, Bruce I., and Seidman, Larry J.

Published
2011
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5. Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: Results from the Consortium on Genetics of Schizophrenia

Author

Olincy, Ann, Braff, David L., Adler, Lawrence E., Cadenhead, Kristin S., Calkins, Monica E., Dobie, Dorcas J., Green, Michael F., Greenwood, Tiffany A., Gur, Raquel E., Gur, Reuben C., Light, Gregory A., Mintz, James, Nuechterlein, Keith H., Radant, Allen D., Schork, Nicholas J., Seidman, Larry J., Siever, Larry J., Silverman, Jeremy M., Stone, William S., Swerdlow, Neal R., Tsuang, Debby W., Tsuang, Ming T., Turetsky, Bruce I., Wagner, Brandie D., and Freedman, Robert

Published
2010
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6. Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives: Findings from the Consortium on the Genetics of Schizophrenia

Author

Horan, William P., Braff, David L., Nuechterlein, Keith H., Sugar, Catherine A., Cadenhead, Kristin S., Calkins, Monica E., Dobie, Dorcas J., Freedman, Robert, Greenwood, Tiffany A., Gur, Raquel E., Gur, Ruben C., Light, Gregory A., Mintz, James, Olincy, Ann, Radant, Allan D., Schork, Nicholas J., Seidman, Larry J., Siever, Larry J., Silverman, Jeremy M., Stone, William S., Swerdlow, Neal R., Tsuang, Debbie W., Tsuang, Ming T., Turetsky, Bruce I., and Green, Michael F.

Published
2008
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7. Abnormal Auditory N100 Amplitude: A Heritable Endophenotype in First-Degree Relatives of Schizophrenia Probands

Author

Turetsky, Bruce I., Greenwood, Tiffany A., Olincy, Ann, Radant, Allen D., Braff, David L., Cadenhead, Kristin S., Dobie, Dorcas J., Freedman, Robert, Green, Michael F., Gur, Raquel E., Gur, Ruben C., Light, Gregory A., Mintz, James, Nuechterlein, Keith H., Schork, Nicholas J., Seidman, Larry J., Siever, Larry J., Silverman, Jeremy M., Stone, William S., Swerdlow, Neal R., Tsuang, Debby W., Tsuang, Ming T., and Calkins, Monica E.

Published
2008
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10. Multi-site studies of acoustic startle and prepulse inhibition in humans: Initial experience and methodological considerations based on studies by the Consortium on the Genetics of Schizophrenia

Author

Swerdlow, Neal R., Sprock, Joyce, Light, Gregory A., Cadenhead, Kristin, Calkins, Monica E., Dobie, Dorcas J., Freedman, Robert, Green, Michael F., Greenwood, Tiffany A., Gur, Raquel E., Mintz, Jim, Olincy, Ann, Nuechterlein, Keith H., Radant, Allen D., Schork, Nicholas J., Seidman, Larry J., Siever, Larry J., Silverman, Jeremy M., Stone, William S., Tsuang, Debbie W., Tsuang, Ming T., Turetsky, Bruce I., and Braff, David L.

Published
2007
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11. Successful multi-site measurement of antisaccade performance deficits in schizophrenia

Author

Radant, Allen D., Dobie, Dorcas J., Calkins, Monica E., Olincy, Ann, Braff, David L., Cadenhead, Kristin S., Freedman, Robert, Green, Michael F., Greenwood, Tiffany A., Gur, Raquel E., Light, Gregory A., Meichle, Sean P., Mintz, Jim, Nuechterlein, Keith H., Schork, Nicholas J., Seidman, Larry J., Siever, Larry J., Silverman, Jeremy M., Stone, William S., Swerdlow, Neal R., Tsuang, Ming T., Turetsky, Bruce I., and Tsuang, Debby W.

Published
2007
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12. Initial Heritability Analyses of Endophenotypic Measures for Schizophrenia: The Consortium on the Genetics of Schizophrenia

Author

Greenwood, Tiffany A., Braff, David L., Light, Gregory A., Cadenhead, Kristin S., Calkins, Monica E., Dobie, Dorcas J., Freedman, Robert, Green, Michael F., Gur, Raquel E., Gur, Ruben C., Mintz, Jim, Nuechterlein, Keith H., Olincy, Ann, Radant, Allen D., Seidman, Larry J., Siever, Larry J., Silverman, Jeremy M., Stone, William S., Swerdlow, Neal R., Tsuang, Debby W., Tsuang, Ming T., Turetsky, Bruce I., and Schork, Nicholas J.

Published
2007

13. The Consortium on the Genetics of Endophenotypes in Schizophrenia: Model Recruitment, Assessment, and Endophenotyping Methods for a Multisite Collaboration

Author

Calkins, Monica E., Dobie, Dorcas J., Cadenhead, Kristin S., Olincy, Ann, Freedman, Robert, Green, Michael F., Greenwood, Tiffany A., Gur, Raquel E., Gur, Ruben C., Light, Gregory A., Mintz, Jim, Nuechterlein, Keith H., Radant, Allen D., Schork, Nicholas J., Seidman, Larry J., Siever, Larry J., Silverman, Jeremy M., Stone, William S., Swerdlow, Neal R., Tsuang, Debby W., Tsuang, Ming T., Turetsky, Bruce I., and Braff, David L.

Published
2007

22. Genome-Wide Linkage Analyses of 12 Endophenotypes for Schizophrenia From the Consortium on the Genetics of Schizophrenia.

Author

Greenwood, Tiffany A., Swerdlow, Neal R., Gur, Raquel E., Cadenhead, Kristin S., Calkins, Monica E., Dobie, Dorcas J., Freedman, Robert, Green, Michael F., Gur, Ruben C, lazzeroni, taura C., Nuechterlein, Keith H., Oiincy, Ann, Radant, Allen D., Ray, Amrita, Schork, Nicholas J., Seidman, Larry J., Siever, Larry J., Silverman, Jeremy M., Stone, William S., and Sugar, Catherine A.

Subjects
GENETICS of schizophrenia, PHENOTYPES, HERITABILITY, REGRESSION analysis, NEURODEGENERATION, CONTINUOUS performance test, SINGLE nucleotide polymorphisms
Abstract

Objective: The Consortium on the Genetics of Schizophrenia has undertaken a large multisite study to characterize 12 neurophysiological and neurocognitive endophenotypic measures as a step toward understanding the complex genetic basis of schizophrenia. The authors previously demonstrated the heritability of these endophenotypes; in the present study, genetic linkage was evaluated. Method: Each family consisted of a proband with schizophrenia, at least one unaffected sibling, and both parents. A total of 1,286 participants from 296 families were genotyped in two phases, and 1,004 individuals were also assessed for the endophenotypes. Linkage analyses of the 6,055 singlenucleotide polymorphisms that were successfully assayed, 5,760 of which were common to both phases, were conducted using both variance components and pedigreewide regression methods. Results: Linkage analyses of the 12 endophenotypes collectively identified one region meeting genome-wide significance criteria, with a LOD (log of odds) score of 4.0 on chromosome 3p14 for the antisaccade task, and another region on 1p36 nearly meeting genome-wide significance, with a LOD score of 3.5 for emotion recognition. Chromosomal regions meeting genome-wide suggestive criteria with LOD scores >2.2 were identified for spatial processing (2p25 and 16q23), sensorimotor dexterity (2q24 and 2q32), prepulse inhibition (5p15), the California Verbal Learning Test (8q24), the degradedstimulus Continuous Performance Test (10q26), face memory (10q26 and 12p12), and the Letter-Number Span (14q23). Conclusions: Twelve regions meeting genome-wide significant and suggestive criteria for previously identified heritable, schizophrenia-related endophenotypes were observed, and several genes of potential neurobiological interest were identified. Replication and further genomic studies are needed to assess the biological significance of these results. [ABSTRACT FROM AUTHOR]

Published
2013
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23. Antisaccade performance in schizophrenia patients, their first-degree biological relatives, and community comparison subjects: Data from the COGS study.

Author

Radant, Allen D., Dobie, Dorcas J., Calkins, Monica E., Olincy, Ann, Braff, David L., Cadenhead, Kristin S., Freedman, Robert, Green, Michael F., Greenwood, Tiffany A., Gur, Raquel E., Gur, Ruben C., Light, Gregory A., Meichle, Sean P., Millard, Steve P., Mintz, Jim, Nuechterlein, Keith H., Schork, Nicholas J., Seidman, Larry J., Siever, Larry J., and Silverman, Jeremy M.

Subjects
*EYE movements, *PEOPLE with schizophrenia, *SCHIZOTYPAL personality disorder, *PERFORMANCE evaluation, *GENETIC polymorphisms, *PSYCHOPHYSIOLOGY
Abstract

The antisaccade task is a widely used technique to measure failure of inhibition, an important cause of cognitive and clinical abnormalities found in schizophrenia. Although antisaccade performance, which reflects the ability to inhibit prepotent responses, is a putative schizophrenia endophenotype, researchers have not consistently reported the expected differences between first-degree relatives and comparison groups. Schizophrenia participants ( n=219) from the large Consortium on the Genetics of Schizophrenia (COGS) sample ( n=1078) demonstrated significant deficits on an overlap version of the antisaccade task compared to their first-degree relatives ( n=443) and community comparison subjects (CCS; n=416). Although mean antisaccade performance of first-degree relatives was intermediate between schizophrenia participants and CCS, a linear mixed-effects model adjusting for group, site, age, and gender found no significant performance differences between the first-degree relatives and CCS. However, admixture analyses showed that two components best explained the distributions in all three groups, suggesting two distinct doses of an etiological factor. Given the significant heritability of antisaccade performance, the effects of a genetic polymorphism is one possible explanation of our results. [ABSTRACT FROM AUTHOR]

Published
2010
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24. Screening for Substance Abuse and Psychiatric Disorders Among Women Patients in a VA Health Care System.

Author

Davis, Tania M., Bush, Kristen R., Kivlahan, Daniel R., Dobie, Dorcas J., and Bradley, Katharine A.

Abstract

Objective: This study of women Veterans Affairs (VA) health care patients screened for the prevalence of past-year smoking, hazardous and problem drinking, other drug abuse, and psychiatric disorders. Methods: A survey was mailed to women veterans who had received care from VA Puget Sound Health Care System between October 1, 1996, and January 1, 1998. Screening measures included questions about cigarettes; questions from the Alcohol Use Disorders Identification Test about consumption (hazardous drinking); the TWEAK test (problem drinking); a drug abuse screen; the Patient Health Questionnaire (psychiatric conditions); and the PTSD (posttraumatic stress disorder) Checklist. Results: Of eligible patients, 1,257 (65 percent) returned surveys with complete substance use data. Patients reported a relatively high rate of past-year smoking (29.1 percent) and hazardous drinking, problem drinking, or both (31.1 percent). The rate of past-year drug use was much lower (4.9 percent). Younger age was strongly associated with greater substance abuse: 59 percent of women under age 35 screened positive for smoking, hazardous or problem drinking, or drug abuse. Screening positive for a psychiatric condition (N=504) was also associated with substance abuse: The rate of past-year drug abuse among women screening positive for a psychiatric condition (9.7 percent) was double the rate for the entire sample. Of the women who screened positive for depression, PTSD, eating disorders, or panic disorders, 57 percent screened positive for substance abuse (including smoking). Conclusions: Substance abuse is common among women VA patients and is associated with younger age and with screening positive for other psychiatric conditions. Providers are expected to follow up on positive screening tests, and these data indicate substantial provider burden. [ABSTRACT FROM AUTHOR]

Published
2003
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37. A brief readiness to change drinking algorithm: Concurrent validity in female VA primary care patients

Author

Epler, Amee J., Kivlahan, Daniel R., Bush, Kristen R., Dobie, Dorcas J., and Bradley, Katharine A.

Subjects
*ALCOHOL, *ALGORITHMS, *ALCOHOL drinking, *MEDICAL care
Abstract

Brief primary care interventions for alcohol use should be tailored to patients'' readiness to change; however, validated measures of readiness to change are too lengthy to be practical in most primary care settings. We compared a readiness to change drinking algorithm (RTC Algorithm) based on three standardized questions to a validated 12-item readiness to change questionnaire (Rollnick RTCQ) in 85 hazardous drinking female Veterans Affairs (VA) patients. Results from comparisons of mean Rollnick RTCQ scale scores across RTC Algorithm categories suggest good concurrent validity. Regular assessment using the RTC Algorithm questions may help primary care providers tailor alcohol-related discussions with hazardous drinking patients. [Copyright &y& Elsevier]

Published
2005
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