414 results on '"Dick, C"'
Search Results
2. Predicting and measuring service disruption recovery time in railway gravity hump classification yards
- Author
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Zhao, Jiaxi and Dick, C. Tyler
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- 2024
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3. Addressing genetic and environmental sources of cardiometabolic disease
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Watts, Gerald F. and Chan, Dick C.
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- 2024
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4. Real-world experience of long-term efficacy and safety of evinacumab in patients with homozygous familial hypercholesterolemia treated and not treating with lipoprotein apheresis
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Stefanutti, Claudia, Chan, Dick C., Dip, Giovanna Zeppa, and Watts, Gerald F.
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- 2024
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5. Radiology reporting of incidental osteoporotic vertebral fragility fractures present on CT studies: results of UK national re-audit
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Barrett, A., Chandegra, A., Dabbas, A., Dhillon, A., Elstob, A., Kamalasanan, A., Mirza, A., Mohamed, A., Neelakantan, A., Paddon, A., Patel, A., Radhakrishnan, A., Shah, A., Shenton, A., Teibe, A., Dharmarajah, B., Chisholm, C., Cummins, C., Dick, C., Hauff, C., McKeown, C., O'Mahony, C., Campbell, D., Howarth, D., Kitsos, D., Temperley, D., Hubraq, A., Adiotomre, E., Gerety, E., Jackson, E., Skondras, E., Barley, F., Chinwalla, F., Haque, F., Williams, F., Witham, F., Agrawal, G., Tse, G., Tudor, G., Conley, H., Halbert, H., Kolanjian, H., Moss, H., Anwar, I., Ghany, J., Green, J., Hare, J., Howard, J., Jalli, J., Lastik, J., Moloney, J., Taylor, J., Walker, J., Warner, J., Wylie, J., J-Y Chan, Asante, K., Faraj, K., Harrison, K., Hodnett, K., Hussain, K., Karamani, K., Muir, K., Patel, K., Shirodkar, K., Singh, K., Tan, K., Taylor, K., Boyce, L., Chandrasekharan, L., Abdallah, M., Alkhouly, M., Bodoceanu, M., Brochwicz-Lewinski, M., Clark, M., Drumea, M., Fahmy, M., Hassan, M., Kamal, M., Kay, M., Mohan, M., Portet, M., Sampson, M., Siddiqui, M., Srivastava, M., Szewczyk-Bieda, M., Tapp, M., Hattangadi, N., Lyle, N., Matcham, N., Cram, O., Thomas, O., Govind, P., Patel, P., Sharma, P., Vasanthraj, P., Blacow, R., Dwarkanath, R., Frost, R., Gray, R., Greenhalgh, R., Gupta, R., Holmes, R., Jagdale, R., Patel, R., Smyth, R., Thiagarajah, R., Walker, R., Atwal, S., Cordell, S., David, S., Gaba, S., Green, S., Hashem, S., Kanan, S., Kaneria, S., Leach, S., Lim, S., Meena, S., Patel, S., Singh, S., Thampy, S., Amies, T., Ninan, T., Thomas, T., Bhopal, U., Raja, U., Dhir, V., Gnanananthan, V., Rao, V., Pang, W., Wu, Y., Arnold, T., Howlett, D.C., Drinkwater, K.J., Mahmood, N., Salman, L., Griffin, J., Javaid, M.K., Retnasingam, G., and Marzoug, A.
- Published
- 2023
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6. Adherence to pharmacotherapy: sine qua non for reducing cumulative risk of premature coronary disease in familial hypercholesterolemia
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Pang, Jing, Sanfilippo, Frank M., Chan, Dick C., and Watts, Gerald F.
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- 2024
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7. The Promise of PCSK9 and Lipoprotein(a) as Targets for Gene Silencing Therapies
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Chan, Dick C. and Watts, Gerald F.
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- 2023
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8. RNA interference therapy for targeting ANGPTL3 and atherogenic lipoproteins: Findings and implications of a recent phase I study
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Gerald F. Watts and Dick C. Chan
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Medicine (General) ,R5-920 - Published
- 2023
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9. Probabilistic risk analysis of unit trains versus manifest trains for transporting hazardous materials
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Kang, Di, Zhao, Jiaxi, Tyler Dick, C., Liu, Xiang, Bian, Zheyong, Kirkpatrick, Steven W., and Lin, Chen-Yu
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- 2023
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10. Cost impact of undertaking detection and management of familial hypercholesterolaemia in Australian general practice
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Li, Ian W, Watts, Rory, Brett, Tom, Radford, Jan, Heal, Clare, Gill, Gerard, Hespe, Charlotte, Vargas-Garcia, Cristian, Sullivan, David R, Vickery, Alistair W, Pang, Jing, Arnold-Reed, Diane E, Chan, Dick C, and Watts, Gerald F
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- 2022
11. An Analysis of the Gut Microbiota and Related Metabolites following PCSK9 Inhibition in Statin-Treated Patients with Elevated Levels of Lipoprotein(a)
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Jose A. Caparrós-Martín, Patrice Maher, Natalie C. Ward, Montserrat Saladié, Patricia Agudelo-Romero, Stephen M. Stick, Dick C. Chan, Gerald F. Watts, and Fergal O’Gara
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PCSK9 ,alirocumab ,statins ,LDL ,cholesterol ,gut microbiota ,Biology (General) ,QH301-705.5 - Abstract
Background. Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of global mortality, often associated with high blood levels of LDL cholesterol (LDL-c). Medications like statins and PCSK9 inhibitors, are used to manage LDL-c levels and reduce ASCVD risk. Recent findings connect the gut microbiota and its metabolites to ASCVD development. We showed that statins modulate the gut microbiota including the production of microbial metabolites involved in the regulation of cholesterol metabolism such as short chain fatty acids (SCFAs) and bile acids (BAs). Whether this pleiotropic effect of statins is associated with their antimicrobial properties or it is secondary to the modulation of cholesterol metabolism in the host is unknown. In this observational study, we evaluated whether alirocumab, a PCSK9 inhibitor administered subcutaneously, alters the stool-associated microbiota and the profiles of SCFAs and BAs. Methods. We used stool and plasma collected from patients enrolled in a single-sequence study using alirocumab. Microbial DNA was extracted from stool, and the bacterial component of the gut microbiota profiled following an amplicon sequencing strategy targeting the V3-V4 region of the 16S rRNA gene. Bile acids and SCFAs were profiled and quantified in stool and plasma using mass spectrometry. Results. Treatment with alirocumab did not alter bacterial alpha (Shannon index, p = 0.74) or beta diversity (PERMANOVA, p = 0.89) in feces. Similarly, circulating levels of SCFAs (mean difference (95% confidence interval (CI)), 8.12 [−7.15–23.36] µM, p = 0.25) and BAs (mean difference (95% CI), 0.04 [−0.11–0.19] log10(nmol mg−1 feces), p = 0.56) were equivalent regardless of PCSK9 inhibition. Alirocumab therapy was associated with increased concentration of BAs in feces (mean difference (95% CI), 0.20 [0.05–0.34] log10(nmol mg−1 feces), p = 0.01). Conclusion. In statin-treated patients, the use of alirocumab to inhibit PCSK9 leads to elevated levels of fecal BAs without altering the bacterial population of the gut microbiota. The association of alirocumab with increased fecal BA concentration suggests an additional mechanism for the cholesterol-lowering effect of PCSK9 inhibition.
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- 2024
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12. A variant in the fibronectin (FN1) gene, rs1250229-T, is associated with decreased risk of coronary artery disease in familial hypercholesterolaemia
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Page, Michael M., Ellis, Katrina L., Chan, Dick C., Pang, Jing, Hooper, Amanda J., Bell, Damon A., Burnett, John R., Moses, Eric K., and Watts, Gerald F.
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- 2022
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13. Cascade testing for elevated lipoprotein(a) in relatives of probands with high lipoprotein(a)
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Chakraborty, Anindita, Chan, Dick C., Ellis, Katrina L., Pang, Jing, Barnett, Wendy, Woodward, Ann Marie, Vorster, Mary, Norman, Richard, Moses, Eric K., and Watts, Gerald F.
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- 2022
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14. Recent advances in demystifying the metabolism of lipoprotein(a)
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Chemello, Kévin, Chan, Dick C., Lambert, Gilles, and Watts, Gerald F.
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- 2022
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15. Cascade testing for elevated lipoprotein(a) in relatives of probands with familial hypercholesterolaemia and elevated lipoprotein(a)
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Chakraborty, Anindita, Pang, Jing, Chan, Dick C., Ellis, Katrina L., Hooper, Amanda J., Bell, Damon A., Burnett, John R., Moses, Eric K., and Watts, Gerald F.
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- 2022
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16. Is type 2 diabetes associated dementia a microvascular early-Alzheimer’s phenotype induced by aberrations in the peripheral metabolism of lipoprotein-amyloid?
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Ryusuke Takechi, Arazu Sharif, Emily Brook, Maimuna Majimbi, Dick C. Chan, Virginie Lam, Gerald F. Watts, and John C. L. Mamo
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amyloid ,diabetes ,Alzheimer’s ,lipoprotein ,triglycerides ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
There is increasing evidence of a positive association of type 2 diabetes with Alzheimer’s disease (AD), the most prevalent form of dementia. Suggested pathways include cerebral vascular dysfunction; central insulin resistance, or exaggerated brain abundance of potentially cytotoxic amyloid-β (Aβ), a hallmark feature of AD. However, contemporary studies find that Aβ is secreted in the periphery by lipogenic organs and secreted as nascent triglyceride-rich lipoproteins (TRL’s). Pre-clinical models show that exaggerated abundance in blood of TRL-Aβ compromises blood-brain barrier (BBB) integrity, resulting in extravasation of the TRL-Aβ moiety to brain parenchyme, neurovascular inflammation and neuronal degeneration concomitant with cognitive decline. Inhibiting secretion of TRL-Aβ by peripheral lipogenic organs attenuates the early-AD phenotype indicated in animal models, consistent with causality. Poorly controlled type 2 diabetes commonly features hypertriglyceridemia because of exaggerated TRL secretion and reduced rates of catabolism. Alzheimer’s in diabetes may therefore be a consequence of heightened abundance in blood of lipoprotein-Aβ and accelerated breakdown of the BBB. This review reconciles the prevailing dogma of amyloid associated cytotoxicity as a primary risk factor in late-onset AD, with substantial evidence of a microvascular axis for dementia-in-diabetes. Consideration of potentially relevant pharmacotherapies to treat insulin resistance, dyslipidaemia and by extension plasma amyloidemia in type 2 diabetes are discussed.
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- 2023
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17. Awareness of familial hypercholesterolaemia in Australian primary care: A qualitative descriptive study
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Bulsara, Caroline, Brett, Tom, Radford, Jan, Heal, Clare, Gill, Gerard, Hespe, Charlotte Mary, Vargas‑Garcia, Cristian, Li, Ian W, Sullivan, David R, Vickery, Alistair W, Pang, Jing, Arnold-Reed, Diane, Chan, Dick C, and Watts, Gerald F
- Published
- 2021
18. Implications of new clinical practice guidance on familial hypercholesterolaemia for Australian general practitioners
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Brett, Tom, Radford, Jan, Heal, Clare, Hespe, Charlotte Mary, Garton-Smith, Jacquie, Kirke, Andrew, Chan, Dick C, Pang, Jing, and Watts, Gerald F
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- 2021
19. Influence of mainline schedule flexibility and volume variability on railway classification yard performance
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Dick, C. Tyler
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- 2021
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20. Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study
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Glasbey, James, Ademuyiwa, Adesoji, Adisa, Adewale, AlAmeer, Ehab, Arnaud, Alexis P, Ayasra, Faris, Azevedo, José, Minaya-Bravo, Ana, Costas-Chavarri, Ainhoa, Edwards, John, Elhadi, Muhammed, Fiore, Marco, Fotopoulou, Christina, Gallo, Gaetano, Ghosh, Dhruva, Griffiths, Ewen A, Harrison, Ewen, Hutchinson, Peter, Lawani, Ismail, Lawday, Samuel, Lederhuber, Hans, Leventoglu, Sezai, Li, Elizabeth, Gomes, Gustavo Mendonça Ataíde, Mann, Harvinder, Marson, Ella J, Martin, Janet, Mazingi, Dennis, McLean, Kenneth, Modolo, Maria, Moore, Rachel, Morton, Dion, Ntirenganya, Faustin, Pata, Francesco, Picciochi, Maria, Pockney, Peter, Ramos-De la Medina, Antonio, Roberts, Keith, Roslani, April Camilla, Kottayasamy Seenivasagam, Rajkumar, Shaw, Richard, Simões, Joana Filipa Ferreira, Smart, Neil, Stewart, Grant D, Sullivan, Richard, Sundar, Sudha, Tabiri, Stephen, Taylor, Elliott H, Vidya, Raghavan, Nepogodiev, Dmitri, Bhangu, Aneel, Glasbey, James C, Bhangu, Aneel A, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Chaudhry, Daoud, Dawson, Brett E, Evans, Jonathan P, Gujjuri, Rohan R, Heritage, Emily, Jones, Conor S, Kamarajah, Sivesh K, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Mann, Harvinder S, McLean, Kenneth A, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Tiwari, Abhinav, Simoes, Joana FF, Trout, Isobel M, Venn, Mary L, Wilkin, Richard JW, Smart, Neil J, Moug, Susan, Di Saverio, Salomone, Vallance, Abigail, Vimalchandran, Dale, Evans, Richard PT, Townend, Philip, McKay, Siobhan, Isaac, John, Satoi, Sohei, Coonar, Aman S, Marchbank, Adrian, Caruana, Edward J, Layton, Georgia R, Patel, Akshay, Brunelli, Alessandro, Ford, Samuel, Desai, Anant, Gronchi, Alessandro, Almond, Max, Tirotta, Fabio, Dumitra, Sinziana, Kolias, Angelos, Price, Stephen J, Fountain, Daniel M, Jenkinson, Michael D, Marcus, Hani J, Piper, Rory J, Lippa, Laura, Servadei, Franco, Esene, Ignatius, Freyschlag, Christian, Neville, Iuri, Rosseau, Gail, Schaller, Karl, Demetriades, Andreas K, Robertson, Faith, Alamri, Alex, Schache, Andrew G, Winter, Stuart C, Ho, Michael, Nankivell, Paul, Rey Biel, Juan, Batstone, Martin, Ganly, Ian, Wilkins, Alex, Singh, Jagdeep K, Thekinkattil, Dinesh, Leung, Elaine YL, Khan, Tabassum, Chiva, Luis, Sehouli, Jalid, Fagotti, Anna, Cohen, Paul, Gutelkin, Murat, Ghebre, Rahel, Konney, Thomas, Pareja, Rene, Bristow, Rob, Dowdy, Sean, Shylasree, TS, Ng, Joe, Fujiwara, Keiichi, Lamb, Benjamin, Narahari, Krishna, McNeill, Alan, Colquhoun, Alexandra, McGrath, John S, Bromage, Steve, Barod, Ravi, Kasivisvanathan, Veeru, Klatte, Tobias, Abbott, Tom EF, Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeier, Markus, Alser, Osaid, Alshaar, Muhammad, Alshryda, Sattar, Augestad, Knut Magne, Bankhead-Kendall, Brittany K, Barlow, Emma, Beard, David, Blanco-Colino, Ruth, Brar, Amanpreet, Breen, Kerry A, Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Cunha, Miguel F, Davidson, Giana H, Drake, Thomas M, Edwards, John G, Emile, Sameh, Farik, Shebani, Fitzgerald, J Edward, Garmanova, Tatiana, Grecinos, Gustavo, Gruendl, Magdalena, Halkias, Constantine, Harrison, Ewen M, Hisham, Intisar, Hutchinson, Peter J, Hwang, Shelley, Isik, Arda, Jonker, Pascal, Kaafarani, Haytham MA, Keller, Debby, Kruijff, Schelto, Litvin, Andrey, Loehrer, Andrew, Löffler, Markus W, Lorena, Maria Aguilera, Modolo, Maria Marta, Major, Piotr, Mashbari, Hassan N, Metallidis, Symeon, Mohan, Helen M, Moszkowicz, David, Ng-Kamstra, Joshua S, Maimbo, Mayaba, Negoi, Ionut, Niquen, Milagros, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Rivera, Carlos Jose Perez, Pinkney, Thomas D, van der Plas, Willemijn, Qureshi, Ahmad, Radenkovic, Dejan, Richards, Toby, Roslani, April C, Rutegård, Martin, Segura-Sampedro, Juan José, Santos, Irène, Sayyed, Raza, Schache, Andrew, Schnitzbauer, Andreas A, Seyi-Olajide, Justina O, Sharma, Neil, Shaw, Catherine A, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Sund, Malin, Tsoulfas, Georgios, van Ramshorst, Gabrielle H, Vimalachandran, Dale, Warren, Oliver J, Wedderburn, Duane, Wright, Naomi, EuroSurg, Booth, Lesley, Runigamugabo, Emmy, Barker, Margaret, Barker, Neil, Cooke, Shirley, Doré, Suzanne, Horwood, Nigel, Tierney Weir, Carrie, Dajti, I, Allemand, C, Boccalatte, LA, Figari, M, Lamm, M, Larrañaga, J, Marchitelli, C, Noll, F, Odetto, D, Perrotta, M, Saadi, J, Zamora, L, Ballester, AM, Tapper, KE, Zeff, N, Valenzuela, JI, Alurralde, C, Anastasio, J, Apas Perez de Nucci, A, Caram, EL, Eskinazi, D, Mendoza, JP, Usandivaras, M, Badra, R, Esteban, A, García, JS, García, PM, Gerchunoff, JI, Lucchini, SM, NIgra, MA, Vargas, L, Hovhannisyan, T, Stepanyan, A, Vasey, CE, Watson, EGR, Ip, C, Kealey, J, Lim, CSH, Sengupta, S, Ward, S, Wong, E, Gould, T, Gourlay, R, Griffiths, B, Gananadha, S, McLaren, M, Cecire, J, Joshi, N, Salindera, S, Sutherland, A, Ahn, JH, Charlton, G, Chen, S, Gauri, N, Hayhurst, R, Jang, S, Jia, F, Mulligan, C, Yang, W, Ye, G, Zhang, H, Ballal, M, Gibson, D, Hayne, D, McMillan, H, Moss, J, Pugliese, MJ, Richards, T, Seow, YTN, Thian, A, Viswambaram, P, Vo, UG, Bennetts, J, Bright, T, Brooke-Smith, M, Fong, R, Gricks, B, Huang, L, Lam, YH, Nathan, A, Ong, BS, Ooi, E, Szpytma, M, Watson, D, Bagraith, K, Caird, S, Chan, E, Dawson, C, Ho, D, Hui, N, Izwan, S, Jeyarajan, E, Jordan, S, Liang, R, Lim, A, Nolan, GJ, Oar, A, Parker, D, Puhalla, H, Quennell, A, Rutherford, L, Sommerville, C, Townend, P, Von Papen, M, Wullschleger, M, Dawson, AC, Drane, A, Blatt, A, Cope, D, Egoroff, N, Fenton, M, Gani, J, Lott, N, Pockney, P, Shugg, N, Elliott, M, Phung, D, Phan, D, Townend, D, Bong, C, Gundara, J, Frankel, A, Bowman, S, Guerra, GR, Gerns, N, McGeorge, S, Riddell, A, Roberts, M, Rukin, N, Bolt, J, Buddingh, K, Dudi-Venkata, NN, Jog, S, Kroon, HM, Sammour, T, Smith, R, Stranz, C, Batstone, M, Lah, K, McGahan, W, Mitchell, D, Morton, A, Pearce, A, Sheahan, G, Swinson, B, Waldron, A, Walker, P, Alam, N, Banting, S, Chong, L, Choong, P, Clatworthy, S, Foley, D, Fox, A, Hii, MW, Knowles, B, Mack, J, Read, M, Rowcroft, A, Wright, G, Lun, EWY, Lanner, M, Burtscher, J, Trivik-Barrientos, F, Königsrainer, I, Bauer, M, Freyschlag, C, Kafka, M, Messner, F, Öfner, D, Tsibulak, I, Holawe, S, Zimmermann, M, Emmanuel, K, Grechenig, M, Gruber, R, Harald, M, Öhlberger, L, Presl, J, Wimmer, A, Namazov, I, Samadov, E, Barker, D, Boyce, R, Corbin, S, Doyle, A, Eastmond, A, Gill, R, Haynes, A, Millar, S, O'Shea, M, Padmore, G, Paquette, N, Phillips, E, St. John, S, Walkes, K, Abeloos, J, De Backer, T, De Ceulaer, J, Dick, C, Diez-Fraile, A, Lamoral, P, Spaas, C, Ceelen, W, Pattyn, P, Van de putte, D, Van Nieuwenhove, Y, Van Ramshorst, G, Willaert, W, Bazzett-Matabele, L, Chiyapo, SP, Ramogola-Masire, D, Ramontshonyana, G, Seiphetlheng, A, Vuylsteke, P, Abdallah, EA, Aguiar Júnior, S, Baiocchi, G, Carvalho, GB, Coimbra, FJF, Kowalski, LP, Makdissi, F, Marques, N, Marques, T, Soares Dos Santos, S, Tirapelli Gonçalves, B, Vartanian, JG, Dos Reis, R, Camara, P, De Lima, RK, Della Giustina, E, Hoffmann, PV, Gatti, A, Nardi, C, Oliva, R, Nacif, L, Carvalho Ferro, C, Gomes Mendonça Ataíde, G, Lima Buarque, I, Lira dos Santos Leite, A, Pol-Fachin, L, Santos Bezerra, T, Maylson Ramos da Silva, A, Windson de Araújo Silvestre, D, Vieira Barros, A, Campbell, L, De Cicco, R, Cecconello, I, Gregorio, P, Pontual Lima, L, Ribeiro Junior, U, Takeda, FR, Terra, RM, Faccini Teixeira, M, Kulcsar, MAV, Matos, LL, Nunes, KS, Laporte, G, Salem, M, Barakat Awada, J, Ijichi, TR, Kim, NJ, Marreiro, A, Muller, B, Nunes, R, Bodanese, B, Eidt, ER, Isoton, JC, Lemos Vieira da Cunha, M, Regina de Sampaio, L, Vendrame, C, Zeni, M, Zortéa, JA, Zortéa, MR, Sokolov, M, Kidane, B, Srinathan, S, Munro, A, Helyer, L, McKeen, D, Boutros, M, Caminsky, NG, Ghitulescu, G, Jamjoum, G, Moon, J, Pelletier, J, Vanounou, T, Wong, S, Cheng, D, MacNeil, SD, Martin, J, Dumitra, S, Kouyoumdjian, A, Schmid, S, Spicer, J, Agarwal, A, Brar, A, Dada, J, Dare, A, Hameed, U, Osman, F, Johnston, B, Russell, C, Groot, G, Persad, A, Pham, H, Wood, M, Ko, M, Rajendran, L, Demyttenaere, S, Garfinkle, R, Brown, C, Karimuddin, A, Lee, N, Liu, J, Madani Kia, T, Phang, PT, Raval, M, Tom, K, Abou-Khalil, J, Martel, A, Nessim, C, Stevenson, J, Al Riyami, S, Bali, K, Bigam, D, Dajani, K, Dell, A, Modolo, MM, Ramirez Nieto, P, Sepulveda, R, Molero, A, Bolbaran, A, Ruiz, I, Heredia, F, Bellolio, F, Besser, N, Grasset, E, Guaman, JO, Inzunza, M, Irarrázaval, MJ, Jarry, C, Quintana Martinic, M, Riquoir Altamirano, C, Romero Manqui, CA, Ruiz Esquide, M, Vargas Añazco, C, Almeciga, A, Fletcher, A, Merchan, A, Quijano, T, Sanabria, D, Arias-Amézquita, F, Cétares, C, Cortes Murgueitio, N, Gomez-Mayorga, JL, Herrera-Almario, G, Rodriguez, J, Iglesias, P, Puentes, LO, Calvache, JA, Orozco-Chamorro, CM, Rojas, DA, Sánchez-Gómez, A, Abadia, M, Acosta, J, Angel Aristizabal, J, Bonilla, A, Caicedo, L, Calderon Quiroz, PH, Cervera Bonilla, S, Diaz, S, Facundo, H, Garcia Mora, M, Guevara, O, Guzman, L, Herrera Mora, DR, Jimenez Ramirez, LJ, Lehmann, C, Manrique, E, Mariño, I, Medina, M, Pinilla Morales, RE, Puerto, A, Puerto Horta, J, Quintero, M, Rey Ferro, M, Saénz, A, Santana, D, Serrano, W, Suescun, O, Trujillo Sanchez, LM, Velasquez Cuasquen, BG, Mendoza Quevedo, J, Bacic, G, Karlovic, D, Kršul, D, Zelic, M, Luksic, I, Mamic, M, Bacic, I, Bakmaz, B, Coza, I, Dijan, E, Katusic, Z, Mihanovic, J, Morovic, D, Rakvin, I, Almezghwi, H, Arslan, K, Besim, H, Özant, A, Özçay, N, Frantzeskou, K, Gouvas, N, Kokkinos, G, Papatheodorou, P, Pozotou, I, Stavrinidou, O, Yiallourou, A, Martinek, L, Skrovina, M, Straka, M, Szubota, I, Peteja, M, Žatecký, J, Javurkova, V, Klat, J, Antony, S, Avlund, T, Berg, KD, Borre, M, Christensen, P, Elkjær, MC, Ernst, A, Fensman, SK, Haldrup, M, Harbjerg, JL, Iversen, LH, Jensen, PT, Jeppesen, TD, Kjaer, DW, Kristensen, HØ, Lund, N, Maigaard Axelsen, S, Mekhael, M, Mikic, N, Ostenfeld, EB, Ebbehøj, AL, Krarup, P, Schlesinger, N, Smith, H, Batista, S, Crespo, A, Díaz, PJ, Rivas, R, Rodriguez-Abreu, J, Tactuk, N, El Kassas, M, Omar, W, Tawheed, A, Talaat, M, Abdelsamed, A, Azzam, AY, Salem, H, Seleim, A, Abdelmajeed, A, Abdou, M, Abosamak, NE, AL Sayed, M, Ashoush, F, Atta, R, Elazzazy, E, Elnemr, M, Elsayed Hewalla, ME, Elsherbini, I, Essam, E, Ewedah, M, Ghallab, I, Hassan, E, Ibrahim, M, Metwalli, M, Mourad, M, Qatora, MS, Ragab, M, Sabry, A, Saifeldin, H, Samih, A, Samir Abdelaal, A, Shehata, S, Shenit, K, Attia, D, Kamal, N, Osman, N, Abbas, AM, Abd Elazeem, HAS, Abd-Elkariem, AY, Abdelkarem, MM, Alaa, S, Ashraf, M, Ayman, A, Azizeldine, MG, Elkhayat, H, Emad Mashhour, A, Gaber, M, Hamza, HM, Hawal, I, Hetta, HF, K. Ali, A, M.elghazaly, S, Mohammed, MM, Monib, FA, Nageh, MA, Saad, A, Saad, MM, Shahine, M, Yousof, EA, Youssef, A, El-Deeb, M, Fawzy, M, Ghaly, G, Ibraheem, M, Eldaly, A, Esmail, E, ElFiky, M, Nabil, A, Alrahawy, M, Sakr, A, Soliman, H, Soltan, H, Amira, G, Sallam, I, Sherief, M, Sherif, A, Abdelrahman, A, Aboulkassem, H, Hamdy, R, Morsi, A, Sherif, G, Abdeldayem, H, Abdelkader Salama, I, Balabel, M, Fayed, Y, Sherif, AE, Elmorsi, R, Emile, S, Refky, B, Abd-elsalam, S, Badr, H, Elbahnasawy, M, Elzoghby, M, Essa, M, Gamal Badr, S, Ghoneim, A, Hamad, O, Hamada, M, Hammad, M, Hawila, A, Morsy, MS, Salman, S, Sarsik, S, Bekele, K, Kauppila, JH, Sarjanoja, E, Helminen, O, Huhta, H, Beyrne, C, Jouffret, L, Lugans, L, Marie-Macron, L, Chouillard, E, De Simone, B, Fredon, F, Roux, A, Bettoni, J, Dakpé, S, Devauchelle, B, Lavagen, N, Testelin, S, Boucher, S, Breheret, R, Gueutier, A, Kahn, A, Kün-Darbois, J, Barrabe, A, Lakkis, Z, Louvrier, A, Manfredelli, S, Mathieu, P, Chebaro, A, Drubay, V, El amrani, M, Eveno, C, Lecolle, K, Legault, G, Martin, L, Piessen, G, Pruvot, FR, Truant, S, Zerbib, P, Ballouhey, Q, Barrat, B, Fourcade, L, Laloze, J, Salle, H, Taibi, A, Tricard, J, Usseglio, J, Bergeat, D, Merdrignac, A, Le Roy, B, Perotto, LO, Scalabre, A, Gornes, H, Vaysse, C, Vergriete, K, Aimé, A, Ezanno, A, Malgras, B, Arnaud, AP, Fustec, E, Lavoue, V, Tesson, C, Bouche, P, Tzedakis, S, Cotte, E, Glehen, O, Lifante, J, Bendjemar, L, Braham, H, Charre, L, El Arbi, N, Morel-chevillet, L, Police, A, Villefranque, V, Volpin, E, D'Urso, A, Felli, E, Mutter, D, Pessaux, P, Seeliger, B, Barbé, Y, Bardet, J, Barret, E, Berry, R, Boddaert, G, Bonnet, S, Brian, E, Cathala, N, Cathelineau, X, Denet, C, Fuks, D, Gossot, D, Grigoroiu, M, Laforest, A, Levy-Zauberman, Y, Louis-Sylvestre, C, Macek, P, Mombet, A, Moumen, A, Pourcher, G, Rozet, F, Sanchez Salas, R, Seguin-givelet, A, Tribillon, E, Crenn, V, De Vergie, S, Duchalais, E, Espitalier, F, Ferron, C, Fragnaud, H, Malard, O, Regenet, N, Rigaud, J, Varenne, Y, Waast, D, Bork, U, Distler, M, Fritzmann, J, Kirchberg, J, Praetorius, C, Riediger, C, Weitz, J, Welsch, T, Wimberger, P, Beyer, K, Kamphues, C, Lauscher, J, Loch, FN, Schineis, C, Albertsmeier, M, Angele, M, Kappenberger, A, Niess, H, Schiergens, T, Werner, J, Becker, R, Jonescheit, J, Doerner, J, Seiberth, R, Pergolini, I, Reim, D, Herzberg, J, Honarpisheh, H, Strate, T, Boeker, C, Hakami, I, Mall, J, Liokatis, P, Smolka, W, Vassos, N, Nowak, K, Reinhard, T, Hölzle, F, Modabber, A, Winnand, P, Anthuber, M, Shiban, E, Sommer, B, Sommer, F, Wolf, S, Howaldt, H, Knitschke, M, Kauffmann, P, Wolfer, S, Kleeff, J, Lorenz, K, Michalski, C, Ronellenfitsch, U, Schneider, R, Bertolani, E, Königsrainer, A, Löffler, MW, Quante, M, Steidle, C, Überrück, L, Yurttas, C, Betz, CS, Bewarder, J, Böttcher, A, Burg, S, Busch, C, Dreimann, M, Frosch, KH, Gosau, M, Heuer, A, Izbicki, J, Klatte, TO, Koenig, D, Moeckelmann, N, Nitschke, C, Perez, D, Priemel, M, Reiter, A, Smeets, R, Speth, U, Stangenberg, M, Thole, S, Uzunoglu, FG, Viezens, L, Vollkommer, T, Zeller, N, Battista, MJ, Gillen, K, Hasenburg, A, Krajnak, S, Linz, VC, Schwab, R, Amo-Antwi, K, Appiah-kubi, A, Konney, T, Tawiah, A, Boatey, S, Issaka, A, Korsah, MA, Sheriff, M, Angelou, K, Haidopoulos, D, Rodolakis, A, Antonakis, P, Bramis, K, Chardalias, L, Contis, I, Dafnios, N, Dellaportas, D, Fragulidis, G, Gklavas, A, Konstadoulakis, M, Memos, N, Papaconstantinou, I, Polydorou, A, Theodosopoulos, T, Vezakis, A, Antonopoulou, MI, Manatakis, DK, Tasis, N, Arkadopoulos, N, Danias, N, Economopoulou, P, Frountzas, M, Kokoropoulos, P, Larentzakis, A, Michalopoulos, N, Nastos, C, Parasyris, S, Pikoulis, E, Selmani, J, Sidiropoulos, T, Vassiliu, P, Bouchagier, K, Klimopoulos, S, Paspaliari, D, Stylianidis, G, Akrivou, D, Baxevanidou, K, Bouliaris, K, Chatzikomnitsa, P, Delinasios, G, Doudakmanis, C, Efthimiou, M, Giaglaras, A, Kalfountzos, C, Kolla, C, Koukoulis, G, Zervas, K, Zourntou, S, Baloyiannis, I, Diamantis, A, Gkrinia, E, Hajiioannou, J, Korais, C, Koukoura, O, Perivoliotis, K, Saratziotis, A, Skoulakis, C, Symeonidis, D, Tepetes, K, Tzovaras, G, Zacharoulis, D, Alexoudi, V, Antoniades, K, Astreidis, I, Christidis, P, Deligiannidis, D, Grivas, T, Ioannidis, O, Kalaitsidou, I, Loutzidou, L, Mantevas, A, Michailidou, D, Nikolaidou, E, Papadopoulou, S, Paraskevopoulos, K, Politis, S, Stavroglou, A, Tatsis, D, Tilaveridis, I, Vahtsevanos, K, Venetis, G, Karaitianos, I, Tsirlis, T, Dinas, K, Margioula-Siarkou, C, Petousis, S, Baili, E, Charalabopoulos, A, Liakakos, T, Schizas, D, Spartalis, E, Syllaios, A, Zografos, C, Anthoulakis, C, Christou, CD, Papadopoulos, V, Tooulias, A, Tsolakidis, D, Tsoulfas, G, Zouzoulas, D, Athanasakis, E, Chrysos, E, Tsiaoussis, I, Xenaki, S, Xynos, E, Barrios Duarte, A, Lopez Muralles, I, Lowey, MJ, Portilla, AL, Recinos, G, Chan, JYK, Chan, SM, Chong, CCN, Futaba, K, Ho, MF, Hon, SF, Lau, RWH, Mak, TWC, Ng, CF, Ng, CSH, Ng, KKC, Ng, SSM, Teoh, AYB, Teoh, JY, Foo, CC, Banky, B, Suszták, N, Misra, S, Pareek, P, Vishnoi, JR, Ambre, S, Balasubiramaniyan, V, Chappity, P, Chaudhary, I, Colney, L, Das, MK, Imaduddin, M, Jain, A, Jena, SK, Kar, M, Mandal, S, Mishra, A, Mishra, SS, Mishra, TS, Mitra, JK, Mittal, Y, Muduly, DK, Nayak, P, Parida, PK, Pradhan, P, Rajan, DK, Rebba, E, Samal, DK, Singh, A, Sultania, M, Agarwal, SP, Agrawal, A, Arora, RK, Chaturvedi, J, Garg, PK, Gaurav, A, Gupta, A, Kottayasamy Seenivasagam, R, Maharaj, DD, Majumdar, KS, Mishra, N, Mittal, A, Narain, TA, Nirjhar, R, Poonia, DR, Sadhasivam, S, Singh, MP, Tiwari, AR, Akula, AK, Bandegudda, SK, Bindlish, RP, Chaitanya, A, Chandrasekhara Rao, LM, Dalakoti, P, Dasu, S, Giridhar, A, Gorijavolu, NB, Iyer, RR, Jayakarthik, Y, Jonathan, GT, Kalla, MB, Kheni, Y, Kumar, CS, Murtuza, SA, Naidu, CCK, Nalukurthi, RK, Nemade, HO, Nusrath, S, Patnaik, SC, Raju, KVVN, Ramalingam, PR, Rao, KV, Rayani, BK, Reddy Kallam, SM, Reddy, SRR, Saksena, AR, Sebastian, JA, Sharma, RM, Thammineedi, SR, Krishnamurthy, A, Madhupriya, S, Raja, A, Ramakrishnan, AS, Dutt, UK, Ghosh, DN, Grewal, S, Hans, P, Haque, PD, Jain, R, Kingsley, PA, Mahajan, A, Mandrelle, K, Michael, V, Mukherjee, P, Varghese, A, Varghese, SS, Veetil, SK, Gaikwad, P, George, AJ, James, SM, Jesudason, MR, Mittal, R, Moorthy, M, Riju, J, Sebastian, A, Sen, S, Singh, S, Sreekar, D, Thomas, V, Titus, DK, Yezzaji, HS, Aggarwal, M, Dhamija, P, Kumar, A, Chisthi, MM, Gejoe, G, Gopakumar, D, Kollengode, VV, Kuttanchettiyar, KG, Yadev, I, Balasubramanian, A, Chaturvedula, L, Dharanipragada, K, Kalayarasan, R, Manikandan, R, Penumadu, P, Lakshminarayana, B, Mathew, S, Reddihalli, PV, Shivdas, S, Akhtar, N, Chaturvedi, A, Gupta, S, Kumar, V, Rajan, S, Agrawal, N, Ahluwalia, P, Arora, A, Batra-Modi, K, Biswas, M, Chaturvedi, H, Gautam, G, Jain, M, Jain, S, Kumar, S, Nayyar, R, Tiwari, A, Bhushan Rangappa, V, Kadapathri, A, Kolur, T, Pethkar, R, Pillai, V, Popli, G, Sharma, J, Shetty, V, Subramaniam, N, Williams, J, Agarwal, P, Agarwal, V, Baghel, A, Sharma, DB, Silodia, A, Singh, KN, Yadav, SK, Aziz, G, Chowdri, N, Mehraj, A, Parray, FQ, Shah, ZA, Wani, RA, Ahmed, Z, Bali, RS, Bhat, MA, Laharwal, AR, Mahmood, M, Mir, IS, Muzamil, J, Najar, FA, Rashid, A, Rather, MH, Zaieem, M, Aggarwal, G, Agrawal, V, Ahmed, A, Ahmed, R, Bhaumik, J, Ghosh, A, Jain, D, Jain, PV, Kewlani, V, Pipara, A, Shakya, S, Sharma, A, Thambudorai, R, Badwe, RA, Bakshi, G, Chandankhede, U, Chaudhari, V, Chaukar, D, Chitkara, G, Dash, B, Deshmukh, A, deSoouza, A, Gulia, A, Maheshwari, A, Moiyadi, A, Nair, D, Nair, NS, Niyogi, D, Pal, M, Pandey, D, Patkar, S, Poddar, P, Pramesh, CS, Puri, A, Saklani, A, Shetty, P, Shrikhande, SV, Singh, V, Thiagarajan, S, Islam, AA, Kembuan, G, Pajan, H, Rahim, F, Brouki Milan, P, Mozafari, M, Rezaei Tavirani, M, Tizmaghz, A, Safari, H, Aremu, M, Canas-Martinez, A, Cullivan, O, Murphy, C, Owens, P, Pickett, L, Akmenkalne, L, Byrne, J, Corrigan, M, Cullinane, C, Daly, A, Fleming, C, Jordan, P, Kayyal, MY, Killeen, S, Lynch, N, McCarthy, A, Mustafa, H, O'Brien, S, O'Leary, P, Syed, WAS, Vernon, L, O'Duffy, F, McHugh, A, Moran, T, Callanan, D, Dias, A, Ionescu, A, Sheahan, P, Balasubramanian, I, Boland, M, Carrington, E, Conlon, K, Evoy, D, Fagan, J, Fearon, N, Gallagher, T, Geary, E, Geraghty, J, Hanly, A, Heneghan, H, Kennedy, N, Kennelly, R, Maguire, D, Martin, ST, McCartan, D, McDermott, EW, McPartland, D, Ng, KC, Prichard, RS, Stafford, T, Winter, D, Alazawi, D, Barry, C, Boyle, T, Butt, W, Connolly, E, Donlon, N, Donohue, C, Fahey, BA, Farrell, R, Fitzgerald, C, Kinsella, J, Larkin, J, Lennon, P, Maguire, PJ, Mccormick, P, Mehigan, BJ, Mohan, H, Nugent, TS, O'Sullivan, H, Ravi, N, Reynolds, JV, Rogers, A, Shokuhi, P, Smith, J, Smith, LA, Timon, C, Bashir, Y, Bass, G, Connelly, T, Creavin, B, Earley, H, Elliott, JA, Gillis, A, Kavanagh, D, Madden, A, Manecksha, RP, Neary, P, O'Connell, C, O'riordan, J, Reynolds, IS, Rice, D, Ridgway, P, Thomas, A, Umair, M, Whelan, M, Carroll, P, Collins, C, Corless, K, Finnegan, L, Fowler, AL, Hogan, A, Kerin, M, Lowery, A, McAnena, P, McKevitt, K, Nugent, E, Ryan, É, Coffey, JC, Cunningham, RM, Devine, M, Nally, DM, Peirce, C, Tormey, S, Hardy, N, O'Malley, S, Ryan, M, Gaziants, V, Gold- Deutch, R, Lavy, R, Kalmovich-Muallem, L, Zmora, O, Macina, S, Mariani, NM, Opocher, E, Pisani Ceretti, A, Ferrari, F, Odicino, F, Sartori, E, Cotsoglou, C, Granieri, S, Bianco, F, Camillo', A, Colledan, M, Tornese, S, Zambelli, MF, Bissolotti, G, Fusetti, S, Lemma, F, Marino, M, Marino, MV, Mirabella, A, Vaccarella, G, Sena, G, Agostini, C, Alemanno, G, Bartolini, I, Bergamini, C, Bruscino, A, Checcucci, C, De Vincenti, R, Di Bella, A, Fambrini, M, Fortuna, L, Maltinti, G, Muiesan, P, Petraglia, F, Prosperi, P, Ringressi, MN, Risaliti, M, Sorbi, F, Taddei, A, Tucci, R, Bassi, C, Bortolasi, L, Campagnaro, T, Casetti, L, Conci, S, De Pastena, M, Esposito, A, Fontana, M, Guglielmi, A, Landoni, L, Malleo, G, Marchegiani, G, Nobile, S, Paiella, S, Pedrazzani, C, Rattizzato, S, Ruzzenente, A, Salvia, R, Turri, G, Tuveri, M, Altomare, DF, Papagni, V, Picciariello, A, Bellora, P, D'Aloisio, G, Ferrari, M, Francone, E, Gentilli, S, Nikaj, H, Andreani, L, Bianchini, M, Capanna, R, Caretto, M, Chiarugi, M, Coccolini, F, Cremonini, C, Di Franco, G, Domenici, L, Furbetta, N, Gadducci, A, Garibaldi, S, Gianardi, D, Giannini, A, Guadagni, S, Morelli, L, Musetti, S, Palmeri, M, Perutelli, A, Simoncini, T, Tartaglia, D, Anania, G, Carcoforo, P, Chiozza, M, De Troia, A, Koleva Radica, M, Portinari, M, Sibilla, MG, Urbani, A, Fabbri, N, Feo, CV, Gennari, S, Parini, S, Righini, E, Ampollini, L, Arcuri, MF, Bellanti, L, Bergonzani, M, Bertoli, G, Bocchialini, G, Cattelani, L, D'Angelo, G, Gussago, F, Lanfranco, D, Manigrasso, E, Musini, L, Poli, T, Polotto, S, Santoro, GP, Varazzani, A, Aguzzoli, L, Annessi, V, Borgonovo, G, Castro Ruiz, C, Coiro, S, Falco, G, Mandato, VD, Mastrofilippo, V, Montella, MT, Zizzo, M, Grossi, U, Novello, S, Romano, M, Rossi, S, Zanus, G, Esposito, G, Frongia, F, Pisanu, A, Podda, M, Belluco, C, Lauretta, A, Montori, G, Moras, L, Olivieri, M, Bussu, F, Carta, AG, Cossu, ML, Cottu, P, Fancellu, A, Feo, CF, Ginesu, GC, Giuliani, G, Madonia, M, Perra, T, Piras, A, Porcu, A, Rizzo, D, Scanu, AM, Tedde, A, Tedde, M, Aversano, A, Carbone, F, Delrio, P, Di Lauro, K, Fares Bucci, A, Rega, D, Spiezio, G, Pirozzolo, G, Recordare, A, Vignotto, C, Badalamenti, G, Campisi, G, Cordova, A, Franza, M, Maniaci, G, Rinaldi, G, Toia, F, Calabrò, M, Farnesi, F, Lunghi, EG, Muratore, A, Pipitone Federico, NS, D'Andrea, G, Familiari, P, Picotti, V, De Palma, G, Luglio, G, Pagano, G, Tropeano, FP, Antonelli, B, Baldari, L, Beltramini, GA, Boni, L, Cassinotti, E, Gianni', A, Pignataro, L, Rossi, G, Torretta, S, Abatini, C, Baia, M, Biasoni, D, Bogani, G, Cadenelli, P, Capizzi, V, Cioffi, SPB, Citterio, D, Comini, LV, Cosimelli, M, Fiore, M, Folli, S, Gennaro, M, Giannini, L, Gronchi, A, Guaglio, M, Macchi, A, Martinelli, F, Mazzaferro, V, Mosca, A, Pasquali, S, Piazza, C, Raspagliesi, F, Rolli, L, Salvioni, R, Sarpietro, G, Sarre, C, Sorrentino, L, Agnes, A, Alfieri, S, Belia, F, Biondi, A, Cauteruccio, M, Cozza, V, D'Ugo, D, De Simone, V, Fagotti, A, Gasparini, G, Gordini, L, Litta, F, Lombardi, CP, Lorenzon, L, Maccauro, G, Marra, AA, Marzi, F, Moro, A, Parello, A, Perrone, E, Persiani, R, Ratto, C, Rosa, F, Saponaro, G, Scambia, G, Scrima, O, Sganga, G, Tudisco, R, Vitiello, R, Ziranu, A, Belli, A, Granata, V, Izzo, F, Palaia, R, Patrone, R, Carrano, FM, Carvello, MM, De Virgilio, A, Di Candido, F, Ferreli, F, Gaino, F, Mercante, G, Rossi, V, Spinelli, A, Spriano, G, De Nardi, C, Donati, DM, Frisoni, T, Palmerini, E, Aprile, A, Barra, F, Batistotti, P, Ferrero, S, Fregatti, P, Massobrio, A, Pertile, D, Scabini, S, Soriero, D, Sparavigna, M, Adamoli, L, Ansarin, M, Cenciarelli, S, Chu, F, De Berardinis, R, Fumagalli Romario, U, Mastrilli, F, Pietrobon, G, Tagliabue, M, Badellino, E, Biglia, N, Chiado' Piat, F, Ferrero, A, Massobrio, R, De Manzoni Garberini, A, Mazzotti, F, Pasini, F, Ugolini, G, Barone, R, Birolo, SL, Caccetta, M, Deirino, A, Garino, M, Grasso, M, Marafante, C, Masciandaro, A, Moggia, E, Mungo, S, Murgese, A, Raggio, E, Federico, P, Maida, P, Marra, E, Marte, G, Petrillo, A, Tammaro, T, Tufo, A, Berselli, M, Borroni, G, Cocozza, E, Conti, L, Desio, M, Livraghi, L, Marchionni, V, Quintodei, V, Rizzi, A, Baldi, C, Corbellini, C, Sampietro, GM, Bordoni, P, Clarizia, G, Fleres, F, Franzini, M, Grechi, A, Longhini, A, Spolini, A, Cellerino, P, Galfrascoli, E, Iacob, G, Baldini, E, Capelli, P, Isolani, SM, Ribolla, M, Bondurri, A, Colombo, F, Ferrario, L, Guerci, C, Maffioli, A, Armao, T, Ballabio, M, Bisagni, P, Gagliano, A, Longhi, M, Madonini, M, Pizzini, P, Baietti, AM, Biasini, M, Maremonti, P, Neri, F, Prucher, GM, Ricci, S, Ruggiero, F, Zarabini, AG, Impellizzeri, H, Inama, M, Moretto, G, Barmasse, R, Mochet, S, Usai, A, Incollingo, P, Giacometti, M, Zonta, S, Marino Cosentino, L, Sagnotta, A, Dell'Oro, C, Fruscio, R, Grassi, T, Negri, S, Nespoli, LC, Tamini, N, Zambetti, B, Anastasi, A, Bartalucci, B, Bellacci, A, Canonico, G, Capezzuoli, L, Di Martino, C, Ipponi, P, Linari, C, Montelatici, M, Nelli, T, Spagni, G, Tirloni, L, Vitali, A, Abate, E, Casati, M, Casiraghi, T, Laface, L, Schiavo, M, Arminio, A, Cotoia, A, Lizzi, V, Vovola, F, Vergari, R, D'Ugo, S, Depalma, N, Spampinato, MG, Annicchiarico, A, Catena, F, Giuffrida, M, Perrone, G, Baronio, G, Carissimi, F, Montuori, M, Pinotti, E, Bartolucci, P, Binda, B, Brachini, G, Bruzzaniti, P, Chiappini, A, Chiarella, V, Ciccarone, F, Cicerchia, PM, Cirillo, B, Crocetti, D, De Toma, G, Di bartolomeo, A, Duranti, G, Fiori, E, Fonsi, GB, Franco, G, Frati, A, Giugliano, M, Iannone, I, La Torre, F, Lapolla, P, Leonardo, C, Marruzzo, G, Meneghini, S, Mingoli, A, Ribuffo, D, Salvati, M, Santoro, A, Sapienza, P, Scafa, AK, Simonelli, L, Zanacana, G, Zambon, M, Zuppi, E, Capolupo, GT, Carannante, F, Caricato, M, Mascianà, G, Mazzotta, E, Gattolin, A, Migliore, M, Rimonda, R, Sasia, D, Travaglio, E, Chessa, A, Fiorini, A, Norcini, C, Colletti, G, Confalonieri, M, Costanzi, A, Frattaruolo, C, Mari, G, Monteleone, M, Bandiera, A, Bocciolone, L, Bonavina, G, Candiani, M, Candotti, G, De Nardi, P, Gagliardi, F, Medone, M, Mortini, P, Negri, G, Parise, P, Piloni, M, Sileri, P, Vignali, A, Belvedere, A, Bernante, P, Bertoglio, P, Boussedra, S, Brunocilla, E, Cervellera, M, Cescon, M, Cipriani, R, Cisternino, G, De Crescenzo, E, De Iaco, P, Del Gaudio, M, Dondi, G, Droghetti, M, Germinario, G, Gori, A, Frio, F, Jovine, E, Mineo Bianchi, F, Morezzi, D, Neri, J, Parlanti, D, Perrone, AM, Pezzuto, AP, Pignatti, M, Pinto, V, Poggioli, G, Ravaioli, M, Rottoli, M, Russo, IS, Sartarelli, L, Schiavina, R, Serenari, M, Serra, M, Solli, P, Tonini, V, Taffurelli, M, Tanzanu, M, Tesei, M, Violante, T, Zanotti, S, Borghi, F, Cianflocca, D, Di Maria Grimaldi, S, Donati, D, Gelarda, E, Geretto, P, Giraudo, G, Giuffrida, MC, Maione, F, Marano, A, Palagi, S, Pellegrino, L, Peluso, C, Giaccardi, S, Testa, V, Agresta, F, Prando, D, Zese, M, Aquila, F, Gambacciani, C, Lippa, L, Pieri, F, Santonocito, OS, Armatura, G, Bertelli, G, Frena, A, Marinello, P, Notte, F, Patauner, S, Scotton, G, Fulginiti, S, Gallo, G, Sammarco, G, Vescio, G, Balercia, P, Catarzi, L, Consorti, G, Asti, ELG, Bernardi, D, Bonavina, L, Lovece, A, Di Marzo, F, Fujiwara, H, Hashimoto, D, Yamaki, S, Yamamoto, T, Daiko, H, Ishikawa, M, Ishiyama, K, Iwata, S, Kanematsu, K, Kanemitsu, Y, Kato, T, Kawai, A, Kobayashi, E, Kobayashi Kato, M, Moritani, K, Nakagawa, M, Nakatani, F, Oguma, J, Tanase, Y, Uno, M, Hada, T, Iwahashi, H, Miyamoto, M, Suminokura, J, Takano, M, Fujiwara, K, Fujiwara, N, Kurosaki, A, Ababneh, H, Al Abdallah, M, Ayasra, F, Ayasra, Y, Hammad, F, Qasem, A, Abu Za'nouneh, FJ, Al-Shraideh, AA, Fahmawee, T, Hmedat, A, Ibrahim, A, Obeidat, K, Abdel Al, S, Abdel Jalil, R, Abou Chaar, MK, Al-Masri, M, Al-Najjar, H, Alawneh, F, Alsaraireh, O, Elayyan, M, Ghanem, R, Lataifeh, I, Fakhradiyev, I, Saliev, T, Tanabayeva, S, Almahmeed, H, Almazeedi, S, Alsabah, S, Jamal, M, Aldokali, N, Senossi, O, Subhi, MT, Algallai, M, Alwarfly, S, AlZAEDE, S, Gahwagi, M, Moftah, M, Abusannoga, M, Alawami, A, Alawami, M, Albashri, M, Malek, A, Burgan, D, Kamoka, E, Kilani, AI, Salamah, A, Shuwayyah, A, Abdelkabir, M, Altomi, I, Altoumi, M, Bouhuwaish, A, Elmabri, A, Omar, M, Taher, AS, Abdulwahed, E, Alshareea, E, Aribi, N, Aribi, S, Biala, M, Ghamgh, R, Morgom, M, Alansari, SAA, Aldayri, Z, Alsoufi, A, Elhadi, A, Elhajdawe, F, Ellojli, I, ERgebi, AAD, Kredan, A, Msherghi, A, Nagib, T, Abudher, A, Alshareef, K, Elamin, F, Bradulskis, S, Dainius, E, Kubiliute, E, Kutkevicius, J, Parseliunas, A, Subocius, A, Venskutonis, D, Rasoaherinomenjanahary, F, Razafindrahita, JB, Samison, LH, Ong, EC, Abdul Maei, N, Ngo, CW, Ramasamy, S, Hamdan, KH, Ibrahim, MR, Tan, JA, Thanapal, MR, Choong, E, Lim, RZM, Amin Sahid, N, Hayati, F, Jayasilan, J, Sriram, RK, Subramaniam, S, Ibrahim, AF, Che jusoh, A, Hussain, AH, Mohamed Sidek, AS, Mohd Yunus, MF, Soh, JY, Wong, MP, Zakaria, AD, Zakaria, Z, Kampan, N, Mohd Azman, ZA, Nur Azurah, AG, Zainuddin, AA, Fadzli, AN, Fathi, NQ, Koh, PS, Liew, YT, Roslani, AC, Tang, CY, Teoh, LY, Wong, WJ, Xavier, R, Yahaya, AS, Alvarez, MR, Arrangoiz, R, Cordera, F, De la Rosa Abaroa, MA, Gómez-Pedraza, A, Hernandez, R, Maffuz-Aziz, A, Posada, JA, Lupián-Angulo, AI, Soulé Martínez, CE, Aboharp Hasan, Z, Alvarado Silva, C, Bazan Soto, A, Hernández Rubio, A, Jiménez Villanueva, X, Otoniel, LR, Sosa Duran, EE, Becerra García, FC, Melchor-Ruan, J, Romero Bañuelos, E, Vilar-Compte, D, Alfaro-Goldaracena, A, Buerba, GA, Castillejos-Molina, RA, Chan, C, Dominguez-Rosado, I, Medina-Franco, H, Mercado, MÁ, Oropeza-Aguilar, M, Peña Gómez Portugal, E, Posadas-Trujillo, OE, Rodriguez-Covarrubias, F, Salgado-Nesme, N, Vilatoba, M, Arkha, Y, Bechri, H, El Ouahabi, A, Oudrhiri, MY, El Azhari, A, Louraoui, SM, Rghioui, M, Bougrine, M, Derkaoui hassani, F, El abbadi, N, Amrani, L, Belkhadir, ZH, Benkabbou, A, Chakib, O, El Ahmadi, B, El Bouazizi, Y, Essangri, H, Ghannam, A, Majbar, AM, Mohsine, R, Souadka, A, Borgstein, ABJ, Gisbertz, SS, Van Berge Henegouwen, MI, Hompes, R, Meima-van Praag, EM, Pronk, A, Sharabiany, S, Grotenhuis, B, Hartveld, L, Reijers, S, Van Houdt, W, Baaij, J, Bolster-van Eenennaam, M, De Graaff, M, Sloothaak, D, Van Duijvendijk, P, Ebben, LDA, Kuiper, SZ, Melenhorst, J, Poeze, M, Sluijpers, NRF, Vaassen, LAA, Posma-Bouman, L, Derksen, T, Franken, J, Oosterling, S, De Bree, R, Konsten, J, Van Heinsbergen, M, Adeyeye, A, Akinmade, A, Enoch, E, Fayose, S, Abur, P, Fidelis, L, Nwabuoku, SE, Oyelowo, N, Sholadoye, TT, Tolani, MA, Olaogun, J, Abiyere, H, Adebara, I, Adeniyi, A, Adeyemo, O, Babalola, O, Bakare, A, Banjo, O, Okunlola, A, Adeniran, A, Atobatele, K, Eke, G, Faboya, O, Ogunyemi, A, Omisanjo, O, Oshodi, O, Oshodi, Y, Williams, O, Ademuyiwa, A, Afolabi, B, Akinajo, O, Alakaloko, F, Atoyebi, O, Balogun, O, Belie, O, Bode, C, Chibuike George, I, Elebute, O, Ladipo-Ajayi, O, Ohazurike, E, Okunowo, A, Olajide, TO, Seyi-Olajide, J, Daniel, A, Egbuchulem, IK, Lawal, TA, Nwaorgu, O, Ogundoyin, O, Olulana, D, Onakoya, P, Oyelakin, O, Abdullahi, H, Agida, E, Aisuodionoe-Shadrach, O, Ajibola, H, Akaba, G, Sani, AS, Chinda, J, Dawang, Y, Garba, S, Mshelbwala, P, Obande, J, Olori, S, Olute, A, Osagie, O, Pius Ogolekwu, I, Umar, A, Abdur-Rahman, L, Adeleke, N, Aremu, I, Bello, J, Olasehinde, O, Popoola, A, Raji, HO, Massoud, JG, Massoud, R, Sorour, TM, Abassy, J, Ahmed, K, Alvi, A, Arshad, M, Khan, S, Pirzada, A, Saleem, A, Siddiqui, T, Turk, K, Hanif, F, Haroon, M, Khan, MI, Jamal, A, Kerawala, AA, Memon, AS, Nafees Ahmed, R, Rai, L, Javed, S, Mahmood, U, Shabbir, RK, Yaqoob, E, Afzal, A, Ahmed Riaz, S, Akbar, A, Ali, AA, Ali, G, Janjua, A, Mohsin, M, Naqi, SA, Saleem, I, Shaukat, A, Sohail, M, Afzal, MF, Khokhar, MI, Latif, F, Ayub, B, Hassan, N, Martins, RS, Ramesh, P, Sayyed, R, Ayyaz, M, Butt, U, Kashif, M, Khan, WH, Qureshi, AU, Umar, M, Waris Farooka, M, Wasim, T, Bhatti, ABH, Ayubi, A, Rashid, I, Waqar, SH, Al-Slaibi, I, I. A. Alzeerelhouseini, H, Jobran, F, Abukhalaf, SA, Arrue, E, Cukier, M, Rodriguez-Zentner, H, Borda-Luque, G, León Palacios, JL, Lizzetti, G, Vasquez Ojeda, XP, Falcon Pacheco, GM, Robles, R, Jocson, R, Teh, C, Uy Magadia, E, Major, P, Bak, M, Dubienska, K, Lawnicka, A, Murawa, D, Bobinski, M, Kotarski, J, Rasoul-Pelinska, K, Brociek, A, Chloupek, A, Janik, M, Kowalewski, P, Kwiatkowski, A, Panasiewicz, P, Roszkowski, R, Rot, P, Sroczynski, P, Waledziak, M, Azevedo, C, Machado, D, Mendes, F, De Sousa, X, Fernandes, U, Ferreira, C, Guidi, G, Leal, C, Marçal, A, Marques, R, Martins, D, Melo, A, Tenreiro, N, Vaz Pereira, R, Vieira, B, Almeida, JI, Almeida-Reis, R, Correia de Sá, T, Costa, MJMA, Fernandes, V, Ferraz, I, Lima da Cruz, L, Lima da Silva, C, Lopes, L, Machado, N, Marialva, J, Nunes Coelho, M, Pedro, J, Pereira, C, Ribeiro, A, Ribeiro, CG, Santos, R, Saraiva, P, Silva, RL, Tavares, F, Teixeira, M, Valente, P, Almeida, AC, Amaral, MJ, Andrade, R, Athayde Nemésio, R, Breda, D, Camacho, C, Canhoto, C, Colino, M, Correia, S, Costa, M, De Barros, J, De Oliveira López, AL, Duque, M, Garrido, S, Guerreiro, P, Guimarães, A, Lázaro, A, Lopes, C, Martins, R, Nogueira, O, Oliveira, A, Oliveira, JM, Rodrigues, M, Ruivo, A, Santos, E, Silva, M, Simões, J, Valente da Costa, A, Almeida, A, Castanheira Rodrigues, S, Cavaleiro Leitão de Carvalho, AS, Devezas, V, Faria, CS, Jácome, F, Magalhães Maia, M, Nogueiro, J, Pereira, A, Pereira-Neves, A, Pina-Vaz, T, Santos-Sousa, H, Silveira, H, Vaz, S, Vieira, P, Gomes da Costa, A, Lobo Antunes, I, Pinto, J, Tojal, A, Cardoso, N, Cardoso, P, Domingues, JC, Henriques, P, Manso, MI, Martins dos Santos, G, Morais, H, Pereira, R, Revez, T, Ribeiro, R, Ribeiro, VI, Soares, A, Sousa, S, Teixeira, J, Amorim, E, Baptista, VH, Cunha, MF, Dias, B, Fazenda, A, Melo Neves, JP, Policarpo, F, Sampaio da Nóvoa Gomes Miguel, II, Veiga, D, Bandovas, JP, Borges, N, Branquinho, A, Chumbinho, B, Correia, J, Fidalgo, H, Figueiredo de Barros, I, Frade, S, Gomes, J, Kam da Silva Andrade, A, Maciel, J, Pereira Rodrigues, A, Pina, S, Silva, N, Silveira Nunes, I, Sousa, R, Ascensão, J, Azevedo, P, Costeira, B, Cunha, C, Garrido, R, Gomes, H, Lourenço, I, Mendinhos, G, Miranda, P, Nobre Pinto, A, Peralta Ferreira, M, Ribeiro, J, Rio Rodrigues, L, Sousa Fernandes, M, Azevedo, J, Galvão, D, Soares, AC, Vieira, A, Patrício, B, Santos, PMDD, Vieira Paiva Lopes, AC, Cunha, R, Faustino, A, Freitas, A, Jacob Oliveira, B, Martins, AB, Mendes, JR, Parreira, R, Rosa, J, Teves, M, Abreu da Silva, A, Claro, M, Costa Santos, D, Deus, AC, Grilo, JV, Castro Borges, F, Corte Real, J, Henriques, S, Lima, MJ, Matos Costa, P, Alagoa Joao, A, Camarneiro, R, Capunge, I, Fragoso, M, Frazão, J, Martins, A, Pedro, V, Pera, R, Ramalho de Almeida, F, Sampaio Soares, A, Vale, R, Vasconcelos, M, Brito da Silva, F, Caiado, A, Fonseca, F, Ângelo, M, Baiao, JM, Martins Jordão, D, Vieira Caroço, T, Messias, J, Millan, A, Salgado, I, Santos, P, Baía, C, Canotilho, R, Correia, AM, Ferreira Pinto, AP, Peyroteo, M, Videira, JF, Escobar, P, Maldonado Santiago, M, Kassir, R, Sauvat, F, Bonci, E, Gata, V, Titu, S, Bezede, C, Chitul, A, Ciofic, E, Cristian, D, Grama, F, Pirtea, L, Secosan, C, Ciubotaru, C, Negoi, I, Negoita, VM, Stoica, B, Ginghina, O, Iordache, N, Iosifescu, RV, Mardare, M, Mirica, RM, Spanu, A, Văcărasu, AB, Zamfir-Chiru-Anton, M, Garmanova, T, Kazachenko, E, Markaryan, D, Rodimov, S, Tsarkov, P, Tulina, I, Abelevich, A, Bazaev, A, Kokobelyan, AK, Yanishev, A, Litvin, A, Litvina, Y, Provozina, A, Agapov, M, Galliamov, E, Kakotkin, V, Kubyshkin, V, Semina, E, Novikova, A, Zakharenko, A, Alshahrani, M, Alsharif, F, Eskander, M, Al Raddadi, R, Majrashi, S, Mashat, A, Akeel, N, Alharthi, M, Aljiffry, M, Basendowah, M, Farsi, A, Ghunaim, M, Khoja, A, Maghrabi, A, Malibary, N, Nassif, M, Nawawi, A, Samkari, A, Trabulsi, N, A Azab, M, Aldosri, M, Alghanem, A, Alguraigari, A, ALjohani, K, Alqahtani, D, Alzaidi, TM, Basyouni, A, Elhussain, E, Jaloun, H, Mudawi, I, Shafei, M, Al Awwad, S, Alghamdi, M, Alnumani, T, Nasser, M, Said bayazeed, A, Abdelrhman, S, Awad, S, Ghedan, S, I Sharara, M, Mashaly, A, Aburahmah, M, Al Otaibi, F, Al-alem, I, Al-Badawi, IA, AlDahash, H, Alhazzaa, N, Alhefdhi, A, Alhelal, B, AlKattan, K, Almalik, O, Alomair, A, Alomar, O, Alotaibi, NH, Alresaini, F, Alrifai, O, Alsakka, M, Alsalamah, R, Alsemari, M, Alsobhi, S, AlSumai, T, Farrash, F, Khan, P, Mahasin, Z, Othman, E, Pant, R, Robaidi, H, Saleh, W, Shaheen, M, Spangenberg, P, Velagapudi, S, Al Habes, H, Alkarak, S, Alqannas, M, Alyami, M, Alzamanan, M, Cortés-Guiral, D, Elawad, A, Adi, H, Al ahmad, F, Al Ayed, A, Al zahrani, A, Alalawi, Y, Alishi, Y, Alqahtani, B, AlAamer, O, Alriyees, L, Alselaim, N, Alfaifi, J, Alkreedees, N, Almutrafi, SN, Alramadhan, M, Alshitwi, A, D'Souza, J, Abdulkareem, A, Ajlan, A, Akkour, K, Al-Habib, A, Al-Khayal, K, Alatar, A, Alburakan, A, Alhalal, H, Alhassan, B, Alhassan, N, Aljassir, F, Alobeed, O, Alsaif, A, Alsaif, F, Alshammari, S, Alshaygy, I, Barry, M, Bin Nasser, A, Bin Traiki, T, Bokhari, A, Elwatidy, S, Helmi, H, Madkhali, A, Nouh, T, Rabah, PD, Zubaidi, A, Al Amri, A, Abdulfattah, F, Al Hasan, I, Al-Kharashi, E, Alanazi, F, Albaqami, F, Alghamdi, A, Alghuliga, A, Aljaber, F, Alsowaina, K, Alsuhaibani, A, Arab, N, Badahdah, F, Alobaysi, S, Alshahrani, A, Paunovic, I, Slijepcevic, N, Aleksic, L, Antic, A, Barisic, G, Ceranic, M, Ebrahimi, K, Galun, D, Grubac, Ž, Ivanovic, N, Jelenkovic, J, Kecmanovic, D, Kmezic, S, Knezevic, D, Krivokapic, Z, Latincic, S, Markovic, V, Matic, S, Miladinov, M, Pavlov, M, Pejovic, I, Radenkovic, D, Sabljak, P, Skrobic, O, Šljukic, V, Tadic, B, Vasljevic, J, Velickovic, D, Zivanovic, M, Doklestic, K, Gregoric, P, Ivancevic, N, Loncar, Z, Micic, D, Perovic, M, Srbinovic, L, Andrijasevic, S, Bozanovic, T, Cerovic Popovic, R, Dokic, M, Janjic, T, Jeremic, K, Kadija, S, Ladjevic Likic, I, Mirkovic, L, Pantovic, S, Pilic, I, Radojevic, M, Stefanovic, A, Vidakovic, S, Vilendecic, Z, Antic, S, Dunderovic, D, Jelovac, D, Jezdic, Z, Konstantinovic, V, Kotlar, B, Kuzmanovic, C, Lazic, M, Pajic, S, Petrovic, M, Popovic, F, Pucar, A, Romic, M, Sumrak, S, Vujanac, V, Bascarevic, V, Bogdanovic, I, Grujicic, D, Ilic, R, Jokovic, M, Milicevic, M, Milisavljevic, F, Miljkovic, A, Paunovic, A, Šcepanovic, V, Stanimirovic, A, Todorovic, M, Folic, M, Jotic, A, Krejovic Trivic, S, Milovanovic, J, Trivic, A, Bumbasirevic, U, Dzamic, Z, Kajmakovic, B, Prijovic, N, Zivkovic, M, Buta, M, Cvetkovic, A, Djurisic, I, Gacic, S, Goran, M, Inic, Z, Jeftic, N, Jevric, M, Jokic, V, Markovic, I, Milanovic, M, Nikolic, S, Pejnovic, L, Savkovic, N, Spurnic, I, Stevic, D, Stojiljkovic, D, Vucic, N, Zegarac, M, Karamarkovic, A, Kenic, M, Kovacevic, B, Krdzic, I, Milutinovic, V, Savic, G, Chan, CW, Lieske, B, Gális, B, Šimko, K, Cokan, A, Crnobrnja, B, Dovnik, A, Knez, J, Pakiž, M, Almgla, N, Bernon, M, Boutall, A, Cairncross, L, Chinnery, G, Herman, A, Hilton, T, Jonas, E, Kloppers, C, Malherbe, F, Mugla, W, Nel, D, Rayamajhi, S, Scriba, M, Van Wyngaard, T, Vogel, J, Castaño-Leon, AM, Delgado Fernandez, J, Eiriz Fernandez, C, Espino Segura-Illa, M, Esteban Sinovas, O, Garcia Perez, D, Gomez, P, Jimenez-Roldan, L, Lagares, A, Moreno-Gomez, L, Paredes, I, Pérez Núñez, A, Sánchez Aniceto, G, Santas Alegret, M, Fernández Rodríguez, P, Paniagua García Señorans, M, Sanchez-Santos, R, Vigorita, V, Acrich, E, Baena Sanfeliu, E, Barrios, O, Golda, T, Santanach, C, Serrano-Navidad, M, Sorribas Grifell, M, Vives, RV, Arce Gil, J, Escolà, D, Jiménez, A, Alcázar, JA, Angoso-Clavijo, M, Blanco-Antona, F, Carabias-Orgaz, A, Díaz Maag, R, Eguía Larrea, M, Esteban Velasco, C, Garcia, J, García-Plaza, AGP, Gonzalez-Muñoz, JI, Muñoz-Bellvis, L, Parreño-Manchado, FC, Sánchez Tocino, JM, Sanchez-Casado, AB, Trebol, J, Hernandez Gutierrez, J, Tébar Zamora, A, Sánchez Mozo, A, Cayetano Paniagua, L, Gomez Fernandez, L, Artigues, E, Bernal-Sprekelsen, JC, Catalá Bauset, JC, Gilabert-Estellés, J, Collera, P, Diaz Del Gobbo, R, Farre Font, R, Flores Clotet, R, Gómez Díaz, CJ, Guàrdia, N, Guariglia, CA, Osorio, A, Sanchez Jimenez, R, Sanchon, L, Soto Montesinos, C, Albi Martin, B, García Villayzán, JE, Alonso-Lamberti, L, Assaf, M, Baeza Pintado, N, Carabias, A, García-Quijada, J, Huertas Fernandez, MA, Jimenez Miramón, J, Jimenez, V, Jover, JM, Landeo Agüero, SA, Leon, R, Martín Salamanca, MB, Pérez Simón, V, Ponce, S, Rodriguez, JL, Salazar, A, Valle Rubio, A, Aguado, H, Aldecoa Ansorregui, I, Bravo Infante, R, De Lacy, FB, Di Somma, A, Díaz-Feijoo, B, Enseñat Nora, J, Fabregas, N, Ferrés, A, Gil Ibañez, B, Gonzalez Sanchez, JJ, Gracia, I, Hoyos Castro, JA, Lacy, AM, Langdon, C, Momblán, D, Morales, X, Oleaga, L, Otero, A, Pedrosa, L, Poblete Carrizo, J, Reyes Figueroa, LA, Roldan Ramos, P, Rumia-Arboix, J, Tercero-Uribe, AI, Topczewski, TE, Torales, J, Torne, A, Torné, R, Turrado-Rodriguez, V, Valero, R, Valverde, S, Anula, R, Avellana, R, Camarero Rodríguez, E, Catalán Garza, V, Dziakova, J, García Alonso, M, Lasses Martínez, B, López Antoñanzas, L, Muguerza, JM, Ochagavía, S, Peña Soria, MJ, Rivera-Alonso, D, Saez Carlin, P, Sánchez del Pueblo, C, Sanz Ortega, G, Sanz-Lopez, R, Torres, A, Garcés-Albir, M, Lopez, F, Martín-Arévalo, J, Moro-Valdezate, D, Pla-Marti, V, Beltrán de Heredia, J, De Andrés-Asenjo, B, Gómez Sanz, T, Jezieniecki, C, Nuñez Del Barrio, H, Ortiz de Solórzano Aurusa, FJ, Romero de Diego, A, Ruiz Soriano, M, Trujillo Díaz, J, Vazquez Fernandez, A, Lora-Cumplido, P, Sosa, MV, Balague, C, Ballester, E, Moral, A, Sánchez López, A, Targarona, EM, Galvan-Perez, A, Gonzalez-Gonzalez, E, Minaya Bravo, AM, San Miguel-Mendez, C, Alonso de la Fuente, N, Cazador Labat, M, Cecchini, L, Espinosa, CA, Jimenez Toscano, M, López Campillo, A, Mancebo, G, Martorell, P, Munarriz, M, Grau-Talens, EJ, Martin-Perez, B, Benavides Buleje, JA, Carrasco Prats, M, Fernández, PV, Fernández-López, A, García Escudero, D, García Porcel, VJ, Garcia Soria, V, Giménez Francés, C, González Valverde, FM, Gurrea-Almela, E, López-Morales, P, Marco Garrido, A, Martínez Alonso, JA, Medina, E, Muñoz Camarena, JM, Parra Baños, PA, Peña Ros, E, Ramirez Faraco, M, Ruiz-Marín, M, Sanchez Rodriguez, C, Valero Soriano, M, Allué Cabañuz, M, Colsa Gutiérrez, P, García Domínguez, M, Gimenez Maurel, T, Martín Anoro, LF, Ponchietti, L, Rodriguez Artigas, JM, Roldón Golet, M, Utrilla Fornals, A, Estaire Gómez, M, Fernández Camuñas, Á, Garcia Santos, EP, Jimenez Higuera, E, López de la Manzanara Cano, CA, Martínez-Pinedo, C, Moreno Pérez, A, Muñoz-Atienza, V, Padilla-Valverde, D, Picón Rodríguez, R, Redondo Calvo, FJ, Sánchez-García, S, Sanchez-Pelaez, D, Curtis Martínez, C, Fernández-Candela, A, Sánchez-Guillén, L, Colombari, RC, Del valle, E, Fernández, M, Lozano Lominchar, P, Rey Valcarcel, C, Steiner, MA, Tudela, M, Zorrilla Ortúzar, J, Alcaide Matas, F, García Pérez, JM, Troncoso Pereira, P, Blas Laina, JL, Cros, B, Escartin, J, Garcia Egea, J, Nogués, A, Talal El-Abur, I, Yánez, C, Mora-Guzmán, I, Cárdenas Puiggrós, L, Abellán, M, Achalandabaso Boira, M, Jorba, R, Memba Ikuga, R, Olona, C, Sales Mallafré, R, Aguilo, O, Cavallé Busquets, P, Gavalda Pellice, MGP, Jorda Sole, M, Mateu, I, Miralles Curto, M, Salinas Peña, J, Fernández Martínez, D, García Flórez, LJ, Solar-Garcia, L, Aragon Achig, EJ, Barbier, L, Caja Vivancos, P, Gainza, A, García Gutierrez, JJ, García-Operé, G, Gómez-Suárez, J, Jiménez-Jiménez, M, Mallabiabarrena Ormaechea, G, Marín, H, Martin Playa, P, Melchor Corcóstegui, I, Municio-Martín, JA, Oñate, M, Pascua-Gómez, LA, Pesántez Peralta, MA, Prieto Calvo, M, Rodriguez Fraga, A, Villalabeitia Ateca, I, De Andres Olabarria, U, Durán Ballesteros, M, Fernández Pablos, FJ, Ibáñez-Aguirre, FJ, Sanz Larrainzar, A, Ugarte-Sierra, B, Acosta Mérida, MA, Ortiz López, D, Yepes Cano, AF, Correa Bonito, A, De la Hoz Rodríguez, Á, Delgado Búrdalo, L, Di Martino, M, García Sánz, I, García Septiem, J, Maqueda González, R, Martin-Perez, E, Muñoz de Nova, JL, Calvo Espino, P, Guillamot Ruano, P, Colao García, L, Díaz Pérez, D, Esteban Agustí, E, Galindo Jara, P, Gutierrez Samaniego, M, Hernandez Bartolome, MA, Serrano González, J, Alonso Poza, A, Diéguez, B, García-Conde, M, Hernández-García, M, Losada, M, Chiesa-Estomba, CM, González García, JÁ, Larruscain, E, Sistiaga-Suárez, JA, Alvarez, E, Chavarrias, N, Frías, L, García Pineda, V, Gegúndez Simón, A, Gómez Rivas, J, Gortázar de las Casas, S, Gracia, M, Guevara, J, Hernández Gutierrez, A, Loayza, A, María Dolores, DT, Martí, C, Melendez, M, Moreno-Palacios, E, Perez, Y, Prieto Nieto, MI, Ramos-Martín, P, Rubio-Perez, I, Saavedra, J, Sánchez Méndez, JI, Siegrist Ridruejo, J, Toribio Vazquez, C, Urbieta, A, Yebes, A, Zapardiel, I, Aparicio-López, D, Cantalejo diaz, M, De Miguel Ardevines, MDC, Dobón Rascón, MÁ, Duque-Mallén, V, Gascon Ferrer, I, González-Nicolás Trébol, MT, Gracia-Roche, C, Herrero Lopez, M, Jariod Ferrer, UM, Kälviäinen, H, Lanzon, A, Martinez German, A, Matute, M, Redondo, C, Sánchez Fuentes, N, Santero-Ramirez, MS, Saudí, S, Simón Sanz, MV, Uson, T, Blazquez Martin, A, Diez Alonso, M, García Rico, E, Garcia-Loarte Gomez, E, Garcia-Moreno Nisa, F, Gutierrez Calvo, A, Hernandez, P, Lasa, I, Mendoza-Moreno, F, Morales Palacios, N, Ovejero Merino, E, Vera Mansilla, C, Acero, J, Haddad, A, Barranquero, AG, Caballero Silva, U, Cabañero Sánchez, A, Cavestany Garcia-Matres, C, Cerro Zaballos, C, Fra Fernández, S, Moreno Mata, N, Muñoz Molina, GM, Núñez, J, Ocaña, J, Ramos, D, Acebes García, F, Bailón, M, Bueno Cañones, AD, Choolani Bhojwani, E, Marcos-Santos, P, Miguel, T, Pacheco Sánchez, D, Pérez-Saborido, B, Sanchez Gonzalez, J, Tejero-Pintor, FJ, Alconchel, F, Conesa, A, Gil Martínez, J, Gutiérrez Fernández, AI, Lopez Abad, A, Nicolás-López, T, Ramirez Romero, P, Roca Calvo, MJ, Rodrigues, K, Ruiz Manzanera, JJ, Soriano, AI, Cano, A, Capitan-Morales, L, Cintas Catena, J, Gomez-Rosado, J, Oliva Mompean, F, Pérez Sánchez, MA, Río Lafuente, FD, Torres Arcos, C, Valdes-Hernandez, J, Bruna Esteban, M, Cholewa, H, Domingo, S, Frasson, M, Lago, V, Marina Martin, T, Martínez Chicote, C, Sancho-Muriel, J, Estraviz-Mateos, B, Fernández Gómez Cruzado, L, González de Miguel, M, Landaluce-olavarria, A, Lecumberri, D, Abad Gurumeta, A, Abad-Motos, A, Martínez-Hurtado, E, Ripollés-Melchor, J, Ruiz Escobar, A, Cuadrado-García, A, Garcia-Sancho Tellez, L, Heras Aznar, J, Maté Mate, P, Ortega Vázquez, I, Picardo, AL, Rojo López, JA, Sanchez Cabezudo Noguera, F, Serralta de Colsa, D, Anchuelo Latorre, J, Cagigas Fernandez, C, Caiña Ruiz, R, Fernandez Diaz, MJ, Gomez Ruiz, M, Hernanz, F, Jimeno Fraile, J, Martínez-Pérez, P, Poch, C, Santarrufina Martinez, S, Valbuena Jabares, V, Moliner-Sachez, C, Pingarron-Martin, L, Rey-Biel, J, Ruiz Martin, I, Cagigal Ortega, EP, Cervera, I, Díaz Peña, P, Garcia de Castro Rubio, E, Enjuto, D, Fernández Bernabé, P, Garcés García, R, Gonzalez, J, Hernández, I, Herrera-Merino, N, Marqueta De Salas, M, Martinez Pascual, P, Perez Gonzalez, M, Ramos Bonilla, A, Rodríguez Gómez, L, Alfonso Garcia, M, Craus-Miguel, A, Fernández Vega, L, Ferrer-Inaebnit, E, Gil Catalán, A, González Argente, FX, Jeri, S, Oseira, A, Pujol Cano, N, Segura-Sampedro, JJ, Soldevila Verdeguer, C, Villalonga, B, Bescós, C, Blanco-Colino, R, Brana, I, Caimari, B, De Pablo García-Cuenca, A, Duran-Valles, F, Espin-Basany, E, Giralt López de Sagredo, J, Pamias, J, Pellino, G, Prat, N, Pujol Pina, R, Saez barba, M, Arulanantham, A, Bandara, GBKD, Jayarajah, U, Ravindrakumar, S, Rodrigo, VSD, Ali Adil, AA, Elhafiz, MHY, Ali, EE, Awadelkarim, M, Bakheit, I, Elbahri, H, Hamid, HKS, Essa, MEA, Ahmed, AA, Hassan, A, Hilles, MMY, Saleh, M, Arkani, S, Freedman, J, Elbe, P, Lindqvist, EK, Angenete, E, Park, J, Taflin, H, Greiff, L, Hagander, L, Älgå, A, Heinius, G, Nordberg, M, Pieniowski, E, Gkekas, I, Löfgren, N, Rutegård, M, Sund, M, Arigoni, M, Bernasconi, M, Christoforidis, D, Di Giuseppe, M, La Regina, D, Mongelli, F, Chevallay, M, Dwidar, O, Gialamas, E, Sauvain, M, Giger, R, Hool, S, Klenke, F, Kollàr, A, Kurze, C, Mueller, SA, Kiessling, S, Stoeckli, S, Adamina, M, Bächler, T, Crugnale, AS, Giardini, M, Guglielmetti, L, Peros, G, Solimene, F, Gass, M, Metzger, J, Scheiwiller, A, Gutschow, C, Turina, M, Al Asadi, T, Alkhateb, S, Altom, R, Bakkar, B, Maa Albared, S, Melhem, S, Hamdan, A, Hammed, A, Hammed, S, Hossain, M, Mahfoud, M, Moussa, A, Alsayyad, R, Alsrouji, S, Ashour, G, Hareth Al-Nahr, M, Slitin, A, Tanos, C, Kacem, MJ, Maghrebi, H, Sebai, A, Aghayeva, A, Hamzaoglu, I, Sahin, I, Akaydin, E, Aliyeva, Z, Aytac, E, Baca, B, Dülgeroglu, O, Ozben, V, Ozmen, BB, Uras, C, Arikan, AE, Bilgin, IA, Bozkirli, B, Ceyhan, GO, Kara, H, Karahasanoglu, T, Celik, H, Meydanli, MM, Akbas, A, Altinel, Y, Calikoglu, F, Ercan, G, Ercetin, C, Hacim, NA, Meriç, S, Tokocin, M, Vartanoglu, T, Yigitbas, H, Akilli, H, Ayhan, A, Kuscu, E, Dogangün, M, Iflazoglu, N, Yalkin, Ö, Turna, A, Onan, MA, Akgor, U, Cennet, O, Dincer, HA, Erol, T, Gultekin, M, Orhan, N, Ozgul, N, Salman, MC, Soyak, B, Aydemir, L, Basaran, B, Sen, C, Ulusan, M, Açikgöz, AS, Alhamed, A, Aykanat, Y, Bese, T, Cebi, S, Demirkiran, F, Ergün, S, Kayan, B, OZcelik, MF, Sanli, AN, Uludag, SS, Velidedeoglu, M, Zengin, AK, Bozkurt, MA, Kara, Y, Kocatas, A, Candas Altinbas, B, Çekiç, AB, Eyuboglu, K, Guner, A, Türkyilmaz, S, Usta, MA, Cimenoglu, B, Demirhan, R, Saracoglu, K, Azamat, IF, Balik, E, Bugra, D, Giray, B, Kulle, CB, Taskiran, C, Vatansever, D, Güler, SA, Güresin, A, Tatar, OC, Utkan, NZ, Yildirim, A, Yüksel, E, Abbasov, A, Yanar, H, Ugurlu, MU, Akin, E, Altintoprak, F, Bayhan, Z, Cakmak, G, Çapoglu, R, Çelebi, F, Demir, H, Dikicier, E, Firat, N, Gönüllü, E, Kamburoglu, MB, Kocer, B, Küçük, IF, Mantoglu, B, Çolak, E, Kucuk, GO, Uyanik, MS, Goksoy, B, Bozkurt, E, Citgez, B, Mihmanli, M, Tanal, M, Yetkin, G, Akalin, M, Arican, C, Avci, EK, Aydin, C, Demirli Atici, S, Emiroglu, M, Kaya, T, Kebabçi, E, Kilinc, G, Kirmizi, Y, Ögücü, H, Salimoglu, S, Sert, I, Tugmen, C, Tuncer, K, Uslu, G, Yesilyurt, D, Karaman, E, Kolusari, A, Yildiz, A, Gultekin, FA, Lule, H, Oguttu, B, Abdelgalil, K, Agilinko, J, Ahmeidat, A, Barabasz, M, Bekheit, M, Cheung, LK, Colloc, T, Cymes, W, Elhusseini, M, Gradinariu, G, Hannah, A, Kamera, BS, Mignot, G, Shaikh, S, Sharma, P, Abu-Nayla, I, Al-Mohammad, A, Ali, S, Ashcroft, J, Azizi, A, Baker, O, Balakrishnan, A, Byrne, M, Colquhoun, A, Cotter, A, Coughlin, P, Davies, RJ, Durrani, A, Elshaer, M, Fordington, S, Forouhi, P, Georgiades, F, Grimes, H, Habeeb, A, Hudson, V, Hutchinson, P, Irune, E, Jah, A, Khan, DZ, Kolias, A, Kyriacou, H, Lamb, B, Liau, S, Luke, L, Mahmoud, R, Mannion, R, Masterson, L, Mitrofan, C, Mohan, M, Morris, A, Murphy, S, O'Neill, JR, Price, S, Pushpa-rajah, J, Raby-Smith, W, Ramzi, J, Rooney, SM, Santarius, T, Singh, AA, Stewart, GD, Tan, XS, Townson, A, Tweedle, E, Walker, C, Waseem, S, Yordanov, S, Jones, T, Kattakayam, A, Loh, C, Lunevicius, R, Nunes, Q, Pringle, S, Schache, A, Shaw, R, Sheel, A, Sud, A, Sundhu, M, Rossborough, C, Angelou, D, Choynowski, M, McAree, B, McCanny, A, Neely, D, Kamel, F, Kumar, L, Madani, R, Nisar, P, Tutoveanu, G, Bittar, MN, Creanga, M, Elniel, M, Law, J, Youssef, M, Ahad, S, De La Cruz Monroy, MFI, Hashem, M, Langlands, F, Mosley, F, Oktseloglou, V, Omar, I, Patel, F, Alanbuki, A, Patel, M, Shabana, A, Rathinaezhil, R, Perera, E, Raveendran, D, Ravi-Shankar, K, Thiruchelvam, J, Che Bakri, NA, Jawad, Z, Jiao, L, Nazarian, S, Vashisht, R, Arrowsmith, L, Campbell, W, Grove, T, Kontovounisios, C, Warren, O, Rolland, P, Aggarwal, A, Brown, S, Jelley, C, Neal, N, Kaur, R, Leung, E, Sundar, S, Doulias, T, Li, M, Martin, E, Rodwell, H, Clifford, R, Eardley, N, Krishnan, E, Manu, N, Roy Mahapatra, S, Serevina, OL, Smith, C, Vimalachandran, D, Bordenave, M, Houston, R, Putnam, G, Robson, A, Tustin, H, Emslie, K, Labib, PL, Marchbank, A, Miller, D, Minto, G, Natale, J, Nwinee, H, Panahi, P, Rogers, L, Abubakar, A, Akhter Rahman, MM, O'Brien, H, Sasapu, K, Inglis, R, Ng, HJ, De Gea Rico, A, Ghazali, N, Lambert, J, Markose, G, Math, S, Sarantitis, I, Shreshtha, D, Simpson, R, Sonanis, S, Sultana, A, Taggarsi, M, Timbrell, S, Vaz, OP, Vitone, L, Day, A, Dent, H, Fahim, M, Waheed, S, Hunt, A, Laskar, N, Steinke, J, Thrumurthy, S, Massie, E, McGivern, K, Rutherford, D, Wilson, M, Hardie, J, Kazzaz, S, Bacarese-Hamilton, T, Ip, M, James, A, Salerno, G, Stockdale, T, Handa, S, Kaushal, M, Kler, A, Patel, P, Redfern, J, Tezas, S, Aawsaj, Y, Amonkar, S, Blackwell, L, Blake, D, Carter, J, Emerson, H, Fisher, A, Katory, M, Korompelis, P, McCormick, W, Mustafa, A, Pearce, L, Ratnavelu, N, Reehal, R, Damola, A, Kretzmer, L, Lalou, L, Lim, P, Manku, B, Parwaiz, I, Sandher, M, Stafford, J, Abdelkarim, M, Asqalan, A, Gala, T, Ibrahim, S, Maw, A, Mithany, R, Morgan, R, Sundaram Venkatesan, G, Holroyd, D, Jamieson, N, Jones, C, Shin, JS, Ang, K, Caruana, EJ, Chandarana, K, Chowdhry, MF, Mohammad, A, Nakas, A, Rathinam, S, Banfield, D, Boal, M, Brown, O, Dean, H, Dwerryhouse, S, Higgs, S, Vallance, A, Boyd, E, Irvine, V, Kirk, A, Bakolas, G, Boulton, A, Chandock, A, Khan, T, Kumar, M, Agoston, P, Billè, A, Challacombe, B, Fraser, S, Harrison-Phipps, K, King, J, McCrindle, S, Mehra, G, Mills, L, Najdy, M, Nath, R, Okiror, L, Pilling, J, Rizzo, V, Routledge, T, Sayasneh, A, Stroman, L, Wali, A, Fehervari, M, Fotopoulou, C, Habib, N, Hamrang-Yousefi, S, Pai, M, Ploski, J, Rajagopal, P, Saso, S, Sodergren, M, Spalding, D, Laws, S, Hardie, C, McNaught, C, Alam, R, Budacan, A, Cahill, J, Kalkat, M, Karandikar, S, Kenyon, L, Naumann, D, Patel, A, Chen, F, Cheung, J, Ayorinde, J, Chase, T, Cuming, T, Ghanbari, A, Humphreys, L, Tayeh, S, Aboelkassem Ibrahim, A, Bichoo, R, Cao, H, Chai, AKW, Choudhury, J, Evans, C, Fitzjohn, H, Ikram, H, Khalifa, E, Langstroth, M, Loubani, M, McMillan, A, Nazir, S, Qadri, SSA, Robinson, A, Ross, E, Sehgal, T, Wilkins, A, Dixon, J, Dunning, J, Freystaetter, K, Jha, M, Kusuma, VRM, Lester, S, Madhavan, A, Thulasiraman, SV, Viswanath, Y, Curl-Roper, T, Delimpalta, C, Liao, CCL, Velchuru, V, Westwood, E, Belcher, E, Bond-Smith, G, Chidambaram, S, Di Chiara, F, Fasanmade, K, Fraser, L, Fu, H, Ganau, M, Gore, S, Goricar, M, Graystone, J, Jeyaretna, D, Khatkar, H, Lami, M, Maher, M, Mastoridis, S, McVeigh, J, Mihai, R, Myatt, R, Piper, R, Prabhu, S, Risk, OBF, Selbong, U, Shah, K, Silva, P, Smillie, R, Soleymani majd, H, Sravanam, S, Stavroulias, D, Tebala, GD, Vatish, M, Verberne, C, Wallwork, K, Williams, MA, Winter, SC, Ahmed, I, Djouani, A, Eddy, B, Folkard, S, Hassan, F, Kommu, S, Papadopoulos, G, Simoes, A, Streeter, E, Tait-Bailey, J, Thomas, M, Wang, W, Yao, M, Anscomb, N, Baldwin-Smith, R, Davies, M, Grainger, C, Haji, A, Haq, A, Nunoo-Mensah, JW, Rizk, M, Bhatti, MI, Boyd-Carson, H, Elsey, E, Gemmill, E, Herrod, P, Jibreel, M, Lenzi, E, Saafan, T, Sapre, D, Sian, T, Watson, N, Athanasiou, A, Borg, E, Bourke, G, Bradshaw, L, Brunelli, A, Burke, J, Coe, P, Costigan, F, Elkadi, H, Ho, M, Johnstone, J, Kanatas, A, Kantola, V, Kaufmann, A, Laios, A, Lam, S, MacInnes, E, Munot, S, Nahm, C, Otify, M, Pompili, C, Raslan, M, Salminen, H, Smith, I, Theophilou, G, Toogood, G, Wade, R, Ward, D, West, C, Al-Harbawee, A, Alharawee, A, Annamalai, S, Ashmore, C, Boddy, A, Hossain, T, Irvine, E, Kassam, K, Kourdouli, A, Chean, CS, Dharamavaram, S, Gvaramadze, A, Jibril, A, Kulkarni, N, Pereira, I, Prusty, L, Shanthakunalan, K, Srikumar, B, Thekkinkattil, D, Adegbola, S, Menakaya, C, Noel, J, Harky, A, Shackcloth, M, Askari, A, Cirocchi, N, Kudchadkar, S, Patel, K, Sagar, J, Shaw, S, Talwar, R, Abdalla, M, Edmondson, R, Ismail, O, Jones, D, Newton, K, Stylianides, N, Aderombi, A, Andaleeb, U, Bajomo, O, Beatson, K, Garrett, W, Mehmood, M, Ng, V, Al-Habsi, R, Brimioulle, M, Divya, GS, Keeler, B, Soulsby, RE, Taylor, A, Al-Sarireh, B, Clancy, R, Cripps, P, Dobbs, T, Egan, R, Fabre, I, Harries, R, Henry, A, Kittur, M, Li, Z, Parkins, K, Soliman, F, Spencer, N, Thompson, D, Burgess, C, Gemmell, C, Grieco, C, Hollyman, M, Hunt, L, Morrison, J, Ojha, S, Abbadessa, F, Barnard, S, Dawe, N, Hammond, J, Koshy, RM, Mahmoud Ali, F, McPherson, I, Mellor, C, Moir, J, Pandanaboyana, S, Powell, J, Rai, B, Roy, C, Sachdeva, A, Saleh, C, Tingle, S, Williams, T, Manickavasagam, J, McDonald, C, McGrath, N, McSorley, N, Ragupathy, K, Ramsay, L, Solth, A, Aristotelous, C, Kakisi, O, Seebah, K, Shaikh, I, Sreedharan, L, Touil, L, Shah, J, Ameerally, P, Baguley, M, Gnanachandran, C, Heer, B, Rogers, M, Woods, R, Aujayeb, A, Mills, S, Abu, J, Addae-Boateng, E, Bratt, D, Brock, L, Burnside, N, Cadwell-Sneath, S, Gajjar, K, Gan, C, Grundy, C, Hallam, K, Hassell, K, Hawari, M, Joshi, A, Khout, H, Konstantinidi, K, Lee, RXN, Nunns, D, Schiemer, R, Walton, T, Weaver, H, Whisker, L, Williamson, K, Ahmed, ME, Bukhari, SI, Illingworth, B, Kanthasamy, S, Knights, E, Ong, SL, Pujari, R, Tan, KHM, Vanker, R, Michel, M, Patil, S, Ravindran, S, Sarveswaran, J, Scott, L, Biliatis, I, Edmond, M, King, E, Babawale, O, Hodgson, D, Ismail, M, Khan, J, Lokman, U, Phan, YC, Almond, M, Bhangu, A, Breik, O, Cato, LD, Chowdhury, YA, Desai, A, Ford, S, Griffiths, E, Idle, M, Kamal, M, Karia, K, Kisiel, A, Kulkarni, R, Mak, JKC, Martin, T, Nankivell, P, Parente, A, Parmar, S, Pathanki, AM, Phelan, L, Praveen, P, Saeed, S, Sharma, N, Singh, J, Solomou, G, Soon, WC, Stevens, A, Tirotta, F, Topham, C, Ughratdar, I, Vijayan, D, Ballantyne, K, Barker, L, Chapman, K, Charalambous, M, Chianakwalam, C, English, C, Evans, J, Fell, A, Frimpong, D, Halkias, C, Iyer, R, Merh, R, Neagu, G, Nikolaou, S, Poddar, A, Pronisceva, V, Reddy, V, Williams, N, Alakandy, L, Bhattathiri, P, Brown, J, Canty, M, Day, E, Geddes, A, Grivas, A, Hassan, S, Lammy, S, Littlechild, P, Maseland, C, Mathieson, C, McCaul, J, McMahon, J, O'Kane, R, St. George, E, Suttner, N, Taylor, W, Tilling, E, English, W, Kaul, S, Khan, AH, Khan, F, Mansuri, A, Mukherjee, S, Sarigul, M, Tan, KL, Vulliamy, P, Woodham, A, Yang, YH, Adiamah, A, Brewer, H, Chowdhury, A, Humes, D, Jackman, J, Koh, A, Lewis-Lloyd, C, Navarro, A, Oyende, O, Reilly, J, Vohra, R, Worku, D, Cool, P, Cribb, G, Shepherd, K, Bisset, C, Moug, S, Chadha, R, Elson, N, Galleano, R, Faulkner, G, Langone, A, Panayi, Z, Saleh, P, Tuminello, F, Underwood, C, Brixton, G, Findlay, L, Klatte, T, Majkowska, A, Manson, J, Potter, R, Al-Khyatt, W, Bhalla, A, Chia, Z, Daliya, P, Goyal, A, Grimley, E, Hamad, A, Malcolm, FL, Ng, JCK, Phillips, A, Theophilidou, E, Williams, S, Bowden, J, Campain, N, Daniels, I, Fowler, G, John, J, Massey, L, McDermott, F, McGrath, J, McLennan, A, Ng, M, Pascoe, J, Rajaretnam, N, Angamuthu, N, Bulathsinhala, S, Chowdhury, S, Davidson, B, Fusai, G, Gilliland, J, Hart, C, Hidalgo Salinas, C, Knowles, J, Machairas, N, Mirnezami, R, Pissanou, T, Pollok, JM, Raptis, DA, Soggiu, F, Tzerbinis, H, Varcada, M, Xyda, S, Beamish, A, Davies, E, Foulkes, R, Magowan, D, Nassa, H, Ooi, R, Price, C, Smith, L, Solari, F, Tang, A, Williams, G, Abd Kahar, NN, Al-Tamimi, Y, Bacon, A, Beasley, N, Catto, J, Chan, LH, Chew, D, Crank, M, Ilenkovan, N, Macdonald, M, Narice, B, Rominiyi, O, Saad, S, Sinha, S, Thompson, A, Varley, I, Brennan, P, Drake, T, Harrison, EM, Linder, G, Mayes, J, McGregor, R, Pasricha, R, Skipworth, RJE, Zamvar, V, Hawkin, P, Raymond, T, Ryska, O, Baron, R, Dunne, D, Gahunia, S, Halloran, C, Howes, N, McKinney, R, McNicol, F, Rajput, K, Russ, J, Sutton, R, Szatmary, P, Tan, JR, Whelan, P, Anzak, A, Banerjee, A, Fuwa, O, Hughes, F, Jayasinghe, JD, Knowles, C, Kocher, HM, Leal Silva, I, Ledesma, FS, Minicozzi, A, Navaratne, L, Patki, P, Rahman, R, Ramamoorthy, R, Sohrabi, C, Tanabalan, C, Thaha, M, Thakur, B, Venn, M, Yip, V, Baumber, R, Parry, J, Evans, S, Jeys, L, Morris, G, Parry, M, Ahmadi, N, Aresu, G, Barrett-Brown, ZM, Coonar, A, Durio Yates, H, Gearon, D, Hogan, J, King, M, Peryt, A, Pradeep, IS, Adishesh, M, Atherton, R, Baxter, K, Brocklehurst, M, Chaudhury, M, Krishnamohan, N, McAleer, J, Owens, G, Parkin, E, Patkar, P, Phang, I, Aladeojebi, A, Ali, M, Barmayehvar, B, Gaunt, A, Gowda, M, Halliday, E, Kitchen, M, Mansour, F, Nanjaiah, P, Zakai, D, Abbassi-Ghadi, N, Assalaarachchi, H, Currie, A, Flavin, M, Frampton, A, Hague, M, Hammer, C, Hopper, J, Horsnell, J, Humphries, S, Kamocka, A, Madhuri, TK, Preston, S, Singh, P, Stebbing, J, Tailor, A, Walker, D, Coomber, E, Jaunoo, S, Kennedy, L, Airey, A, Bunni, J, Crowley, R, Fairhurst, K, Frost, J, George, R, Lee, S, Mitchell, S, Phull, J, Richards, S, Aljanadi, F, Campbell, A, Glass, A, Hraishawi, I, Jones, M, McIlmunn, C, McIntosh, S, Mhandu, P, O'Donnell, C, Turkington, R, Al-Ishaq, Z, Bhasin, S, Bodla, AS, Burahee, A, Crichton, A, El-Ghobashy, A, Fossett, R, Pigadas, N, Rahman, E, Snee, D, Vidya, R, Yassin, N, Fountain, D, Hasan, MT, Karabatsou, K, Laurente, R, Pathmanaban, O, Barlow, C, Ding, D, Foster, J, Longstaff, L, Brett-Miller, C, Buruiana, FE, Al-mukhtar, A, Edwards, J, Giblin, A, Kelty, C, Lee, M, Lye, G, Newman, T, Sharkey, A, Steele, C, Sureshkumar Shah, N, Whitehall, E, Blair, J, Lakhiani, A, Parry-Smith, W, Sahu, B, Athwal, R, Baker, A, Jones, L, Konstantinou, C, Ramcharan, S, Vatish, J, Wilkin, R, Alzetani, A, Amer, K, Badran, A, Colvin, HV, Ethunandan, M, Sekhon, GK, Shakoor, Z, Shields, H, Singh, R, Talbot, T, Wensley, F, Lawday, S, Lyons, A, Newman, S, Chung, E, Hagger, R, Hainsworth, A, Hunt, I, Karim, A, Owen, H, Ramwell, A, Santhirakumaran, G, Smelt, J, Tan, C, Vaughan, P, Williams, K, Baker, C, Davies, A, Gossage, J, Kelly, M, Knight, W, Bromage, S, Hall, J, Kaushik, V, Rudic, M, Vallabh, N, Zhang, Y, Harris, G, James, G, Kang, C, Lin, DJ, Rajgor, AD, Royle, T, Scurrah, R, Steel, B, Watson, LJ, Choi, D, Hutchison, R, Luoma, V, Marcus, HJ, May, R, Menon, A, Pramodana, B, Webber, L, Hayes, A, Jones, R, Sivarajah, G, Smith, M, Smrke, A, Strauss, D, Abouelela, FAM, Aneke, IA, Asaad, P, Brown, B, Collis, J, Duff, S, Khan, A, Moura, F, Taylor, M, Wadham, B, Warburton, H, Elmoslemany, T, Jenkinson, MD, Millward, CP, Zakaria, R, Mccluney, S, Parmar, C, Shah, S, Allison, J, Babar, MS, Bowen, J, Collard, B, Goodrum, S, Lau, K, Sargent, M, Scott, R, Thomas, E, Whitmore, H, Balasubramaniam, D, Jayasankar, B, Kapoor, S, Ramachandran, A, Semple, C, Elhamshary, A, Imam, SMB, Kapriniotis, K, Kasivisvanathan, V, Lindsay, J, Rakhshani-Moghadam, S, Beech, N, Chand, M, Green, L, Kalavrezos, N, Kiconco, H, McEwen, R, Schilling, C, Sinha, D, Pereca, J, Chopra, S, Egbeare, D, Thomas, R, Arumugam, S, Ibrahim, B, Khan, K, Combellack, T, Hill, G, Jones, S, Kornaszewska, M, Mohammed, M, Tahhan, G, Valtzoglou, V, Blencowe, N, Eskander, P, Gash, K, Gourbault, L, Hanna, M, Maccabe, TA, Main, B, Olivier, J, Newton, C, Roswadowski, S, Ryan, N, Teh, E, West, D, Al-omishy, H, Baig, M, Bates, H, Di Taranto, G, Dickson, K, Dunne, N, Gill, C, Howe, D, Jeevan, D, Khajuria, A, Martin-Ucar, A, McEvoy, K, Naredla, P, Robertson, S, Sait, M, Sarma, DR, Shanbhag, S, Shortland, T, Simmonds, S, Skillman, J, Tewari, N, Walton, G, Akhtar, MA, Brunt, A, McIntyre, J, Milne, K, Rashid, MM, Sgrò, A, Stewart, KE, Turnbull, A, Abou-Foul, AK, Gossedge, G, O'Donnell, S, Oldfield, F, Thomson, S, Aguilar Gonzalez, M, Talukder, S, Boyle, C, Fernando, D, Gallagher, K, Laird, A, Tham, D, Bath, M, Basnyat, P, Davis, H, Montauban, P, Shrestha, A, Agarwal, K, Arif, T, Magee, C, Nambirajan, T, Powell, S, Vinayagam, R, Flindall, I, Hanson, A, Mahendran, V, Green, S, Lim, M, MacDonald, L, Miu, V, Onos, L, Sheridan, K, Young, R, Alam, F, Griffiths, O, Houlden, C, Kolli, VS, Lala, AK, Leeson, S, Peevor, R, Seymour, Z, Consorti, E, Gonzalez, R, Grolman, R, Kwan-Feinberg, R, Liu, T, Merzlikin, O, Brown, A, Cooper, Z, Hirji, S, Jolissaint, J, Mahvi, D, Okafor, B, Raut, CP, Roxo, V, Salim, A, Bessen, S, Chen, L, Dagrosa, L, Fay, K, Fleischer, C, Hasson, R, Henderson, E, Leech, M, Loehrer, A, Markey, C, Paydarfar, J, Rosenkranz, K, Telma, K, Tocci, N, Wilkinson-Ryan, I, Bokenkamp, M, Brown, K, Fleming, D, Heron, C, Hill, C, Kay, H, Leede, E, McElhinney, K, Olson, KA, Osterberg, EC, Riley, C, Srikanth, P, Barbour, J, Blazer, D, DiLalla, GA, Fayanju, O, Hwang, ES, Kahmke, R, Kazaure, H, Lazarides, A, Lee, W, Lidsky, M, Menendez, C, Moris, D, Plichta, J, Pradhan, MC, Puscas, L, Rice, HE, Rocke, D, Rosenberger, L, Scheri, R, Smith, BD, Stang, MT, Tolnitch, L, Turnage, K, Visgauss, J, Walton, FS, Watts, T, Zani, S, Farma, J, Cardona, K, Russell, MC, Clark, J, Kwon, D, Goel, N, Kronenfeld, J, Bigelow, B, Etchill, E, Gabre-Kidan, A, Jenny, H, Kent, A, Ladd, MR, Long, C, Malapati, H, Margalit, A, Rapaport, S, Rose, J, Stevens, K, Tsai, L, Vervoort, D, Yesantharao, P, Dehal, A, Klaristenfeld, D, Huynh, K, Kaafarani, H, Naar, L, Qadan, M, Brown, L, Ganly, I, Mullinax, JE, Alpert, N, Gillezeau, C, Miles, DDS, Taioli, E, Cha, DE, Gleeson, E, Horn, C, Sarpel, U, Gusani, N, Hazelton, J, Maines, J, Oh, JS, Ssentongo, A, Ssentongo, P, Bhama, A, Colling, K, Najarian, M, Azam, M, Choudhry, A, Marx, W, Abedin, Y, Arzumanov, G, Chokshi, R, Gabrilovich, S, Glass, N, Kalyoussef, E, Parvin-Nejad, FP, Roden, D, Stein, J, Suarez-Ligon, A, Tsui, G, Zhao, K, Fleming, J, Fuson, A, Gigliotti, J, Ovaitt, A, Ying, Y, Abel, MK, Andaya, V, Bigay, K, Boeck, MA, Chern, H, Corvera, C, El-Sayed, I, Glencer, A, Ha, P, Hamilton, BCS, Heaton, C, Hirose, K, Jablons, DM, Kirkwood, KS, Kornblith, LZ, Kratz, JR, Lee, RH, Miller, PN, Nakakura, EK, Nunez-Garcia, B, O'Donnell, RJ, Ozgediz, D, Park, P, Robinson, B, Sarin, A, Sheu, B, Varma, MG, Wai, KC, Wustrack, R, Xu, MJ, Zimel, M, Beswick, D, Goddard, J, Manor, J, Song, J, Cioci, A, Pavlis, W, Rakoczy, K, Ruiz, G, Saberi, R, Fullmer, T, Gaskill, C, Gross, N, Kiong, K, Roland, CL, Zafar, SN, Abdallah, M, Abouassi, A, Aigbivbalu, E, Eid, J, George, B, Kulkarni, G, Marwan, H, Mehdi, M, San Andrés, M, Sundaresan, J, Aoun, SG, Ban, VS, Batjer, HH, Bosler, K, Caruso, J, Sumer, B, Abbott, D, Acher, A, Aiken, T, Barrett, J, Foley, E, Schwartz, PB, Hawkins, AT, Maiga, A, Ruzgar, NM, Sion, M, Ullrich, S, Laufer, J, Scasso, S, Al-Naggar, H, Al-Shehari, M, Almassaudi, A, Alsayadi, M, Alsayadi, R, Nahshal, M, Shream, S, AL-Ameri, S, and Aldawbali, M
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- 2021
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21. Unravelling lipoprotein metabolism with stable isotopes: tracing the flow
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Ying, Qidi, Chan, Dick C., Barrett, P. Hugh R., and Watts, Gerald F.
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- 2021
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22. Lipoprotein(a) in Patients With Type 2 Diabetes and Premature Coronary Artery Disease in the Coronary Care Unit
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Lan, Nick S.R., Chan, Dick C., Pang, Jing, Fegan, P. Gerry, Yeap, Bu B., Rankin, James M., Schultz, Carl J., Watts, Gerald F., and Bell, Damon A.
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- 2021
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23. Gaps in the Care of Familial Hypercholesterolaemia in Australia: First Report From the National Registry
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Pang, Jing, Sullivan, David R., Hare, David L., Colquhoun, David M., Bates, Timothy R., Ryan, Jacqueline D.M., Bishop, Warrick, Burnett, John R., Bell, Damon A., Simons, Leon A., Mirzaee, Sam, Kostner, Karam M., Nestel, Paul J., Wilson, Andrew M., O’Brien, Richard C., Janus, Edward D., Clifton, Peter M., Ardill, Justin J., Chan, Dick C., van Bockxmeer, Frank, and Watts, Gerald F.
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- 2021
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24. Illustrating the implications of moving blocks on railway traffic flow behavior with fundamental diagrams
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Diaz de Rivera, Adrian and Dick, C. Tyler
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- 2021
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25. Cascade testing for elevated lipoprotein(a) in relatives of probands with high lipoprotein(a)
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Anindita Chakraborty, Dick C. Chan, Katrina L. Ellis, Jing Pang, Wendy Barnett, Ann Marie Woodward, Mary Vorster, Richard Norman, Eric K. Moses, and Gerald F. Watts
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Lipoprotein(a) ,Cascade testing ,Cardiovascular disease ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 ,Public aspects of medicine ,RA1-1270 - Abstract
Objective: Elevated lipoprotein(a) [Lp(a)] is a common inherited condition associated with cardiovascular disease. This study investigated whether cascade testing for Lp(a) was effective in detecting new cases of elevated Lp(a) in families. Methods: Relatives from adult probands with Lp(a) concentration ≥100 mg/dL were tested for elevated Lp(a) (≥50 mg/dL) via a cascade testing program in a tertiary hospital setting. The prevalence and yield of detecting new cases of elevated Lp(a) among the relatives were assessed. Results: Of the 83 probands, 43.4% had familial combined hyperlipidemia (FCHL) and 34.9% common hypercholesterolemia (CH). Among 182 relatives tested (151 adults and 31 children), elevated Lp(a) was found in 68.1%, with 32.9% having Lp(a) between 50 and 99 mg/dL and 35.2% having Lp(a) ≥100 mg/dL. One new case of elevated Lp(a) ≥50 mg/dL was identified for every 1.5 relatives tested and 1 new case of elevated Lp(a) ≥100 mg/dL for every 2.8 relatives tested. The proportion of relatives detected with elevated Lp(a) was significantly higher when tested from probands with Lp(a) >150 mg/dL compared with those with Lp(a) between 100 and 150 mg/dL (81.1% vs. 55.5%; P = 0.001). The concordance rates (kappa coefficient) for the detection of elevated Lp(a) with FCHL and CH were 34.8% (0.026) and 53.2% (0.099), respectively. Conclusion: Cascade testing for elevated Lp(a) from affected probands with phenotypic dyslipidemia is highly effective in identifying new cases of high Lp(a) in families. The yield of detecting elevated Lp(a) is greater when probands have higher levels of Lp(a) and exceeds the detection of relatives with FCHL and CH.
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- 2022
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26. ANGPTL3 as a therapeutic target for treating homozygous familial hypercholesterolaemia: a shot in the arm for evinacumab.
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Watts, Gerald F, Zadeh, Seyed Saeed Tamehri, and Chan, Dick C
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FAMILIAL hypercholesterolemia ,HOMOZYGOUS familial hypercholesterolemia ,ANGIOPOIETIN-like proteins ,LIPOPROTEIN lipase ,CLINICAL trials ,RNA interference - Abstract
The article discusses the use of evinacumab as a potential therapeutic target for treating homozygous familial hypercholesterolaemia (HoFH). HoFH is a rare genetic condition characterized by extremely high levels of LDL-cholesterol and a high risk of cardiovascular disease. Current treatments are generally ineffective in lowering LDL-cholesterol to recommended levels. Evinacumab, an antibody that inhibits ANGPTL3, has shown promise in reducing LDL-cholesterol levels in patients with HoFH. The article presents data from a phase III trial demonstrating the long-term efficacy and safety of evinacumab in reducing LDL-cholesterol levels in HoFH patients. The study also discusses the mode of action of evinacumab and its potential role in the management of other conditions related to high cholesterol. [Extracted from the article]
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- 2024
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27. Familial Hypercholesterolemia and Elevated Lipoprotein(a): Cascade Testing and Other Implications for Contextual Models of Care
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Wann Jia Loh, Dick C. Chan, Pedro Mata, and Gerald F. Watts
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cascade testing ,familial hypercholesterolemia ,lipoprotein (a) ,Lp(a) ,inherited hypercholesterolemia ,hyper-Lp(a) ,Genetics ,QH426-470 - Abstract
Elevated lipoprotein(a) [Lp(a)], a predominantly genetic disorder, is a causal risk factor for atherosclerotic cardiovascular disease (ASCVD) and calcific aortic valvular disease, particularly in patients with familial hypercholesterolemia (FH), a Tier I genomic condition. The combination from birth of the cumulative exposure to elevated plasma concentrations of both Lp(a) and low-density lipoprotein is particularly detrimental and explains the enhanced morbidity and mortality risk observed in patients with both conditions. An excellent opportunity to identify at-risk patients with hyper-Lp(a) at increased risk of ASCVD is to test for hyper-Lp(a) during cascade testing for FH. With probands having FH and hyper-Lp(a), the yield of detection of hyper-Lp(a) is 1 individual for every 2.1–2.4 relatives tested, whereas the yield of detection of both conditions is 1 individual for every 3–3.4 relatives tested. In this article, we discuss the incorporation of assessment of Lp(a) in the cascade testing in FH as a feasible and crucial part of models of care for FH. We also propose a simple management tool to help physicians identify and manage elevated Lp(a) in FH, with implications for the care of Lp(a) beyond FH, noting that the clinical use of RNA therapeutics for specifically targeting the overproduction of Lp(a) in at risk patients is still under investigation.
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- 2022
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28. Coronary artery disease and the risk-associated LPA variants, rs3798220 and rs10455872, in patients with suspected familial hypercholesterolaemia
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Page, Michael M., Ellis, Katrina L., Pang, Jing, Chan, Dick C., Hooper, Amanda J., Bell, Damon A., Burnett, John R, and Watts, Gerald F
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- 2020
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29. PCSK9 Inhibition with alirocumab increases the catabolism of lipoprotein(a) particles in statin-treated patients with elevated lipoprotein(a)
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Watts, Gerald F., Chan, Dick C., Pang, Jing, Ma, Louis, Ying, Qidi, Aggarwal, Shashi, Marcovina, Santica M., and Barrett, P. Hugh R.
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- 2020
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30. An age-matched computed tomography angiographic study of coronary atherosclerotic plaques in patients with familial hypercholesterolaemia
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Pang, Jing, Abraham, Arun, Vargas-García, Cristian, Bates, Timothy R., Chan, Dick C., Hooper, Amanda J., Bell, Damon A., Burnett, John R., Schultz, Carl J., and Watts, Gerald F.
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- 2020
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31. Fractional turnover of apolipoprotein(a) and apolipoprotein B-100 within plasma lipoprotein(a) particles in statin-treated patients with elevated and normal Lp(a) concentration
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Ma, Louis, Chan, Dick C., Ooi, Esther M.M., Barrett, P. Hugh R., and Watts, Gerald F.
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- 2019
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32. Long-Term Efficacy and Safety of Evinacumab in Patients with Homozygous Familial Hypercholesterolemia: Real-World Clinical Experience
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Claudia Stefanutti, Dick C. Chan, Serafina Di Giacomo, Claudia Morozzi, and Gerald F. Watts
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angiopoietin-like 3 protein inhibitors ,atherosclerotic cardiovascular disease ,familial hypercholesterolemia ,lipoprotein apheresis ,low-density lipoprotein ,Medicine ,Pharmacy and materia medica ,RS1-441 - Abstract
Homozygous familial hypercholesterolemia (HoFH) is a rare, genetic condition characterized by markedly elevated plasma low-density lipoprotein cholesterol (LDL-C) concentrations from birth and increased risk of premature atherosclerotic cardiovascular disease. Evinacumab is an inhibitor of angiopoietin-like 3 protein that offers a new approach for correcting high LDL-C in HoFH. Evinacumab was administered intravenously (15 mg/kg Q4W) for 24 months in 7 patients with genetically confirmed HoFH, receiving background lipoprotein apheresis (LA) and/or lipid-lowering treatment (LLT). Assessment of efficacy and safety were carried out before and after 24 months of evinacumab treatment. The LDL-C lowering effect of evinacumab without LA were also investigated in the 7 HoFH patients after a subsequent compassionate extension period. Twenty-four months of treatment with evinacumab against background LA and LLT resulted in a significant reduction in LDL-C (−46.8%; p < 0.001). LDL-C reduction with evinacumab was maintained during the compassionate extensions period in the absence of treatment with LA (−43.4%; mean follow-up of 208 ± 90 days). Evinacumab was well-tolerated, with no major adverse event reported or significant changes in liver and muscle enzyme concentrations. Our findings suggest that evinacumab is a safe and effective treatment for patients with HoFH receiving best standard of care in a routine setting.
- Published
- 2022
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33. Comparative aspects of the care of familial hypercholesterolemia in the “Ten Countries Study”
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Pang, Jing, Chan, Dick C., Hu, Miao, Muir, Lauretta A., Kwok, See, Charng, Min-Ji, Florkowski, Christopher M., George, Peter M., Lin, Jie, Loi, Do Doan, Marais, A. David, Nawawi, Hapizah M., Gonzalez-Santos, Lourdes E., Su, Ta-Chen, Truong, Thanh Huong, Santos, Raul D., Soran, Handrean, Tomlinson, Brian, Yamashita, Shizuya, Ademi, Zanfina, and Watts, Gerald F.
- Published
- 2019
- Full Text
- View/download PDF
34. Recent dynamic studies of the metabolism of atherogenic lipoproteins: elucidating the mode of action of new therapies
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Chan, Dick C., Ying, Qidi, and Watts, Gerald F.
- Published
- 2021
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35. Plasma lipoprotein(a) is associated with calcification activity of the thoracic aorta and aortic valve in statin naïve individuals with diabetes mellitus.
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Bellinge, Jamie W., Chan, Dick C., Pang, Jing, Francis, Roslyn J., Page, Michael M., Watts, Gerald F., and Schultz, Carl J.
- Subjects
- *
AORTIC valve , *LIPOPROTEIN A , *THORACIC aorta , *POSITRON emission tomography computed tomography , *CALCIFICATION , *DIABETES , *CAROTID intima-media thickness - Abstract
This article explores the relationship between plasma lipoprotein(a) (Lp(a)) levels and calcification activity in the thoracic aorta and aortic valve in individuals with diabetes mellitus who have not taken statin therapy. The study used 18F‐Sodium Fluoride Positron Emission Tomography (18F‐NaF PET) to detect calcification activity and found that Lp(a) is a causal risk factor for cardiovascular disease (CVD) and may contribute to arterial calcification. The findings provide valuable insights into the complex pathophysiology of arterial calcification in individuals with diabetes mellitus. Further research is needed to explore potential therapeutic interventions. [Extracted from the article]
- Published
- 2024
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36. New Insights Into the Regulation of Lipoprotein Metabolism by PCSK9: Lessons From Stable Isotope Tracer Studies in Human Subjects
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Qidi Ying, Dick C. Chan, and Gerald F. Watts
- Subjects
PCSK9 ,PCSK9 inhibitor ,LDL-cholesterol ,lipoprotein(a) ,lipoprotein metabolism ,stable isotope tracer study ,Physiology ,QP1-981 - Abstract
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a convertase enzyme mostly produced by the liver. It is a key regulator of LDL metabolism because of its ability to enhance degradation of the LDL receptor. PCSK9 also regulates the metabolism of lipoprotein(a) [Lp(a)] and triglyceride-rich lipoproteins (TRLs). Its key role in modulating atherosclerotic cardiovascular disease (ASCVD) is supported by genetic studies and clinical outcome trials. Kinetic studies provide mechanistic insight into the role of PCSK9 in regulating the physiology and pathophysiology of plasma lipids and lipoproteins. Kinetic data have demonstrated that plasma PCSK9 concentration is inversely associated with the clearance of LDL in men. Gain-of-function mutations of PCSK9 markedly increase plasma LDL-cholesterol concentrations due to impaired LDL-apoB catabolism. Conversely, PCSK9 deficiency results in low LDL-cholesterol associated with enhanced LDL-apoB clearance. Inhibition of PCSK9 with monoclonal antibodies (such as evolocumab or alirocumab) lowers plasma LDL-cholesterol and apoB levels chiefly by upregulating the catabolism of LDL particles in healthy individuals. As monotherapy, PCSK9 inhibitor reduced Lp(a) concentrations by decreasing the production rate. However, as combination therapy, it reduced the plasma concentration of Lp(a) by increasing the fractional catabolism of Lp(a) particles. In statin-treated patients with high Lp(a), PCSK9 inhibition lowers plasma Lp(a) concentrations by accelerating the catabolism of Lp(a) particles. The effect of PCSK9 inhibition on TRL metabolism has been studied in healthy individuals and in patients with type 2 diabetes. These findings suggest that PCSK9 appears to play a less important role in TRL than LDL metabolism. Kinetic studies of PCSK9 inhibition therapy on lipoprotein metabolism in diverse high risk patient populations (such as familial hypercholesterolemia) and new therapeutic combination also merit further investigation.
- Published
- 2021
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37. Therapeutic inhibition of angiopoietin-like protein 3 for hypertriglyceridaemia and residual risk of ASCVD: beginning of the end or end of the beginning?
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Watts, Gerald F and Chan, Dick C
- Published
- 2024
- Full Text
- View/download PDF
38. Development and testing of a novel offshore pumped storage concept for storing energy at sea − Stensea
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Puchta, M., Bard, J., Dick, C., Hau, D., Krautkremer, B., Thalemann, F., and Hahn, H.
- Published
- 2017
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39. Association of Serum Lipoprotein (a) With the Requirement for a Peripheral Artery Operation and the Incidence of Major Adverse Cardiovascular Events in People With Peripheral Artery Disease
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Jonathan Golledge, Sophie Rowbotham, Ramesh Velu, Frank Quigley, Jason Jenkins, Michael Bourke, Bernie Bourke, Shivshankar Thanigaimani, Dick C. Chan, and Gerald F. Watts
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Peripheral artery disease ,surgical treatment ,lipoprotein (a) ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background The aim of this study was to assess the relationship between serum lipoprotein (a) (Lp[a]) concentration and the requirement for peripheral artery disease (PAD) operations or incidence of major adverse cardiovascular events. Methods and Results A total of 1472 people with PAD presenting with intermittent claudication (n=355), abdominal aortic aneurysm (n=989) or critical limb ischemia (n=128) were prospectively recruited from 4 outpatient clinics in Australia. Lp(a) was measured in serum samples collected at recruitment using an immunoassay. Participants were followed for a median (interquartile range) of 2.4 (0.1–6.1) years to record requirement for any PAD operation, defined to include any open or endovascular PAD intervention (lower limb peripheral revascularization, abdominal aortic aneurysm repair, other aneurysm repair, or carotid artery revascularization). Myocardial infarctions, strokes, and deaths were also recorded. The association of Lp(a) with events was assessed using Cox proportional hazard analysis adjusting for traditional risk factors. Participants with Lp(a) ≥30 mg/dL had a greater requirement for any PAD operation (hazard ratio, 1.20, 95% CI, 1.02–1.41) and lower limb peripheral revascularization alone (hazard ratio 1.33, 95% CI, 1.06–1.66) but no increased risk of major adverse cardiovascular events or all‐cause mortality. Lp(a) ≥50 mg/dL and a 40 mg/dL increase in Lp(a) were also associated with an increased risk of lower limb peripheral revascularization alone but not with other outcomes. Conclusions In participants with PAD referred for hospital management those with high Lp(a) had greater requirement for lower limb peripheral revascularization but Lp(a) was not consistently associated with other clinical events.
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- 2020
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40. Prevalence and predictors of depression and well-being after hysterectomy: An observational study
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Theunissen, Maurice, Peters, Madelon L., Schepers, Jan, Schoot, Dick C., Gramke, Hans-Fritz, and Marcus, Marco A.
- Published
- 2017
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41. Adherence to pharmacotherapy: sine qua non for reducing cumulative risk of premature coronary disease in familial hypercholesterolemia.
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Jing Pang, Sanfilippo, Frank M., Chan, Dick C., and Watts, Gerald F.
- Published
- 2024
- Full Text
- View/download PDF
42. Cascade testing of children and adolescents for elevated Lp(a) in pedigrees with familial hypercholesterolaemia.
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Loh, Wann Jia, Pang, Jing, Chakraborty, Anindita, Ward, Natalie C., Chan, Dick C., Hooper, Amanda J., Bell, Damon A., Burnett, John R., Martin, Andrew C., and Watts, Gerald F.
- Subjects
CARDIOVASCULAR diseases ,HYPERLIPOPROTEINEMIA ,FAMILIAL hypercholesterolemia ,GENEALOGY ,LIPOPROTEINS ,DESCRIPTIVE statistics ,PEDIATRICS ,CLINICAL pathology ,GENETIC techniques ,COMPARATIVE studies ,GENETIC testing ,SENSITIVITY & specificity (Statistics) ,ADOLESCENCE ,CHILDREN - Abstract
• Cascade testing for elevated Lp(a) from index cases with FH and elevated Lp(a) is effective by identifying 1 new case of elevated Lp(a) for every 2 children/adolescents tested. • Incorporating the detection of elevated Lp(a) into cascade testing for FH among children and adolescents is feasible. • More research is required to determine the clinical impact and value of identifying children and adolescents with elevated Lp(a). Elevated plasma lipoprotein(a) [Lp(a)] is a common, inherited condition independently causing cardiovascular disease. Recent expert recommendations suggest opportunistically testing for elevated Lp(a) during cascade testing for familial hypercholesterolaemia (FH). We investigated the effectiveness of detecting elevated Lp(a) in 103 children and adolescents who were first-degree relatives of 66 adult index FH cases as part of an established FH cascade screening program. The yield of detection of elevated Lp(a) using a threshold of ≥30 mg/dL in children and adolescents was assessed. Cascade testing from FH index cases with elevated Lp(a) ≥50 mg/dL identified 1 case of Lp(a) ≥30 mg/dL for every 2 children or adolescents tested. In contrast, opportunistic screening from index cases with FH but normal Lp(a) levels demonstrated 1 case of Lp(a) ≥30 mg/dL for every 7.5 children or adolescents tested (p < 0.001). In conclusion, cascade testing for elevated Lp(a) from index cases with FH and elevated Lp(a) is effective in identifying new cases of elevated Lp(a). [ABSTRACT FROM AUTHOR]
- Published
- 2024
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- View/download PDF
43. An Analysis of the Gut Microbiota and Related Metabolites following PCSK9 Inhibition in Statin-Treated Patients with Elevated Levels of Lipoprotein(a).
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Caparrós-Martín, Jose A., Maher, Patrice, Ward, Natalie C., Saladié, Montserrat, Agudelo-Romero, Patricia, Stick, Stephen M., Chan, Dick C., Watts, Gerald F., and O'Gara, Fergal
- Subjects
CHOLESTEROL metabolism ,GUT microbiome ,SHORT-chain fatty acids ,INDUCTIVELY coupled plasma mass spectrometry ,CALPROTECTIN ,BILE acids ,METABOLITES ,LIPOPROTEIN A - Abstract
Background. Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of global mortality, often associated with high blood levels of LDL cholesterol (LDL-c). Medications like statins and PCSK9 inhibitors, are used to manage LDL-c levels and reduce ASCVD risk. Recent findings connect the gut microbiota and its metabolites to ASCVD development. We showed that statins modulate the gut microbiota including the production of microbial metabolites involved in the regulation of cholesterol metabolism such as short chain fatty acids (SCFAs) and bile acids (BAs). Whether this pleiotropic effect of statins is associated with their antimicrobial properties or it is secondary to the modulation of cholesterol metabolism in the host is unknown. In this observational study, we evaluated whether alirocumab, a PCSK9 inhibitor administered subcutaneously, alters the stool-associated microbiota and the profiles of SCFAs and BAs. Methods. We used stool and plasma collected from patients enrolled in a single-sequence study using alirocumab. Microbial DNA was extracted from stool, and the bacterial component of the gut microbiota profiled following an amplicon sequencing strategy targeting the V3-V4 region of the 16S rRNA gene. Bile acids and SCFAs were profiled and quantified in stool and plasma using mass spectrometry. Results. Treatment with alirocumab did not alter bacterial alpha (Shannon index, p = 0.74) or beta diversity (PERMANOVA, p = 0.89) in feces. Similarly, circulating levels of SCFAs (mean difference (95% confidence interval (CI)), 8.12 [−7.15–23.36] µM, p = 0.25) and BAs (mean difference (95% CI), 0.04 [−0.11–0.19] log10(nmol mg
−1 feces), p = 0.56) were equivalent regardless of PCSK9 inhibition. Alirocumab therapy was associated with increased concentration of BAs in feces (mean difference (95% CI), 0.20 [0.05–0.34] log10(nmol mg−1 feces), p = 0.01). Conclusion. In statin-treated patients, the use of alirocumab to inhibit PCSK9 leads to elevated levels of fecal BAs without altering the bacterial population of the gut microbiota. The association of alirocumab with increased fecal BA concentration suggests an additional mechanism for the cholesterol-lowering effect of PCSK9 inhibition. [ABSTRACT FROM AUTHOR]- Published
- 2024
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- View/download PDF
44. Metabolism of lipoprotein(a): new findings, implications and outstanding issues
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Chan, Dick C. and Watts, Gerald F.
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- 2020
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45. Lipoprotein(a) Particle Production as a Determinant of Plasma Lipoprotein(a) Concentration Across Varying Apolipoprotein(a) Isoform Sizes and Background Cholesterol‐Lowering Therapy
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Dick C. Chan, Gerald F. Watts, Blai Coll, Scott M. Wasserman, Santica M. Marcovina, and P. Hugh R. Barrett
- Subjects
apolipoprotein ,cardiovascular disease risk factors ,cholesterol‐lowering drugs ,lipids and lipoprotein metabolism ,low‐density lipoprotein ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Elevated lipoprotein(a) (Lp(a)), a low‐density lipoprotein‐like particle bound to the polymorphic apolipoprotein(a) (apo(a)), may be causal for cardiovascular disease. However, the metabolism of Lp(a) in humans is poorly understood. Methods and Results We investigated the kinetics of Lp(a)‐apo(a) and low‐density lipoprotein‐apoB‐100 in 63 normolipidemic men. The fractional catabolic rate (FCR) and production rate PR) were studied. Plasma apo(a) concentration was significantly and inversely associated with apo(a) isoform size (r=−0.536, P0.05) in subjects with smaller apo(a) isoform size. In contrast, both apo(a) PR and FCR were significantly associated with plasma apo(a) concentrations (r=0.744 and −0.389, respectively, P
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- 2019
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46. Familial combined hyperlipidemia and hyperlipoprotein(a) as phenotypic mimics of familial hypercholesterolemia: Frequencies, associations and predictions
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Ellis, Katrina L., Pang, Jing, Chan, Dick C., Hooper, Amanda J., Bell, Damon A., Burnett, John R., and Watts, Gerald F.
- Published
- 2016
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- View/download PDF
47. Thermal analysis of calcium sulfate dihydrate sources used to manufacture gypsum wallboard
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Engbrecht, Dick C. and Hirschfeld, Deidre A
- Published
- 2016
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48. Angiographic progression of coronary atherosclerosis in patients with familial hypercholesterolaemia treated with non-statin therapy: Impact of a fat-modified diet and a resin
- Author
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Watts, Gerald F., Pang, Jing, Chan, Dick C., Brunt, John N.H., and Lewis, Barry
- Published
- 2016
- Full Text
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49. Plasma Proprotein Convertase Subtilisin Kexin Type 9 as a Predictor of Carotid Atherosclerosis in Asymptomatic Adults
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Chan, Dick C., Pang, Jing, McQuillan, B.M., Hung, Joseph, Beilby, John P., Barrett, P. Hugh R., and Watts, Gerald F.
- Published
- 2016
- Full Text
- View/download PDF
50. Elevated lipoprotein(a), hypertension and renal insufficiency as predictors of coronary artery disease in patients with genetically confirmed heterozygous familial hypercholesterolemia
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Chan, Dick C., Pang, Jing, Hooper, Amanda J., Burnett, John R., Bell, Damon A., Bates, Timothy R., van Bockxmeer, Frank M., and Watts, Gerald F.
- Published
- 2015
- Full Text
- View/download PDF
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