280 results on '"Das, Sunit"'
Search Results
2. Treatment, healthcare utilization and outcomes in patients with glioblastoma in Ontario: a 10-year cohort study
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Baqri, Wafa, Rzadki, Kathryn, Habbous, Steven, and Das, Sunit
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- 2024
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3. One-carbon-mediated purine synthesis underlies temozolomide resistance in glioblastoma
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Ghannad-Zadeh, Kimia, Ivanova, Alyona, Wu, Megan, Wilson, Taylor M., Lau, Alyssa, Flick, Robert, Munoz, David G., and Das, Sunit
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- 2024
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4. Patterns of T2-FLAIR discordance across a cohort of adult-type diffuse gliomas and deviations from the classic T2-FLAIR mismatch sign
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Malik, Prateek, Soliman, Radwa, Chen, Yingming Amy, Munoz, David G., Das, Sunit, Bharatha, Aditya, and Mathur, Shobhit
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- 2024
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5. Predictors of Tumor Dynamics Over a 6-Week Course of Concurrent Chemoradiotherapy for Glioblastoma and the Effect on Survival
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Ong, Wee Loon, Stewart, James, Sahgal, Arjun, Soliman, Hany, Tseng, Chia-Lin, Detsky, Jay, Chen, Hanbo, Ho, Ling, Das, Sunit, Maralani, Pejman, Lipsman, Nir, Stanisz, Greg, Perry, James, Lim-Fat, Mary Jane, Atenafu, Eshetu G., Lau, Angus, Ruschin, Mark, and Myrehaug, Sten
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- 2024
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6. A brave new framework for glioma drug development
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Hotchkiss, Kelly M, Karschnia, Philipp, Schreck, Karisa C, Geurts, Marjolein, Cloughesy, Timothy F, Huse, Jason, Duke, Elizabeth S, Lathia, Justin, Ashley, David M, Nduom, Edjah K, Long, Georgina, Singh, Kirit, Chalmers, Anthony, Ahluwalia, Manmeet S, Heimberger, Amy, Bagley, Stephen, Todo, Tomoki, Verhaak, Roel, Kelly, Patrick D, Hervey-Jumper, Shawn, de Groot, John, Patel, Anoop, Fecci, Peter, Parney, Ian, Wykes, Victoria, Watts, Colin, Burns, Terry C, Sanai, Nader, Preusser, Matthias, Tonn, Joerg Christian, Drummond, Katharine J, Platten, Michael, Das, Sunit, Tanner, Kirk, Vogelbaum, Michael A, Weller, Michael, Whittle, James R, Berger, Mitchel S, and Khasraw, Mustafa
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- 2024
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7. Post-conflict recovery of tigers (Panthera tigris) in a transboundary landscape: The case of Manas National Park, India
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Lahkar, Dipankar, Ahmed, M. Firoz, Begum, Ramie H., Das, Sunit Kumar, Sarma, Hiranya Kumar, Swargowari, Anindya, Jhala, Y.V., Samad, Imran, and Harihar, Abishek
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- 2024
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8. Re-irradiation for recurrent high-grade glioma: an analysis of prognostic factors for survival and predictors of radiation necrosis
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Moore-Palhares, Daniel, Chen, Hanbo, Keith, Julia, Wang, Michael, Myrehaug, Sten, Tseng, Chia-Lin, Detsky, Jay, Perry, James, Lim-Fat, Mary Jane, Heyn, Chris, Maralani, Pejman, Lipsman, Nir, Das, Sunit, Sahgal, Arjun, and Soliman, Hany
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- 2023
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9. Dose-Escalated Radiation Therapy Is Associated With Improved Outcomes for High-Grade Meningioma
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Zeng, K. Liang, Soliman, Hany, Myrehaug, Sten, Tseng, Chia-Lin, Detsky, Jay, MD, Chen, Hanbo, MD, Lim-Fat, Mary-Jane, Ruschin, Mark, Atenafu, Eshetu G., Keith, Julia, Lipsman, Nir, Heyn, Chris, Maralani, Pejman, Das, Sunit, Pirouzmand, Farhad, and Sahgal, Arjun
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- 2024
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10. Human Epidermal Growth Factor Receptor 2–Low Breast Cancer Brain Metastases: An Opportunity for Targeted Systemic Therapies in a High-Need Patient Population
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Chehade, Rania, Nofech-Mozes, Sharon, Plotkin, Anna, Fan, Kevin Yijun, Das, Sunit, Sahgal, Arjun, Moravan, Veronika, and Jerzak, Katarzyna Joanna
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- 2024
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11. Brain Metastases in the Setting of Stable Versus Progressing Extracranial Disease Among Patients With Metastatic Breast Cancer
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Kojundzic, Isabella, Chehade, Rania, Gonzalez, Carlos A. Carmona, Fritz, Jamie, Moravan, Veronika, Sahgal, Arjun, Warner, Ellen, Das, Sunit, and Jerzak, Katarzyna J.
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- 2024
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12. Re-examining prophylactic cranial irradiation in small cell lung cancer: a systematic review and meta-analysis
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Gaebe, Karolina, Erickson, Anders W., Li, Alyssa Y., Youssef, Andrew N., Sharma, Bhagyashree, Chan, Kelvin K.W., Lok, Benjamin H., and Das, Sunit
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- 2024
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13. Detection of lung cancer metastasis from blood using L-MISC nanosensor: Targeting circulating metastatic cues for improved diagnosis
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Premachandran, Srilakshmi, Dhinakaran, Ashok Kumar, Das, Sunit, Venkatakrishnan, Krishnan, Tan, Bo, and Sharma, Mansi
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- 2024
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14. Hypofractionated stereotactic radiosurgery (HSRS) as a salvage treatment for brain metastases failing prior stereotactic radiosurgery (SRS)
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Yan, Michael, Lee, Minha, Myrehaug, Sten, Tseng, Chia-Lin, Detsky, Jay, Chen, Hanbo, Das, Sunit, Yeboah, Collins, Lipsman, Nir, Costa, Leodante Da, Holden, Lori, Heyn, Chinthaka, Maralani, Pejman, Ruschin, Mark, Sahgal, Arjun, and Soliman, Hany
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- 2023
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15. Diffusion-weighted imaging on an MRI-linear accelerator to identify adversely prognostic tumour regions in glioblastoma during chemoradiation
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Lawrence, Liam S.P., Chan, Rachel W., Chen, Hanbo, Stewart, James, Ruschin, Mark, Theriault, Aimee, Myrehaug, Sten, Detsky, Jay, Maralani, Pejman J., Tseng, Chia-Lin, Soliman, Hany, Jane Lim-Fat, Mary, Das, Sunit, Stanisz, Greg J., Sahgal, Arjun, and Lau, Angus Z.
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- 2023
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16. Fractionated radiotherapy for surgically resected intracranial meningiomas: A multicentre retrospective cohort study
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Wang, Justin Z., Nassiri, Farshad, Landry, Alexander P, Patil, Vikas, Rebchuk, Alexander, Merali, Zamir A., Gui, Chloe, Lee, Grace, Rogers, Lauren, Sinha, Jessica, Patel, Zeel, Zuccato, Jeffrey A., Voisin, Mathew R., Munoz, David, Spears, Julian, Cusimano, Michael D., Das, Sunit, Makarenko, Serge, Yip, Stephen, Gao, Andrew, Laperriere, Normand, Tsang, Derek S., and Zadeh, Gelareh
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- 2023
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17. Gamma knife icon based hypofractionated stereotactic radiosurgery (GKI-HSRS) for brain metastases: impact of dose and volume
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Yan, Michael, Holden, Lori, Wang, Michael, Soliman, Hany, Myrehaug, Sten, Tseng, Chia-Lin, Detsky, Jay, Ruschin, Mark, Tjong, Michael, Atenafu, Eshetu G., Das, Sunit, Lipsman, Nir, Heyn, Chinthaka, Sahgal, Arjun, and Husain, Zain
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- 2022
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18. Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries
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Glasbey, James C, Abbott, Tom EF, Ademuyiwa, Adesoji, Adisa, Adewale, AlAmeer, Ehab, Alshryda, Sattar, Arnaud, Alexis P, Bankhead-Kendall, Brittany, Abou Chaar, M K, Chaudhry, Daoud, Costas-Chavarri, Ainhoa, Cunha, Miguel F, Davies, Justine I, Desai, Anant, Elhadi, Muhammed, Fiore, Marco, Fitzgerald, James Edward, Fourtounas, Maria, Fowler, Alex James, Futaba, Kay, Gallo, Gaetano, Ghosh, Dhruva, Gujjuri, Rohan R, Hamilton, Rebecca, Haque, Parvez, Harrison, Ewen M, Hutchinson, Peter, Hyman, Gabriella, Isik, Arda, Jayarajah, Umesh, Kaafarani, Haytham MA, Kadir, Bryar, Lawani, Ismail, Lederhuber, Hans, Li, Elizabeth, Löffler, Markus W, Lorena, Maria Aguilera, Mann, Harvinder, Martin, Janet, Mazingi, Dennis, McClain, Craig D, McLean, Kenneth A, Meara, John G, Ramos-De La Medina, Antonio, Mengesha, Mengistu, Minaya, Ana, Modolo, Maria Marta, Moore, Rachel, Morton, Dion, Nepogodiev, Dmitri, Ntirenganya, Faustin, Pata, Francesco, Pearse, Rupert, Picciochi, Maria, Pinkney, Thomas, Pockney, Peter, van Ramshorst, Gabrielle H, Richards, Toby, Roslani, April Camilla, Satoi, Sohei, Sayyed, Raza, Shaw, Richard, Simões, Joana FF, Smart, Neil, Sullivan, Richard, Sund, Malin, Sundar, Sudha, Tabiri, Stephen, Taylor, Elliott H, Venn, Mary L, Wickramasinghe, Dakshitha, Wright, Naomi, Yip, Sebastian Bernardo Shu, Bhangu, Aneel, Omar, Omar, Harrison, Ewen, Bhangu, Aneel A, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Dawson, Brett E, Evans, Jonathan P, Heritage, Emily, Jones, Conor S, Kamarajah, Sivesh K, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Lawday, Samuel, Mann, Harvinder S, Marson, Ella J, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Tiwari, Abhinav, Trout, Isobel M, Wilkin, Richard JW, Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeier, Markus, Alser, Osaid, Alshaar, Muhammad, Augestad, Knut Magne, Ayasra, Faris, Azevedo, José, Bankhead-Kendall, Brittany K, Barlow, Emma, Beard, David, Blanco-Colino, Ruth, Brar, Amanpreet, Minaya-Bravo, Ana, Breen, Kerry A, Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Caruana, Edward J, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Davidson, Giana H, Di Saverio, Salomone, Drake, Thomas M, Edwards, John G, Emile, Sameh, Farik, Shebani, Ford, Samuel, Garmanova, Tatiana, Gomes, Gustavo Mendonça Ataíde, Grecinos, Gustavo, Griffiths, Ewen A, Gruendl, Magdalena, Halkias, Constantine, Hisham, Intisar, Hutchinson, Peter J, Hwang, Shelley, Jenkinson, Michael D, Jonker, Pascal, Keller, Debby, Kolias, Angelos, Kruijff, Schelto, Leventoglu, Sezai, Litvin, Andrey, Loehrer, Andrew, Major, Piotr, Mashbari, Hassan N, Metallidis, Symeon, Mohan, Helen M, Moszkowicz, David, Moug, Susan, Ng-Kamstra, Joshua S, Maimbo, Mayaba, Negoi, Ionut, Niquen, Milagros, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Rivera, Carlos Jose Perez, Pinkney, Thomas D, Plas, Willemijn van der, Qureshi, Ahmad, Radenkovic, Dejan, Revell, Elliot J, Roberts, Keith, Roslani, April C, Rutegård, Martin, Segura-Sampedro, Juan José, Santos, Irène, Schache, Andrew, Schnitzbauer, Andreas A, Seyi-Olajide, Justina O, Sharma, Neil, Shaw, Catherine A, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Stewart, Grant D, Townend, Philip, Tsoulfas, Georgios, Vidya, Raghavan, Vimalachandran, Dale, Warren, Oliver J, Wedderburn, Duane, EuroSurg, NA, European Society of Coloproctology (ESCP), NA, Global Initiative for Children's Surgery, NA, GlobalSurg, NA, GlobalPaedSurg, NA, ItSURG, NA, PTSurg, NA, SpainSurg, NA, Italian Society of Colorectal Surgery, NA, Association of Surgeons in Training, NA, Irish Surgical Research Collaborative (ISRC), NA, Transatlantic Australasian Retroperitoneal Sarcoma Working, NA, Italian Society of Surgical Oncology, NA, Booth, Lesley, Barker, Margaret, Barker, Neil, Cooke, Shirley, Doré, Suzanne, Horwood, Nigel, Runigamugabo, Emmy, Weir, Carrie Tierney, Bahrami-Hessari, Mike, Riaz, Asad, Shah, Jaffer, Safi, Mohammed, Thereska, Dariel, Dajti, Irida, Cheddadi, Riadh, Tidjane, Anisse, Quinteros, Carlos A, khelfaoui, Ahmed, Salem, Khalifa M, Riffi, Omar, Kacimi, Salah Eddine O, Loudjedi, Salim, Damerdji, Tidjani, Pantoja Pachajoa, Diana A, Palacios Huatuco, René M, Alvarez, Fernando A, Doniquian, Alejandro M, Abeldaño Zuñiga, Roberto A, Schlottmann, Francisco, Cobos, Carlos M, Gigena, Cecilia, Forneris, Agustin Albani, Duro, Agustin, García-Mansilla, Agustín M, Busnelli, Virginia Cano, Poggi, Catalina, Mercado, Pedro L, González, Marcos, Castro Lalin, Agustina F, Mayer, Horacio F, Brandariz, Rodrigo, Slullitel, Pablo A, Boudou, Rocio, Lobos, Pablo A, Uffelmann, María C, Petersen, Maria L, Luzzi, Emilia, Padilla Lichtenberger, Fernando L, Crespi Amor, María S, Zarratea, Celeste S, Esteves, Tomas A, Gemelli, Nicolas A, Tirapegui, Sebastián, Liyo, Juan, Scherñuk, Jordán, Boccalatte, Luis A, Balmaceda, Ruben D, D'Addino, Jose L, Caubet, María M, Calderón Arancibia, José A, Chwat, Carina, Morris, Brian, Avellaneda, Nicolas, Pedraza Salazar, Ivana I, Eskinazi, Diego G, Vargas, Lara, Muriel, María E, Lucchini, Sergio M, Gosselink, Martijn P, Davis, Amelia L, Barker, John C, Qin, Kirby R, Proud, David M, Cox, Daniel RA, Goh, Su Kah, Liu, David S, Wu, Damien M, Merrett, Neil D, Badiani, Sarit S, Sengupta, Shomik, Jain, Anshini, Steen, Christopher J, Wong, Enoch, Ip, Christopher CK, Leaning, Matthew G, McCartney, Conor B, Gananadha, Sivakumar, Yeap, Evie FW, Stevens, Sean G, Vu, Anh N, Martin, Sarah A, Stanley, Guy H M, Watson, David I, Townend, Philip J, Young, Thomas K, Cox, Georgia T, Dawson, Amanda C, Laura, Sharon E, Lun, Elizabeth W Y, Liang, Ina X, O'Neill, Christine J, Lott, Natalie J, Chuan, Alwin, Saravanan, SK, Gundara, Justin, Ong, Bee Shan, Nataraja, Ramesh M, Pacilli, Maurizio, Foley, Daniel M, Ooi, Geraldine J, Traeger, Luke, MacDermid, Ewan, Daruwalla, Jurstine, Hodgson, Russell, Heriot, Alexander G, Mulligan, Christopher S, Blefari, Nicholas D A, Purcell, Shaun S, Frankel, Adam J, Guerra, Glen R, Tefay, Joan S, Liang, Rhea W Y, Kroon, Hidde M, Farfus, Anthony W, Warren, Leigh R, Roy, Jennifer M, Whitfield, Robert J, Moller, Cea-Cea B, Davis, Sean S, Sammour, Tarik, Lam, Yick Ho, Kour, Kevin, Gan, Siang Wei, Coventry, Brendon J, Dawson, Joseph A, Batstone, Martin D, King, Sebastian K, Scott, Nathan J, Foo, Jonathan W, Shepherd, Talia, Page, Richard S, Choong, Peter F, Badgery, Henry E, Chong, Lynn, Taylor, Lillian, Hii, Michael W, Wright, Gavin M, Kong, Joseph CH, Watson, Matthew M, Bock, Jacob, Lidder, Surjit S, Elias, Patrick, Kanavathy, Sathisvaran, Koh, Cherry E, Chennakesavan, Srinivas Kondalsamy, Panuganti, Vishwakar, Latif, Haider, Yeung, Justin MC, Besson, Alex J, Tse, Eunice Q Y, Pitcher, Meron E, Taylor, Danielle L, Nahm, Christopher B, Lim, Alicia, Tree, Kevin, Aigner, Felix, Dawoud, Christopher, Foessleitner, Philipp, Zimmermann, Matthias, Wiedemann, Dominik, Findl, Oliver, Messner, Franka, Bauer, Marlies, Nägele, Felix, Kronberger, Irmgard E, Öfner, Dietmar, Härter, Bettina, Bicz, Nina Ru B, Zwittag, Paul M, Poier, Nikolaus, Navarro, Francisco Ruiz, Zebuhr, Yorck A, Köglberger, Paul, Wiesinger, Clemens G, Mathew, Erwin, Trivik-Barrientos, Felipe, Königsrainer, Ingmar, Djedovic, Gabriel, Cohnert, Tina U, Lumenta, David B, Singer, Georg, Leithner, Andreas, Kamolz, Lars-Peter, Andrianakis, Alexandros, Puchwein, Paul, Mikalauskas, Saulius, Kirchweger, Patrick, Függer, Reinhold, Mittermair, Christof, Russe, Elisabeth, Paal, Peter, Grünbart, Martin, de Cillia, Michael, Weiss, Helmut G, Steiner, Florian, Binder, Alf Dorian, Samadov, Elgun, Ibrahimli, Arturan, Muslumov, Gurbankhan, Bayramov, Nuru Y, Saunders, Jada M, Almoosa, Noora, Haj-Ibrahim, Huzifa, Maresch, Martin, Ezzdean, Weaam K, Juma, Isam M, Hasan, Layla H, Haider, Fayza HA, Alfaqawi, Ghassan Salman, Alam, Mohammed S, Islam, Shahnoor, Basher, AKM K, Mitul, Ashrarur Rahman, Islam, Nazmul, Oosterkamp, Antje E, Ahmed, Tanveer, Hannan, M Jafrul, Padmore, Greg M, Doyle, Alex F, LaCorbiniere, Karisha L, Boyce, Rico D R, Ragoobar, Paul T, Walkes, Keisha M Y, Haynes, Amelia A, Corbin, Sasha M, Litvina, Yauheniya A, Makhmudov, Anvar, Strypstein, Sébastien, Dhondt, Bert, Rasschaert, Ricky, Farid, Yasser, Wahib, El Mahdi, Pigeolet, Manon, Belle, Koen Van, De Wachter, Stefan, Komen, Niels, Vandeputte, Mathieu PJ, Jansen, Yanina JL, Stijns, Jasper, Eynde, Jef Van den, Olowo, Benedicte I, Feraudy, Israel C, Dragisic, Vedran, Martinovic, Vlatka, Barišić, Tatjana, Penava, Nikolina, Hudic, Igor, Delibegovic, Samir, Bogdanović, Gordana, Grgić, Gordana, Cerovac, Anis, Cerovac, Elmedina, Bedada, Alemayehu G, Baiocchi, Glauco, Wainstein, Alberto, Moisés, Elaine Christine D, Zani, Ana Carolina Tagliatti, de Campos Prado, Caio Antonio, Panis, Carolina, Rech, Daniel, Soares da Silva, Ruan Gabriel, Joviliano, Edwaldo E, Rezende, Ricardo F, Reis, Igor G N, Pires, Robinson E S, Christiano, Adriana Borgonovi, Consani, Heitor F X, Pugliesi, Felipe G, Takeda, Flavio R, Mariani, Alessandro W, Valadares, Ricardo J B, Andreollo, Nelson A, Lopes, Luiz Roberto, Tonello, Cristiano, Alonso, Nivaldo, dos Santos, Carlos Ferreira, Lima, Leonardo S, Salgado, Wilson, Pereira, Thiago H S, Gatti, Arthur Paredes, Oliva, Ramon N L, Nardi, Caroline N, Sousa, Alvaro F L, Ribeiro, Ivonizete P, Carvalho, Herica E F, Oliveira, Layze B, Schneider, Guilherme, Casteleins, William Augusto, Silva, Larissa M, Gomes, Carlos Augusto, da Cunha Viana Júnior, Alonço, Cruz, Ricardo P, Gomes, Gustavo MA, Buarque, Igor L, Barros, Aldo V, Marangon, Gustavo B, Flumignan, Ronald LG, Nakano, Luís CU, Pascoal, Patrícia IF, Santos, Brena C, Kuramoto, Danielle AB, Correia, Rebeca M, Amaral, Fabio CF, Flumignan, Carolina DQ, Dussán-Sarria, Jairo A, Simões, Romeo L, Amorim, Robson L, Silva, Jeancarllo S, Lyra Junior, Humberto F, Julio, Nathalia S, Gerber, Marlus T, dos Santos, José Mauro, de Oliveira, Joao Carlos C, Palamim, Camila VC, Marson, Fernando AL, Gomes, Iolanda M, Oliveira, Priscila R, Lima, Ana Lucia L M, Carvalho, Vladimir C, Silva, Jorge S, NA, Ulysses Ribeiro, Laporte, Gustavo Andreazza, Gonçalves, Mateus Capuzzo, Botacin, Lais S, Avelino, Melissa AG, Brito, Luiz Gustavo O, Hristova, Evguenia T, Stoyanov, Vladislav Valentinov, Sakakushev, Boris E, Dardanov, Dragomir D, Sokolov, Manol B, Mehta, Ananya, Gyokova, Elitsa H, Abdullahi, Mohamed, Karamanliev, Martin P, Dimitrov, Dobromir D, Slavchev, Mihail T, Atanasov, Boyko Ch, Yotsov, Tsanko I, Hadzhiev, Dimitar Bozhidarov, Stock, Simon E, Nwegbu, Chukwuemeka Gerald, Tanyi, Tanyi John, Brown, James A, Arneja, Jugpal S, Lee, Susan M, Kancherla, Ramya, Kidane, Biniam, Champagne, Pierre-Olivier, Ma, Xiya, Munro, Allana, McKeen, Dolores M, Glinka, Juan, Vasarhelyi, Edward M, Subramani, Yamini, Alfaro, Hilda, Shah, Ushma J, Gonzalez, Nelson J, MacNeil, S Danielle, Nagappa, Mahesh, Malthaner, Richard A, Brackstone, Muriel, Alkhamesi, Nawar A, Qiabi, Mehdi, Arango-Ferreira, Camila, Prempeh, Agya B A, Dumitra, Sinziana, Spence, Richard T, Bedard, Eric LR, Luc, Jessica GY, Johnston, Brian R, Attabib, Najmedden, Persad, Amit RL, Das, Sunit, Khoshbin, Amir, Ladha, Karim S, Sankar, Ashwin, Teja, Bijan, Daza, Julian F, Chan, Veronica F, Baertschiger, Reto M, Zani, Augusto, Nessim, Carolyn, McIsaac, Daniel I, Singh, Mandeep, Behzadi, Abdollah, Dell, Angela J, Al Riyami, Salim M, Dajani, Khaled Z, Bigam, David, Manikala, Vinod K, Street, John T, Mayson, Kelly V, Wallis, Christopher J D, Mimica, Ximena, Villanueva, Julio, Altamirano, Roberto, Waissbluth, Sofia, Marín, Diego I, Fonseca, Bruno Catoia, Hodali, Andrés J, Ramos, Andrea I, Valenzuela, Marco A, Torres, Janina J, Song, Yi, Yang, Wah, Aldanakh, Abdullah, Alradhi, Mohammed, Lyu, Yidong, Chen, Yan, Fletcher, Angélica V, Camargo, Daniela, Casanova, Rafael Figueroa, Medina, Camilo Andres Caicedo, Bolivar, Dinimo, Garcia, Tatiana Carolina Beltran, Pedraza, Nestor F, Garcia-Lopez, Andrea, Patino-Jaramillo, Nasly G, Giron, Fernando A, Rivera, Carlos J- Perez, Nieto-Calvache, Albaro José, Ariza, Fredy, Orozco-Chamorro, Claudia Milena, Nanez, Maria A, Garces, Diana S, Figueroa, Luis M, Badiel, Marisol, Martinez, Delio F, Coll-Tello, Brenda, Camelo, Hector F, Montoya Casella, Antonio J, Ordoñez, Sebastian, Velez Sanchez, Paola A, Salcedo, Juan C, Villegas, Lina M, Holguín, Jorge A, Cardozo, Jesús Hernán Tovar, Perdomo, Jorman Harvey Tejada, Perdomo, Valentina Gutiérrez, Rivera-Rincon, Natalia A, Gomez, Paula Torres, Delgado-Nieto, Elena Leonor, Isaza-Restrepo, Andres, Vargas, Felipe, Vargas, Ana M, Castro, Arnulfo Andrade, Navarro, Jorge A, Vargas, Saul E, Calvache, Jose A, Mendoza-Arango, Maria C, Bernal, Jorge Luis Vélez, Gonzalez, Felipe O, šantak, Goran, Kirac, Iva, Kršul, Dorian, Versic, Ana Bosak, Augustin, Goran, Kulis, Tomislav, Kastelan, Zeljko, Hadzibegovic, Ana Danic, Grsic, Kresimir, Hudolin, Tvrtko, Tarle, Marko, Mamic, Matija, Lorencin, Mia, Luksic, Ivica, Habek, Dubravko, Konjevoda, Suzana, Mihanovic, Jakov, Antoniou, Stavros A, Almezghwi, Heyam A, Gouvas, Nikolaos, Martinek, Lubomir, Novysedlak, Rene, Žatecký, Jan, Meyhoff, Christian S, Ellebæk, Mark Bremholm, Batista, Sylvia Jeanne, Rodriguez, Julia, Mejia De la Cruz, Dolores, Jimenez, Mirna Giselle Santiago, Dominguez, Carla M, Negrete, José R, Campuzano, Pedro N, Mogrovejo, Daniel L, Armas, Maria J, Arboleda-Bustan, Jenny E, Lincango-Naranjo, Eddy P, El-Kassas, Mohamed, Awad, Ahmed K, Alazab, Emad, Abdulmaseh, Kyrillos G, Diab, Sherein, El Wahab, Mostafa HAbd, Darwesh, Amr, Mostafa, Badr E, Abdelgalil, Mahmoud Shaban, Elbadawy, Merihan A, Reda, Ali M, Asla, Amir Fathi, Fayed, Notaila M, Ahmed, Mohamed S, Elsadek, Menan Ahmed, Gad, Dalia Elsayed, El Saadany, Aya Gameel, Elsadek, Aalaa Mohamed, Sayed, Ahmed E, Naeem, Ahmed, Al-Mallah, Abdullah, Abdelsamed, Ahmed A, Ewedah, Moataz, Soliman, Mohamed O, Tanas, Yousef, Hamouda, Mohammed, Mahfouz, Marina H, Abdo, Manal E, Dean, Yomna E, Lka, Karim, Abodeeb, Aya O, Ashoush, Fouad M F B, Elsherbiny, Roqaia R, Gadelkarim, Mohamed, Osman, Nermin A, MIbrahim, Maya, Youssef, Nehal G, Ibrahim, Mohamed Hamdy, Soliman, Antonios, Gadelkareem, Rabea A, Abbas, Ahmed M, Mohamed Hussein, Aliae AR, Abdelsattar, Khaled, Maher, Ahmed, Elabd, Mohamed M, Abdelazim, Hassan, Ibraheem, Maher H, Noureldin, Yasser A, Elfiky, Mahmoud, Ebrahim, Mohamed A, Abdelrahman, Ahmed Saber Mohamed, Marei, Mahmoud Marei, Elkhalawy, Aya M, Azzam, Ahmed Y, Azab, Mohammed A, Elmasry, Ahmed H, Elgazar, Amr, Shalaby, Mahmoud Mohamed Mohamed, Mahmoud, Mohammad S, Qassem, Mohamed G, Kinani, Hussein, Wahba, Abdelrahman M, Ezzat, Rana Hisham, Ahmed, Mai H, Elshawy, Mohamed Elemam, Faragalla, Hazem Metwally, Mahmoud, Khalid D, Nafea, Ahmed M, Abdel-Maboud, Mohamed, Abozied, Hesham, Moharam, Modather, Shehata, Ashraf H, ElKafrawy, Samir A, Tayiawi, Mosaab M, Elghadban, Hosam M, Emara, Moataz M, Shehta, 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- 2022
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19. Stereotactic radiosurgery versus whole brain radiotherapy in patients with intracranial metastatic disease and small-cell lung cancer: a systematic review and meta-analysis
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Gaebe, Karolina, Li, Alyssa Y, Park, Amy, Parmar, Ambica, Lok, Benjamin H, Sahgal, Arjun, Chan, Kelvin K W, Erickson, Anders W, and Das, Sunit
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- 2022
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20. Anxiety and depression in patients with intracranial meningioma: a mixed methods analysis
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Kasper, Graham, Hart, Shannon, Samuel, Nardin, Fox, Colleen, and Das, Sunit
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- 2022
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21. An ethical analysis of clinical triage protocols and decision-making frameworks: what do the principles of justice, freedom, and a disability rights approach demand of us?
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Zhu, Jane, Brenna, Connor T. A., McCoy, Liam G., Atkins, Chloë G. K., and Das, Sunit
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- 2022
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22. Radioresistance and brain metastases: a review of the literature and applied perspective.
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Youssef, Andrew, Sahgal, Arjun, and Das, Sunit
- Abstract
Intracranial metastatic disease is a serious complication of cancer, treated through surgery, radiation, and targeted therapies. The central role of radiation therapy makes understanding the radioresistance of metastases a priori a key interest for prognostication and therapeutic development. Although historically defined clinic-radiographically according to tumour response, developments in new techniques for delivering radiation treatment and understanding of radioprotective mechanisms led to a need to revisit the definition of radioresistance in the modern era. Factors influencing radioresistance include tumour-related factors (hypoxia, cancer stem cells, tumour kinetics, tumour microenvironment, metabolic alterations, tumour heterogeneity DNA damage repair, non-coding RNA, exosomes, methylomes, and autophagy), host-related factors (volume effect & dose-limiting non-cancerous tissue, pathophysiology, and exosomes), technical factors, and probabilistic factors (cell cycle and random gravity of DNA damage). Influences on radioresistance are introduced and discussed in the context of brain metastases. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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- View/download PDF
23. Toward standardized brain tumor tissue processing protocols in neuro-oncology: a perspective for gliomas and beyond.
- Author
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Rodriguez, Analiz, Ahluwalia, Manmeet S., Bettegowda, Chetan, Brem, Henry, Carter, Bob S., Chang, Susan, Das, Sunit, Eberhart, Charles, Garzon-Muvdi, Tomas, Hadjipanayis, Costas G., Hawkins, Cynthia, Jacques, Thomas S., Khalessi, Alexander A., McDermott, Michael W., Mikkelsen, Tom, Orr, Brent A., Phillips, Joanna J., Rosenblum, Mark, Shelton, William J., and Solomon, David A.
- Subjects
INDIVIDUALIZED medicine ,SURGICAL excision ,GLIOMAS ,OPERATING rooms ,ADVISORY boards ,BRAIN tumors - Abstract
Implementation of standardized protocols in neurooncology during the surgical resection of brain tumors is needed to advance the clinical treatment paradigms that use tissue for diagnosis, prognosis, bio-banking, and treatment. Currently recommendations on intraoperative tissue procurement only exist for diffuse gliomas but management of other brain tumor subtypes can also benefit from these protocols. Fresh tissue from surgical resection can now be used for intraoperative diagnostics and functional precision medicine assays. A multidisciplinary neuro-oncology perspective is critical to develop the best avenues for practical standardization. This perspective from the multidisciplinary Oncology Tissue Advisory Board (OTAB) discusses current advances, future directions, and the imperative of adopting standardized protocols for diverse brain tumor entities. There is a growing need for consistent operating room practices to enhance patient care, streamline research efforts, and optimize outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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- View/download PDF
24. Hypofractionated Stereotactic Radiation Therapy for Intact Brain Metastases in 5 Daily Fractions: Effect of Dose on Treatment Response
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Myrehaug, Sten, Hudson, John, Soliman, Hany, Ruschin, Mark, Tseng, Chia-Lin, Detsky, Jay, Husain, Zain, Keith, Julia, Atenafu, Eshetu G., Maralani, Pejman, Heyn, Chris, Das, Sunit, Lipsman, Nir, and Sahgal, Arjun
- Published
- 2022
- Full Text
- View/download PDF
25. Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response
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Johnson, Kevin C., Anderson, Kevin J., Courtois, Elise T., Gujar, Amit D., Barthel, Floris P., Varn, Frederick S., Luo, Diane, Seignon, Martine, Yi, Eunhee, Kim, Hoon, Estecio, Marcos R. H., Zhao, Dacheng, Tang, Ming, Navin, Nicholas E., Maurya, Rahul, Ngan, Chew Yee, Verburg, Niels, de Witt Hamer, Philip C., Bulsara, Ketan, Samuels, Michael L., Das, Sunit, Robson, Paul, and Verhaak, Roel G. W.
- Published
- 2021
- Full Text
- View/download PDF
26. Quantitating Interfraction Target Dynamics During Concurrent Chemoradiation for Glioblastoma: A Prospective Serial Imaging Study
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Stewart, James, Sahgal, Arjun, Lee, Young, Soliman, Hany, Tseng, Chia-Lin, Detsky, Jay, Husain, Zain, Ho, Ling, Das, Sunit, Maralani, Pejman Jabehdar, Lipsman, Nir, Stanisz, Greg, Perry, James, Chen, Hanbo, Atenafu, Eshetu G., Campbell, Mikki, Lau, Angus Z., Ruschin, Mark, and Myrehaug, Sten
- Published
- 2021
- Full Text
- View/download PDF
27. A new paradigm for short-range forecasting of severe weather over the Indian region
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Sen Roy, Soma, Sharma, Pradeep, Sen, Bikram, Sathi Devi, K., Sunitha Devi, S., Gopal, Neetha K., Kumar, Naresh, Mishra, Krishna, Katyar, Shobhit, Singh, Surendra Pratap, Balakrishnan, Shibin, Singh, Charan, Srivastava, Kuldeep, Lotus, Sonam, Paul, Surendra, Singh, Bikram, Gupta, J. P., Bandopadhyay, S., Das, Ganesh, Shankar, Anand, Kotal, S. D., Biswas, H. R., Shaw, S. O’Neil, Das, Sunit, Phukan, Ranjan, Nagarathna, K., Balachandran, S., Puviarasan, N., Stella, S., Bibraj, R., Mini, V. K., Rahul, M., Agnihotri, G., Sarkar, J., Mohanty, M., Singh, Ved Prakash, Hosalikar, K., Nitha, T. S., Sahu, M. L., Kumari, Bhawna, Kashyapi, Anupam, Singh, Manmohan, Singh, H. A. K., Sharma, Radhey Shyam, Raha, G. N., Reddy, Y. K., Ramesh, K. J., and Mohapatra, M.
- Published
- 2021
- Full Text
- View/download PDF
28. Local control and patterns of failure for “Radioresistant” spinal metastases following stereotactic body radiotherapy compared to a “Radiosensitive” reference
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Zeng, K. Liang, Sahgal, Arjun, Husain, Zain A., Myrehaug, Sten, Tseng, Chia-Lin, Detsky, Jay, Sarfehnia, Arman, Ruschin, Mark, Campbell, Mikki, Foster, Monica, Das, Sunit, Lipsman, Nir, Bjarnason, Georg A., Atenafu, Eshetu G., Maralani, Pejman Jabehdar, and Soliman, Hany
- Published
- 2021
- Full Text
- View/download PDF
29. High‐intensity rainfall over northeast India: Spatial pattern, short‐term fluctuations and associated multiscale oscillations.
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Das, Sunit, Mohapatra, Mrutyunjay, Sahoo, Uttam K., and Baisya, Himadri
- Subjects
- *
HIERARCHICAL clustering (Cluster analysis) , *MADDEN-Julian oscillation , *PHASE oscillations , *CLIMATOLOGY , *CLUSTER analysis (Statistics) - Abstract
Northeast India (NEI) receives most of its rainfall in the southwest monsoon (SWM) season. The region is known to have frequent and persistent rainfall events of high intensities and the region is vulnerable to potential high‐impact meteorological events. This study analyses observed daily rainfall data for the SWM months (JJAS) during 1991–2020 to better understand the climatology of high‐intensity rainfall (HIR) occurrences and their persistence. The agglomerative hierarchical cluster analysis has delineated four distinct clusters and Cramer's t test indicates no significant fluctuations at 5% significant level in the HIR events in these clusters. ERA‐5 reanalysis data have been used to find the moisture transport for synoptic‐scale (3–7 days), quasi‐bi‐weekly oscillations (10–20 days) and intraseasonal oscillations (30–60 days) for each cluster. Under positive synoptic‐scale phases, HIR in the clusters on southern latitudes of NEI occurs due to moisture incursion from the Bay of Bengal from southwesterlies at 850 hPa, and in the clusters on the northern latitudes, it is primarily due to westerlies. For, quasi‐bi‐weekly oscillations, westerlies at 850 hPa are favourable for moisture transport in most of the clusters during its positive phase. On the other hand, for positive phase of intraseasonal oscillations, westerlies at 850 hPa dominate the moisture transport in all the clusters. Also, most of the HIR events occur whenever Madden–Julian Oscillation (MJO) is in phase 1 and 2 with higher amplitude (RMM ≥1). [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
30. Adverse Radiation Effect After Hypofractionated Stereotactic Radiosurgery in 5 Daily Fractions for Surgical Cavities and Intact Brain Metastases
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Faruqi, Salman, Ruschin, Mark, Soliman, Hany, Myrehaug, Sten, Zeng, K. Liang, Husain, Zain, Atenafu, Eshetu, Tseng, Chia-Lin, Das, Sunit, Perry, James, Maralani, Pejman, Heyn, Chris, Mainprize, Todd, and Sahgal, Arjun
- Published
- 2020
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31. Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity
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Richards, Laura M., Whitley, Owen K. N., MacLeod, Graham, Cavalli, Florence M. G., Coutinho, Fiona J., Jaramillo, Julia E., Svergun, Nataliia, Riverin, Mazdak, Croucher, Danielle C., Kushida, Michelle, Yu, Kenny, Guilhamon, Paul, Rastegar, Naghmeh, Ahmadi, Moloud, Bhatti, Jasmine K., Bozek, Danielle A., Li, Naijin, Lee, Lilian, Che, Clare, Luis, Erika, Park, Nicole I., Xu, Zhiyu, Ketela, Troy, Moore, Richard A., Marra, Marco A., Spears, Julian, Cusimano, Michael D., Das, Sunit, Bernstein, Mark, Haibe-Kains, Benjamin, Lupien, Mathieu, Luchman, H. Artee, Weiss, Samuel, Angers, Stephane, Dirks, Peter B., Bader, Gary D., and Pugh, Trevor J.
- Published
- 2021
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32. Quantitative CEST and MT at 1.5T for monitoring treatment response in glioblastoma: early and late tumor progression during chemoradiation
- Author
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Chan, Rachel W., Chen, Hanbo, Myrehaug, Sten, Atenafu, Eshetu G., Stanisz, Greg J., Stewart, James, Maralani, Pejman Jabehdar, Chan, Aimee K. M., Daghighi, Shadi, Ruschin, Mark, Das, Sunit, Perry, James, Czarnota, Gregory J., Sahgal, Arjun, and Lau, Angus Z.
- Published
- 2021
- Full Text
- View/download PDF
33. PRMT5 inhibition disrupts splicing and stemness in glioblastoma
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Sachamitr, Patty, Ho, Jolene C., Ciamponi, Felipe E., Ba-Alawi, Wail, Coutinho, Fiona J., Guilhamon, Paul, Kushida, Michelle M., Cavalli, Florence M. G., Lee, Lilian, Rastegar, Naghmeh, Vu, Victoria, Sánchez-Osuna, María, Coulombe-Huntington, Jasmin, Kanshin, Evgeny, Whetstone, Heather, Durand, Mathieu, Thibault, Philippe, Hart, Kirsten, Mangos, Maria, Veyhl, Joseph, Chen, Wenjun, Tran, Nhat, Duong, Bang-Chi, Aman, Ahmed M., Che, Xinghui, Lan, Xiaoyang, Whitley, Owen, Zaslaver, Olga, Barsyte-Lovejoy, Dalia, Richards, Laura M., Restall, Ian, Caudy, Amy, Röst, Hannes L., Bonday, Zahid Quyoom, Bernstein, Mark, Das, Sunit, Cusimano, Michael D., Spears, Julian, Bader, Gary D., Pugh, Trevor J., Tyers, Mike, Lupien, Mathieu, Haibe-Kains, Benjamin, Artee Luchman, H., Weiss, Samuel, Massirer, Katlin B., Prinos, Panagiotis, Arrowsmith, Cheryl H., and Dirks, Peter B.
- Published
- 2021
- Full Text
- View/download PDF
34. Glioma consensus contouring recommendations from a MR-Linac International Consortium Research Group and evaluation of a CT-MRI and MRI-only workflow
- Author
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Tseng, Chia-Lin, Stewart, James, Whitfield, Gillian, Verhoeff, Joost J. C., Bovi, Joseph, Soliman, Hany, Chung, Caroline, Myrehaug, Sten, Campbell, Mikki, Atenafu, Eshetu G., Heyn, Chinthaka, Das, Sunit, Perry, James, Ruschin, Mark, and Sahgal, Arjun
- Published
- 2020
- Full Text
- View/download PDF
35. Effect of bilateral scalp nerve blocks on postoperative pain and discharge times in patients undergoing supratentorial craniotomy and general anesthesia: a randomized-controlled trial
- Author
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Rigamonti, Andrea, Garavaglia, Marco M., Ma, Kan, Crescini, Charmagne, Mistry, Nikhil, Thorpe, Kevin, Cusimano, Michael D., Das, Sunit, Hare, Gregory M. T., and Mazer, C. David
- Published
- 2020
- Full Text
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36. Advanced Age Is Not a Universal Predictor of Poorer Outcome in Patients Undergoing Neurosurgery
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Maslink, Colin, Cheng, Kathleen, Smith, Timothy R., and Das, Sunit
- Published
- 2019
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- View/download PDF
37. Single-Fraction Stereotactic Radiosurgery Versus Hippocampal-Avoidance Whole Brain Radiation Therapy for Patients With 10 to 30 Brain Metastases: A Dosimetric Analysis
- Author
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Nguyen, Timothy K., Sahgal, Arjun, Detsky, Jay, Soliman, Hany, Myrehaug, Sten, Tseng, Chia-Lin, Husain, Zain A., Carty, Anne, Das, Sunit, Yang, Victor, Lee, Young, Sarfehnia, Arman, Chugh, Brige P., Yeboah, Collins, and Ruschin, Mark
- Published
- 2019
- Full Text
- View/download PDF
38. A chloromethyl-triazole fluorescent chemosensor for O6-methylguanine DNA methyltransferase.
- Author
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Ayan, Seylan, Rotaru, Adrian M., Kaye, Esther G., Juneau, Gabrielle, Das, Sunit, Wilds, Christopher J., and Beharry, Andrew A.
- Published
- 2024
- Full Text
- View/download PDF
39. Choreographed expansion of services results in decreased patient burden without compromise of outcomes: An assessment of the Ontario experience.
- Author
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Rzadki, Kathryn, Baqri, Wafa, Yermakhanova, Olga, Habbous, Steven, and Das, Sunit
- Subjects
REGIONAL medical programs ,TRAVEL time (Traffic engineering) ,GEOGRAPHIC information systems ,WATERSHEDS ,CHOREOGRAPHY ,SPATIAL systems - Abstract
Background Neuro-oncology care in Ontario, Canada has been historically centralized, at times requiring significant travel on the part of patients. Toward observing the goal of patient-centered care and reducing patient burden, 2 additional regional cancer centres (RCC) capable of neuro-oncology care delivery were introduced in 2016. This study evaluates the impact of increased regionalization of neuro-oncology services, from 11 to 13 oncology centers, on healthcare utilization and travel burden for glioblastoma (GBM) patients in Ontario. Methods We present a cohort of GBM patients diagnosed between 2010 and 2019. Incidence of GBM and treatment modalities were identified using provincial health administrative databases. A geographic information system and spatial analysis were used to estimate travel time from patient residences to neuro-oncology RCCs. Results Among the 5242 GBM patients, 79% received radiation as part of treatment. Median travel time to the closest RCC was higher for patients who did not receive radiation as part of treatment than for patients who did (P = .03). After 2016, the volume of patients receiving radiation at their local RCC increased from 62% to 69% and the median travel time to treatment RCCs decreased (P = .0072). The 2 new RCCs treated 35% and 41% of patients within their respective catchment areas. Receipt of standard of care, surgery, and chemoradiation (CRT), increased by 11%. Conclusions Regionalization resulted in changes in the healthcare utilization patterns in Ontario consistent with decreased patient travel burden for patients with GBM. Focused regionalization did not come at the cost of decreased quality of care, as determined by the delivery of a standard of care. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
40. Effect of Cobalt-60 Treatment Dose Rate on Arteriovenous Malformation Obliteration After Stereotactic Radiosurgery With Gamma Knife.
- Author
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Anthes, Victoria B., Schwartz, Michael, Cusimano, Michael, Radovanovic, Ivan, Kulkarni, Abhaya V., Laperriere, Normand, Payne, David, Heaton, Robert, van Prooijen, Monique, Das, Sunit, and Tsang, Derek S.
- Published
- 2024
- Full Text
- View/download PDF
41. Angiogenic patterning by STEEL, an endothelial-enriched long noncoding RNA
- Author
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Man, H. S. Jeffrey, Sukumar, Aravin N., Lam, Gabrielle C., Turgeon, Paul J., Yan, Matthew S., Ku, Kyung Ha, Dubinsky, Michelle K., Ho, J. J. David, Wang, Jenny Jing, Das, Sunit, Mitchell, Nora, Oettgen, Peter, Sefton, Michael V., and Marsden, Philip A.
- Published
- 2018
42. Enhancing glioblastoma treatment using cisplatin-gold-nanoparticle conjugates and targeted delivery with magnetic resonance-guided focused ultrasound
- Author
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Coluccia, Daniel, Figueiredo, Carlyn A., Wu, Megan YiJun, Riemenschneider, Alexandra N., Diaz, Roberto, Luck, Amanda, Smith, Christian, Das, Sunit, Ackerley, Cameron, O’Reilly, Meaghan, Hynynen, Kullervo, and Rutka, James T.
- Published
- 2018
- Full Text
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43. DNA hypermethylation within TERT promoter upregulates TERT expression in cancer
- Author
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Lee, Donghyun D., Leao, Ricardo, Komosa, Martin, Gallo, Marco, Zhang, Cindy H., Lipman, Tatiana, Remke, Marc, Heidari, Abolfazl, Nunes, Nuno Miguel, Apolonio, Joana D., Price, Aryeh J., De Mello, Ramon Andrade, Dias, Joao S., Huntsman, David, Hermanns, Thomas, Wild, Peter J., Vanner, Robert, Zadeh, Gelareh, Karamchandani, Jason, Das, Sunit, Taylor, Michael D., Hawkins, Cynthia E., Wasserman, Jonathan D., Figueiredo, Arnaldo, Hamilton, Robert J., Minden, Mark D., Wani, Khalida, Diplas, Bill, Yan, Hai, Aldape, Kenneth, Akbari, Mohammad R., Danesh, Arnavaz, Pugh, Trevor J., Dirks, Peter B., Castelo-Branco, Pedro, and Tabori, Uri
- Subjects
Cancer -- Genetic aspects -- Research ,Gene mutation -- Research ,Methylation -- Genetic aspects ,Telomeres -- Research ,Health care industry - Abstract
Replicative immortality is a hallmark of cancer cells governed by telomere maintenance. Approximately 90% of human cancers maintain their telomeres by activating telomerase, driven by the transcriptional upregulation of telomerase reverse transcriptase (TERT). Although TERT promoter mutations (TPMs) are a major cancer-associated genetic mechanism of TERT upregulation, many cancers exhibit TERT upregulation without TPMs. In this study, we describe the TERT hypermethylated oncological region (THOR), a 433-bp genomic region encompassing 52 CpG sites located immediately upstream of the TERT core promoter, as a cancer-associated epigenetic mechanism of TERT upregulation. Unmethylated THOR repressed TERT promoter activity regardless of TPM status, and hypermethylation of THOR counteracted this repressive function. THOR methylation analysis in 1,352 human tumors revealed frequent (>45%) cancer-associated DNA hypermethylation in 9 of 11 (82%) tumor types screened. Additionally, THOR hypermethylation, either independently or along with TPMs, accounted for how approximately 90% of human cancers can aberrantly activate telomerase. Thus, we propose that THOR hypermethylation is a prevalent telomerase-activating mechanism in cancer that can act independently of or in conjunction with TPMs, further supporting the utility of THOR hypermethylation as a prognostic biomarker., IntroductionReplicative immortality is an attribute of cancer cells governed by telomere maintenance (1). Telomeres are repetitive nucleoprotein structures that protect chromosomal ends and shorten after each replicative cycle, playing important [...]
- Published
- 2019
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- View/download PDF
44. COUNTERPOINT: Is It Ethically Permissible to Use Frailty Scoring to Determine the Allocation of Medical Resources Under Conditions of Scarcity in the Medical ICU? No.
- Author
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Atkins, Chloë G.K. and Das, Sunit
- Subjects
- *
RESOURCE allocation , *SCARCITY , *FRAILTY - Published
- 2024
- Full Text
- View/download PDF
45. To Assess or Not to Assess? Physician-Patient Disagreement as the Primary Trigger for Capacity Testing in Clinical Practice.
- Author
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Cho, Matthew, Brenna, Connor T. A., Chen, Stacy S., McCoy, Liam G., and Das, Sunit
- Subjects
SELF-injurious behavior ,DOCUMENTATION ,RESPONSIBILITY ,DECISION making in clinical medicine ,DECISION making ,PHYSICIAN-patient relations ,PATIENT decision making ,QUALITY assurance ,HEALTH care teams - Abstract
A commentary on the 2024 article "Affect, Values and Problems Assessing Decision-Making Capacity," by J. Hawkins is presented. Topics covered include how models, including Hawkins,' tend to fall short, a proposed model of capacity assessment and the possible scenarios following a patient decision. It also discusses the issue of testing bias in capacity assessment.
- Published
- 2024
- Full Text
- View/download PDF
46. No adults allowed: Adolescents and Medical Decision Making.
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Nemetz, Elisheva T A, Huang, Ryan S, and Das, Sunit
- Subjects
PARENT attitudes ,ETHICAL decision making ,INFORMED consent (Medical law) ,PATIENT decision making ,PATIENT refusal of treatment ,LAW ,LEGISLATION - Abstract
The majority of the literature focused on whether consent should be extended to the adolescent population arises from themes adapted from American tort law. In contrast to the USA, Ontario does not delineate an age of consent for medical treatment and relying on American guidelines to guide practice in Ontario is problematic. While the literature is saturated with discussions for and against seeking adolescent consent, there are currently no bioethical guidelines on adolescent consent in the province of Ontario. This paper explores adolescent refusal of care and adolescent request for care in opposition to parental wishes. The paper seeks to answer the following questions: What is the difference between an adolescent and an adult in medical decision-making? What are the barriers to seeking adolescent consent? And, can the neurobiological argument be an accurate guide for obtaining adolescent consent? [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
47. Rescue bevacizumab following symptomatic pseudoprogression of a tectal glioma post-radiotherapy: a case report and review of the literature
- Author
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Nguyen, Timothy K., Perry, James, Sundaram, Arun N. E., Detsky, Jay, Maralani, Pejman J., Calabrese, Eirena, Das, Sunit, and Sahgal, Arjun
- Published
- 2019
- Full Text
- View/download PDF
48. Artificial Intelligence and Clinical Decision Making: The New Nature of Medical Uncertainty
- Author
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Harish, Vinyas, Morgado, Felipe, Stern, Ariel D., and Das, Sunit
- Published
- 2021
- Full Text
- View/download PDF
49. Unique molecular, clinical, and treatment aspects of gliomas in adolescents and young adults: a review.
- Author
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Lim-Fat, Mary Jane and Das, Sunit
- Published
- 2023
- Full Text
- View/download PDF
50. Awake craniotomy using dexmedetomidine and scalp blocks: a retrospective cohort study
- Author
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McAuliffe, Niamh, Nicholson, Stuart, Rigamonti, Andrea, Hare, Gregory M. T., Cusimano, Michael, Garavaglia, Marco, Pshonyak, Iryna, and Das, Sunit
- Published
- 2018
- Full Text
- View/download PDF
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