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1. New role of endoplasmic reticulum chaperones in regulating metaplasia during tumorigenesis

Author

Jieli Shen, Daisy F. Rangel, Dat Ha, and Amy S. Lee

Subjects
er chaperone, grp78, grp94, metaplasia, mouse models, pancreatic cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Metaplasia is emerging as a key process in tumorigenesis. We discovered that 2 essential endoplasmic reticulum (ER) chaperones, 78-kilodalton glucose-regulated protein (GRP78) and 94-kilodalton glucose-regulated protein (GRP94) have a role in metaplasia. Grp78 haploinsufficiency in the mouse pancreas impairs acinar-to-ductal metaplasia, whereas in the uterus, Grp94 loss induces squamous cell metaplasia; both resulting in tumor suppression.

Published
2017
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