1. Ebola Hemorrhagic Fever Outbreaks in Gabon, 1994–1997: Epidemiologic and Health Control Issues
- Author
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Paul I. Obiang, Minh Trinh Ngoc, Carol Tevi Benissan, David D. Bénoni, Jacques P. Amblard, André A. Renaut, Eric J. Bertherat, J. Lansoud-Soukate, Alain J. Georges, Marie Claude Georges-Courbot, Eric M. Leroy, Sylvain Baize, René J. Nabias, J. P.M. Lepage, E. Jean Wickings, and J. M. Milleliri
- Subjects
Time Factors ,Epidemiologic Factors ,Genes, Viral ,Filoviridae ,Antibodies, Viral ,medicine.disease_cause ,Virus ,Disease Outbreaks ,Microbiology ,Ebola Hemorrhagic Fever ,Yellow Fever ,Humans ,Immunology and Allergy ,Medicine ,Gabon ,Mononegavirales ,Antigens, Viral ,Molecular Epidemiology ,Ebola virus ,biology ,business.industry ,Yellow fever ,Outbreak ,Hemorrhagic Fever, Ebola ,Ebolavirus ,biology.organism_classification ,medicine.disease ,Virology ,Infectious Diseases ,Immunoglobulin M ,Immunoglobulin G ,Democratic Republic of the Congo ,Viral disease ,business - Abstract
From the end of 1994 to the beginning of 1995, 49 patients with hemorrhagic symptoms were hospitalized in the Makokou General Hospital in northeastern Gabon. Yellow fever (YF) virus was first diagnosed in serum by use of polymerase chain reaction followed by blotting, and a vaccination campaign was immediately instituted. The epidemic, known as the fall 1994 epidemic, ended 6 weeks later. However, some aspects of this epidemic were atypical of YF infection, so a retrospective check for other etiologic agents was undertaken. Ebola (EBO) virus was found to be present concomitantly with YF virus in the epidemic. Two other epidemics (spring and fall 1996) occurred in the same province. GP and L genes of EBO virus isolates from all three epidemics were partially sequenced, which showed a difference of
- Published
- 1999
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