1. Growth hormone response to growth hormone-releasing peptide-2 in growth hormone-deficient Little mice
- Author
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Cibele N. Peroni, Cesar Y. Hayashida, Nancy Nascimento, Viviane C. Longuini, Rodrigo A. Toledo, Paolo Bartolini, Cyril Y. Bowers, and Sergio P.A. Toledo
- Subjects
Ghrelin ,GH ,GHRH-R ,GHRP-2 ,Leptin ,Little mouse ,Medicine (General) ,R5-920 - Abstract
OBJECTIVE: To investigate a possible direct, growth hormone-releasing, hormone-independent action of a growth hormone secretagogue, GHRP-2, in pituitary somatotroph cells in the presence of inactive growth hormonereleasing hormone receptors. MATERIALS AND METHODS: The responses of serum growth hormone to acutely injected growth hormone-releasing P-2 in lit/litmice, which represent a model of GH deficiency arising frommutated growth hormone-releasing hormonereceptors, were compared to those observed in the heterozygous (lit/+) littermates and wild-type (+/+) C57BL/6J mice. RESULTS: After the administration of 10 mcg of growth hormone-releasing P-2 to lit/lit mice, a growth hormone release of 9.3±1.5 ng/ml was observed compared with 1.04±1.15 ng/ml in controls (p
- Published
- 2012
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