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3. Major and Minor League Occupancy at Cleveland's League Park, 1914-15

Author

Cohen, Alan

Subjects
Cleveland, Ohio -- Social aspects, Baseball (Professional) -- History, Sports associations -- History, Baseball fields -- History, History, Sports and fitness, Sports, sporting goods and toys industry
Abstract

In 1914 and 1915, for the only time in baseball history, two baseball teams, one a major league team and the other a minor league team, played a full schedule [...]

Published
2024

7. Investigating Teachers' Understanding through Topic Modeling: A Promising Approach to Studying Teachers' Knowledge

Author

Copur-Gencturk, Yasemin, Choi, Hye-Jeong, and Cohen, Alan

Abstract

Examining teachers' knowledge on a large scale involves addressing substantial measurement and logistical issues; thus, existing teacher knowledge assessments have mainly consisted of selected-response items because of their ease of scoring. Although open-ended responses could capture a more complex understanding of and provide further insights into teachers' thinking, scoring these responses is expensive and time consuming, which limits their use in large-scale studies. In this study, we investigated whether a novel statistical approach, topic modeling, could be used to score teachers' open-ended responses and if so, whether these scores would capture nuances of teachers' understanding. To test this hypothesis, we used topic modeling to analyze teachers' responses to a proportional reasoning task and examined the associations of the topics identified through this method with categories identified by a separate qualitative analysis of the same data as well as teachers' performance on a measure of ratios and proportional relationships. Our findings suggest that topic modeling seemed to capture nuances of teachers' responses and that such nuances differentiated teachers' performance on the same concept. We discuss the implications of this study for education research.

Published
2023
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20. Biomarkers of aging for the identification and evaluation of longevity interventions

Author

Moqri, Mahdi, Herzog, Chiara, Poganik, Jesse R., Justice, Jamie, Belsky, Daniel W., Higgins-Chen, Albert, Moskalev, Alexey, Fuellen, Georg, Cohen, Alan A., Bautmans, Ivan, Widschwendter, Martin, Ding, Jingzhong, Fleming, Alexander, Mannick, Joan, Han, Jing-Dong Jackie, Zhavoronkov, Alex, Barzilai, Nir, Kaeberlein, Matt, Cummings, Steven, Kennedy, Brian K., Ferrucci, Luigi, Horvath, Steve, Verdin, Eric, Maier, Andrea B., Snyder, Michael P., Sebastiano, Vittorio, and Gladyshev, Vadim N.

Published
2023
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30. The evolution of mean arterial pressure in critically ill patients on vasopressors before and during a trial comparing a specific mean arterial pressure target to usual care

Author

Masse, Marie-Hélène, Adhikari, Neill K. J., Théroux, Xavier, Battista, Marie-Claude, D’Aragon, Frédérick, Pinto, Ruxandra, Cohen, Alan, Mayette, Michaël, St-Arnaud, Charles, Kho, Michelle, Chassé, Michaël, Lebrasseur, Martine, Watpool, Irene, Porteous, Rebecca, Wilcox, M. Elizabeth, and Lamontagne, François

Published
2022
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32. The Power of a Complex Systems Perspective to Elucidate Aging.

Author

Cohen, Alan A and Rikkert, Marcel G M Olde

Subjects
*COMPLEXITY (Philosophy), *AGE factors in disease, *AGING, *THEORY-practice relationship, *FRAILTY
Abstract

It is becoming highly accepted that aging, age-related diseases, and geriatric healthcare can move forward if reductionist research is complemented by integrative research uniting knowledge on specific aging mechanisms, multiple biomedical, social, psychological, lifestyle, and environmental factors and their interactions. In this special issue, we present exciting papers that illustrate how complexity science theory and practice can be applied to aging research and provide a better understanding and quantification of healthy aging and vulnerability to disease. Recent insights on biomarkers, clocks of aging, frailty, and resilience are covered and studied in interaction with a dynamic multiscale perspective. The editorial and closing viewpoint guide you through basic principles of gerontological complexity science and shed light on new research horizons, including innovative systems-based interventions. [ABSTRACT FROM AUTHOR]

Published
2024
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33. PIK-III exerts anti-fibrotic effects in activated fibroblasts by regulating p38 activation.

Author

Sanchez, Santiago, McDowell-Sanchez, Aaron K., Al-Meerani, Sharaz B., Cala-Garcia, Juan D., Waich Cohen, Alan R., Ochsner, Scott A., McKenna, Neil J., Celada, Lindsay J., Wu, Minghua, Assassi, Shervin, Rosas, Ivan O., and Tsoyi, Konstantin

Subjects
GENE silencing, PHOSPHATIDYLINOSITOL 3-kinases, CELL contraction, SYSTEMIC scleroderma, EXTRACELLULAR matrix, LUNGS
Abstract

Systemic sclerosis (SSc), also known as scleroderma, is an autoimmune-driven connective tissue disorder that results in fibrosis of the skin and internal organs such as the lung. Fibroblasts are known as the main effector cells involved in the progression of SSc through the induction of extracellular matrix (ECM) proteins and myofibroblast differentiation. Here, we demonstrate that 4'-(cyclopropylmethyl)-N2-4-pyridinyl-[4,5'-bipyrimidine]-2,2'-diamine (PIK-III), known as class III phosphatidylinositol 3-kinase (PIK3C3/VPS34) inhibitor, exerts potent antifibrotic effects in human dermal fibroblasts (HDFs) by attenuating transforming growth factor-beta 1 (TGF-β1)-induced ECM expression, cell contraction and myofibroblast differentiation. Unexpectedly, neither genetic silencing of PIK3C3 nor other PIK3C3 inhibitors (e.g., SAR405 and Autophinib) were able to mimic PIK-III-mediated antifibrotic effect in dermal fibroblasts, suggesting that PIK-III inhibits fibroblast activation through another signaling pathway. We identified that PIK-III effectively inhibits p38 activation in TGF-β1-stimulated dermal fibroblasts. Finally, PIK-III administration significantly attenuated dermal and lung fibrosis in bleomycin-injured mice. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Arthur Falck and the Nuremberg Laws.

Author

Cohen, Alan

Subjects
*REFUGEE camps, *PERSONAL names, *GERMAN Jews, *STEPFAMILIES, *GENEALOGY, *AMERICAN Jews, *FATHERS
Abstract

The article delves into the life of Arthur Falck, a German Jew impacted by the Nuremberg Laws during World War II, which led to discrimination and persecution based on Jewish ancestry. It follows Arthur's personal history, marriages, and legal challenges under the racial purity laws, highlighting the devastating effects of Nazi policies on individuals and families. The narrative also explores the fate of Arthur's daughter Ruth, who was deported to Auschwitz, while her husband Martin survived forced labor in concentration camps and eventually moved to the USA with his family. The text concludes with the post-war lives of Martin's descendants, including his son Hans Peter in Milwaukee, and Paula Cohen, who lived in London until her passing in 1972. [Extracted from the article]

Published
2024

45. In the June 2024 Issue of the Quarterly.

Author

COHEN, ALAN B.

Subjects
*SERIAL publications, *DATA security, *SOCIAL determinants of health, *HEALTH policy, *HEALTH insurance, *ARTIFICIAL intelligence, *PUBLIC health, *HEALTH equity, *DRUGS, *OBESITY, *CHRISTIANITY
Published
2024
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