1. Drug survival of cyclosporine in the treatment of hand eczema: a multicentre, daily use study.
- Author
-
Christoffers, W.A., Politiek, K., Coenraads, P.J., Schaft, J., Bruin ‐ Weller, M.S., and Schuttelaar, M.L.A.
- Subjects
- *
TREATMENT of eczema , *VESICULAR stomatitis , *CYCLOSPORINE , *KAPLAN-Meier estimator , *UNIVERSITY hospitals - Abstract
Background: Hand eczema is a common condition; it is often chronic and can be difficult to treat. Cyclosporine is used off-label to treat severe hand eczema; however, the evidence for this treatment is scarce. Objective: To examine the drug survival of cyclosporine in a daily practice cohort of patients with chronic hand eczema. Methods: This retrospective daily use study included hand eczema patients who were treated with cyclosporine between 01-06-1999 and 01-06-2014 in two Dutch university hospitals. Patient and treatment characteristics were retrospectively collected from medical charts. First treatment episodes were analysed by means of Kaplan-Meier drug survival curves. Possible determinants of drug survival were analysed by Cox regression models. Treatment effectiveness was analysed with a retrospective physician's global assessment. Results: A total of 102 patients were treated with cyclosporine. The median drug survival rate was 0.86 years (10.3 months). The overall drug survival rate after 6 months, 1, 2 and 3 years were 61.7%, 45.2%, 18.6% and 13.9% respectively. Main reasons for discontinuation were adverse events, especially early in treatment, and ineffectiveness. After 3 months, a good response to treatment was recorded in 62.9% of the patients. Conclusion: Cyclosporine had a median drug survival of 10.3 months. Especially patients with recurrent vesicular hand eczema showed a good treatment response. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF