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Deepak Choudhary,1 Brande Brown,2 Nayaab Khawar,2 Pramod Narula,2 Levon Agdere2 1Department of Pediatrics Emergency Medicine, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital, Little Rock, AR 72202, USA; 2New York-Presbyterian Brooklyn Methodist Hospital, Brooklyn, NY 11215, USACorrespondence: Brande BrownNew York-Presbyterian Brooklyn Methodist Hospital, 506 6th Street, Brooklyn, NY 11215, USATel +1 718-780-5260Email bmb9005@nyp.orgObjective: Health professionals and patients should follow comprehensive screening guidelines to recognize early signs of long-term complications for insulin-dependent type 1 diabetes mellitus (T1DM). The aim of this study is to demonstrate that utilization of electronic medical record (EMR) templates for diabetes management improves adherence to International Society for Pediatric and Adolescent Diabetes (ISPAD) screening guidelines.Methods: All patients with T1DM who were seen in the outpatient pediatric endocrine clinic (age 0– 22 years old) at an urban community-based community hospital during the 2014 calendar year were enrolled in the study (n=49). A retrospective chart review was performed and audited against ISPAD guidelines. An EMR template and order set was then created based on ISPAD screening guidelines with the aim of improving compliance. The templates were implemented in 2015 (initial phase) and 2016 (maintenance phase) and these data were compared to baseline data. A chi-squared test was performed to analyze the differences between the data using SAS version 9.4 (SAS Institute, Inc). A p-value less than 0.05 was considered significant.Results: Significant improvements (p< 0.05) in screening guideline adherence from baseline to maintenance phase data were found for annual retinopathy (0% to 45%) and neuropathic foot (0% to 64%) exams, screening for microalbuminuria (49% to 79%), celiac disease (6% to 81%), lipids (63% to 86%), and basic metabolic panel (69% to 88%). Of note, thyroid function testing was also increased, but was not statistically significant between the years.Conclusion: The utilization of EMR templates and order sets for T1DM are valuable tools to aid medical providers in adhering to ISPAD screening guideline.Keywords: type 1 diabetes, electronic medical record, screening tool, disease management, chronic disease, benchmarking, quality improvement, pediatrics, standardized documentation

Henry M Smilowitz,1 Lauren J Tarmu,1–3 Mary Melinda Sanders,4 John A Taylor III,5 Dharamainder Choudhary,6 Crystal Xue,7 Nathaniel A Dyment,8 Dan Sasso,1 Xiaomeng Deng,9 James F Hainfeld10 1Department of Cell Biology, University of Connecticut Health Center, Farmington, CT, 2Department of Human Behavior, College of Southern Nevada, North Las Vegas, 3Department of Anthropology, University of Nevada, Las Vegas, NV, 4Department of Anatomic Pathology, University of Connecticut Health Center, Farmington, CT, 5Department of Urology, University of Kansas Medical Center, Kansas City, KS, 6Department of Surgery, University of Connecticut Health Center, Farmington, CT, 7George Washington University School of Medicine, Washington, DC, 8Department of Orthopedic Surgery, University of Pennsylvania, Philadelphia, PA, 9David Geffen School of Medicine at UCLA, Los Angeles, CA, 10Nanoprobes, Inc, Yaphank, NY, USA Abstract: Bladder-sparing options are being developed for muscle-invasive bladder cancer in place of radical cystectomy, including the combination of chemotherapy and radiation therapy. We reasoned that improving the radiotherapy component of chemoradiation could improve the control of locally advanced disease. Previously, we showed that gold nanoparticles (AuNPs) are potent enhancers of radiation therapy. We hypothesized that if AuNPs were to preferentially localize to bladder tumors, they may be used to enhance the radiation component of muscle-invasive bladder tumor therapy. Mice were treated with the carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) for 17, 20, and 22 weeks – long enough to induce muscle-invasive tumors. Mice were then anesthetized and injected intravenously with 1.9 nm AuNPs of which most were rapidly cleared from the blood and excreted after a 30–50 minute residence time in the bladder. We found AuNPs distributed throughout the bladder wall, but most of the AuNPs were associated with the stroma surrounding the tumor cells or extracellular keratin produced by the tumor cells. There were relatively few AuNPs in the tumor cells themselves. The AuNPs therefore localized to tumor-associated stroma and this tumor specificity might be useful for specific X-ray dose enhancement therapy of muscle-invasive bladder carcinomas. Keywords: N-butyl-N-(4-hydroxybutyl)nitrosamine, BBN, muscle-invasive bladder cancer, gold nanoparticles, mouse model

World produces 360 million tons of plastic every year, out of which only 7% plastic undergo recycling leaving majority of this waste lying around that get accumulated in the environment, thus posing a serious threat especially in the form of microplastics (MPs) to the large group of organisms on earth. Microplastics have been observed both in freshwater as well as in marine environment; however, recently, the occurrence of MPs in the fresh water that will ultimately lead to pollution in drinking water is emerging as one of the major concern for the scientific community. Till now, relative to the marine environment, the MPs pollution in the fresh water system is not very well understood and still an area of research that needs to be explored in detail. A detailed understanding of the origin, qualification, quantification, hazardous effects, etc. has be established to develop a proper waste management process for the MPs found in fresh water system. This review focuses on the sources, distribution, sampling methods, separation methods, methods of characterization and toxicological effects of microplastics in the freshwater environment. Various factors that affect the transportation and distribution of microplastics in fresh water system are reviewed. It is recommended that a standard protocol must be developed for identification of microplastics for scientific community across the world. The present study will help us to understand the source, transport, and effects of microplastics on the freshwater environment which would thereafter help to standardize the process for quantification and identification of microplastics in the freshwater environment. A combination of methods for the detection and prevention of microplastics in freshwater environment has also been suggested. [ABSTRACT FROM AUTHOR]

Nepal's farmers report fertilizer shortages yearly, especially for rice, wheat, and maize production. A reliable and established approach to estimating the actual demand for fertilizers for different crops and cropping seasons is lacking. Therefore, it is difficult to project the types and quantity of fertilizer to import and allocate across various regions in the country. With the direct involvement of the Government of Nepal (GoN) in fertilizer import, price (subsidy), and distribution, together with the high affinity of farmers for the subsidy, there is no incentive for the private sector to import and distribute fertilizers. Thus, farmers' access to fertilizers in the country depends primarily on the subsidy budget, quantity and types of fertilizers imported, and their distribution management. In this study, the fertilizer demands, both at the national and sub-national levels, were estimated through a survey of cooperatives that distribute subsidized fertilizers in the country. Our estimate suggests that the fertilizer supplied in 2018/19 was only 60% of the total effective demand in the country. With this estimate of the demand-supply gap and the price variability across provinces, short, medium, and long-term policy recommendations are made to improve the supply of chemical fertilizer in the country. [ABSTRACT FROM AUTHOR]

The present study was aimed to incorporate herbal growth promoter Turmeric (Curcuma longa) and Neem (Azadirachta indica) in poultry ration as an alternative of growth promoting antimicrobial drugs and its effect on growth of broiler chick was evaluated. A feeding trial of 35 days, using 210 day-old broiler chicks (cobb-400) randomly distributed in completely randomized block design. The seven treatments were designated as T1 i.e. control group served as basal diet, T2 and T3 treatment groups supplemented with 0.5 per cent and 1 per cent level of Turmeric powder, similarly T4 and T5 supplemented with Neem leaf powder in the experimental broiler starter and finisher ration, respectively. T6 and T7 treatment groups were supplemented with 0.25 per cent and 0.5 per cent level of both Turmeric powder and Neem leaf powder in combination, respectively. All the treatment groups were further divided in two replicates namely R1 and R2 having 15 birds in each replicate. The body weight, body weight gain, feed consumption, feed conversion ratio (FCR), performance index and protein efficiency ratio were recorded for all seven treatment groups. Significant effect on feed consumption and feed conversion ratio were observed, whereas on body weight, body weight gain, performance index, average daily body weight gain (ADG) and protein efficiency ratio the effect was observed to be non-significant. Supplementation of Turmeric powder and Neem leaf powder at graded levels either alone or in combination reduce the overall cost of feed per kg gain as compare to control but maximum reduction in overall cost of feed per kg gain was obtained in T7 i.e. 8.57 per cent reduction over control. [ABSTRACT FROM AUTHOR]

Cities can identify trends and needs by analyzing data from IOT devices and sensors. Wireless sensor networks (WSNs) are generally used in numerous field of interest to detect phenomena, process the detected data and take appropriate actions. Due to the limited sources of stationary sensor nodes, WSNs must work with mobile robots such as unmanned aerial vehicles (UAVs) and Unmanned Ground Vehicles(UGVs) in their development. Consequently, it is necessary to maintain the energy efficiency of UAVs since they are approved by data centers so they must be deployed and charged frequently. Researchers worked on this area and came across various schemes for efficient data collection with minimal energy usage. This paper gives a structured and extensive review of different schemes proposed by different authors around the globe. This paper also evaluates the datasets utilized by different researchers for data collection method. Finally, the challenges involved in data collection method and power consumption are highlighted in conclusion section. We have also listed the future work in conclusion section.

Cancer is a wide-spreading disease. Its count goes on increasing and became the second leading cause of death in respect of diseases. New cancer-targeting molecules are explored. In this study, we tried to collect information about one such molecule, OTX015. Articles were searched across reputed search engines and publishers such as Cochrane, EMBASE, The Lancet, PubMed, GoogleScholar, ScienceDirect, Wiley Online, Springer and Bentham Science by using different keywords: “OTX015”, “Cancer”, “Small molecule PROTACs”, “BRD/BET” and “BET inhibitors”. The quality papers were retrieved, studied, categorized into different sections, analyzed, and used for article writing.OTX015 is a novel molecule in clinical trials. It showed some promising results in various cancers as well as other diseases like latent-HIV with the least side-effects.This article will give an insight into Small Molecules as PROTACs, their advantages and disadvantages, OTX015 and its PROTAC ARV- 825. It is advised that more research/studies are required to be carried out to know more about OTX015 and other PROTACs, their advancements, receptors, and mechanism/ mode of action to know their abilities to work against proteins involving diseases.

Ni2+ substituted spinel ferrites with formula CdxNi1-xFe2O4 were prepared by microwave Sol-gel method. The XRD analysis of the synthesized ferrite confirms the formation of cubic spinel structure of ferrite. Rietveld refined XRD patterns revealed the cubic spinel phase with Fd-3m space group. The oxygen position and the cation distribution are determined by means of Rietveld analysis, indicating the existence of mixed ferrites in each sample. The magnetic properties of all ferrites were studied by using a vibration sample magnetometer. The fast synthesis of spinel ferrites is yielded due to use of the microwave sintering technique. [ABSTRACT FROM AUTHOR]

Context. We study a fragment of a large quiescent filament observed on May 29, 2017 by the Interferometric BIdimensional Spectropolarimeter (IBIS) mounted at the Dunn Solar Telescope. We focus on its quiescent stage prior to its eruption. Aims. We analyse the spectral observations obtained in the Hα line to derive the thermodynamic properties of the plasma of the observed fragment of the filament. Methods. We used a 2D filament model employing radiative transfer computations under conditions that depart from the local thermodynamic equilibrium. We employed a forward modelling technique in which we used the 2D model to produce synthetic Hα line profiles that we compared with the observations. We then found the set of model input parameters, which produces synthetic spectra with the best agreement with observations. Results. Our analysis shows that one part of the observed fragment of the filament is cooler, denser, and more dynamic than its other part that is hotter, less dense, and more quiescent. The derived temperatures in the first part range from 6000 K to 10 000 K and in the latter part from 11 000 K to 14 000 K. The gas pressure is 0.2–0.4 dyn cm−2 in the first part and around 0.15 dyn cm−2 in the latter part. The more dynamic nature of the first part is characterised by the line-of-sight velocities with absolute values of 6–7 km s−1 and microturbulent velocities of 8–9 km s−1. On the other hand, the latter part exhibits line-of-sight velocities with absolute values 0–2.5 km s−1 and microturbulent velocities of 4–6 km s−1. [ABSTRACT FROM AUTHOR]

Habitat-imposed abiotic and biotic stress is a serious condition and is also a land-degradation problem in arid and semi-arid regions, causing major problem for crop productivity. Most of the cultivable and a least half of irrigated lands around the world are severely affected by environmental stresses. However, in these conditions, there are plant populations successfully adapted and evolutionarily different in their strategy of stress tolerance. Vascular plants do not function as autonomous individuals, but house diverse communities of symbiotic microbes. The role of these microbes can no longer be ignored. Microbial interactions are critical not only for host but also for fungal survival in stressed environments. Plants benefit extensively by harboring these associated microbes; they promote plant growth and confer enhanced resistance to various pathogens by producing antibiotics. To date, improvements in plant quality, production, abiotic and biotic stress resistance, nutrient, and water use have relied largely on manipulating plant genomes by breeding and genetic modification. Increasing evidence indicates that the function of symbiotic microbes seems to parallel more than one of these characteristics. [ABSTRACT FROM AUTHOR]

In subsistence agricultural systems, crop yields are directly dependent on the inherent soil fertility and on microbial processes that govern the mineralization and mobilization of nutrients required for plant growth. An impact of different crop species that are used in various combinations is likely to be an important factor in determining the structure of plant beneficial microbial communities that function in nutrient cycling, the production of plant growth hormones, and suppression of root diseases. In addition, studies are needed to elucidate the signal transduction pathways that result from treatment of plants with plant growth-promoting rhizobacteria under stress conditions. In the present review an emphasis has been given on plant-microbe interactions and their mitigation under abiotic and biotic stresses. [ABSTRACT FROM AUTHOR]

Despite evaluation of large number of agroindustrial wastes for their use as casing material for Agaricus bisporus (Lange) Imbach cultivation, scant attention has been given to the importance of biological properties of casing materials. In the present study, an attempt was made to characterize the bacterial flora in casing layer, namely, Farm Yard Manure (FYM) and Spent Mushroom Substrate/spent compost (SMS/SC) (FYM+SC, 3 : 1) and FYM and Vermi Compost (VC) (FYM+VC, 3 : 1), employing partial 16S rDNA sequencing. Available data showed a significant variety of organisms that included Acinetobacter and Pseudomonas of the γ-proteobacteria, that were the most frequently encountered genera. This is the first preliminary report on the microbial diversity of casing soils and demonstrates the presence of Acinetobacter spp. that has not been previously described in casing material. [ABSTRACT FROM AUTHOR]

Abstract: In this paper, we undertake a quantitative analysis of the reported metallic and semiconducting behaviour of electrical resistivity in perovskite manganites La1− x Na x MnO3 (x =0.07, 0.13). We have formulated an effective inter-ionic interaction potential (EIoIP) with the long-range Coulomb, van der Waals (vdW) interaction and the short-range repulsive interaction up to second neighbor ions within the Hafemeister and Flygare approach to deduce Debye (θD ), and Einstein temperature (θE ). The temperature-dependent resistivity for temperatures less than metal–insulator transition (TMI ), is theoretically analysed within the framework of the classical electron–phonon model of resistivity. Due to inherent low-frequency acoustic phonon as well high-frequency optical phonons, the contributions to the resistivity have been estimated. For low doping (x =0.07; TMI = 194K), the electron–phonon interaction is sufficient to describe the resistivity behaviour. However, additional electron–electron scattering (power temperature dependence) contribution to resistivity is required for higher doping as x = 0.13 (TMI = 301K). For temperatures, T > TMI , the semiconducting nature is discussed with Mott’s variable range hopping (VRH) model and small polaron conduction (SPC) model. The SPC model consistently retraces the higher temperature resistivity behaviour (T > θD /2). The metallic and semiconducting behaviour of resistivity is theoretically discussed for the first time to our knowledge for La1− x Na x MnO3 in various compositions. [Copyright &y& Elsevier]

The association of CYP1B1 gene alterations in primary congenital glaucoma individuals has been known for about a decade. Recent evidence has shown the involvement of CYP1B1 mutations in a number of forms of glaucoma and anterior segment disorders. This suggests a wide role for CYP1B1 in ocular physiology. Histochemical studies of eyes from individuals with primary congenital glaucoma revealed abnormalities in the anterior chamber angle, the region between the cornea and the iris, containing the trabecular meshwork. The cells of the trabecular meshwork serve as a filter to allow drainage of the aqueous humour, the fluid formed by the ciliary body that fills the anterior chamber. Mutations in CYP1B1 that affect its activity have frequently been shown to influence development of the trabecular meshwork, and it is thought that CYP1B1, a monooxygenase, acts to form or degrade some endobiotic compound that is necessary for proper development of the filtering structures. The rapidly developing area of stem cell research suggests a potential therapeutic approach for glaucomas resulting from deleterious mutations in CYP1B1, that is, the transfer of stem cells, differentiated to a specific lineage, containing wild-type CYP1B1 to specific regions of the eye, where they will develop into normal cells of that region and rectify the defect. [ABSTRACT FROM AUTHOR]

Six accessions of geranium ( Pelargonium sp. 'hybrid') were introduced in temperate and subtropical regions of Jammu and Kashmir. The herbaceous parts in the commercial distillation gave 0.09-0.13% oil on fresh weight basis. The calculated herbage yield (tonnes/ha) and oil yield (litre/ha) varied from 31.5 ± 1.87 to 49.1 ± 2.73 and 32.40 to 57.12, respectively. The geranium oil produced in different regions of Jammu and Kashmir was comparable to that produced in other geranium-growing areas in India in terms of its major constituents, citronellol (22.5-34.5%) and geraniol (13.9-24.7%), respectively. This suggests that geranium can be successfully grown in the state of Jammu and Kashmir. Copyright © 2006 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Expression of 10 CYP orthologs (Families 1–3) in developing mouse conceptus is constitutive. These forms have specific temporal and spatial expression. Studies on CYP1B1 indicate its requirement for normal eye development, both in human and mouse. The distribution of the enzyme in the mouse eye is in three regions, which may reflect three different, perhaps equally important, functions in this organ. Its presence in the inner ciliary and lens epithelia appears to be necessary for normal development of the trabecular meshwork and its function in regulating intraocular pressure. Its expression in the retinal ganglion and inner nuclear layers may reflect a role in maintenance of the visual cycle. Its expression in the corneal epithelium may indicate a function in metabolism of environmental xenobiotics. [ABSTRACT FROM AUTHOR]

We describe the clinical, hematological and histomorphological features in children of primary myelodysplastic syndrome (MDS) seen at the All India Institute of Medical Sciences over three years (Jan 2001–Jan 2004). Twenty-one patients of primary MDS aged 17 year or less were classified using the latest proposed WHO classification for Pediatric MDS. The median age was 9 years with male predominance (80%). Pallor was present in all the cases while fever and bleeding diathesis was present in more than 50% of the cases. Morphological assessment of the peripheral blood showed macrocytosis in 50%, pancytopenia in 15% and blast cells in 45% of cases. A complete analysis of clinical features in conjunction with the bone marrow profile revealed 8 cases of refractory cytopenia (RC), 3 cases of refractory anemia with excess blasts (RAEB), 5 cases of refractory anemia with excess blasts in transformation (RAEB-T), 4 cases of Juvenile myelomonocytic leukemia (JMML) and a solitary cases of acute myeloid leukemia (AML) in Downs syndrome. These children were followed up from 1–36 months (mean 15 months). Three patients of RAEB-T progressed to AML within 3–4 months. RC had the best prognosis and all are alive and under regular follow up. The solitary case of AML of Downs syndrome died 1.5 months after initial diagnosis. All 3 cases of RAEB are under regular follow-up and doing well. Three cases of RAEB-T died (all had progressed to AML); the remaining 2 cases were lost to follow up. Of the 4 cases of JMML 1 died within 6 months of diagnosis; the other 3 cases are under regular follow up of whom 1 has a progressively increasing blast count. We conclude that the latest proposed WHO classification for Pediatric MDS can be successfully applied to all cases of primary MDS. [ABSTRACT FROM AUTHOR]

We have carried out systematic studies on the response of ferrous sulphate-benzoic acid-xylenol orange (FBX)—a highly sensitive chemical dosimeter in liquid form to accelerated charged particles of different LET. Dosimeters were exposed in the form of thin layers to graded fluence of 7Li ion beam with three different energies Viz, 46, 38 and 27 MeV corresponding to average LETs of 6.3, 7.5 and 11 eV A˚−1 and 12C ion beam with energy 45.6 MeV corresponding to average LET of 52.5 eV A˚−1. From the investigations, the corresponding G(Fe+3) values were found to be (51.7±1.3)×10−7, (35.4±0.7)×10−7, (19.3±0.6)×10−7 and (8.4±0.1)×10−7 mol J−1, respectively. For gamma radiation, with estimated LET of 0.02 eV A˚−1, G(Fe+3) value was observed to be (56.1±0.4)×10−7 mol J−1. Clearly, G(Fe+3) values were found to decrease with increasing LET of the particle beam. However, the dosimeter showed no dependence on LET up to about 6 eV A˚−1 unlike the Fricke dosimeter. The results confirm the response of FBX dosimeter is non-linear for doses exceeding 5 Gy for 60Co gamma rays. More importantly, the present study using 7Li and 12C ions clearly shows that response of the FBX dosimeter is linear for high LET radiations at low as well as high doses. [Copyright &y& Elsevier]

This study is the first systematic investigation of the gestational age-dependent and adult tissue-specific expression patterns of each known mouse CYP family (40 genes) using normalized cDNA panels and uniform reverse transcriptase polymerase chain reaction-based assays. Twenty-seven of the P450s were constitutively expressed during development. The number gradually increased through the phases of gastrulation E7 (n=14), neural patterning and somitogenesis E11 (n=17), organogenesis E15 (n=20), and fetal period E17 (n=21). Cyp2s1, Cyp8a1, Cyp20, Cyp21a1, Cyp26a1, Cyp46, and Cyp51 were detected in each of the four stages studied. Members of family CYP1 demonstrated complex, nonoverlapping embryonic patterns of expression, indicating that Cyp1a1 and Cyp1a2 may not compensate for Cyp1b1 deficiency associated with abnormal eye development. Multiple Cyp forms were found to be constitutively expressed in each of the adult tissues studied: liver (n=31), kidney (n=30), testis (n=26), lung (n=24), and heart (n=13). The tissue-specific P450-expression profiles reported in this study provide a reference for more focused analysis of the tissue-specific and developmental functions of the cytochrome P450 monooxygenases. [Copyright &y& Elsevier]

Somatic chromosome morphology and induced tetraploidy in Papaver somniferum L. variety Dhaturia has been studied. Detailed studies on total chromosome length, relative length and arm ratio have been made and presented. [ABSTRACT FROM AUTHOR]

The presence of methyl eugenol in the oil and the difficulty experienced in its separation was considered to be a negative attribute in the Cymbopogon flexuosus (var. RRL-59). A mutation breeding programme was initiated to rectify this inherent defect. A massive screening of irradiated vegetative slips of this essential oil-bearing plant resulted in the isolation of a methyl-eugenol deficient mutant. Our results show that once the methyl eugenol is absent from the oil, the oil as such closely resembles the oil of citronella (Java type) and can be a good substitute for the same. This investigation supports the view that beneficial mutations at specific gene loci once isolated in a vegetatively propagated species can be easily stabilised and propagated. [ABSTRACT FROM AUTHOR]

Objetivos: O desuso pelo repouso no leito, pela imobilização de membros ou por missões espaciais provoca a perda óssea rápida. Fez-se este estudo para investigar os efeitos terapêuticos do ácido zoledrônico (ZOL), isoladamente e em combinação ao alfacalcidol (ALF), em um modelo de rato com osteoporose por desuso. Métodos: Ratos Wistar machos de três meses foram submetidos à imobilização da pata traseira direita (IPTD) por 10 semanas para induzir a osteopenia; em seguida, foram divididos em quatro grupos: 1 – IPTD para controle positivo; 2 – IPTD mais ZOL (50 µg/kg, dose única intravenosa); 3 – IPTD mais ALF (0,5 µg/kg, via oral diariamente); 4 – IPTD mais ALF (0,5 µg/kg, via oral diariamente) mais ZOL (50 µg/kg, dose única intravenosa) por outras 10 semanas. Um grupo de ratos não imobilizados foi usado como controle negativo. No fim do tratamento, os fêmures foram removidos e testaram-se a porosidade do osso e suas propriedades mecânicas, além do peso seco e das cinzas do osso. Resultados: A terapia combinada com ZOL mais ALF foi mais eficaz em reduzir a porosidade do osso do que a monoterapia com um dos fármacos administrado isoladamente em ratos submetidos à IPTD. No que diz respeito à melhoria da resistência mecânica da diáfise femoral média, o tratamento combinado com ZOL mais ALF foi mais eficaz do que a monoterapia com um dos fármacos administrado isoladamente. Além disso, a terapia combinada com ZOL mais ALF foi mais eficaz na melhoria do peso seco e das cinzas do osso do que a monoterapia com ZOL ou ALF em ratos submetidos à IPTD. Conclusões: Esses dados sugerem que a terapia combinada com ZOL mais ALF representa uma opção terapêutica potencialmente útil para o tratamento da osteoporose por desuso.

The incidence of placenta accreta is increasing as a consequence of rising number of cesarean sections and advancing maternal age. A series of seven cases of placenta accreta observed in a short span of four months is being presented. Complication rates in the present series are post partum hemorrhage and major transfusion support (100%), peripartum hysterectomy (100%), ICU admission in four (57%), fever (14%) and bladder injury in one case (14%). [ABSTRACT FROM AUTHOR]