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12 results on '"Chigrinova, Ekaterina"'

3. Two main genetic pathways lead to the transformation of chronic lymphocytic leukemia to Richter syndrome

Author

Chigrinova, Ekaterina, Rinaldi, Andrea, Kwee, Ivo, Rossi, Davide, Rancoita, Paola M.V., Strefford, Jonathan C., Oscier, David, Stamatopoulos, Kostas, Papadaki, Theodora, Berger, Francoise, Young, Ken H., Murray, Fiona, Rosenquist, Richard, Greiner, Timothy C., Chan, Wing C., Orlandi, Ester M., Lucioni, Marco, Marasca, Roberto, Inghirami, Giorgio, Ladetto, Marco, Forconi, Francesco, Cogliatti, Sergio, Votavova, Hana, Swerdlow, Steven H., Stilgenbauer, Stephan, Piris, Miguel A., Matolcsy, Andras, Spagnolo, Dominic, Nikitin, Eugene, Zamò, Alberto, Gattei, Valter, Bhagat, Govind, Ott, German, Zucca, Emanuele, Gaidano, Gianluca, and Bertoni, Francesco

Published
2013
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4. The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation

Author

Rossi, Davide, Spina, Valeria, Deambrogi, Clara, Rasi, Silvia, Laurenti, Luca, Stamatopoulos, Kostas, Arcaini, Luca, Lucioni, Marco, Rocque, Gabrielle B., Xu-Monette, Zijun Y., Visco, Carlo, Chang, Julie, Chigrinova, Ekaterina, Forconi, Francesco, Marasca, Roberto, Besson, Caroline, Papadaki, Theodora, Paulli, Marco, Larocca, Luigi M., Pileri, Stefano A., Gattei, Valter, Bertoni, Francesco, Foà, Robin, Young, Ken H., and Gaidano, Gianluca

Published
2011
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5. Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome

Author

Rinaldi, Andrea, Mian, Michael, Chigrinova, Ekaterina, Arcaini, Luca, Bhagat, Govind, Novak, Urban, Rancoita, Paola M.V., De Campos, Cassio P., Forconi, Francesco, Gascoyne, Randy D., Facchetti, Fabio, Ponzoni, Maurilio, Govi, Silvia, Ferreri, Andrés J.M., Mollejo, Manuela, Piris, Miguel A., Baldini, Luca, Soulier, Jean, Thieblemont, Catherine, Canzonieri, Vincenzo, Gattei, Valter, Marasca, Roberto, Franceschetti, Silvia, Gaidano, Gianluca, Tucci, Alessandra, Uccella, Silvia, Tibiletti, Maria Grazia, Dirnhofer, Stephan, Tripodo, Claudio, Doglioni, Claudio, Dalla Favera, Riccardo, Cavalli, Franco, Zucca, Emanuele, Kwee, Ivo, and Bertoni, Francesco

Published
2011
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6. Integrated profiling of diffuse large B-cell lymphoma with 7q gain

Author

Chigrinova, Ekaterina, Mian, Michael, Shen, Yulei, Greiner, Timothy C., Chan, Wing C., Vose, Julie M., Inghirami, Giorgio, Chiappella, Annalisa, Baldini, Luca, Ponzoni, Maurilio, Ferreri, Andrés J. M., Franceschetti, Silvia, Gaidano, Gianluca, Tucci, Alessandra, Facchetti, Fabio, Lazure, Thierry, Lambotte, Olivier, Montes-Moreno, Santiago, Piris, Miguel A., Zucca, Emanuele, Kwee, Ivo, and Bertoni, Francesco

Published
2011
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7. Genomic lesions associated with a different clinical outcome in diffuse large B-Cell lymphoma treated with R-CHOP-21

Author

Scandurra, Marta, Mian, Michael, Greiner, Timothy C., Rancoita, Paola M. V., De Campos, Cassio P., Chan, Wing C., Vose, Julie M., Chigrinova, Ekaterina, Inghirami, Giorgio, Chiappella, Annalisa, Baldini, Luca, Ponzoni, Maurilio, Ferreri, Andres J.M., Franceschetti, Silvia, Gaidano, Gianluca, Montes-Moreno, Santiago, Piris, Miguel A., Facchetti, Fabio, Tucci, Alessandra, Nomdedeu, Josep Fr., Lazure, Thierry, Lambotte, Olivier, Uccella, Silvia, Pinotti, Graziella, Pruneri, Giancarlo, Martinelli, Giovanni, Young, Ken H., Tibiletti, Maria Grazia, Rinaldi, Andrea, Zucca, Emanuele, Kwee, Ivo, and Bertoni, Francesco

Published
2010
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8. Single nucleotide polymorphism-arrays provide new insights in the pathogenesis of post-transplant diffuse large B-cell lymphoma

Author

Rinaldi, Andrea, Capello, Daniela, Scandurra, Marta, Greiner, Timothy C., Chan, Wing C., Bhagat, Govind, Rossi, Davide, Morra, Enrica, Paulli, Marco, Rambaldi, Alessandro, Rancoita, Paola M. V., Inghirami, Giorgio, Ponzoni, Maurilio, Moreno, Santiago M., Piris, Miguel A., Mian, Michael, Chigrinova, Ekaterina, Zucca, Emanuele, Favera, Riccardo D., Gaidano, Gianluca, Kwee, Ivo, and Bertoni, Francesco

Published
2010
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9. Diffuse large B-cell lymphoma with concordant bone marrow involvement has peculiar genomic profile and poor clinical outcome.

Author

Chigrinova, Ekaterina, Mian, Michael, Scandurra, Marta, Greiner, Timothy C., Chan, Wing C., Vose, Julie M., Inghirami, Giorgio, Chiappella, Annalisa, Baldini, Luca, Ponzoni, Maurilio, Ferreri, Andrés J.M., Franceschetti, Silvia, Gaidano, Gianluca, Tucci, Alessandra, Facchetti, Fabio, Lazure, Thierry, Lambotte, Olivier, Montes-Moreno, Santiago, Piris, Miguel A., and Nomdedeu, Josep Fr.

Published
2011
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10. Genomic profiling of Richter's syndrome: recurrent lesions and differences with de novo diffuse large B-cell lymphomas.

Author

Scandurra, Marta, Rossi, Davide, Deambrogi, Clara, Rancoita, Paola MV, Chigrinova, Ekaterina, Mian, Michael, Cerri, Michaela, Rasi, Silvia, Sozzi, Elisa, Forconi, Francesco, Ponzoni, Maurilio, Moreno, Santiago M, Piris, Miguel A, Inghirami, Giorgio, Zucca, Emanuele, Gattei, Valter, Rinaldi, Andrea, Kwee, Ivo, Gaidano, Gianluca, and Bertoni, Francesco

Abstract

Richter's syndrome (RS) represents the transformation of chronic lymphocytic leukaemia (CLL) to aggressive lymphoma and is mostly represented by diffuse large B-cell lymphoma (DLBCL), with a post-germinal centre (GC) phenotype, clonally related to the pre-existing CLL. RS has a very poor prognosis and its pathogenetic mechanisms are poorly understood. In order to gain additional hints in RS pathogenesis, we performed a genome-wide DNA profiling study of 13 RS phases and eight matched CLL phases using the Affymetrix Human Mapping 250K NspI SNP arrays. Individual genomic profiles were heterogeneous, with no individual lesions occurring in more than half of the cases. However, several observations suggest that MYC pathway might be involved in RS. The 13q13.3-qter region containing MIRHG1 (MIR-17-92), a cluster of microRNA interacting with c-MYC, was acquired at the time of transformation. The 13q gain was coupled with the gain of c-MYC and loss of TP53. Translocation of c-MYC was acquired at transformation in a fraction of cases and this event appeared mutually exclusive with gain of MIRHG1. MYCN, a c-MYC homologue, was also recurrently gained. By comparing RS with 48 de novo DLBCL, RS presented a significantly lower prevalence of deletions affecting the PRDM1 and TNFAIP3, genes on 6q, known to be associated with a post-GC phenotype. In conclusion, the genomic profile of RS seems to differ from what observed in de novo DLBCL and in other transformed DLBCL. Genomic lesions occurring in RS are heterogeneous suggesting the existence of different RS subsets, possibly due to different transforming mechanisms. A deregulation of MYC pathway might represent one of the main transformation events in the pathogenesis of a subset of RS clonally related to the previous CLL. Copyright © 2009 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2010
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