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1. Evaluating Dual Language Education Programs in Taiwan: Structure, Instruction, and Learning Outcomes

Author

Cheng-Ji Lai

Abstract

Despite the increasing popularity of dual language education programs in Taiwan, limited research assesses their effectiveness. This study evaluated eight English Immersion Programs (EIPs) in Taiwan, representing a dual language education model, using the "Guiding Principles for Dual Language Education" (GPDLE) framework. Interviews with the management team and a questionnaire for Native English Teachers (NETs) assessed the alignment of program structure and instruction with the GPDLE. A quasi-experimental design, including pre-tests and post-tests, examined the English listening and reading outcomes of 74 fourth to sixth-grade students in two randomly-selected EIPs over a year. The findings reveal that 83% of the EIPs fully adhered to the program structure outlined in the GPDLE, while only 33% of teacher instruction exhibited full alignment, with an additional 57% demonstrating partial alignment. Notably, significant improvements in reading were observed among fourth-grade students, and both reading and listening skills showed substantial enhancements in the fifth and sixth-grade students. The study recommends adopting a financially sustainable, user-paid model for an after-school English immersion program, supporting Taiwan's 2030 Bilingual National Initiative.

Published
2024

8. International Alliance of Urolithiasis (IAU) consensus on miniaturized percutaneous nephrolithotomy

Author

Zeng, Guo-Hua, Zhong, Wen, Mazzon, Giorgio, Zhu, Wei, Lahme, Sven, Khadgi, Sanjay, Desai, Janak, Agrawal, Madhu, Schulsinger, David, Gupta, Mantu, Montanari, Emanuele, Martinez, Juan Manuel Lopez, Almousawi, Shabir, Malonzo, Vincent Emanuel F., Sriprasad, Seshadri, Chai, Chu Ann, Arumuham, Vimoshan, Ferretti, Stefania, Kamal, Wissam, Xu, Ke-Wei, Cheng, Fan, Gao, Xiao-Feng, Cheng, Ji-Wen, Somani, Bhaskar, Duvdevani, Mordechai, Git, Kah Ann, Seitz, Christian, Bernardo, Norberto, Ibrahim, Tarek Ahmed Amin, Aquino, Albert, Yasui, Takahiro, Fiori, Cristian, Knoll, Thomas, Papatsoris, Athanasios, Gadzhiev, Nariman, Zhanbyrbekuly, Ulanbek, Angerri, Oriol, Ramos, Hugo Lopez, Saltirov, Iliya, Moussa, Mohamad, Giusti, Guido, Vicentini, Fabio, Suarez, Edgar Beltran, Pearle, Margaret, Preminger, Glenn M., Wu, Qing-Hui, Durutovic, Otas, Ghani, Khurshid, Maroccolo, Marcus, Brehmer, Marianne, Osther, Palle J., Zawadzki, Marek, Tursunkulov, Azimdjon, Kytaibekovich, Monolov Nurbek, Abuvohidov, Abdusamad Abdukakhorovich, Lara, Cesar Antonio Recalde, Noori, Zamari, Zanetti, Stefano Paolo, Shrestha, Sunil, de la Rosette, Jean, Denstedt, John, Ye, Zhang-Qun, Sarica, Kemal, and Choong, Simon

Published
2024
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42. Exosomal hsa_circ_000200 as a potential biomarker and metastasis enhancer of gastric cancer via miR-4659a/b-3p/HBEGF axis

Author

Xiao-juan Huang, Yan Wang, Hui-ting Wang, Zhao-feng Liang, Cheng Ji, Xiao-xi Li, Lei-lei Zhang, Run-bi Ji, Wen-rong Xu, Jian-hua Jin, and Hui Qian

Subjects
Exosomes, hsa_circ_000200, Gastric cancer, Liquid biopsy marker, miR-4659a/b-3p, HBEGF, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671
Abstract

Abstract Background Exosome, a component of liquid biopsy, loaded protein, DNA, RNA and lipid gradually emerges as biomarker in tumors. However, exosomal circRNAs as biomarker and function mechanism in gastric cancer (GC) are not well understood. Methods Differentially expressed circRNAs in GC and healthy people were screened by database. The identification of hsa_circ_000200 was verified by RNase R and sequencing, and the expression of hsa_circ_000200 was evaluated using qRT-PCR. The biological function of hsa_circ_000200 in GC was verified in vitro. Western blot, RIP, RNA fluorescence in situ hybridization, and double luciferase assay were utilized to explore the potential mechanism of hsa_circ_000200. Results Hsa_circ_000200 up-regulated in GC tissue, serum and serum exosomes. Hsa_circ_000200 in serum exosomes showed better diagnostic ability than that of tissues and serum. Combined with clinicopathological parameters, its level was related to invasion depth, TNM staging, and distal metastasis. Functionally, knockdown of hsa_circ_000200 inhibited GC cells proliferation, migration and invasion in vitro, while its overexpression played the opposite role. Importantly, exosomes with up-regulated hsa_circ_000200 promoted the proliferation and migration of co-cultured GC cells. Mechanistically, hsa_circ_000200 acted as a “ceRNA” for miR-4659a/b-3p to increase HBEGF and TGF-β/Smad expression, then promoted the development of GC. Conclusions Our findings suggest that hsa_circ_000200 promotes the progression of GC through hsa_circ_000200/miR-4659a/b-3p/HBEGF axis and affecting the expression of TGF-β/Smad. Serum exosomal hsa_circ_000200 may serve as a potential biomarker for GC.

Published
2023
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48. Forkhead box L2 is a target of miR‐133b and plays an important role in the pathogenesis of non‐small cell lung cancer

Author

Juan Li, Lirong Gao, Anqi Wang, Huiwen Qian, Jianjie Zhu, Shundong Ji, Jun Chen, Zeyi Liu, and Cheng Ji

Subjects
carcinoma, non‐small‐cell lung cancer (NSCLC), epithelial–mesenchymal transition (EMT), forkhead box protein L2 (FOXL2), miR‐133b, TGF‐β/Smad signaling, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Forkhead box L2 (FOXL2) has been recognized as a transcription factor in the progression of many malignancies, but its role in non‐small cell lung cancer (NSCLC) remains unclear. This research clarified on the role of FOXL2 and the specific molecular mechanism in NSCLC. Methods RNA and protein levels were detected by quantitative real‐time polymerase chain reaction (qRT–PCR) and western blotting assays. Cell proliferation was examined by cell counting kit‐8 (CCK‐8) and clonogenic assays. Transwell and wound healing assays were used to detect cell invasion and migration. Cell cycle alterations were assessed by flow cytometry. The relationship between FOXL2 and miR‐133b was verified by dual‐luciferase reporter assays. In vivo metastasis was monitored in the tail vein‐injected mice. Results FOXL2 was upregulated in NSCLC cells and tissues. Downregulation of FOXL2 restrained cell proliferation, migration, and invasion and arrested the cell cycle of NSCLC cells. Moreover, FOXL2 promoted the epithelial–mesenchymal transition (EMT) process of NSCLC cells by inducing the transforming growth factor‐β (TGF‐β)/Smad signaling pathway. miR‐133b directly targeted the 3′‐UTR of FOXL2 and negatively regulated FOXL2 expression. Knockdown of FOXL2 blocked metastasis in vivo. Conclusions miR‐133b downregulates FOXL2 by targeting the 3′‐UTR of FOXL2, thereby inhibiting cell proliferation, EMT and metastasis induced by the TGF‐β/Smad signaling pathway in NSCLC. FOXL2 may be a potential molecular target for treating NSCLC.

Published
2023
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49. B7-H3 chimeric antigen receptor-modified T cell shows potential for targeted treatment of acute myeloid leukaemia

Author

Shuangshuang Fan, Tian Wang, Fengtao You, Tingting Zhang, Yafen Li, Cheng Ji, Zhichao Han, Binjie Sheng, Xiaochen Zhai, Gangli An, Huimin Meng, and Lin Yang

Subjects
Chimeric antigen receptor-T cell, Immunotherapy, Acute myeloid leukaemia, B7-H3, Medicine
Abstract

Abstract Background and aims Chimeric antigen receptor (CAR)-T cell therapy is a novel type of immunotherapy. However, the use of CAR-T cells to treat acute myeloid leukaemia (AML) has limitations. B7-H3 is expressed in several malignancies, including some types of AML cells. However, its expression in normal tissues is low. Therefore, B7-H3 is ideal for targeted AML therapy. Materials and methods First, we constructed B7-H3 CAR that can target B7-H3, and then constructed B7-H3-CAR-T cells in vitro, which were co-incubated with six AML cell lines expressing different levels of B7-H3, respectively. The toxicity and cytokines were detected by flow cytometry. In vivo, AML model was established in B-NSG mice to study the toxicity of B7-H3-CAR T on AML cells. Results In vitro functional tests showed that B7-H3-CAR-T cells were cytotoxic to B7-H3-positive AML tumor cells and had good scavenging effect on B7-H3-expressing AML cell lines, and the cytokine results were consistent. In vivo, B7-H3-CAR-T cells significantly inhibited tumor cell growth in a mouse model of AML, prolonging mouse survival compared with controls. Conclusion B7-H3-CAR-T cells may serve as a novel therapeutic method for the targeted treatment of AML.

Published
2023
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