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Your search keyword '"Chen, Yi-Ming Arthur"' showing total 168 results
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168 results on '"Chen, Yi-Ming Arthur"'

2. Molecular epidemiology of hepatitis B, hepatitis C, and HIV-1 co-infections in Ethiopia: Implications for disease burden and intervention strategies

Author

Bezabeh, Asmamaw, Berhe, Rezene, Medhin, Girmay, Taddesse, Gizachew, Bane, Abate, Redae, Berhane, Zealiyas, Kidist, Gelibo, Terefe, Challa, Feyissa, Belay, Yohannes, Kassa, Desta, Bekele, Abebe, Gebremicael, Gebremedhin, Girma, Mulu, Getaneh, Yimam, Kidane, Eleni, Chalchisa, Dinkinesh, Adane, Sisay, Abdella, Saro, Tollera, Getachew, Hailu, Messay, Weldemariam, Atsbeha Gebreegziabxier, Lin, Su-I, Li, Wei-You, Wolday, Dawit, Yang, Ming-Hui, Alemu, Yibeltal Assefa, Sarusi, Deborah, Maayan, Shlomo, Chen, Yi-Ming Arthur, Chuang, Kuo-Pin, Tyan, Yu-Chang, and Dai, Chia-Yen

Published
2024
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21. Folic Acid Ameliorates Renal Injury in Experimental Obstructive Nephropathy: Role of Glycine N-Methyltransferase.

Author

Kuo, Ko-Lin, Chiang, Chin-Wei, Chen, Yi-Ming Arthur, Yu, Chih-Chin, and Lee, Tzong-Shyuan

Subjects
DIABETIC nephropathies, RENAL fibrosis, GLYCINE, KIDNEY diseases, FOLIC acid, URETERIC obstruction, LIVER proteins
Abstract

Folic acid exerts both anti-inflammatory and antifibrotic effects. Glycine N-methyltransferase (GNMT), the major folic acid-binding protein in the liver, is a crucial enzyme that regulates the cellular methylation process by maintaining S-adenosylmethionine levels. However, as yet neither the therapeutic effects of folic acid in renal fibrosis nor whether GNMT is involved in these folic acid-associated mechanisms has been investigated. First, the expression of GNMT was examined in human kidneys with or without obstructive nephropathy. Later, wild-type and GNMT knockout (GNMT−/−) mice were subjected to unilateral ureteral obstruction (UUO) and then treated with either folic acid or vehicle for 14 days. Renal tubular injury, inflammation, fibrosis, and autophagy were evaluated by histological analysis and Western blotting. We observed increased expression of GNMT in humans with obstructive nephropathy. Furthermore, UUO significantly increased the expression of GNMT in mice; in addition, it caused renal injury as well as the development of both hydronephrosis and tubular injury. These were all alleviated by folic acid treatment. In contrast, GNMT−/− mice exhibited exacerbated UUO-induced renal injury, but the protective effect of folic acid was not observed in GNMT−/− mice. We propose a novel role for folic acid in the treatment of renal fibrosis, which indicates that GNMT may be a therapeutic target. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Reversal of High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease by Metformin Combined with PGG, an Inducer of Glycine N-Methyltransferase.

Author

Yang, Ming-Hui, Li, Wei-You, Wu, Ching-Fen, Lee, Yi-Ching, Chen, Allan Yi-Nan, Tyan, Yu-Chang, and Chen, Yi-Ming Arthur

Subjects
NON-alcoholic fatty liver disease, SUGAMMADEX, REVERSE transcriptase polymerase chain reaction, HEAT shock proteins, METFORMIN, RIBOSOMAL proteins, FATTY liver
Abstract

Nonalcoholic fatty liver disease (NAFLD) is a major cause of liver-related morbidities and mortality, and no effective drug treatment currently exists. We aimed to develop a novel treatment strategy to induce the expression of glycine N-methyltransferase (GNMT), which is an important enzyme regulating S-adenosylmethionine metabolism whose expression is downregulated in patients with NAFLD. Because 1,2,3,4,6-pentagalloyl glucose (PGG) is a GNMT inducer, and metformin was shown to upregulate liver mitochondrial GNMT protein expression, the effect of PGG and metformin was evaluated. Biochemical analysis, histopathological examination, immunohistochemical staining, reverse transcription-quantitative PCR (RT-qPCR), Western blotting (WB), proteomic analysis and Seahorse XF Cell Mito Stress Test were performed. The high-fat diet (HFD)-induced NAFLD mice were treated with PGG and metformin. Combination of PGG and metformin nearly completely reversed weight gain, elevation of serum aminotransferases, and hepatic steatosis and steatohepatitis. In addition, the downregulated GNMT expression in liver tissues of HFD-induced NAFLD mice was restored. The GNMT expression was further confirmed by RT-qPCR and WB analysis using both in vitro and in vivo systems. In addition, PGG treatment was shown to increase oxygen consumption rate (OCR) maximum capacity in a dose-dependent manner, and was capable of rescuing the suppression of mitochondrial OCR induced by metformin. Proteomic analysis identified increased expression of glutathione S-transferase mu 4 (GSTM4), heat shock protein 72 (HSP72), pyruvate carboxylase (PYC) and 40S ribosomal protein S28 (RS28) in the metformin plus PGG treatment group. Our findings show that GNMT expression plays an important role in the pathogenesis of NAFLD, and combination of an inducer of GNMT and metformin can be of therapeutic potential for patients with NAFLD. [ABSTRACT FROM AUTHOR]

Published
2022
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42. Cohort Profile: The PharmAccess African (PASER-M) and the TREAT Asia (TASER-M) Monitoring Studies to Evaluate Resistance—HIV drug resistance in sub-Saharan Africa and the Asia-Pacific

Author

Hamers, Raph L, Oyomopito, Rebecca, Kityo, Cissy, Phanuphak, Praphan, Siwale, Margaret, Sungkanuparph, Somnuek, Conradie, Francesca, Kumarasamy, Nagalingeswaran, Botes, Mariette E, Sirisanthana, Thira, Abdallah, Saade, Li, Patrick C K, Ngorima, Nicoletta, Kantipong, Pacharee, Osibogun, Akin, Lee, Christopher K C, Stevens, Wendy S, Kamarulzaman, Adeeba, Derdelinckx, Inge, Chen, Yi-Ming Arthur, Schuurman, Rob, van Vugt, Michèle, and Rinke de Wit, Tobias F

Published
2012
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