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Your search keyword '"Chang, Chia-Wei"' showing total 335 results
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10. A chimeric antigen receptor uniquely recognizing MICA/B stress proteins provides an effective approach to target solid tumors

Author

Goulding, John, Yeh, Wen-I, Hancock, Bryan, Blum, Robert, Xu, Tianhao, Yang, Bi-Huei, Chang, Chia-Wei, Groff, Brian, Avramis, Earl, Pribadi, Mochtar, Pan, Yijia, Chu, Hui-Yi, Sikaroodi, Shohreh, Fong, Lauren, Brookhouser, Nicholas, Dailey, Thomas, Meza, Miguel, Denholtz, Matthew, Diaz, Evelyn, Martin, Judy, Szabo, Peter, Cooley, Sarah, Ferrari de Andrade, Lucas, Lee, Tom T., Bjordahl, Ryan, Wucherpfennig, Kai W., and Valamehr, Bahram

Published
2023
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18. Temporal and Spatial Variations in Zebrafish Hairy/E(spl) Gene Expression in Response to Mib1-Mediated Notch Signaling During Neurodevelopment.

Author

Chen, Yi-Chieh, Hsieh, Fu-Yu, Chang, Chia-Wei, Sun, Mu-Qun, and Cheng, Yi-Chuan

Subjects
GENE expression, NEURAL development, BRAIN tumors, SPATIAL variation, NERVOUS system, NOTCH genes
Abstract

Notch signaling is a conserved pathway crucial for nervous system development. Disruptions in this pathway are linked to neurodevelopmental disorders, neurodegenerative diseases, and brain tumors. Hairy/E(spl) (HES) genes, major downstream targets of Notch, are commonly used as markers for Notch activation. However, these genes can be activated, inhibited, or function independently of Notch signaling, and their response to Notch disruption varies across tissues and developmental stages. MIB1/Mib1 is an E3 ubiquitin ligase that enables Notch receptor activation by processing ligands like Delta and Serrate. We investigated Notch signaling disruption using the zebrafish Mib1 mutant line, mib1ta52b, focusing on changes in the expression of Hairy/E(spl) (her) genes. Our findings reveal significant variability in her gene expression across different neural cell types, regions, and developmental stages following Notch disruption. This variability questions the reliability of Hairy/E(spl) genes as universal markers for Notch activation, as their response is highly context-dependent. This study highlights the complex and context-specific nature of Notch signaling regulation. It underscores the need for a nuanced approach when using Hairy/E(spl) genes as markers for Notch activity. Additionally, it provides new insights into Mib1's role in Notch signaling, contributing to a better understanding of its involvement in Notch signaling-related disorders. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Fabrication of patterned and anti‐patterned azopolymer nanoarrays via the light‐induced nanowetting method.

Author

Yan, Ai‐Ling, Chang, Chia‐Wei, Tsai, Tsung‐Hung, Huang, Meng‐Ru, Lin, Kuan‐Ting, Karapala, Vamsi Krishna, Ho, Jhih‐Hao, Dai, Wei‐You, and Chen, Jiun‐Tai

Subjects
*REVERSIBLE phase transitions, *GLASS transition temperature, *ALUMINUM oxide, *POLYMERS, *AZOBENZENE
Abstract

The template wetting method is a common method used for preparing one‐dimensional polymer nanostructures, which can be widely applied in many fields. Although the template wetting method has generality in controlling the morphology of nanomaterials, it still poses challenges in generating patterned polymer nanoarrays. Here, we present the fabrication of patterned and anti‐patterned azopolymer (PAzo) nanoarrays via the light‐induced nanowetting method. By shining UV lights, the trans‐PAzo converts to cis‐PAzo, causing a reduction of the glass transition temperature (Tg) of the PAzo below room temperature. Consequently, the PAzo polymers can undergo reversible solid–liquid transitions by shining UV and visible lights. When PAzo films are covered with photomasks and anodic aluminum oxide (AAO) templates, followed by shining UV lights, patterned PAzo nanoarrays can be generated. We further apply the concept that cis‐PAzo films can be selectively removed by solvents to generate anti‐patterned PAzo nanoarrays. By covering PAzo films with photomasks and illuminating UV lights, the unmasked areas can be converted to cis‐form, which can then be selectively removed by selected solvents. The patterned PAzo films are then covered with AAO templates, followed by shining UV lights, forming hierarchical anti‐patterned PAzo nanoarrays. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Better Detection of Peripheral Arterial Disease with Toe-Brachial Index Compared to Ankle-Brachial Index among Taiwanese Patients with Diabetic Kidney Disease.

Author

Chang, Chia-Wei, Sung, Ya-Wen, Huang, Yu-Ting, Chung, Yong-Chuan, and Lee, Mei-Yueh

Subjects
*ANKLE brachial index, *DIABETIC nephropathies, *PERIPHERAL vascular diseases, *PEOPLE with diabetes, *TYPE 2 diabetes, *ARTERIAL calcification
Abstract

Background: Ankle-brachial index (ABI) is a simple method for diagnosing peripheral artery disease (PAD) but has limited reliability in patients with diabetes mellitus (DM) because of medial artery calcification. Our study aims to investigate whether the toe brachial index (TBI) or the cardio-ankle vascular index (CAVI) has a better detection over the ABI for diagnosing PAD in diabetic kidney disease (DKD). Materials and Methods: A cohort of 368 patients (mean age 68.59 ± 13.14 years, 190 males and 178 females) with type 2 DM underwent ABI, TBI, and CAVI measurements at our outpatient clinic. Results: Of all enrolled patients, the TBI is significant in evaluating PAD, especially in patients whose chronic kidney disease (CKD) stage 3a with adjusted odds ratio (AOR) = 6.50, 95% confidence interval (CI) 1.63–25.97, p = 0.0080, stage 3b AOR = 7.47, 95% CI 1.52–36.81, p = 0.0135, and stage 4–5 AOR = 20.13, 95% CI 1.34–94.24, p = 0.0116. CAVI is also significant in CKD stage 1 with AOR = 0.16, 95% CI 0.03–0.77, p = 0.0223, stage 2 with AOR = 0.18, 95% CI 0.04–0.74, p = 0.0180, and stage 3a AOR = 0.31, 95% CI 0.10–0.93, p = 0.0375. Conclusion: TBI has a better yield of detection of PAD compared to ABI among Taiwanese patients with DKD. CAVI may play a role in the early stage of DKD. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Investigation of ZnO/V2O5 hybrid nanocomposite-based ultraviolet photodetector and hydrogen gas sensor.

Author

Huang, Wen-Chang, Lin, Ya-Hsuan, Zhang, Yu-He, Chang, Chia-Wei, Wang, Deng-Yi, Chuang, Chi-Chih, Huang, Yi-Hsuan, Lin, Tien-Chai, Wu, YewChung Sermon, and Chen, Hsiang

Subjects
HYDROGEN detectors, GAS detectors, PHOTODETECTORS, CRYSTAL defects, INDIUM gallium zinc oxide, GASES
Abstract

In this study, ZnO/V2O5 hybrid nanocomposites were fabricated for UV light/H2 gas dual sensing device. V2O5 were sputtered on hydrothermally grown ZnO nanorods (NRs) for various times, and multiple material characterizations were performed on the nanostructures. Results indicate that the increase of defects and lattice strain may enhance the UV light photo-sensing capability, while the wrapping of V2O5 on ZnO NRs may block the gas molecule transport and degrade the hydrogen gas sensitivity. Addition of V2O5 was distinct from the stuttering of WO3 and IGZO on ZnO NRs. ZnO/V2O5 NRs are promising for future compact light/gas modulation devices. [ABSTRACT FROM AUTHOR]

Published
2023
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