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14. The Human Marginal Zone B Cell.

Author

DONO, MARIELLA, ZUPO, SIMONA, COLOMBO, MONICA, MASSARA, ROSANNA, GAIDANO, GIANLUCA, TABORELLI, GIUSEPPE, CEPPA, PAOLA, BURGIO, VITO L., CHIORAZZI, NICHOLAS, and FERRARINI, MANLIO

Published
2003
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15. Leptin Has No Role in Determining Severity of Steatosis and Fibrosis in Patients With Chronic Hepatitis C.

Author

Giannini, Edoardo, Ceppa, Paola, Botta, Federica, Mastracci, Luca, Romagnoli, Paola, Comino, Ilaria, Pasini, Andrea, Risso, Domenico, Lantieri, Pasquale B., Icardi, Giancarlo, Barreca, Tommaso, and Testa, Roberto

Subjects
FATTY degeneration, HEPATITIS C, LEPTIN, FIBROSIS, VIRAL hepatitis
Abstract

OBJECTIVE: The presence of steatosis is a common histological finding in patients with chronic hepatitis C (CHC). The causes of the severity of this condition arc not yet clear, although both metabolic and viral factors supposedly are involved. In this study our aim was to examine the possible influence that leptin levels, hepatitis C virus (HCV) RNA levels, and hepatitis G virus (HGV) infection have on the severity of steatosis and on the presence and degree of fibrosis in patients with CHC. METHODS: One hundred eighty-two CHC patients with histological findings of steatosis were chosen from among a cohort of patients referred to our center for staging of liver disease. Among them 48 CHC patients were accurately selected so as to rule out possible confounding factors for the presence of steatosis (diabetes mellitus, hyperlipemia, obesity, alcohol). Leptin levels, HCV RNA levels, and HCV genotype, and the presence of HGV RNA were assessed in these patients and related to histological findings. RESULTS: We found that leptin levels in CHC patients were similar to those in healthy subjects. No relationship was found between leptin levels and severity of steatosis. HCV RNA levels, HCV genotype, and the presence of HGV infection were no different among CHC patients with various degrees of steatosis. Leptin was not related to different degrees of fibrosis, whereas higher viral load was the only parameter associated to higher fibrosis scores. CONCLUSIONS: These findings suggest that the degree of steatosis in patients with CHC does not seem to depend on serum leptin levels or on viral factors, at least as far as HCV viremia and genotype and HGV infection are concerned. The severity of fibrosis does not seem to be influenced by leptin levels, whereas HCV viral load does seem to play some role. [ABSTRACT FROM AUTHOR]

Published
2000
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17. Chronic liver disease related to hepatitis C virus: age of patients seems to be a determinant of severity independently of viral genotype.

Author

Giannini, Edoardo, Botta, Federica, Caglieris, Sergio, Fasoli, Alberto, Risso, Domenico, Ceppa, Paola, Cresta, Elena, Venturino, Valentina, icardi, Giancarlo, Lantieri, Pasquale B., Celle, Guido, Testa, Roberto, Giannini, E, Botta, F, Caglieris, S, Fasoli, A, Risso, D, Ceppa, P, Cresta, E, and Venturino, V

Published
1999
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18. Coeliac disease: The histology report.

Author

Villanacci, Vincenzo, Ceppa, Paola, Tavani, Enrico, Vindigni, Carla, and Volta, Umberto

Subjects
CELIAC disease diagnosis, INTESTINAL biopsy, MORPHOLOGY, DIFFERENTIAL diagnosis, T cells, MALABSORPTION syndromes, IMMUNOGLOBULINS, HISTOPATHOLOGY
Abstract

Abstract: To this day intestinal biopsy is justly considered the “gold standard” for the diagnosis of coeliac disease (CD). The aim of the authors in setting up these guidelines was to assist pathologists in formulating a more precise morphological evaluation of a duodenal biopsy in the light of clinical and laboratory data, to prepare histological samples with correctly oriented biopsies and in the differential diagnosis with other pathological entities and complications of the disease. A further intention was to promote the conviction for the need of a close collaborative relationship between different specialists namely the concept of a “multidisciplinary team”. [Copyright &y& Elsevier]

Published
2011
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21. Mucoepidermoid carcinoma of the thyroid gland arising from...

Author

Arezzo, Alberto, Patetta, Roberta, Ceppa, Paola, Borgonovo, Giacomo, Torre, Giancarlo, and Mattioli, Francesco P.

Subjects
*THYROID diseases, *ETIOLOGY of cancer
Abstract

Presents information on a case of mucoepidermoid carcinoma of the thyroid gland. Etiology of the disease; Result of the pathological examination; Discussion on the occurrence of the disease.

Published
1998

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