28 results on '"Celesti, Consuelo"'
Search Results
2. A novel 2D-GO@WS2 electrochemical platform for the determination of thiram fungicide
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Abid, Khouloud, Iannazzo, Daniela, Celesti, Consuelo, Khaskhoussi, Amani, Foti, Antonino, Maalej, Ramzi, Gucciardi, Pietro Giuseppe, and Neri, Giovanni
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- 2024
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3. Electrochemical bottom-up synthesis of biomass-derived carbon dots for promoting Knoevenagel condensation
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Michenzi, Cinzia, Espro, Claudia, Bressi, Viviana, Celesti, Consuelo, Vetica, Fabrizio, Salvitti, Chiara, and Chiarotto, Isabella
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- 2023
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4. Enhancement of biological effects of oxidised nano- and microplastics in human professional phagocytes
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Visalli, Giuseppa, Laganà, Antonio, Facciolà, Alessio, Iaconis, Antonella, Curcio, Jessica, Pollino, Santa, Celesti, Consuelo, Scalese, Silvia, Libertino, Sebania, Iannazzo, Daniela, and Di Pietro, Angela
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- 2023
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5. Affinity of deep eutectic solvents with aromatic molecules and aromatic nanostructures in chemical transformations
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Giofrè, Salvatore V., Celesti, Consuelo, Mistretta, Giuseppe, and Tiecco, Matteo
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- 2023
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6. Modified Gold Screen-Printed Electrodes for the Determination of Heavy Metals.
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Celesti, Consuelo, Giofrè, Salvatore Vincenzo, Espro, Claudia, Legnani, Laura, Neri, Giovanni, and Iannazzo, Daniela
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GOLD electrodes , *HEAVY metals , *METAL detectors , *METAL ions , *SQUARE waves - Abstract
Screen-printed electrodes (SPEs) are reliable, portable, affordable, and versatile electrochemical platforms for the real-time analytical monitoring of emerging analytes in the environmental, clinical, and agricultural fields. The aim of this study was to evaluate the electrochemical behavior of gold screen-printed electrodes (SPGEs) modified with molecules containing amino (Tr-N) or α-aminophosphonate (Tr-P) groups for the selective and sensitive detection of the toxic metal ions Pb2+ and Hg2+ in aqueous samples. After optimizing the analytical parameters (conditioning potential and time, deposition potential and time, pH and concentration of the supporting electrolyte), anodic square wave stripping voltammetry (SWASV) was used to evaluate and compare the electrochemical performance of bare or modified electrodes for the detection of Hg2+ and Pb2+, either alone or in their mixtures in the concentration range between 1 nM and 10 nM. A significative improvement in the detection ability of Pb2+ ions was recorded for the amino-functionalized gold sensor SPGE-N, while the presence of a phosphonate moiety in SPGE-P led to greater sensitivity towards Hg2+ ions. The developed sensors allow the detection of Pb2+ and Hg2+ with a limit of detection (LOD) of 0.41 nM and 35 pM, respectively, below the legal limits for these heavy metal ions in drinking water or food, while the sensitivity was 5.84 µA nM−1cm−2 and 10 µA nM−1cm−2, respectively, for Pb2+ and Hg2+. The reported results are promising for the development of advanced devices for the in situ and cost-effective monitoring of heavy metals, even in trace amounts, in water resources. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Waste-derived carbon nanodots for fluorimetric and simultaneous electrochemical detection of heavy metals in water.
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Bressi, Viviana, Celesti, Consuelo, Ferlazzo, Angelo, Len, Thomas, Moulaee, Kaveh, Neri, Giovanni, Luque, Rafael, and Espro, Claudia
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- 2024
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8. Theranostic Applications of 2D Graphene-Based Materials for Solid Tumors Treatment.
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Iannazzo, Daniela, Celesti, Consuelo, Giofrè, Salvatore V., Ettari, Roberta, and Bitto, Alessandra
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TUMOR treatment , *NANOMEDICINE , *CANCER relapse , *GRAPHENE oxide , *GRAPHENE synthesis , *TUMOR growth , *QUANTUM dots - Abstract
Solid tumors are a leading cause of cancer-related deaths globally, being characterized by rapid tumor growth and local and distant metastases. The failures encountered in cancer treatment are mainly related to the complicated biology of the tumor microenvironment. Nanoparticles-based (NPs) approaches have shown the potential to overcome the limitations caused by the pathophysiological features of solid cancers, enabling the development of multifunctional systems for cancer diagnosis and therapy and allowing effective inhibition of tumor growth. Among the different classes of NPs, 2D graphene-based nanomaterials (GBNs), due to their outstanding chemical and physical properties, easy surface multi-functionalization, near-infrared (NIR) light absorption and tunable biocompatibility, represent ideal nanoplatforms for the development of theranostic tools for the treatment of solid tumors. Here, we reviewed the most recent advances related to the synthesis of nano-systems based on graphene, graphene oxide (GO), reduced graphene oxide (rGO), and graphene quantum dots (GQDs), for the development of theranostic NPs to be used for photoacoustic imaging-guided photothermal–chemotherapy, photothermal (PTT) and photodynamic therapy (PDT), applied to solid tumors destruction. The advantages in using these nano-systems are here discussed for each class of GBNs, taking into consideration the different chemical properties and possibility of multi-functionalization, as well as biodistribution and toxicity aspects that represent a key challenge for their translation into clinical use. [ABSTRACT FROM AUTHOR]
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- 2023
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9. Promising Materials in the Fight against Healthcare-Associated Infections: Antibacterial Properties of Chitosan-Polyhedral Oligomeric Silsesquioxanes Hybrid Hydrogels.
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Laganà, Antonio, Facciolà, Alessio, Iannazzo, Daniela, Celesti, Consuelo, Polimeni, Evelina, Biondo, Carmelo, Di Pietro, Angela, and Visalli, Giuseppa
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RHEOLOGY ,DRUG resistance in bacteria ,BIOMEDICAL materials ,SURFACE charges ,CONFOCAL microscopy ,GRAM-positive bacteria ,SILICONES - Abstract
New technologies and materials could help in this fight against healthcare-associated infections. As the majority of these infections are caused by antibiotic-resistant bacteria, the development of materials with intrinsic antibacterial properties is a promising field of research. We combined chitosan (CS), with antibacterial properties, with polyhedral oligomeric silsesquioxanes (POSS), a biocompatible polymer with physico-chemical, mechanical, and rheological properties, creating a hydrogel using cross-linking agent genipin. The antibacterial properties of CS and CS-POSS hydrogels were investigated against nosocomial Gram-positive and Gram-negative bacteria both in terms of membrane damage and surface charge variations, and finally, the anti-biofilm property was studied through confocal microscopy. Both materials showed a good antibacterial capacity against all analyzed strains, both in suspension, with % decreases between 36.36 and 73.58 for CS and 29.86 and 66.04 for CS-POSS, and in plates with % decreases between 55.29 and 78.32 and 17.00 and 53.99 for CS and CS-POSS, respectively. The treated strains compared to the baseline condition showed an important membrane damage, which also determined a variation of surface charges, and finally, for both hydrogels, a remarkable anti-biofilm property was highlighted. Our findings showed a possible future use of these biocompatible materials in the manufacture of medical and surgical devices with intrinsic antibacterial and anti-biofilm properties. [ABSTRACT FROM AUTHOR]
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- 2023
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10. Uptake of Breathable Nano- and Micro-Sized Polystyrene Particles: Comparison of Virgin and Oxidised nPS/mPS in Human Alveolar Cells.
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Laganà, Antonio, Visalli, Giuseppa, Facciolà, Alessio, Celesti, Consuelo, Iannazzo, Daniela, and Di Pietro, Angela
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ATMOSPHERIC deposition ,AIR pollutants ,DNA damage ,HUMAN beings ,MITOCHONDRIA ,SKIN aging - Abstract
Airborne micro- and nanoplastics are widely spread and pose a risk to human health. The third polymer plastic most commonly produced and present in atmospheric fallout is polystyrene (PS). For these reasons and for a more realistic assessment of biological effects, we examined in-home oxidised (ox-, simulating photoaging) nPS/mPS (0.1 and 1 μm), comparing the effects with virgin ones (v-). On human alveolar cells (A549), we quantified the cellular uptake, using FITC-functionalised nPS/mPS, while cytotoxicity, changes in the acidic compartment, ROS production, mitochondrial function, and DNA damage were assessed to study the effects of internalised v- and ox-nPS/mPS. The results showed that the uptake was dose-dependent and very fast (1 h), since, at the lowest dose (1.25 µg/well), it was 20.8% and 21.8% of nPS and mPS, respectively. Compared to v-, significant ROS increases, DNA damage, and mitochondrial impairment were observed after exposure to ox-nPS/mPS. The enhancement of effects due to environmental aging processes highlighted the true potential impact on human health of these airborne pollutants. [ABSTRACT FROM AUTHOR]
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- 2023
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11. Voltammetric Sensor Based on Waste‐Derived Carbon Nanodots for Enhanced Detection of Nitrobenzene.
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Bressi, Viviana, Chiarotto, Isabella, Ferlazzo, Angelo, Celesti, Consuelo, Michenzi, Cinzia, Len, Thomas, Iannazzo, Daniela, Neri, Giovanni, and Espro, Claudia
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CARBON nanofibers ,ELECTROCHEMICAL sensors ,NITROBENZENE ,HYDROTHERMAL carbonization ,ORANGE peel ,TRANSMISSION electron microscopy - Abstract
Carbon dots (CDs) samples were synthesized from orange peel waste (OPW) via a simple and eco‐friendly hydrothermal carbonization (HTC) and electrochemical (EC) bottom‐up synthesis integrated approach. The comprehensive chemical‐physical characterization of CDs samples, carried out by various techniques such as TEM, EDX, XRD, FT‐IR, underlined their morphological and microstructural features. The CDs exhibited attractive electrochemical properties, and thus an electrochemical sensor by modifying a screen printed carbon electrode (CDs/SPCE) for the detection of nitrobenzene (NB) in water was developed. Electroanalytical performances of CDs/SPCE sensor using differential pulse voltammetry (DPV) demonstrated its high sensitivity (9.36 μA μM−1 cm−2) towards NB in a wide linear dynamic range (0.1–2000 μM) and a low limit of detection (LOD=13 nM). The electrochemical sensor also shown high selectivity, long‐term stability, and repeatability. This paper might open the way to a new synergistic HTC‐EC approach for the synthesis of CDs from waste biomass material and their advanced application in highly efficient electrochemical sensors. [ABSTRACT FROM AUTHOR]
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- 2023
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12. Solid Lipid Nanoparticles Containing Morin: Preparation, Characterization, and Ex Vivo Permeation Studies.
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De Gaetano, Federica, Celesti, Consuelo, Paladini, Giuseppe, Venuti, Valentina, Cristiano, Maria Chiara, Paolino, Donatella, Iannazzo, Daniela, Strano, Vincenza, Gueli, Anna M., Tommasini, Silvana, Ventura, Cinzia Anna, and Stancanelli, Rosanna
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NASAL mucosa , *DRUG delivery systems , *CHEMICAL stability , *LIPIDS , *NANOPARTICLES , *MUPIROCIN - Abstract
In recent years, bioactive compounds have been the focus of much interest in scientific research, due to their low toxicity and extraordinary properties. However, they possess poor solubility, low chemical stability, and unsustainable bioavailability. New drug delivery systems, and among them solid lipid nanoparticles (SLNs), could minimize these drawbacks. In this work, morin (MRN)-loaded SLNs (MRN-SLNs) were prepared using a solvent emulsification/diffusion method, using two different lipids, Compritol® 888 ATO (COM) or Phospholipon® 80H (PHO). SLNs were investigated for their physical–chemical, morphological, and technological (encapsulation parameters and in vitro release) properties. We obtained spherical and non-aggregated nanoparticles with hydrodynamic radii ranging from 60 to 70 nm and negative zeta potentials (about −30 mV and −22 mV for MRN-SLNs-COM and MRN-SLNs-PHO, respectively). The interaction of MRN with the lipids was demonstrated via μ-Raman spectroscopy, X-ray diffraction, and DSC analysis. High encapsulation efficiency was obtained for all formulations (about 99%, w/w), particularly for the SLNs prepared starting from a 10% (w/w) theoretical MRN amount. In vitro release studies showed that about 60% of MRN was released within 24 h and there was a subsequent sustained release within 10 days. Finally, ex vivo permeation studies with excised bovine nasal mucosa demonstrated the ability of SLNs to act as a penetration enhancer for MRN due to the intimate contact and interaction of the carrier with the mucosa. [ABSTRACT FROM AUTHOR]
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- 2023
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13. Amphiphilic Cyclodextrin Nanoparticles as Delivery System for Idebenone: A Preformulation Study.
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De Gaetano, Federica, Scala, Angela, Celesti, Consuelo, Lambertsen Larsen, Kim, Genovese, Fabio, Bongiorno, Corrado, Leggio, Loredana, Iraci, Nunzio, Mazzaglia, Antonino, and Ventura, Cinzia Anna
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CYCLODEXTRINS ,NERVE growth factor ,ALZHEIMER'S disease ,INTRANASAL administration ,NANOPARTICLES ,LIPID peroxidation (Biology) ,UBIQUINONES - Abstract
Idebenone (IDE), a synthetic short-chain analogue of coenzyme Q10, is a potent antioxidant able to prevent lipid peroxidation and stimulate nerve growth factor. Due to these properties, IDE could potentially be active towards cerebral disorders, but its poor water solubility limits its clinical application. Octanoyl-β-cyclodextrin is an amphiphilic cyclodextrin (ACyD8) bearing, on average, ten octanoyl substituents able to self-assemble in aqueous solutions, forming various typologies of supramolecular nanoassemblies. Here, we developed nanoparticles based on ACyD8 (ACyD8-NPs) for the potential intranasal administration of IDE to treat neurological disorders, such as Alzheimer's Disease. Nanoparticles were prepared using the nanoprecipitation method and were characterized for their size, zeta potential and morphology. STEM images showed spherical particles, with smooth surfaces and sizes of about 100 nm, suitable for the proposed therapeutical aim. The ACyD8-NPs effectively loaded IDE, showing a high encapsulation efficiency and drug loading percentage. To evaluate the host/guest interaction, UV-vis titration, mono- and two-dimensional NMR analyses, and molecular modeling studies were performed. IDE showed a high affinity for the ACyD8 cavity, forming a 1:1 inclusion complex with a high association constant. A biphasic and sustained release of IDE was observed from the ACyD8-NPs, and, after a burst effect of about 40%, the release was prolonged over 10 days. In vitro studies confirmed the lack of toxicity of the IDE/ACyD8-NPs on neuronal SH-SY5Y cells, and they demonstrated their antioxidant effect upon H
2 O2 exposure, as a general source of ROS. [ABSTRACT FROM AUTHOR]- Published
- 2023
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14. Chitosan/POSS Hybrid Hydrogels for Bone Tissue Engineering.
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Celesti, Consuelo, Iannazzo, Daniela, Espro, Claudia, Visco, Annamaria, Legnani, Laura, Veltri, Lucia, Visalli, Giuseppa, Di Pietro, Angela, Bottino, Paola, and Chiacchio, Maria Assunta
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TISSUE engineering , *HYBRID materials , *CHITOSAN , *RHEOLOGY , *BONE regeneration , *HYDROGELS - Abstract
Hybrid hydrogels composed of chitosan (CS) have shown great potential in bone tissue engineering and regeneration. The introduction of polyhedral oligomeric silsesquioxanes (POSS) in the biopolymeric matrix has been demonstrated to improve the rheological and biological properties of the hybrid composites. In this work, we have integrated the favourable features of chitosan (CS) and POSS nanoparticles to design new nanocomposites for bone tissue regeneration, focusing our attention on the effect of POSS concentration within the CS matrix (0.5, 1, and 1.5 equivalents in weight of POSS with respect to CS) on the chemical, physical, rheological, and in vitro biological properties of the final composites. The drug release ability of the synthesized hydrogel scaffolds were also investigated using, as the model drug, ketoprofen, that was included in the scaffold during the gelling procedure, showing a more controlled release for the hybrids with respect to CS (86–91% of drug released after two weeks). The results of the in vitro biological tests performed on human fetal osteoblastic cells (hFOB 1.19) culture demonstrated the great biocompatibility of the hybrid materials. The hybrids, at the different POSS concentrations, showed values of cell mortality superimposable with control cells (11.1 vs. 9.8%), thus revealing the CS/POSS hydrogels as possible candidates for bone tissue engineering applications. [ABSTRACT FROM AUTHOR]
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- 2022
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15. Orange-Peel-Derived Nanobiochar for Targeted Cancer Therapy.
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Iannazzo, Daniela, Celesti, Consuelo, Espro, Claudia, Ferlazzo, Angelo, Giofrè, Salvatore V., Scuderi, Mario, Scalese, Silvia, Gabriele, Bartolo, Mancuso, Raffaella, Ziccarelli, Ida, Visalli, Giuseppa, and Di Pietro, Angela
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VITAMIN B2 , *CANCER treatment , *FOLIC acid , *HYDROTHERMAL carbonization , *DRUG delivery systems , *CONJUGATED systems , *ANTINEOPLASTIC agents - Abstract
Cancer-targeted drug delivery systems (DDS) based on carbon nanostructures have shown great promise in cancer therapy due to their ability to selectively recognize specific receptors overexpressed in cancer cells. In this paper, we have explored a green route to synthesize nanobiochar (NBC) endowed with graphene structure from the hydrothermal carbonization (HTC) of orange peels and evaluated the suitability of this nanomaterial as a nanoplatform for cancer therapy. In order to compare the cancer-targeting ability of different widely used targeting ligands (TL), we have conjugated NBC with biotin, riboflavin, folic acid and hyaluronic acid and have tested, in vitro, their biocompatibility and uptake ability towards a human alveolar cancer cell line (A549 cells). The nanosystems which showed the best biological performances—namely, the biotin- and riboflavin- conjugated systems—have been loaded with the poorly water-soluble drug DHF (5,5-dimethyl-6a-phenyl-3-(trimethylsilyl)-6,6a-dihydrofuro[3,2-b]furan-2(5H)-one) and tested for their anticancer activity. The in vitro biological tests demonstrated the ability of both systems to internalize the drug in A549 cells. In particular, the biotin-functionalized NBC caused cell death percentages to more than double with respect to the drug alone. The reported results also highlight the positive effect of the presence of oxygen-containing functional groups, present on the NBC surface, to improve the water dispersion stability of the DDS and thus make the approach of using this nanomaterial as nanocarrier for poorly water-soluble drugs effective. [ABSTRACT FROM AUTHOR]
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- 2022
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16. Chemoselective Oxidation of Isoxazolidines with Ruthenium Tetroxide: A Successful Intertwining of Combined Theoretical and Experimental Data.
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Legnani, Laura, Giofré, Salvatore V., Iannazzo, Daniela, Celesti, Consuelo, Veltri, Lucia, and Chiacchio, Maria Assunta
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ISOXAZOLIDINES ,RUTHENIUM ,BIOACTIVE compounds ,ORGANIC chemistry ,CARBOCATIONS - Abstract
The direct oxidation reaction of isoxazolidines plays an important role in organic chemistry, leading to the synthesis of biologically active compounds. In this paper, we report a computational mechanistic study of RuO
4 -catalyzed oxidation of differently N-substituted isoxazolidines 1a–c. Attention was focused on the endo/exo oxidation selectivity. For all the investigated compounds, the exo attack is preferred to the endo one, showing exo percentages growing in parallel with the stability order of transient carbocations found along the reaction pathway. The study has been supported by experimental data that nicely confirm the modeling results. [ABSTRACT FROM AUTHOR]- Published
- 2022
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17. Titanium Surface Modification for Implantable Medical Devices with Anti-Bacterial Adhesion Properties.
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Celesti, Consuelo, Gervasi, Teresa, Cicero, Nicola, Giofrè, Salvatore Vincenzo, Espro, Claudia, Piperopoulos, Elpida, Gabriele, Bartolo, Mancuso, Raffaella, Lo Vecchio, Giovanna, and Iannazzo, Daniela
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MEDICAL equipment , *ARTIFICIAL implants , *TITANIUM , *METALLIC surfaces , *BACTERIAL adhesion - Abstract
Pure titanium and titanium alloys are widely used in dentistry and orthopedics. However, despite their outstanding mechanical and biological properties, implant failure mainly due to post-operative infection still remains a significant concern. The possibility to develop inherent antibacterial medical devices was here investigated by covalently inserting bioactive ammonium salts onto the surface of titanium metal substrates. Titanium discs have been functionalized with quaternary ammonium salts (QASs) and with oleic acid (OA), affording the Ti-AEMAC Ti-GTMAC, Ti-AUTEAB, and Ti-OA samples, which were characterized by ATR-FTIR and SEM-EDX analyses and investigated for the roughness and hydrophilic behavior. The chemical modifications were shown to deeply affect the surface properties of the metal substrates and, as a consequence, their bio-interaction. The bacterial adhesion tests against the Gram-negative Escherichia Coli and Gram-positive Staphylococcus aureus, at 1.5 and 24 h of bacterial contact, showed good anti-adhesion activity for Ti-AUTEAB and Ti-OA samples, containing a long alkyl chain between the silicon atom and the ammonium functionality. In particular, the Ti-AUTEAB sample showed inhibition of bacteria adhesion against Escherichia Coli of about one log with respect to the other samples, after 1.5 h. The results of this study highlight the importance of chemical functionalization in addressing the antimicrobial activity of metal surfaces and could open new perspectives in the development of inherent antibacterial medical devices. [ABSTRACT FROM AUTHOR]
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- 2022
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18. Recent Advances on Graphene Quantum Dots as Multifunctional Nanoplatforms for Cancer Treatment.
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Iannazzo, Daniela, Celesti, Consuelo, and Espro, Claudia
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- 2021
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19. Functionalized polyhedral oligosilsesquioxane (POSS) based composites for bone tissue engineering: synthesis, computational and biological studies.
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Legnani, Laura, Iannazzo, Daniela, Pistone, Alessandro, Celesti, Consuelo, Giofrεave;, Salvatore, Romeo, Roberto, Di Pietro, Angela, Visalli, Giuseppa, Fresta, Monica, Bottino, Paola, Blanco, Ignazio, and Chiacchio, Maria Assunta
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- 2020
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20. Cover Feature: Voltammetric Sensor Based on Waste‐Derived Carbon Nanodots for Enhanced Detection of Nitrobenzene (ChemElectroChem 13/2023).
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Bressi, Viviana, Chiarotto, Isabella, Ferlazzo, Angelo, Celesti, Consuelo, Michenzi, Cinzia, Len, Thomas, Iannazzo, Daniela, Neri, Giovanni, and Espro, Claudia
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NITROBENZENE ,POLLUTANTS ,DETECTORS ,CARBON ,ELECTROCHEMICAL sensors - Abstract
Cover Feature: Voltammetric Sensor Based on Waste-Derived Carbon Nanodots for Enhanced Detection of Nitrobenzene (ChemElectroChem 13/2023) Carbon nanodots, electrochemical sensor, electrochemical bottom-up synthesis, waste valorization, nitrobenzene Keywords: carbon nanodots; electrochemical sensor; electrochemical bottom-up synthesis; waste valorization; nitrobenzene EN carbon nanodots electrochemical sensor electrochemical bottom-up synthesis waste valorization nitrobenzene 1 1 1 07/05/23 20230703 NES 230703 B The Cover Feature b shows groundwater contaminated by environmental pollutants and how a sensor modified by an improved waste is helpful to estimate the presence of contaminants in it. [Extracted from the article]
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- 2023
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21. Study of Protective Layers Based on Crosslinked Glutaraldehyde/3-aminopropyltriethoxysilane.
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Pistone, Alessandro, Scolaro, Cristina, Celesti, Consuelo, and Visco, Annamaria
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PROTECTIVE coatings ,CONTACT angle ,GLUTARALDEHYDE ,DIFFERENTIAL scanning calorimetry ,THERMOGRAVIMETRY ,MICROSCOPY - Abstract
In this paper, we report the synthesis and characterization of novel coatings based on (3-aminopropyl)-triethoxysilane (AP) mixed with different amounts of glutaraldehyde (GA). The synthesized coatings have been layered on a glass substrate and characterized by optical microscopy and roughness measurements, thermogravimetric analyses and differential scanning calorimetry, contact angle analysis, rheological measurement, and an adhesion test. It was observed that the higher the GA content (up to AP:GA ratio of 0.3), the sooner the crosslinking reaction starts, leading to a coating with increased hydrophobic and adhesion features without compromising the final AP cross-linked network. Hence, the obtained results show the effectiveness of AP modification with GA from the perspective of an application as protective coatings. [ABSTRACT FROM AUTHOR]
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- 2022
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22. Electrochemical and Fluorescent Properties of Crown Ether Functionalized Graphene Quantum Dots for Potassium and Sodium Ions Detection.
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Iannazzo, Daniela, Espro, Claudia, Ferlazzo, Angelo, Celesti, Consuelo, Branca, Caterina, and Neri, Giovanni
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CROWN ethers ,SODIUM ions ,POTASSIUM ions ,GRAPHENE ,POTASSIUM channels ,OPTICAL properties - Abstract
The concentration of sodium and potassium ions in biological fluids, such as blood, urine and sweat, is indicative of several basic body function conditions. Therefore, the development of simple methods able to detect these alkaline ions is of outmost importance. In this study, we explored the electrochemical and optical properties of graphene quantum dots (GQDs) combined with the selective chelating ability of the crown ethers 15-crown-5 and 18-crown-6, with the final aim to propose novel composites for the effective detection of these ions. The results obtained comparing the performances of the single GQDs and crown ethers with those of the GQDs-15-crown-5 and GQDs-18-crown-6 composites, have demonstrated the superior properties of these latter. Electrochemical investigation showed that the GQDs based composites can be exploited for the potentiometric detection of Na
+ and K+ ions, but selectivity still remains a concern. The nanocomposites showed the characteristic fluorescence emissions of GQDs and crown ethers. The GQDs-18-crown-6 composite exhibited ratiometric fluorescence emission behavior with the variation of K+ concentration, demonstrating its promising properties for the development of a selective fluorescent method for potassium determination. [ABSTRACT FROM AUTHOR]- Published
- 2021
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23. Smart Biosensors for Cancer Diagnosis Based on Graphene Quantum Dots.
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Iannazzo, Daniela, Espro, Claudia, Celesti, Consuelo, Ferlazzo, Angelo, and Neri, Giovanni
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TUMOR diagnosis ,TUMOR treatment ,BIOSENSORS ,CARBON ,CHEMILUMINESCENCE assay ,TUMOR markers - Abstract
Simple Summary: Graphene quantum dots, the next generation of graphene family, due to their remarkable physical and chemical properties, have been shown to be ideal sensing elements for the early diagnosis of cancer. In this review, we report the recent advances in the synthesis and functionalization of GQDs with different biomolecules able to selectively recognize and convert into a signal specific cancer biomarker, by means of optical, electrochemical and chemiluminescent biosensors. These sensors have shown to ensure the effective and sensitive detection of important cancer biomarkers such as antigens, enzymes, hormones, proteins, cancer related byproducts, biomolecules exposed on the surface of cancer cells and also changes in pH. The developed biosensors can allow the effective diagnosis of cancer diseases as well as the evaluation of the anticancer therapy effectiveness. The timely diagnosis of cancer represents the best chance to increase treatment success and to reduce cancer deaths. Nanomaterials-based biosensors containing graphene quantum dots (GQDs) as a sensing platform show great promise in the early and sensitive detection of cancer biomarkers, due to their unique chemical and physical properties, large surface area and ease of functionalization with different biomolecules able to recognize relevant cancer biomarkers. In this review, we report different advanced strategies for the synthesis and functionalization of GQDs with different agents able to selectively recognize and convert into a signal specific cancer biomarkers such as antigens, enzymes, hormones, proteins, cancer related byproducts, biomolecules exposed on the surface of cancer cells and changes in pH. The developed optical, electrochemical and chemiluminescent biosensors based on GQDs have been shown to ensure the effective diagnosis of several cancer diseases as well as the possibility to evaluate the effectiveness of anticancer therapy. The wide linear range of detection and low detection limits recorded for most of the reported biosensors highlight their great potential in clinics for the diagnosis and management of cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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24. Synthesis and Biological Evaluation of 2,3,4-Triaryl-1,2,4-oxadiazol-5-ones as p38 MAPK Inhibitors.
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Romeo, Roberto, Giofrè, Salvatore V., Chiacchio, Maria A., Veltri, Lucia, Celesti, Consuelo, Iannazzo, Daniela, and Bertinaria, Massimo
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BIOSYNTHESIS ,STILBENE derivatives ,MITOGEN-activated protein kinases ,BIOLOGICAL assay ,CHEMICAL synthesis ,MOLECULAR models - Abstract
A series of azastilbene derivatives, characterized by the presence of the 1,2,4-oxadiazole-5-one system as a linker of the two aromatic rings of stilbenes, have been prepared as novel potential inhibitors of p38 MAPK. Biological assays indicated that some of the synthesized compounds are endowed with good inhibitory activity towards the kinase. Molecular modeling data support the biological results showing that the designed compounds possess a reasonable binding mode in the ATP binding pocket of p38α kinase with a good binding affinity. [ABSTRACT FROM AUTHOR]
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- 2021
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25. Eco-Friendly 1,3-Dipolar Cycloaddition Reactions on Graphene Quantum Dots in Natural Deep Eutectic Solvent.
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Giofrè, Salvatore V., Tiecco, Matteo, Celesti, Consuelo, Patanè, Salvatore, Triolo, Claudia, Gulino, Antonino, Spitaleri, Luca, Scalese, Silvia, Scuderi, Mario, and Iannazzo, Daniela
- Subjects
RING formation (Chemistry) ,QUANTUM dots ,SOLVENTS ,GLYCOLIC acid ,GRAPHENE ,EUTECTICS ,ZWITTERIONS - Abstract
Due to their outstanding physicochemical properties, the next generation of the graphene family—graphene quantum dots (GQDs)—are at the cutting edge of nanotechnology development. GQDs generally possess many hydrophilic functionalities which allow their dispersibility in water but, on the other hand, could interfere with reactions that are mainly performed in organic solvents, as for cycloaddition reactions. We investigated the 1,3-dipolar cycloaddition (1,3-DCA) reactions of the C-ethoxycarbonyl N-methyl nitrone 1a and the newly synthesized C-diethoxyphosphorylpropilidene N-benzyl nitrone 1b with the surface of GQDs, affording the isoxazolidine cycloadducts isox-GQDs 2a and isox-GQDs 2b. Reactions were performed in mild and eco-friendly conditions, through the use of a natural deep eutectic solvent (NADES), free of chloride or any metal ions in its composition, and formed by the zwitterionic trimethylglycine as the -bond acceptor, and glycolic acid as the hydrogen-bond donor. The results reported in this study have for the first time proved the possibility of performing cycloaddition reactions directly to the p-cloud of the GQDs surface. The use of DES for the cycloaddition reactions on GQDs, other than to improve the solubility of reactants, has been shown to bring additional advantages because of the great affinity of these green solvents with aromatic systems. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
26. Chitosan/PAMAM/Hydroxyapatite Engineered Drug Release Hydrogels with Tunable Rheological Properties.
- Author
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Pistone, Alessandro, Iannazzo, Daniela, Celesti, Consuelo, Scolaro, Cristina, Giofré, Salvatore V., Romeo, Roberto, and Visco, Annamaria
- Subjects
HYDROGELS ,HYDROXYAPATITE ,CHITOSAN ,POLYAMIDOAMINE dendrimers ,CONTROLLED release drugs ,MOLECULAR weights ,TISSUE engineering ,HYDROXYAPATITE synthesis - Abstract
In this paper, a new formulation of biodegradable and bioresorbable chitosan-based hydrogel for controlled drug release was investigated. A chitosan–dendrimer–hydroxyapatite hydrogel, obtained by covalently grafting chitosan powder with an hyperbranched PAMAM dendrimer followed by in-situ precipitation of hydroxyapatite and gelification, was synthesized and characterized by FTIR, NMR, TGA, XRD and rheological studies. The hydrogels have been also doped with an anti-inflammatory drug (ketoprofen) in order to investigate their drug release properties. Chemical and chemical-physical characterizations confirmed the successful covalent functionalization of chitosan with PAMAM and the synthesis of nanostructured hydroxyapatite. The developed hydrogel made it possible to obtain an innovative system with tunable rheological and drug-releasing properties relative to the well-known formulation containing chitosan and hydroxyapatite powder. The developed hydrogel showed different rheological and drug-releasing properties of chitosan matrix mixed with hydroxyapatite as a function of dendrimer molecular weight; therefore, the chitosan–dendrimer–hydroxyapatite hydrogel can couple the well-known osteoconductive properties of hydroxyapatite with the drug-release behavior and good processability of chitosan–dendrimer hydrogels, opening new approaches in the field of tissue engineering based on biopolymeric scaffolds. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
27. Engineering of Chitosan-Hydroxyapatite-Magnetite Hierarchical Scaffolds for Guided Bone Growth.
- Author
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Pistone, Alessandro, Iannazzo, Daniela, Celesti, Consuelo, Piperopoulos, Elpida, Ashok, Deepu, Cembran, Arianna, Tricoli, Antonio, and Nisbet, David
- Subjects
TISSUE engineering ,BONE growth ,CHITOSAN ,ELECTRON microscopy ,THERMOGRAVIMETRY ,SYSTEMS development - Abstract
Bioabsorbable materials have received increasing attention as innovative systems for the development of osteoconductive biomaterials for bone tissue engineering. In this paper, chitosan-based composites were synthesized adding hydroxyapatite and/or magnetite in a chitosan matrix by in situ precipitation technique. Composites were characterized by optical and electron microscopy, thermogravimetric analyses (TGA), x-ray diffraction (XRD), and in vitro cell culture studies. Hydroxyapatite and magnetite were found to be homogeneously dispersed in the chitosan matrix and the composites showed superior biocompatibility and the ability to support cell attachment and proliferation; in particular, the chitosan/hydroxyapatite/magnetite composite (CS/HA/MGN) demonstrated superior bioactivity with respect to pure chitosan (CS) and to the chitosan/hydroxyapatite (CS/HA) scaffolds. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
28. A Smart Nanovector for Cancer Targeted Drug Delivery Based on Graphene Quantum Dots.
- Author
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Iannazzo, Daniela, Pistone, Alessandro, Celesti, Consuelo, Triolo, Claudia, Patané, Salvatore, Giofré, Salvatore V., Romeo, Roberto, Ziccarelli, Ida, Mancuso, Raffaella, Gabriele, Bartolo, Visalli, Giuseppa, Facciolà, Alessio, and Di Pietro, Angela
- Subjects
QUANTUM dots ,DRUG delivery systems ,VITAMIN B2 ,PHARMACOLOGY ,TARGETED drug delivery ,BENZOFURANS - Abstract
Graphene quantum dots (GQD), the new generation members of graphene-family, have shown promising applications in anticancer therapy. In this study, we report the synthesis of a fluorescent and biocompatible nanovector, based on GQD, for the targeted delivery of an anticancer drug with benzofuran structure (BFG) and bearing the targeting ligand riboflavin (RF, vitamin B2). The highly water-dispersible nanoparticles, synthesized from multi-walled carbon nanotubes (MWCNT) by prolonged acidic treatment, were linked covalently to the drug by means of a cleavable PEG linker while the targeting ligand RF was conjugated to the GQD by π–π interaction using a pyrene linker. The cytotoxic effect of the synthesized drug delivery system (DDS) GQD-PEG-BFG@Pyr-RF was tested on three cancer cell lines and this effect was compared with that exerted by the same nanovector lacking the RF ligand (GQD-PEG-BFG) or the anticancer drug (GQD@Pyr-RF). The results of biological tests underlined the low cytotoxicity of the GQD sample and the cytotoxic activity of the DDS against the investigated cancer cell lines with a higher or similar potency to that exerted by the BFG alone, thus opening new possibilities for the use of this drug or other anticancer agents endowed of cytotoxicity and serious side effects. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
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