Search

Your search keyword '"Cartenì, M."' showing total 22 results
Start Over Author "Cartenì, M." Search Limiters Peer Reviewed
22 results on '"Cartenì, M."'

11. Gut–liver axis: The impact of gut microbiota on non alcoholic fatty liver disease.

Author

Compare, D., Coccoli, P., Rocco, A., Nardone, O.M., De Maria, S., Cartenì, M., and Nardone, G.

Abstract

Abstract: Aim: To examine the impact of gut microbiota on non alcoholic fatty liver disease (NAFLD) pathogenesis. Data synthesis: Emerging evidence suggests a strong interaction between gut microbiota and liver. Receiving approximately 70% of its blood supply from the intestine, the liver represents the first line of defence against gut-derived antigens. Intestinal bacteria play a key role in the maintenance of gut–liver axis health. Disturbances in the homeostasis between bacteria- and host-derived signals at the epithelial level lead to a break in intestinal barrier function and may foster “bacterial translocation”, defined as the migration of bacteria or bacterial products from the intestinal lumen to mesenteric lymph nodes or other extraintestinal organs and sites. While the full repertoire of gut-derived microbial products that reach the liver in health and disease has yet to be explored, the levels of bacterial lipopolysaccharide, a component of the outer membrane of Gram-negative bacteria, are increased in the portal and/or systemic circulation in several types of chronic liver diseases. Derangement of the gut flora, particularly small intestinal bacterial overgrowth, occurs in a large percentage (20–75%) of patients with chronic liver disease. In addition, evidence implicating the gut–liver axis in the pathogenesis of metabolic liver disorders has accumulated over the past ten years. Conclusions: Complex metabolic diseases are the product of multiple perturbations under the influence of triggering factors such as gut microbiota and diet, thus, modulation of the gut microbiota may represent a new way to treat or prevent NAFLD. [Copyright &y& Elsevier]

Published
2012
Full Text
View/download PDF

12. Porins from Salmonella typhimurium accelerate human blood coagulation in vitro by selective stimulation of thrombin activity: implications in septic shock DIC pathogenesis.

Author

Di Micco, B., Metafora, S., Colonna, G., Cartenì, M., Ragone, R., Macalello, M.A., Di Micco, P., Baroni, A., Catalanotti, P., and Tufano, M.A.

Abstract

The effect of porins, major hydrophobic outer membrane proteins purified from Salmonella typhimurium , on human blood coagulation was investigated. It was found that micromolar concentrations of porins accelerated markedly human blood coagulation in vitro. Using appropriate experiments, data were obtained showing that the main target of the porin-induced procoagulant effect was thrombin. A possible binding of porins with thrombin has been suggested to be the basis of this effect. The implications of this finding in the pathogenesis of the disseminated intravascular coagulation syndrome (DIC) occurring during the Gram-negative septic shock is discussed. [ABSTRACT FROM PUBLISHER]

Published
2001
Full Text
View/download PDF

14. Altered intestinal permeability to mannitol in diabetes mellitus type I.

Author

Carratù, Romano, Secondulfo, Mario, de Magistris, Laura, Iafusco, Dario, Urio, Anna, Carbone, Maria Grazia, Pontoni, Gabriele, Cartenì, Marilena, Prisco, Francesco, Carratù, R, Secondulfo, M, de Magistris, L, Iafusco, D, Urio, A, Carbone, M G, Pontoni, G, Cartenì, M, and Prisco, F

Published
1999

Catalog

Books, media, physical & digital resources
See catalog results