49 results on '"Carrara, Greta"'
Search Results
2. Impact of Risk Factors on COVID‐19 Outcomes in Unvaccinated People With Rheumatic Diseases: A Comparative Analysis of Pandemic Epochs Using the COVID‐19 Global Rheumatology Alliance Registry
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Yazdany, Jinoos, Ware, Anna, Wallace, Zachary S., Bhana, Suleman, Grainger, Rebecca, Hachulla, Eric, Richez, Christophe, Cacoub, Patrice, Hausmann, Jonathan S., Liew, Jean W., Sirotich, Emily, Jacobsohn, Lindsay, Strangfeld, Anja, Mateus, Elsa F., Hyrich, Kimme L., Gossec, Laure, Carmona, Loreto, Lawson‐Tovey, Saskia, Kearsley‐Fleet, Lianne, Schaefer, Martin, Ribeiro, Sandra Lucia Euzebio, Al‐Emadi, Samar, Hasseli, Rebecca, Müller‐Ladner, Ulf, Specker, Christof, Schulze‐Koops, Hendrik, Bernardes, Miguel, Fraga, Vanessa Machado, Rodrigues, Ana Maria, Sparks, Jeffrey A., Ljung, Lotta, Di Giuseppe, Daniela, Tidblad, Liselotte, Wise, Leanna, Duarte‐García, Alí, Ugarte‐Gil, Manuel F., Colunga‐Pedraza, Iris Jazmín, Martínez‐Martínez, Marco Ulises, Alpizar‐Rodriguez, Deshire, Xavier, Ricardo Machado, Isnardi, Carolina A., Pera, Mariana, Pons‐Estel, Guillermo, Izadi, Zara, Gianfrancesco, Milena A., Carrara, Greta, Scirè, Carlo Alberto, Zanetti, Anna, and Machado, Pedro M.
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- 2024
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3. Rationale and design of the PARTHENOPE trial: A two-by-two factorial comparison of polymer-free vs biodegradable-polymer drug-eluting stents and personalized vs standard duration of dual antiplatelet therapy in all-comers undergoing PCI
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Piccolo, Raffaele, Calabrò, Paolo, Varricchio, Attilio, Baldi, Cesare, Napolitano, Giovanni, De Simone, Ciro, Mauro, Ciro, Stabile, Eugenio, Caiazzo, Gianluca, Tesorio, Tullio, Boccalatte, Marco, Tuccillo, Bernardino, Bottiglieri, Giuseppe, Russolillo, Enrico, Di Lorenzo, Emilio, Carrara, Greta, Cassese, Salvatore, Leonardi, Sergio, Biscaglia, Simone, Costa, Francesco, McFadden, Eugene, Heg, Dik, Franzone, Anna, Stefanini, Giulio G., Capodanno, Davide, and Esposito, Giovanni
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- 2023
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4. Geographical heterogeneity of clinical and serological phenotypes of systemic sclerosis observed at tertiary referral centres. The experience of the Italian SIR-SPRING registry and review of the world literature
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Ferri, Clodoveo, De Angelis, Rossella, Giuggioli, Dilia, Bajocchi, Gianluigi, Dagna, Lorenzo, Zanframundo, Giovanni, Foti, Rosario, Cacciapaglia, Fabio, Cuomo, Giovanna, Ariani, Alarico, Rosato, Edoardo, Guiducci, Serena, Girelli, Francesco, Riccieri, Valeria, Zanatta, Elisabetta, Bosello, Silvia, Cavazzana, Ilaria, Ingegnoli, Francesca, De Santis, Maria, Murdaca, Giuseppe, Abignano, Giuseppina, Romeo, Nicoletta, Della Rossa, Alessandra, Caminiti, Maurizio, Iuliano, Annamaria, Ciano, Giovanni, Beretta, Lorenzo, Bagnato, Gianluca, Lubrano, Ennio, De Andres, Ilenia, Giollo, Alessandro, Saracco, Marta, Agnes, Cecilia, Lumetti, Federica, Spinella, Amelia, Magnani, Luca, Campochiaro, Corrado, De Luca, Giacomo, Codullo, Veronica, Visalli, Elisa, Masini, Francesco, Gigante, Antonietta, Bellando-Randone, Silvia, Pellegrino, Greta, Pigatto, Erika, Lazzaroni, Maria Grazia, Franceschini, Franco, Generali, Elena, Mennillo, Gianna, Barsotti, Simone, Mariano, Giuseppa Pagano, Calabrese, Francesca, Furini, Federica, Vultaggio, Licia, Parisi, Simone, Peroni, Clara Lisa, Rozza, Davide, Zanetti, Anna, Carrara, Greta, Landolfi, Giampiero, Scirè, Carlo Alberto, Bianchi, Gerolamo, Fusaro, Enrico, Sebastiani, Gian Domenico, Govoni, Marcello, D'Angelo, Salvatore, Cozzi, Franco, Doria, Andrea, Iannone, Florenzo, Salvarani, Carlo, and Matucci-Cerinic, Marco
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- 2022
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5. Environmental and societal factors associated with COVID-19-related death in people with rheumatic disease: an observational study
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Dahou, Brahim, Gómez, Gimena, Roberts, Karen, Baez, Roberto M, Castro Coello, Vanessa V, Haye Salinas, María J, Maldonado, Federico N, Reyes, Alvaro A, Alle, Gelsomina, Tanten, Romina, Maldonado Ficco, Hernán, Nieto, Romina, Gobbi, Carla, Tissera, Yohana, Pisoni, Cecilia, Paula, Alba, Albiero, Juan A, Schmid, Maria M, Cosatti, Micaela, Gamba, Maria J, Leandro, Carlevaris, Cusa, María A, German, Noelia, Bellomio, Veronica, Takashima, Lorena, Pera, Mariana, Cogo, Karina, Gálvez Elkin, Maria S, Medina, María A, Savio, Veronica, Rojas Tessel, Romina, Alamino, Rodolfo P, Werner, Marina L, Ornella, Sofía, Casalla, Luciana, de la Vega, Maria, Severina, María, García, Mercedes, Gonzalez Lucero, Luciana, Romeo, Cecilia, Moyano, Sebastián, Barbich, Tatiana, Bertoli, Ana, Baños, Andrea, Petruzzelli, Sandra, Matellan, Carla, Conti, Silvana, Lazaro, Maria A, Rodriguez Gil, Gustavo F, Risueño, Fabian, Quaglia, Maria I, Scafati, Julia, Cuchiaro, Natalia L, Rebak, Jonathan E, Pineda, Susana I, Calvo, María E, Picco, Eugenia, Yanzi, Josefina G, Maid, Pablo, Guaglianone, Debora, Morbiducci, Julieta S, Porta, Sabrina, Herscovich, Natalia, Velasco Zamora, José L, Kisluk, Boris, Castaños Menescardi, Maria S, Gallo, Rosana, Martire, María V, Maldini, Carla, Goizueta, Cecilia, de la Vega Fernandez, Sabrina S, Aeschlimann, Carolina, Subils, Gisela, Rath, Eva, Piette, Yves, Devinck, Mieke, Maeyaert, Bea, Machado Ribeiro, Francinne, Euzebio Ribeiro, Sandra L, Pinheiro, Marcelo, Ibáñez, Sebastián, Chassin Trubert, Anne-Marie, Dong, Lingli, Cajas, Lui, Barešić, Marko, Anić, Branimir, Ćulo, Melanie-Ivana, Pavelić, Tea A, Stranski, Kristina K, Karanovic, Boris, Vencovsky, Jiri, Píchová, Marta, Filkova, Maria, Hamoud, Hesham, Vassilopoulos, Dimitrios, Guzman Melgar, Gabriela M, So, Ho, Király, Márta, Vojdanian, Mahdi, Balbir Gurman, Alexandra, Abutiban, Fatemah, Zepa, Julija, Bulina, Inita, Bukauskiene, Loreta, Zazueta Montiel, Beatriz E, Castillo Ortiz, Angel A, Zamora Tehozol, Erick, Vega Morales, David, Cervántes Rosete, Diana, Martín Nares, Eduardo, Rodriguez Reyna, Tatiana S, Rull Gabayet, Marina, Alpízar Rodríguez, Deshiré, Irazoque, Fedra, Jimenez, Xochitl, Geurts van Bon, Lenny, Zijlstra, Theo, Hoekstra, Monique, Al Adhoubi, Nasra, Salim, Babur, Giraldo, Enrique, Salinas, Ariel, Ugarte Gil, Manuel, Nowakowski, Jarosław, Conway, Richard, Flood, Rachael, McCarthy, Geraldine, Felea, Ioana, Filipescu, Ileana, Rednic, Simona, Groseanu, Laura, Tamas, Maria M, Mlynarikova, Vanda, Skamlova, Martina, Zlnay, Martin, Mičeková, Dagmar, Capova, Lubica, Macejova, Zelmira, Šteňová, Emőke, Raffayova, Helena, Belakova, Gabriela, Strakova, Eva, Senčarová, Marieta, Žlnayová, Soňa, Sabová, Anna, Spisakova, Daniela, Oetterová, Mária, Lukacova, Olga, Bakosova, Martina, Hocevar, Alojzija, de la Torre Rubio, Natalia, Alegre Sancho, Juan J, Corteguera Coro, Montserrat, Cobeta Garcia, Juan C, Torres Martin, Maria C, Campos, Jose, Gomez Puerta, Jose A, Yardimci, Gozd K, Akar, Servet, Icacan, Ozan C, ÇELİK, Selda, Vasylets, Viktoriia, Yeoh, Su-Ann, Vandevelde, Claire, Dunt, Sasha, Leeder, Jane, Macphie, Elizabeth, Salerno, Rosaria, Graver, Christine, Williams, Katie, O'Reilly, Sheila, Devine, Kirsty, Tyler, Jennifer, Warner, Elizabeth, Pilcher, James, Patel, Samir, Nikiphorou, Elena, Chadwick, Laura, Jones, Caroline M, Harrison, Beverley, Thornton, Lucy, O'Kane, Diana, Fusi, Lucia, Low, Audrey, Horton, Sarah, Jatwani, Shraddha, Baig, Sara, Bajwa, Hammad, Berglund, Vernon, Dahle, Angela, Dorman, Walter, Hargrove, Jody, Hilton, Maren, Lebedoff, Nicholas, Leonard, Susan, Morgan, Jennifer, Pfeifer, Emily, Skemp, Archibald, Wilson, Jeffrey, Wolff, Anne, Cepeda, Eduardo, Todd, Derrick, Hare, Denise, Calabrese, Cassandra, Adams, Christopher, Khosroshahi, Arezou, Kilian, Adam, White, Douglas, Winter, Melanie, Fields, Theodore, Siegel, Caroline, Daver, Nicole, Harvey, Melissa, Kramer, Neil, Lamore, Concetta, Hogarty, Suneya, Yeter, Karen, Siddique, Faizah, Ban, Byung, Tanner, Tamar, Ruderman, Eric, Davis, William, Quinet, Robert, Scopelitis, Evangeline, Toribio, Karen, Webb Detiege, Tameka, Zakem, Jerald, Abbass, Khurram, Kepecs, Gilbert, Miranda, Lilliam, Guma, Michael, Haikal, Ammar, Mody, Sushama, Mueller, Daric, Jayatilleke, Arundathi, Zell, JoAnn, Bays, Alison, Dao, Kathryn, Ezzati, Fatemeh, Parks, Deborah, Karp, David, Quiceno, Guillermo, Izadi, Zara, Gianfrancesco, Milena A, Schmajuk, Gabriela, Jacobsohn, Lindsay, Katz, Patricia, Rush, Stephanie, Ja, Clairissa, Taylor, Tiffany, Shidara, Kie, Danila, Maria I, Wysham, Katherine D, Strangfeld, Anja, Mateus, Elsa F, Hyrich, Kimme L, Gossec, Laure, Carmona, Loreto, Lawson-Tovey, Saskia, Kearsley-Fleet, Lianne, Schaefer, Martin, Al-Emadi, Samar, Sparks, Jeffrey A, Hsu, Tiffany Y-T, Patel, Naomi J, Wise, Leanna, Gilbert, Emily, Duarte-García, Alí, Valenzuela-Almada, Maria O, Ugarte-Gil, Manuel F, Ljung, Lotta, Scirè, Carlo A, Carrara, Greta, Hachulla, Eric, Richez, Christophe, Cacoub, Patrice, Thomas, Thierry, Santos, Maria J, Bernardes, Miguel, Hasseli, Rebecca, Regierer, Anne, Schulze-Koops, Hendrik, Müller-Ladner, Ulf, Pons-Estel, Guillermo, Nieto, Romina E, Pisoni, Cecilia N, Tissera, Yohana S, Xavier, Ricardo, Lopes Marques, Claudia D, Pileggi, Gecilmara C S, Robinson, Philip C, Machado, Pedro M, Sirotich, Emily, Liew, Jean W, Hausmann, Jonathan S, Sufka, Paul, Grainger, Rebecca, Bhana, Suleman, Gore-Massy, Monique, Wallace, Zachary S, and Yazdany, Jinoos
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- 2022
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6. Cost‐Effectiveness of the Early Arthritis Clinic Organizational Model
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Zanetti, Anna, Sakellariou, Garifallia, Zambon, Antonella, Carrara, Greta, Argnani, Lisa, Mantovani, Lorenzo G., Cortesi, Paolo A., Bugatti, Serena, Montecucco, Carlomaurizio, and Scirè, Carlo A.
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- 2023
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7. Influence of initial glucocorticoid co-medication on mortality and hospitalization in early inflammatory arthritis: an investigation by record linkage of clinical and administrative databases
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Sakellariou, Garifallia, Scirè, Carlo Alberto, Rumi, Federica, Carrara, Greta, Zanetti, Anna, Cerra, Carlo, Migliazza, Simona, Bugatti, Serena, and Montecucco, Carlomaurizio
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- 2022
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8. A Model Predicting the 6-Month Disability of Patients With Traumatic Brain Injury to Assess the Quality of Care in Intensive Care Units: Results from the CREACTIVE Study.
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Nattino, Giovanni, Lemeshow, Stanley, Carrara, Greta, Rossi, Carlotta, Brissy, Obou, Chieregato, Arturo, Csomos, Akos, Fleming, Joanne M., Giugni, Aimone, Gradisek, Primoz, Kaps, Rafael, Kyprianou, Theodoros, Lazar, Isaac, Mikaszewska-Sokolewicz, Malgorzata, Paci, Giulia, Xirouchaki, Nektaria, and Bertolini, Guido
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- 2024
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9. Diagnosis of calcium pyrophosphate crystal deposition disease by ultrasonography: how many and which sites should be scanned?
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Cipolletta, Edoardo, Moscioni, Erica, Sirotti, Silvia, Battista, Jacopo Di, Abhishek, Abhishek, Rozza, Davide, Zanetti, Anna, Carrara, Greta, Scirè, Carlo Alberto, Grassi, Walter, Filippou, Georgios, and Filippucci, Emilio
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CROSS-sectional method ,MEDICAL protocols ,WRIST ,METACARPOPHALANGEAL joint ,ANKLE ,ACADEMIC medical centers ,RECEIVER operating characteristic curves ,T-test (Statistics) ,BODY mass index ,SYNOVIAL fluid ,SHOULDER ,RESEARCH evaluation ,PILOT projects ,LOGISTIC regression analysis ,DESCRIPTIVE statistics ,MANN Whitney U Test ,CHI-squared test ,DISEASE prevalence ,JOINTS (Anatomy) ,LONGITUDINAL method ,HIP joint ,ELBOW ,STATISTICS ,CHONDROCALCINOSIS ,KNEE ,CONFIDENCE intervals ,DATA analysis software ,SENSITIVITY & specificity (Statistics) ,INTER-observer reliability - Abstract
Objective To develop the optimal US scanning protocol for the diagnosis of calcium pyrophosphate crystal deposition (CPPD) disease. Methods In this cross-sectional study, consecutive patients with a crystal-proven diagnosis of CPPD disease, and age-, sex-matched disease controls with a negative synovial fluid analysis were prospectively enrolled in two Italian Institutions. Four rheumatologists, blinded to patients' clinical details, performed US examinations using a standardized scanning protocol including 20 joints (shoulders, elbows, wrists, metacarpophalangeal joints from second to fifth fingers, hips, knees, ankles). CPPD was identified as presence/absence, according to the OMERACT definitions. Reduced US scanning protocols were developed by selecting the most informative joints to be imaged by US using the LASSO technique. Patients were randomly divided into training and validation sets. Their diagnostic accuracy was tested comparing the area under the receiver operating characteristic curves. Results The number of participants enrolled was 204: 102 with CPPD disease and 102 disease controls [age, mean (s. d.): 71.3 (12.0) vs 71.1 (13.5) years; female: 62.8% vs 57.8%]. The median number of joints with US evidence of CPPD was 5 [interquartile range (IQR): 4–7] and 0 (IQR: 0–1) in patients with CPPD disease and controls, respectively (P < 0.01). The detection of CPPD in ≥2 joints using a reduced scanning protocol (bilateral assessment of knees, wrists and hips) showed a sensitivity of 96.7% (95% CI: 82.8, 99.9) and a specificity of 100 (95% CI: 88.8, 100.0) for the diagnosis of CPPD disease and had good feasibility [mean (s. d.): 12.5 (5.3) min]. Conclusion Bilateral US assessment of knees, wrists and hips had excellent accuracy and good feasibility for the diagnosis of CPPD disease. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Prognostic Implications of Declining Hemoglobin Content in Patients Hospitalized With Acute Coronary Syndromes
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Leonardi, Sergio, Gragnano, Felice, Carrara, Greta, Gargiulo, Giuseppe, Frigoli, Enrico, Vranckx, Pascal, Di Maio, Dario, Spedicato, Vanessa, Monda, Emanuele, Fimiani, Luigi, Fioretti, Vincenzo, Esposito, Fabrizio, Avvedimento, Marisa, Magliulo, Fabio, Leone, Attilio, Chianese, Salvatore, Franzese, Michele, Scalise, Martina, Schiavo, Alessandra, Mazzone, Paolo, Esposito, Giovanni, Andò, Giuseppe, Calabrò, Paolo, Windecker, Stephan, and Valgimigli, Marco
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- 2021
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11. Hospitals with and without neurosurgery: a comparative study evaluating the outcome of patients with traumatic brain injury
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Giugni, Aimone, Gamberini, Lorenzo, Carrara, Greta, Antiga, Luca, Brissy, Obou, Buldini, Virginia, Calamai, Italo, Csomos, Akos, De Luca, Alessandra, Ferri, Enrico, Fleming, Joanne M., Gradisek, Primoz, Kaps, Rafael, Kyprianou, Theodoros, Lagomarsino, Silvia, Lazar, Isaac, Martino, Costanza, Mikaszewska-Sokolewicz, Malgorzata, Montis, Andrea, Nardai, Gabor, Nattino, Giovanni, Nattino, Giuseppe, Paci, Giulia, Portolani, Laila, Xirouchaki, Nektaria, Chieregato, Arturo, and Bertolini, Guido
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- 2021
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12. Post-Procedural Bivalirudin Infusion at Full or Low Regimen in Patients With Acute Coronary Syndrome
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Gargiulo, Giuseppe, Carrara, Greta, Frigoli, Enrico, Leonardi, Sergio, Vranckx, Pascal, Campo, Gianluca, Varbella, Ferdinando, Calabrò, Paolo, Zaro, Tiziana, Bartolini, Davide, Briguori, Carlo, Andò, Giuseppe, Ferrario, Maurizio, Limbruno, Ugo, Colangelo, Salvatore, Sganzerla, Paolo, Russo, Filippo, Nazzaro, Marco Stefano, Esposito, Giovanni, Ferrante, Giuseppe, Santarelli, Andrea, Sardella, Gennaro, Windecker, Stephan, and Valgimigli, Marco
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- 2019
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13. Cirrhotic patients admitted to the ICU for medical reasons: Analysis of 5506 patients admitted to 286 ICUs in 8 years
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Skurzak, Stefano, Carrara, Greta, Rossi, Carlotta, Nattino, Giovanni, Crespi, Daniele, Giardino, Michele, and Bertolini, Guido
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- 2018
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14. Bivalirudin or Heparin in Patients Undergoing Invasive Management of Acute Coronary Syndromes
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Gargiulo, Giuseppe, Carrara, Greta, Frigoli, Enrico, Vranckx, Pascal, Leonardi, Sergio, Ciociano, Nestor, Campo, Gianluca, Varbella, Ferdinando, Calabrò, Paolo, Garducci, Stefano, Iannone, Alessandro, Briguori, Carlo, Andò, Giuseppe, Crimi, Gabriele, Limbruno, Ugo, Garbo, Roberto, Sganzerla, Paolo, Russo, Filippo, Lupi, Alessandro, Cortese, Bernardo, Ausiello, Arturo, Ierna, Salvatore, Esposito, Giovanni, Zavalloni, Dennis, Santarelli, Andrea, Sardella, Gennaro, Tresoldi, Simone, de Cesare, Nicoletta, Sciahbasi, Alessandro, Zingarelli, Antonio, Tosi, Paolo, van ’t Hof, Arnoud, Omerovic, Elmir, Brugaletta, Salvatore, Windecker, Stephan, and Valgimigli, Marco
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- 2018
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15. Intensive care medicine in 2050: statistical tools for development of prognostic models (why clinicians should not be ignored)
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Poole, Daniele, Carrara, Greta, and Bertolini, Guido
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Statistical models -- Usage ,Prognosis -- Methods ,Critical care medicine -- Methods -- Forecasts and trends ,Market trend/market analysis ,Health care industry - Abstract
Author(s): Daniele Poole [sup.1] , Greta Carrara [sup.2] , Guido Bertolini [sup.2] Author Affiliations: (1) 0000 0004 1756 7871, grid.410345.7, Anesthesia and Intensive Care Operative Unit, S. Martino Hospital, , [...]
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- 2017
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16. The challenge of the definition of early symptomatic knee osteoarthritis: a proposal of criteria and red flags from an international initiative promoted by the Italian Society for Rheumatology
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Migliore, Alberto, Scirè, Carlo Alberto, Carmona, Loreto, Beaumont, Gabriel Herrero, Bizzi, Emanuele, Branco, Jaime, Carrara, Greta, Chevalier, Xavier, Collaku, Ledio, Aslanidis, Spiros, Denisov, Lev, Di Matteo, Luigi, Bianchi, Gerolamo, Diracoglu, Demirhan, Frediani, Bruno, Maheu, Emmanuel, Martusevich, Natalia, Bagnato, Gian Filippo, Scarpellini, Magda, Minisola, Giovanni, Akkoc, Nurullah, Ramonda, Roberta, Barskova, Tatiana, Babic-Naglic, Durda, Muelas, Jose Vicente Moreno, Ionescu, Ruxandra, Rashkov, Rasho, Damjanov, Nemanja, and Cerinic, Marco Matucci
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- 2017
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17. COVID-19 prognosis in systemic lupus erythematosus compared with rheumatoid arthritis and spondyloarthritis: results from the CONTROL-19 Study by the Italian Society for Rheumatology.
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Scirocco, Chiara, Ferrigno, Sara, Andreoli, Laura, Fredi, Micaela, Lomater, Claudia, Moroni, Luca, Mosca, Marta, Raffeiner, Bernd, Carrara, Greta, Landolfi, Gianpiero, Rozza, Davide, Zanetti, Anna, Alberto Scirè, Carlo, and Sebastiani, Gian Domenico
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- 2023
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18. Relationship between the prevalence of subclinical tenosynovitis and treatment in patients with RA in clinical remission: STARTER study.
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Parisi, Simone, Zanetti, Anna, Carrara, Greta, Scirè, Carlo Alberto, Iagnocco, Annamaria, Filippou, Georgios, and Investigators, the STARTER
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TENOSYNOVITIS ,KRUSKAL-Wallis Test ,COMBINATION drug therapy ,ULTRASONIC imaging ,RHEUMATOID arthritis ,DESCRIPTIVE statistics ,CHI-squared test ,DATA analysis software ,DISEASE remission ,LONGITUDINAL method - Abstract
Objective This study is a sub-analysis from the patient cohort of the STARTER (Sonographic Tenosynovitis Assessment in RheumaToid arthritis patiEnts in Remission) study. The aim was to evaluate differences in ultrasound-detected joint and/or tendon involvement between patients receiving therapies based on a combination of conventional synthetic DMARDs (csDMARDs) and biologic DMARDs (bDMARDs) and those who were treated with either csDMARDs or bDMARDs in monotherapy. Material and methods Four hundred and twenty-seven consecutive patients with a diagnosis of RA were recruited between October 2013 and June 2014. They were divided into three subgroups based on their therapy at baseline: patients with bDMARD in monotherapy, patients with csDMARD in monotherapy and patients in combination therapy (csDMARD + bDMARD). At baseline, 6 months and 12 months, a clinical examination (28 joint count) and an ultrasound evaluation were performed in each patient. A score of grey-scale (GS) and power Doppler (PD) synovitis and tenosynovitis was calculated based on the OMERACT scoring systems. Results Two hundred and fifty-six patients completed the observation period: 48 patients from the bDMARD group (18.75%), 152 patients from the csDMARD group (59.38%) and 56 patients from csDMARD + bDMARD group (21.88%). The analysis showed that GS tenosynovitis and PD tenosynovitis are better controlled in combination therapy than they are with csDMARD alone (P = 0.025 and P = 0.047, respectively); for PD synovitis, there was a better response in those who were treated with the combination therapy when compared with the patients receiving csDMARD (P = 0.01) or bDMARD (P = 0.02) alone. Conclusions The analysis showed a lower prevalence of subclinical inflammatory manifestations detected with ultrasound imaging in those patients treated with the combination therapy than in those in monotherapy. [ABSTRACT FROM AUTHOR]
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- 2023
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19. Musculoskeletal ultrasound may narrow the gap between patients and physicians in the assessment of rheumatoid arthritis disease activity.
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Floris, Alberto, Rozza, Davide, Zanetti, Anna, Carrara, Greta, Bellis, Emanuela, Cauli, Alberto, Iagnocco, Annamaria, Scirè, Carlo Alberto, Piga, Matteo, and investigators, STARTER
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TENOSYNOVITIS ,STATISTICS ,REFERENCE values ,SKELETAL muscle ,SYNOVITIS ,SELF-evaluation ,VISUAL analog scale ,RHEUMATOLOGISTS ,RHEUMATOID arthritis ,SYMPTOMS ,DESCRIPTIVE statistics ,DOPPLER ultrasonography ,DATA analysis ,LOGISTIC regression analysis ,ODDS ratio ,DISEASE remission ,MEDICAL needs assessment ,DISEASE complications - Abstract
Objectives To investigate the association between patient–physician discordance in the assessment of disease activity and residual US synovitis/tenosynovitis in a cohort of patients with RA in clinical remission. Methods A post hoc analysis of the STARTER study, promoted by the Musculoskeletal-US (MSUS) Study Group of the Italian Society for Rheumatology, was performed using data from 361 consecutive patients with RA in clinical remission. The global assessment of disease activity by each patient (PGA) and evaluator/physician (EGA) was recorded on a 100-mm visual analogue scale. The PGA-EGA discordance was classified as positive (PGA>EGA) or negative (PGA
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- 2023
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20. Glucocorticoid tapering and associated outcome in patients with newly diagnosed systemic lupus erythematosus: the real-world GULP prospective observational study.
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Floris, Alberto, Chessa, Elisabetta, Sebastiani, Gian Domenico, Prevete, Immacolata, Iannone, Florenzo, Coladonato, Laura, Govoni, Marcello, Bortoluzzi, Alessandra, Mosca, Marta, Tani, Chiara, Doria, Andrea, Iaccarino, Luca, Franceschini, Franco, Fredi, Micaela, Conti, Fabrizio, Spinelli, Francesca Romana, Bellisai, Francesca, D'Alessandro, Roberto, Zanetti, Anna, and Carrara, Greta
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- 2022
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21. Reliability assessment of the definition of ultrasound enthesitis in SpA: results of a large, multicentre, international, web-based study.
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Matteo, Andrea Di, Cipolletta, Edoardo, Castaniti, Giulia Maria Destro, Smerilli, Gianluca, Airoldi, Carla, Aydin, Sibel Zehra, Becciolini, Andrea, Bonfiglioli, Karina, Bruns, Alessandra, Carrara, Greta, Cazenave, Tomas, Ciapetti, Alessandro, Cosatti, Micaela Ana, Agustín, Juan José de, Carlo, Marco Di, Donato, Eleonora Di, Geso, Luca Di, Duran, Emine, Elliott, Ashley, and Estrach, Cristina
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RELIABILITY (Personality trait) ,RESEARCH ,STATISTICS ,BONES ,RESEARCH evaluation ,CONFIDENCE intervals ,JUVENILE idiopathic arthritis ,ANKYLOSIS ,SPONDYLOARTHROPATHIES ,INTER-observer reliability ,DOPPLER ultrasonography ,DESCRIPTIVE statistics - Abstract
Objectives To investigate the reliability of the OMERACT US Task Force definition of US enthesitis in SpA. Methods In this web exercise, based on the evaluation of 101 images and 39 clips of the main entheses of the lower limbs, the elementary components included in the OMERACT definition of US enthesitis in SpA (hypoechoic areas, entheseal thickening, power Doppler signal at the enthesis, enthesophytes/calcifications, bone erosions) were assessed by 47 rheumatologists from 37 rheumatology centres in 15 countries. Inter- and intra-observer reliability of the US components of enthesitis was calculated using Light's kappa, Cohen's kappa, Prevalence And Bias Adjusted Kappa (PABAK) and their 95% CIs. Results Bone erosions and power Doppler signal at the enthesis showed the highest overall inter-reliability [Light's kappa: 0.77 (0.76–0.78), 0.72 (0.71–0.73), respectively; PABAK: 0.86 (0.86–0.87), 0.73 (0.73–0.74), respectively], followed by enthesophytes/calcifications [Light's kappa: 0.65 (0.64–0.65), PABAK: 0.67 (0.67–0.68)]. This was moderate for entheseal thickening [Light's kappa: 0.41 (0.41–0.42), PABAK: 0.41 (0.40–0.42)], and fair for hypoechoic areas [Light's kappa: 0.37 (0.36–0.38); PABAK: 0.37 (0.37–0.38)]. A similar trend was observed in the intra-reliability exercise, although this was characterized by an overall higher degree of reliability for all US elementary components compared with the inter-observer evaluation. Conclusions The results of this multicentre, international, web-based study show a good reliability of the OMERACT US definition of bone erosions, power Doppler signal at the enthesis and enthesophytes/calcifications. The low reliability of entheseal thickening and hypoechoic areas raises questions about the opportunity to revise the definition of these two major components for the US diagnosis of enthesitis. [ABSTRACT FROM AUTHOR]
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- 2022
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22. Clinical governance of patients with acute coronary syndromes.
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Leonardi, Sergio, Montalto, Claudio, Carrara, Greta, Casella, Gianni, Grosseto, Daniele, Galazzi, Marco, Repetto, Alessandra, Tua, Lorenzo, Portolan, Monica, Ottani, Filippo, Galvani, Marcello, Gentile, Leandro, Cardelli, Laura Sofia, De Servi, Stefano, Antonelli, Andrea, De Ferrari, Gaetano Maria, Visconti, Luigi Oltrona, Campo, Gianluca, ACS Clinical Governance Programme Investigators, and Gazmawi, Rasheed
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- 2022
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23. Benchmark of Intraoperative Activity in Cardiac Surgery: A Comparison between Pre- and Post-Operative Prognostic Models.
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Zamperoni, Anna, Carrara, Greta, Greco, Massimiliano, Rossi, Carlotta, Garbero, Elena, Nattino, Giovanni, Minniti, Giuseppe, Del Sarto, Paolo, Bertolini, Guido, and Finazzi, Stefano
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CARDIAC surgery , *PROGNOSTIC models , *MEDICAL care , *FISCAL year , *HOSPITAL patients - Abstract
Objectives: Despite its large diffusion and improvements in safety, the risks of complications after cardiac surgery remain high. Published predictive perioperative scores (EUROSCORE, STS, ACEF) assess risk on preoperative data only, not accounting for the intraopertive period. We propose a double-fold model, including data collected before surgery and data collected at the end of surgery, to evaluate patient risk evolution over time and assess the direct contribution of surgery. Methods: A total of 15,882 cardiac surgery patients from a Margherita-Prosafe cohort study were included in the analysis. Probability of death was estimated using two logistic regression models (preoperative data only vs. post-operative data, also including information at discharge from the operatory theatre), testing calibration and discrimination of each model. Results: Pre-operative and post-operative models were built and demonstrate good discrimination and calibration with AUC = 0.81 and 0.87, respectively. Relative difference in pre- and post-operative mortality in separate centers ranged from −0.36 (95% CI: −0.44–−0.28) to 0.58 (95% CI: 0.46–0.71). The usefulness of this two-fold preoperative model to benchmark medical care in single hospital is exemplified in four cases. Conclusions: Predicted post-operative mortality differs from predicted pre-operative mortality, and the distance between the two models represent the impact of surgery on patient outcomes. A double-fold model can assess the impact of the intra-operative team and the evolution of patient risk over time, and benchmark different hospitals on patients subgroups to promote an improvement in medical care in each center. [ABSTRACT FROM AUTHOR]
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- 2022
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24. Prognostic Value of a Combination of Circulating Biomarkers in Critically Ill Patients with Traumatic Brain Injury: Results from the European CREACTIVE Study.
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Gradisek, Primoz, Carrara, Greta, Antiga, Luca, Bottazzi, Barbara, Chieregato, Arturo, Csomos, Akos, Fainardi, Enrico, Filekovic, Suada, Fleming, Joanne, Hadjisavvas, Andreas, Kaps, Rafael, Kyprianou, Theodoros, Latini, Roberto, Lazar, Isaac, Masson, Serge, Mikaszewska-Sokolewicz, Malgorzata, Novelli, Deborah, Paci, Giulia, Xirouchaki, Nektaria, and Zanier, Elisa
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BRAIN injuries , *GLIAL fibrillary acidic protein , *PROGNOSIS , *STEM cell factor , *FIBROBLAST growth factors - Abstract
Individualized patient care is essential to reduce the global burden of traumatic brain injury (TBI). This pilot study focused on TBI patients admitted to intensive care units (ICUs) and aimed at identifying patterns of circulating biomarkers associated with the disability level at 6 months from injury, measured by the extended Glasgow Outcome Scale (GOS-E). The concentration of 107 biomarkers, including proteins related to inflammation, innate immunity, TBI, and central nervous system, were quantified in blood samples collected on ICU admission from 80 patients. Patients were randomly selected among those prospectively enrolled in the Collaborative Research on Acute Traumatic Brain Injury in Intensive Care Medicine in Europe (CREACTIVE) observational study. Six biomarkers were selected to be associated with indicators of primary or secondary brain injury: three glial proteins (glial cell–derived neurotrophic factor, glial fibrillary acidic protein, and S100 calcium-binding protein B) and three cytokines (stem cell factor, fibroblast growth factor [FGF] 23 and FGF19). The subjects were grouped into three clusters according to the expression of these proteins. The distribution of the 6-month GOS-E was significantly different across clusters (p < 0.001). In two clusters, the number of 6-month deaths or vegetative states was significantly lower than expected, as calculated according to a customization of the corticosteroid randomization after significant head injury (CRASH) scores (observed/expected [O/E] events = 0.00, 95% confidence interval [CI]: 0.00-0.90 and 0.00, 95% CI: 0.00-0.94). In one cluster, less-than-expected unfavorable outcomes (O/E = 0.50, 95% CI: 0.05-0.95) and more-than-expected good recoveries (O/E = 1.55, 95% CI: 1.05-2.06) were observed. The improved prognostic accuracy of the pattern of these six circulating biomarkers at ICU admission upon established clinical parameters and computed tomography results needs validation in larger, independent cohorts. Nonetheless, the results of this pilot study are promising and will prompt further research in personalized medicine for TBI patients. [ABSTRACT FROM AUTHOR]
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- 2021
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25. Intestinal microbiota changes induced by TNF-inhibitors in IBD-related spondyloarthritis.
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Ditto, Maria Chiara, Parisi, Simone, Landolfi, Gianpiero, Borrelli, Richard, Realmuto, Cristina, Finucci, Annacarla, Caviglia, Gian Paolo, Ribaldone, Davide Giuseppe, Astegiano, Marco, Zanetti, Anna, Carrara, Greta, Scirè, Carlo Alberto, Antivalle, Marco, Sarzi-Puttini, Piercarlo, and Fusaro, Enrico
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- 2021
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26. OMERACT definition and reliability assessment of chronic ultrasound lesions of the axillary artery in giant cell arteritis.
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Schäfer, Valentin Sebastian, Chrysidis, Stavros, Schmidt, Wolfgang A., Duftner, Christina, Iagnocco, Annamaria, Bruyn, George A., Carrara, Greta, De Miguel, Eugenio, Diamantopoulos, Andreas P., Nielsen, Berit Dalsgaard, Fredberg, Ulrich, Hartung, Wolfgang, Hanova, Petra, Hansen, Ib Tønder, Hocevar, Alojzija, Juche, Aaron, Kermani, Tanaz A., Lorenzen, Tove, Macchioni, Pierluigi, and Milchert, Marcin
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To define chronic ultrasound lesions of the axillary artery (AA) in long-standing giant cell arteritis (GCA) and to evaluate the reliability of the new ultrasound definition in a web-based exercise. A structured Delphi, involving an expert panel of the Large Vessel Vasculitis subgroup of the Outcome Measures in Rheumatology (OMERACT) Ultrasound Working Group was carried out. The reliability of the new definition was tested in a 2-round web-based exercise involving 23 experts and using 50 still images each from AA of long-standing and acute GCA patients, as well as 50 images from healthy individuals. The final OMERACT ultrasound definition of chronic changes was based on measurement and appearance of the intima-media complex. The overall reliability of the new definition for chronic ultrasound changes in longstanding GCA of the AA was good to excellent with Light's kappa values of 0.79-0.80 for inter-reader reliability and mean Light's-kappa of 0.88 for intra-reader reliability. The mean inter-rater and intra-rater agreements were 86-87% and 92%, respectively. Good reliabilities were observed comparing the vessels with longstanding versus acute GCA with a mean agreement and kappa values of 81% and 0.63, respectively. The new OMERACT ultrasound definition for chronic vasculitis of the AA in GCA revealed a good to excellent inter- and intra-reader reliability in a web-based exercise of experts. [ABSTRACT FROM AUTHOR]
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- 2021
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27. Improved Pregnancy Outcome in Patients With Rheumatoid Arthritis Who Followed an Ideal Clinical Pathway.
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Bortoluzzi, Alessandra, Andreoli, Laura, Carrara, Greta, Ramoni, Véronique, Rumi, Federica, Padovan, Melissa, Govoni, Marcello, Tincani, Angela, and Scirè, and Carlo Alberto
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PREGNANCY complications ,PERINATAL death ,RHEUMATOID arthritis risk factors ,RHEUMATOID arthritis treatment ,AUTOIMMUNE diseases - Abstract
Objective: To assess the effect of optimal management of pregnancy on a composite outcome of miscarriage and complicated birth among women with rheumatoid arthritis (RA). Methods: Data were extracted from health care databases of the Lombardy Region, Italy (2004–2013) as a part of the Record‐Linkage on Rheumatic Diseases Study. Analyses included women with RA identified through a copayment exemption code (International Classification of Diseases, Ninth Revision, Clinical Modification code 714.0) and controls from the general population, ages 18–50 years. Seven health care quality indicators (HCQI) were constructed and summarized in 3 pathway indicators: diagnostic, therapeutic, and prenatal follow‐up. Complicated birth or miscarriage were used to identify the adverse pregnancy outcome (APO). The relationship between HCQI and APO was analyzed using logistic models, and the results were presented as odds ratios (ORs) and 95% confidence intervals (95% CIs). Results: Data from the study cohort included the first pregnancy observed in 443 patients with RA compared with 6,097 women belonging to the general population. In the RA population, patients who followed the 3 pathway indicators had a reduced risk of overall APO, with an OR of 0.60 (95% CI 0.39–0.94), and reduced risk of miscarriage/perinatal death, with an OR of 0.40 (95% CI 0.24–0.69), compared to those who did not follow the pathway indicators. Compared with the general population, patients with RA who met all HCQI during pregnancy displayed a risk of APO with an OR of 0.92 (95% CI 0.61–1.38) and miscarriage/perinatal death with an OR of 0.77 (95% CI 0.47–1.29). Conclusion: The adherence to an ideal clinical pathway of pregnancy management in women with RA restored the risk of APO to that expected for the general population. [ABSTRACT FROM AUTHOR]
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- 2021
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28. The impact of disease extent and severity detected by quantitative ultrasound analysis in the diagnosis and outcome of giant cell arteritis.
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Monti, Sara, Ponte, Cristina, Pereira, Claudio, Manzoni, Federica, Klersy, Catherine, Rumi, Federica, Carrara, Greta, Hutchings, Andrew, Schmidt, Wolfgang A, Dasgupta, Bhaskar, Caporali, Roberto, Montecucco, Carlomaurizio, and Luqmani, Raashid
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BIOMARKERS ,BIOPSY ,CONFIDENCE intervals ,GIANT cell arteritis ,HEADACHE ,INFLAMMATION ,ISCHEMIA ,MATHEMATICAL models ,PROBABILITY theory ,RISK assessment ,THEORY ,QUANTITATIVE research ,COLOR Doppler ultrasonography ,TREATMENT effectiveness ,SEVERITY of illness index ,AXILLARY artery ,DESCRIPTIVE statistics ,TEMPORAL arteries - Abstract
Objectives To develop a quantitative score based on colour duplex sonography (CDS) to predict the diagnosis and outcome of GCA. Methods We selected patients with positive CDS and confirmed diagnosis of GCA recruited into the TA Biopsy (TAB) vs Ultrasound in Diagnosis of GCA (TABUL) study and in a validation, independent cohort. We fitted four CDS models including combinations of the following: number and distribution of halos at the TA branches, average and maximum intima–media thickness of TA and axillary arteries. We fitted four clinical/laboratory models. The combined CDS and clinical models were used to develop a score to predict risk of positive TAB and clinical outcome at 6 months. Results We included 135 GCA patients from TABUL (female: 68%, age 73 (8) years) and 72 patients from the independent cohort (female: 46%, age 75 (7) years). The best-fitting CDS model for TAB used maximum intima–media thickness size and bilaterality of TA and axillary arteries' halos. The best-fitting clinical model included raised inflammatory markers, PMR, headache and ischaemic symptoms. By combining CDS and clinical models we derived a score to compute the probability of a positive TAB. Model discrimination was fair (area under the receiver operating characteristic curve 0.77, 95% CI: 0.68, 0.84). No significant association was found for prediction of clinical outcome at 6 months. Conclusion A quantitative analysis of CDS and clinical characteristics is useful to identify patients with a positive biopsy, supporting the use of CDS as a surrogate tool to replace TAB. No predictive role was found for worse prognosis. [ABSTRACT FROM AUTHOR]
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- 2020
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29. Risk factors of damage in early diagnosed systemic lupus erythematosus: results of the Italian multicentre Early Lupus Project inception cohort.
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Piga, Matteo, Floris, Alberto, Sebastiani, Gian Domenico, Prevete, Imma, Iannone, Florenzo, Coladonato, Laura, Govoni, Marcello, Bortoluzzi, Alessandra, Mosca, Marta, Tani, Chiara, Doria, Andrea, Iaccarino, Luca, Franceschini, Franco, Fredi, Micaela, Conti, Fabrizio, Spinelli, Francesca Romana, Galeazzi, Mauro, Bellisai, Francesca, Zanetti, Anna, and Carrara, Greta
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CONFIDENCE intervals ,LONGITUDINAL method ,MEDICAL cooperation ,REGRESSION analysis ,RESEARCH ,RISK assessment ,STATISTICS ,SYSTEMIC lupus erythematosus ,PROPORTIONAL hazards models ,SEVERITY of illness index ,EARLY diagnosis ,DESCRIPTIVE statistics - Abstract
Objective To investigate risk factors for damage development in a prospective inception cohort of early diagnosed SLE patients. Methods The Early Lupus Project recruited an inception cohort of patients within 12 months of SLE classification (1997 ACR criteria). At enrolment and every 6 months thereafter, the SLICC/ACR Damage Index was recorded. The contribution of baseline and time-varying covariates to the development of damage, defined as any SLICC/ACR Damage Index increase from 0 to ≥1, was assessed using univariate analysis. Forward-backward Cox regression models were fitted with covariates with P < 0.05 to identify factors independently associated with the risk of damage development. Results Overall, 230 patients with a mean (s. d.) age of 36.5 (14.4) years were eligible for this study; the mean number of visits per patient was 5.3 (2.7). There were 51 (22.2%) patients with SLICC/ACR Damage Index ≥1 after 12 months, 59 (25.6%) after 24 months and 67 (29.1%) after 36 months. Dyslipidaemia [ P = 0.001; hazard ratio (HR) 2.9; 95% CI 1.5, 5.6], older age (P = 0.001; HR 3.0; 95% CI 1.6, 5.5), number of organs/systems involved (P = 0.002; HR 1.4; 95% CI 1.1, 1.8) and cardiorespiratory involvement (P = 0.041; HR 1.9; 95% CI 1.0, 3.7) were independently associated with an increased risk of developing damage. Risk profiles for damage development differed for glucocorticoid-related and -unrelated damage. HCQ use (P = 0.005; HR 0.4; 95% CI 0.2, 0.8) reduced the risk of glucocorticoid-unrelated damage. Conclusion We identified risk factors of damage development, but little effect of glucocorticoids, in this early SLE cohort. Addressing modifiable risk factors from the time of SLE diagnosis might improve patient outcomes. [ABSTRACT FROM AUTHOR]
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- 2020
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30. Novel and reliable DACTylitis glObal Sonographic (DACTOS) score in psoriatic arthritis.
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Zabotti, Alen, Sakellariou, Garifallia, Tinazzi, Ilaria, Idolazzi, Luca, Batticciotto, Alberto, Canzoni, Marco, Carrara, Greta, De Lucia, Orazio, Figus, Fabiana, Girolimetto, Nicolò, Macchioni, Pierluigi, McConnell, Rebecca, Possemato, Niccolò, and Iagnocco, Annamaria
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PSORIATIC arthritis ,ULTRASONIC imaging ,RESEARCH evaluation ,INFLAMMATION ,SEVERITY of illness index ,FINGER joint ,DELPHI method - Abstract
Objectives: Dactylitis is one of the most typical features of psoriatic arthritis (PsA), with a high lifetime prevalence and inclusion in PsA clinical indices. Musculoskeletal ultrasonography (Msk-US) can readily detect inflammatory involvement of finger anatomical structures particular to dactylitis and monitor therapeutic effects. In this study, we aim to identify the characteristic lesions in PsA dactylitis of the hands, assess the reliability of Msk-US in scoring those lesions and develop a DACTylitis glObal Sonographic (DACTOS) score.Methods: After a systematic literature review on the use of Msk-US in PsA dactylitis, 12 rheumatologists participated in a three-round Delphi procedure and consensus meeting to agree on the sonographic elementary lesions characterising dactylitis and on the composition of a global sonographic score. Then, a web-based and a patient-based intra-rater and inter-rater reliability exercise was performed to assess those lesions included in the score.Results: DACTOS score was obtained by summing the scores of each lesion selected in the Delphi survey: subcutaneous soft tissue oedema, flexor tenosynovitis, peritendon extensor inflammation and synovitis. The DACTOS score ranges from 0 to 25. In the reliability exercises, we obtained moderate-to-excellent agreement for the sonographic lesions included in the score.Conclusions: The novel DACTOS score is a reliable measure to interpret the multiple characteristic sonographic features of dactylitis. The DACTOS score provides a useful global analysis of dactylitis of the hand and can represent a support to clinical diagnosis as well as a useful tool for the management and research in patients with PsA with dactylitis. [ABSTRACT FROM AUTHOR]- Published
- 2020
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31. OMERACT agreement and reliability study of ultrasonographic elementary lesions in osteoarthritis of the foot.
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Zabotti, Alen, Filippou, Georgios, Canzoni, Marco, Adinolfi, Antonella, Picerno, Valentina, Carrara, Greta, Balint, Peter, Bruyn, George, D'Agostino, Maria Antonietta, Damjanov, Nemanja, Sedie, Andrea Delle, Filippucci, Emilio, Fernandez, Maria Luz Gonzalez, Hammer, Hilde Berner, Karim, Zunaid, Mandl, Peter, Moller, Ingrid, Lozano, Maria Rosario Morales, Naredo, Esperanza, and Porta, Francesco
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- 2019
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32. Risk of hospitalization for heart failure in rheumatoid arthritis patients treated with etanercept and abatacept.
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Generali, Elena, Selmi, Carlo, Carrara, Greta, Scirè, Carlo A., Kallikourdis, Marinos, Condorelli, Gianluigi, and Bortoluzzi, Alessandra
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IVABRADINE ,GOLIMUMAB - Abstract
To estimate biologic influence on heart failure (HF) risk in rheumatoid arthritis. Retrospective cohort (RECORD Study of Italian Society for Rheumatology) study on administrative healthcare databases. We identified 2527 patients treated with either etanercept (n = 1690) or abatacept (n = 837). HF incidence rate was higher in the abatacept cohort than in the etanercept cohort with a 2.38 (95% CI 1.08-5.27) crude competing risk HR (SHR) for abatacept of developing HF, not confirmed after adjustment for prespecified confounders (SHR 1.43; 95% CI 0.51-3.98). Abatacept, compared to etanercept, is prescribed to patients with a worse cardiovascular profile but does not increase the risk of developing HF, when confounding factors are accounted for. [ABSTRACT FROM AUTHOR]
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- 2019
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33. Outcome Indicators That Really Matter in Traumatic Brain Injury Multi-site Follow-up and Related Challenges: The CREACTIVE Endeavour, the European Model.
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Kokkinou, Mikaella, Bertolini, Guido, Fleming, Joanne, Constantinidou, Fofi, Montis, Andrea, Carrara, Greta, and Kyprianou, Theodoros
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- 2019
34. Comparative Effectiveness of Intracranial Pressure Monitoring on 6-Month Outcomes of Critically Ill Patients With Traumatic Brain Injury.
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Nattino, Giovanni, Gamberini, Lorenzo, Brissy, Obou, Carrara, Greta, Chesnut, Randall, Chiarini, Valentina, Chieregato, Arturo, Csomos, Akos, Fleming, Joanne M., Gradisek, Primoz, Kaps, Rafael, Kyprianou, Theodoros, Lazar, Isaac, Lemeshow, Stanley, Mikaszewska-Sokolewicz, Malgorzata, Paci, Giulia, Rossi, Carlotta, Temkin, Nancy, Xirouchaki, Nektaria, and Giugni, Aimone
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- 2023
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35. Mortality attributable to different Klebsiella susceptibility patterns and to the coverage of empirical antibiotic therapy: a cohort study on patients admitted to the ICU with infection.
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GiViTI Steering Committee, Bertolini, Guido, Nattino, Giovanni, Tascini, Carlo, Poole, Daniele, Viaggi, Bruno, Carrara, Greta, Rossi, Carlotta, Crespi, Daniele, Mondini, Matteo, Langer, Martin, Rossolini, Gian Maria, and Malacarne, Paolo
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KLEBSIELLA infections ,ANTIBIOTICS ,INTENSIVE care patients ,DRUG resistance ,HOSPITAL mortality ,INTENSIVE care units ,KLEBSIELLA ,LONGITUDINAL method ,MICROBIAL sensitivity tests ,CARBAPENEMS ,PHARMACODYNAMICS - Abstract
Purpose: To evaluate the prognostic importance of different Klebsiella spp. sensitivity patterns: multi-susceptible Klebsiella (MS-K), extended-spectrum cephalosporin-resistant, but carbapenem-susceptible Klebsiella (ESCR-CS-K), and carbapenem-resistant Klebsiella (CR-K).Methods: We developed a prognostic model to predict hospital mortality in patients with infection on admission to the intensive care units (ICUs), and assessed its calibration in the subgroups of interest: patients with infections due to MS-K, ESCR-CS-K, CR-K. We assessed the calibration of the model also in ESCR-CS-K treated empirically with carbapenems and with piperacillin-tazobactam.Results: A total of 13,292 adults with an ongoing infection were admitted to 137 Italian ICUs in 2012-2013. Of 801 Klebsiella spp. infected patients, 451 had MS-K, 116 ESCR-CS-K, and 234 CR-K. The prognostic model calibrated well for the MS-K and ESCR-CS-K subgroups. In the CR-K subgroup there were more deaths than predicted (standardized mortality ratio 1.20; 95% CI 1.08-1.31), indicating a negative prognostic role of the infection, mainly in the medium and high risk-of-death patients. When infection was caused by ESCR-CS-K, treatment with piperacillin-tazobactam increased adjusted mortality among the most severe patients (similarly to CR-K), while treatment with carbapenems did not (similarly to MS-K).Conclusions: In low risk-of-death patients admitted to the ICU with a Klebsiella spp. infection, the appropriateness of empirical antibiotic therapy seemed uninfluential to eventual mortality, while it appeared to be crucial in high-risk ones. The use of piperacillin-tazobactam may be inappropriate in severe patients with ESCR-CS-K infection. CR-K is associated to a significant 20% increase of adjusted mortality, only for patients at higher risk of death. [ABSTRACT FROM AUTHOR]- Published
- 2018
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36. Assessing Vasculitis in Giant Cell Arteritis by Ultrasound: Results of OMERACT Patient-based Reliability Exercises.
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Schäfer, Valentin S., Chrysidis, Stavros, Dejaco, Christian, Duftner, Christina, Iagnocco, Annamaria, Bruyn, George A., Carrara, Greta, D'Agostino, Maria Antonietta, De Miguel, Eugenio, Diamantopoulos, Andreas P., Fredberg, Ulrich, Hartung, Wolfgang, Hocevar, Alojzija, Juche, Aaron, Kermani, Tanaz A., Koster, Matthew J., Lorenzen, Tove, Macchioni, Pierluigi, Milchert, Marcin, and Døhn, Uffe Møller
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- 2018
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37. Comparative effectiveness of first-line biological monotherapy use in rheumatoid arthritis: a retrospective analysis of the RECord-linkage On Rheumatic Diseases study on health care administrative databases.
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Silvagni, Ettore, Bortoluzzi, Alessandra, Carrara, Greta, Zanetti, Anna, Govoni, Marcello, and Scirè, Carlo Alberto
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Objective These analyses aim to comparatively evaluate the persistence on treatment of different biological disease-modifying antirheumatic drugs (bDMARDs) when administered in monotherapy compared with combination with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) in rheumatoid arthritis (RA) patients receiving first-line biologics. Design This is a retrospective observational study on Administrative Healthcare Databases. Methods Data were extracted from healthcare databases of the Lombardy Region, Italy (2004-2013), as a part of the RECord-linkage On Rheumatic Diseases study, on behalf of the Italian Society for Rheumatology. Analyses included patients with RA starting first-line approved course of bDMARDs and evaluated drug survival by using Cox proportional hazard models. Results are presented as HRs and 95% CI, crude and adjusted for prespecified confounders (age, sex, disease duration, Charlson Comorbidity Index (CCI), previous infections, use of concomitant glucocorticoids or non-steroidal anti-inflammatory drugs (NSAIDs)). results 4478 patients with RA were included (17.84% monotherapy). Etanercept, adalimumab and infliximab were the most prescribed first-line biologics. bDMARD monotherapy was associated with longer disease duration, higher CCI, lower glucocorticoids and NSAIDs use. Compared with monotherapy, combination associated with a lower risk of failure (adjusted HR 0.79, 95% CI 0.72 to 0.88). Among monotherapies, considering etanercept as reference, adalimumab (1.28, 95% CI 1.03 to 1.59) and infliximab (2.41, 95% CI 1.85 to 3.15) had higher risk of failure. Concomitant methotrexate (0.78, 95% CI 0.70 to 0.87), leflunomide (0.80, 95% CI 0.65 to 0.98) or csDMARD combinations (0.77, 95% CI 0.68 to 0.87) reduced the risk of bDMARD withdrawal. Conclusion Adalimumab and infliximab monotherapies show lower retention rate compared with etanercept. The relatively small number of therapeutic courses different from tumour necrosis factor (TNF) inhibitors makes more difficult to achieve conclusive results with other biologics. Concomitant methotrexate, leflunomide and csDMARDs combination associate with longer survival on bDMARD. Our data confirm the effectiveness of the current practices in the choice of etanercept as first-line anti-TNF monotherapy and strengthen the currently recommended use of bDMARDs in combination with csDMARDs. [ABSTRACT FROM AUTHOR]
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- 2018
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38. The predictive role of ultrasound-detected tenosynovitis and joint synovitis for flare in patients with rheumatoid arthritis in stable remission. Results of an Italian multicentre study of the Italian Society for Rheumatology Group for Ultrasound: the STARTER study.
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Filippou, Georgios, Sakellariou, Garifallia, Scirè, Carlo Alberto, Carrara, Greta, Rumi, Federica, Bellis, Emanuela, Adinolfi, Antonella, Batticciotto, Alberto, Bortoluzzi, Alessandra, Cagnotto, Giovanni, Caprioli, Marta, Canzoni, Marco, Cavatorta, Francesco Paolo, De Lucia, Orazio, Di Sabatino, Valentina, Draghessi, Antonella, Farina, Ilaria, Focherini, Maria Cristina, Gabba, Alessandra, and Gutierrez, Marwin
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Objective: To define the role of ultrasound (US) for the assessment of patients with rheumatoid arthritis (RA) in clinical remission, including joint and tendon evaluation.Methods: A multicentre longitudinal study has been promoted by the US Study Group of the Italian Society for Rheumatology. 25 Italian centres participated, enrolling consecutive patients with RA in clinical remission. All patients underwent complete clinical assessment (demographic data, disease characteristics, laboratory exams, clinical assessment of 28 joints and patient/physician-reported outcomes) and Power Doppler (PD) US evaluation of wrist, metacarpalphalangeal joints, proximal interphalangeal joints and synovial tendons of the hands and wrists at enrolment, 6 and 12 months. The association between clinical and US variables with flare, disability and radiographic progression was evaluated by univariable and adjusted logistic regression models.Results: 361 patients were enrolled, the mean age was 56.20 (±13.31) years and 261 were women, with a mean disease duration of 9.75 (±8.07) years. In the 12 months follow-up, 98/326 (30.1%) patients presented a disease flare. The concurrent presence of PD positive tenosynovitis and joint synovitis predicted disease flare, with an OR (95% CI) of 2.75 (1.45 to 5.20) in crude analyses and 2.09 (1.06 to 4.13) in adjusted analyses. US variables did not predict the worsening of function or radiographic progression. US was able to predict flare at 12 months but not at 6 months.Conclusions: PD positivity in tendons and joints is an independent risk factor of flare in patients with RA in clinical remission. Musculoskeletal ultrasound evaluation is a valuable tool to monitor and help decision making in patients with RA in clinical remission. [ABSTRACT FROM AUTHOR]- Published
- 2018
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39. Identification of calcium pyrophosphate deposition disease (CPPD) by ultrasound: reliability of the OMERACT definitions in an extended set of joints-an international multiobserver study by the OMERACT Calcium Pyrophosphate Deposition Disease Ultrasound Subtask Force.
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Filippou, Georgios, Scirè, Carlo Alberto, Adinolfi, Antonella, Nemanja S. Damjanov, Carrara, Greta, Bruyn, George A. W., Cazenave, Tomas, D'Agostino, Maria Antonietta, Delle Sedie, Andrea, Di Sabatino, Valentina, Cortes, Mario Enrique Diaz, Filippucci, Emilio, Gandjbakhch, Frederique, Gutierrez, Marwin, Maccarter, Daryl K., Micu, Mihaela, Möller Parera, Ingrid, Mouterde, Gaël, Mortada, Mohamed Atia, and Naredo, Esperanza
- Abstract
Objectives: To assess the reliability of the OMERACT ultrasound (US) definitions for the identification of calcium pyrophosphate deposition disease (CPPD) at the metacarpal-phalangeal, triangular fibrocartilage of the wrist (TFC), acromioclavicular (AC) and hip joints.Methods: A web-based exercise and subsequent patient-based exercise were carried out. A panel of 30 OMERACT members, participated at the web-based exercise by evaluating twice a set of US images for the presence/absence of CPPD. Afterwards, 19 members of the panel met in Siena, Italy, for the patient-based exercise. During the exercise, all sonographers examined twice eight patients for the presence/absence of CPPD at the same joints. Intraoberserver and interobserver kappa values were calculated for both exercises.Results: The web-based exercise yielded high kappa values both in intraobserver and interobserver evaluation for all sites, while in the patient-based exercise, inter-reader agreement was acceptable for the TFC and the AC. TFC reached high interobserver and intraobserver k values in both exercises, ranging from 0.75 to 0.87 (good to excellent agreement). AC reached moderate kappa values, from 0.51 to 0.85 (moderate to excellent agreement) and can readily be used for US CPPD identification.Conclusions: Based on the results of our exercise, the OMERACT US definitions for the identification of CPPD demonstrated to be reliable when applied to the TFC and AC. Other sites reached good kappa values in the web-based exercise but failed to achieve good reproducibility at the patient-based exercise, meaning the scanning method must be further refined. [ABSTRACT FROM AUTHOR]- Published
- 2018
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40. Clinical and ultrasonographic predictors for achieving minimal disease activity in patients with psoriatic arthritis: the UPSTREAM (Ultrasound in PSoriatic arthritis TREAtMent) prospective observational study protocol.
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Canzoni, Marco, Piga, Matteo, Zabotti, Alen, Scirè, Carlo Alberto, Carrara, Greta, Olivieri, Ignazio, and Iagnocco, Annamaria
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Introduction Psoriatic arthritis (PsA) occurs in 10%-15% of people with psoriasis and accounts for 10%-20% of early arthritis clinics referral. Only a few prognostic factors of therapeutic response in patients with PsA have been identified. In the last years, the role of imaging has grown up and the European League Against Rheumatism recognised that ultrasound (US) has higher sensitivity than clinical examination to detect inflammatory disease activity. The aims of the Ultrasound in PSoriatic arthritis TREAtMent (UPSTREAM) study are to integrate clinic and US in order to inform whether US has provide an added prognostic value in PsA. Methods and analysis UPSTREAM is an observational prospective cohort study enrolling patients with PsA having clinically active joint disease and starting a new course of therapy. The primary objective is to evaluate the additional value of US over clinical examination in detecting patients achieving minimal disease activity after 6 months. Data will be obtained at baseline and at standard clinical follow-up visits. Patient's clinical assessment will be performed according to the core set proposed by the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis-Outcome Measures in Rheumatology. Sonographic evaluations will be performed by expert sonographers in 42 joints, 36 tendons, 12 entheses and 2 bursae, according to a score that will be purposely developed for PsA by the US Study Group of the Italian Society for Rheumatology. The UPSTREAM study will identify clinical and US predictors of response to treatment in patients with PsA and active peripheral arthritis starting a new course of therapy. Ethics and dissemination Ethic approval for this study has been obtained from the institutional review board (IRB)/independent ethics committee (IEC) Comitato Etico Lazio 1 (Prot. N 198 02-02-2017) and then locally from the IRB/IEC of each participating centre. Results will be published in relevant scientific journals and be disseminated in international conferences. Fully anonymised data will be accessible from authors upon request. [ABSTRACT FROM AUTHOR]
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- 2018
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41. Definitions and reliability assessment of elementary ultrasound lesions in giant cell arteritis: a study from the OMERACT Large Vessel Vasculitis Ultrasound Working Group.
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Chrysidis, Stavros, Duftner, Christina, Dejaco, Christian, Schäfer, Valentin S., Ramiro, Sofia, Carrara, Greta, Scirè, Carlo Alberto, Hocevar, Alojzija, Diamantopoulos, Andreas P., Iagnocco, Annamaria, Mukhtyar, Chetan, Ponte, Cristina, Naredo, Esperanza, De Miguel, Eugenio, Bruyn, George A., Warrington, Kenneth J., Terslev, Lene, Milchert, Marcin, D'Agostino, Maria Antonietta, and Koster, Mattew J.
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- 2018
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42. Definition and Reliability Assessment of Elementary Ultrasonographic Findings in Calcium Pyrophosphate Deposition Disease: A Study by the OMERACT Calcium Pyrophosphate Deposition Disease Ultrasound Subtask Force.
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Filippou, Georgios, Scirè, Carlo A., Damjanov, Nemanja, Adinolfi, Antonella, Carrara, Greta, Picerno, Valentina, Toscano, Carmela, Bruyn, George A., D'Agostino, Maria Antonietta, Sedie, Andrea Delle, Filippucci, Emilio, Gutierrez, Marwin, Micu, Mihaela, Möller, Ingrid, Naredo, Esperanza, Pineda, Carlos, Porta, Francesco, Schmidt, Wolfgang A., Terslev, Lene, and Vlad, Violeta
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- 2017
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43. Influence of aromatase inhibitors therapy on the occurrence of rheumatoid arthritis in women with breast cancer: results from a large population-based study of the Italian Society for Rheumatology.
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Caprioli, Marta, Carrara, Greta, Sakellariou, Garifallia, Silvagni, Ettore, and Scirè, Carlo Alberto
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- 2017
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44. Quantitative chest computed tomography is associated with two prediction models of mortality in interstitial lung disease related to systemic sclerosis.
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Ariani, Alarico, Silva, Mario, Seletti, Valeria, Bravi, Elena, Saracco, Marta, Parisi, Simone, De Gennaro, Fabio, Idolazzi, Luca, Caramaschi, Paola, Benini, Camilla, Cesare Bodini, Flavio, Scirè, Carlo Alberto, Carrara, Greta, Lumetti, Federica, Alfieri, Veronica, Bonati, Elisa, Lucchini, Gianluca, Aiello, Marina, Santilli, Daniele, and Mozzani, Flavio
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MORTALITY risk factors ,CHEST X rays ,COMPUTED tomography ,DIGITAL image processing ,INTERSTITIAL lung diseases ,MEDICAL cooperation ,PROBABILITY theory ,RESEARCH ,PULMONARY function tests ,SYSTEMIC scleroderma ,RETROSPECTIVE studies ,RECEIVER operating characteristic curves ,COMPUTER-aided diagnosis ,DISEASE complications ,DIAGNOSIS - Abstract
Objective. In this multicentre study, we aimed to evaluate the capacity of a computer-assisted automated QCT method to identify patients with SSc-associated interstitial lung disease (SSc-ILD) with high mortality risk according to validated composite clinical indexes (ILD-Gender, Age, Physiology index and du Bois index). Methods. Chest CT, anamnestic data and pulmonary function tests of 146 patients with SSc were retrospectively collected, and the ILD-Gender, Age, Physiology score and DuBois index were calculated. Each chest CT underwent an operator-independent quantitative assessment performed with a free medical image viewer (Horos). The correlation between clinical prediction models and QCT parameters was tested. A value of P<0.05 was considered statistically significant. Results. Most QCT parameters had a statistically different distribution in patients with diverging mortality risk according to both clinical prediction models (P<0.01). The cut-offs of QCT parameters were calculated by receiver operating characteristic curve analysis, and most of them could discriminate patients with different mortality risk according to clinical prediction models. Conclusion. QCT assessment of SSc-ILD can discriminate between well-defined different mortality risk categories, supporting its prognostic value. These findings, together with the operator independence, strengthen the validity and clinical usefulness of QCT for assessment of SSc-ILD. [ABSTRACT FROM AUTHOR]
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- 2017
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45. Ultrasound-detected tenosynovitis independently associates with patient-reported flare in patients with rheumatoid arthritis in clinical remission: results from the observational study STARTER of the Italian Society for Rheumatology.
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Bellis, Emanuela, Scirè, Carlo Alberto, Carrara, Greta, Adinolfi, Antonella, Batticciotto, Alberto, Bortoluzzi, Alessandra, Cagnotto, Giovanni, Caprioli, Marta, Canzoni, Marco, Cavatorta, Francesco Paolo, De Lucia, Orazio, Di Sabatino, Valentina, Draghessi, Antonella, Filippou, Georgios, Farina, Ilaria, Focherini, Maria Cristina, Gabba, Alessandra, Gutierrez, Marwin, Idolazzi, Luca, and Luccioli, Filippo
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CHI-squared test ,CONFIDENCE intervals ,MEDICAL cooperation ,SCIENTIFIC observation ,QUESTIONNAIRES ,RESEARCH ,RHEUMATOID arthritis ,STATISTICS ,TENOSYNOVITIS ,SYNOVITIS ,DATA analysis ,VISUAL analog scale ,DISEASE remission ,DISEASE prevalence ,CROSS-sectional method ,DATA analysis software ,DESCRIPTIVE statistics ,ODDS ratio - Abstract
Objectives. This study aimed to estimate the prevalence of US-detected tenosynovitis in RA patients in clinical remission and to explore its clinical correlates. Methods. A total of 427 RA patients in clinical remission were consecutively enrolled from 25 Italian rheumatology centres. Tenosynovitis and synovitis were scored by US grey scale (GS) and power Doppler (PD) semi-quantitative scoring systems at wrist and hand joints. Complete clinical assessment was performed by rheumatologists blinded to the US results. A flare questionnaire was used to assess unstable remission (primary outcome), HAQ for functional disability and radiographic erosions for damage (secondary outcomes). Cross-sectional relationships between the presence of each US finding and outcome variables are presented as odds ratios (ORs) and 95% CIs, both crude and adjusted for pre-specified confounders. Results. The prevalence of tenosynovitis in clinical remission was 52.5% (95% CI 0.48, 0.57) for GS and 22.7% (95% CI 0.19, 0.27) for PD, while the prevalence of synovitis was 71.6% (95% CI 0.67, 0.76) for GS and 42% (95% CI 0.37, 0.47) for PD. Among clinical correlates, PD tenosynovitis associated with lower remission duration and morning stiffness while PD synovitis did not. Only PD tenosynovitis showed a significant association with the flare questionnaire [OR 1.95 (95% CI 1.17, 3.26)]. No cross-sectional associations were found with the HAQ. The presence of radiographic erosions associated with GS and PD synovitis but not with tenosynovitis. Conclusions. US-detected tenosynovitis is a frequent finding in RA patients in clinical remission and associates with unstable remission. [ABSTRACT FROM AUTHOR]
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- 2016
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46. Development and First Validation of a Disease Activity Score for Gout.
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Scirè, Carlo A., Carrara, Greta, Viroli, Cinzia, Cimmino, Marco A., Taylor, William J., Manara, Maria, Govoni, Marcello, Salaffi, Fausto, Punzi, Leonardo, Montecucco, Carlomaurizio, Matucci-Cerinic, Marco, Minisola, Giovanni, Scirè, Carlo A, and Study Group for the Kick-Off of the Italian Network for Gout Study
- Abstract
Objective: To develop a new composite disease activity score for gout and provide its first validation.Methods: Disease activity has been defined as the ongoing presence of urate deposits that lead to acute arthritis and joint damage. Every measure for each Outcome Measures in Rheumatology core domain was considered. A 3-step approach (factor analysis, linear discriminant analysis, and linear regression) was applied to derive the Gout Activity Score (GAS). Decision to change treatment or 6-month flare count were used as the surrogate criteria of high disease activity. Baseline and 12-month followup data of 446 patients included in the Kick-Off of the Italian Network for Gout cohort were used. Construct- and criterion-related validity were tested. External validation on an independent sample is reported.Results: Factor analysis identified 5 factors: patient-reported outcomes, joint examination, flares, tophi, and serum uric acid (sUA). Discriminant function analysis resulted in a correct classification of 79%. Linear regression analysis identified a first candidate GAS including 12-month flare count, sUA, visual analog scale (VAS) of pain, VAS global activity assessment, swollen and tender joint counts, and a cumulative measure of tophi. Alternative scores were also developed. The developed GAS demonstrated a good correlation with functional disability (criterion validity) and discrimination between patient- and physician-reported measures of active disease (construct validity). The results were reproduced in the external sample.Conclusion: This study developed and validated a composite measure of disease activity in gout. Further testing is required to confirm its generalizability, responsiveness, and usefulness in assisting with clinical decisions. [ABSTRACT FROM AUTHOR]- Published
- 2016
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47. Cardiovascular Comorbidities Relate More than Others with Disease Activity in Rheumatoid Arthritis.
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Crepaldi, Gloria, Scirè, Carlo Alberto, Carrara, Greta, Sakellariou, Garifallia, Caporali, Roberto, Hmamouchi, Ihsane, Dougados, Maxime, and Montecucco, Carlomaurizio
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CARDIOVASCULAR diseases ,RHEUMATOID arthritis ,COMORBIDITY ,BLOOD sedimentation ,DISEASE duration ,HEALTH outcome assessment - Abstract
Objectives: To explore the influence of comorbidities on clinical outcomes and disease activity in rheumatoid arthritis (RA). Methods: In patients included in the cross-sectional observational multicenter international study COMORA, demographics, disease characteristics and comorbidities (hypertension, diabetes, hyperlipidemia, renal failure, ischemic heart disease, stroke, cancer, gastro-intestinal ulcers, hepatitis, depression, chronic pulmonary disease, obesity) were collected. Multivariable linear regression models explored the relationship between each comorbidity and disease activity measures: 28-swollen joint count (SJC), 28-tender joint count (TJC), erythrocyte sedimentation rate (ESR), patient’s and physician’s global assessment (PtGA, PhGA), patient reported fatigue and 28-Disease Activity Score (DAS28). Results are expressed as mean difference (MD) adjusted for the main confounders (age, gender, disease characteristics and treatment). Results: A total of 3,920 patients were included: age (mean ±SD) 56.27 ±13.03 yrs, female 81.65%, disease duration median 7.08 yrs (IQR 2.97–13.27), DAS28 (mean ±SD) 3.74 ± 1.55. Patients with diabetes had more swollen and tender joints and worse PtGA and PhGA (MD +1.06, +0.93, +0.53 and +0.54, respectively). Patients with hyperlipidemia had a lower number of swollen and tender joints, lower ESR and better PtGA and PhGA (MD -0.77, -0.56, -3.56, -0.31 and -0.35, respectively). Patients with history of ischemic heart disease and obese patients had more tender joints (MD +1.27 and +1.07) and higher ESR levels (MD +5.64 and +5.20). DAS28 is influenced exclusively by cardiovascular comorbidities, in particular diabetes, hyperlipidemia, ischemic heart disease and obesity. Conclusions: Cardiovascular comorbidities relate more than others with disease activity in RA. Diabetes and hyperlipidemia in particular seem associated with higher and lower disease activity respectively influencing almost all considered outcomes, suggesting a special importance of this pattern of comorbidities in disease activity assessment and clinical management. [ABSTRACT FROM AUTHOR]
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- 2016
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48. A validation study of a new classification algorithm to identify rheumatoid arthritis using administrative health databases: case-control and cohort diagnostic accuracy studies. Results from the RECord linkage On Rheumatic Diseases study of the Italian Society for Rheumatology.
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Carrara, Greta, Scirè, Carlo A., Zambon, Antonella, Cimmino, Marco A., Cerra, Carlo, Caprioli, Marta, Cagnotto, Giovanni, Nicotra, Federica, Arfè, Andrea, Migliazza, Simona, Corrao, Giovanni, Minisola, Giovanni, and Montecucco, Carlomaurizio
- Abstract
Objectives: To develop and validate a new algorithm to identify patients with rheumatoid arthritis (RA) and estimate disease prevalence using administrative health databases (AHDs) of the Italian Lombardy region. Design: Case-control and cohort diagnostic accuracy study. Methods: In a randomly selected sample of 827 patients drawn from a tertiary rheumatology centre (training set), clinically validated diagnoses were linked to administrative data including diagnostic codes and drug prescriptions. An algorithm in steps of decreasing specificity was developed and its accuracy assessed calculating sensitivity/specificity, positive predictive value (PPV)/negative predictive value, with corresponding CIs. The algorithm was applied to two validating sets: 106 patients from a secondary rheumatology centre and 6087 participants from the primary care. Alternative algorithms were developed to increase PPV at population level. Crude and adjusted prevalence estimates taking into account algorithm misclassification rates were obtained for the Lombardy region. Results: The algorithms included: RA certification by a rheumatologist, certification for other autoimmune diseases by specialists, RA code in the hospital discharge form, prescription of disease-modifying antirheumatic drugs and oral glucocorticoids. In the training set, a four-step algorithm identified clinically diagnosed RA cases with a sensitivity of 96.3 (95% CI 93.6 to 98.2) and a specificity of 90.3 (87.4 to 92.7). Both external validations showed highly consistent results. More specific algorithms achieved >80% PPV at the population level. The crude RA prevalence in Lombardy was 0.52%, and estimates adjusted for misclassification ranged from 0.31% (95% CI 0.14% to 0.42%) to 0.37% (0.25% to 0.47%). Conclusions: AHDs are valuable tools for the identification of RA cases at the population level, and allow estimation of disease prevalence and to select retrospective cohorts. [ABSTRACT FROM AUTHOR]
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- 2015
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49. Gout impacts on function and health-related quality of life beyond associated risk factors and medical conditions: results from the KING observational study of the Italian Society for Rheumatology (SIR).
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Scirè, Carlo Alberto, Manara, Maria, Cimmino, Marco Amedeo, Govoni, Marcello, Salaffi, Fausto, Punzi, Leonardo, Monti, Maria Cristina, Carrara, Greta, Montecucco, Carlomaurizio, Matucci-Cerinic, Marco, and Minisola, Giovanni
- Published
- 2013
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