Search

Your search keyword '"Cabanis, E."' showing total 38 results
Start Over Author "Cabanis, E." Search Limiters Peer Reviewed
38 results on '"Cabanis, E."'

1. La prévention en santé chez les adolescents

Author

Bégué, P., Cabanis, E.-A., Charpentier, B., Dreux, C., Dubois, G., Duhamel, J.-F., Flahault, A., Huguier, M., Jaffiol, C., Lecomte, D., Mantz, J.-M., Mattéi, J.-F., Nicolas, G., Olié, J.-P., Rouëssé, J., Safavian, A., Salle, B., Spira, A., Touitou, Y., Vacheron, A., Blanchet, F., Chast, F., Gobert, J.-G., Trivin, F., Vigneron, C., Wautier, J.-L., Brugère, H., Girard, M., Laplace, J.-P., Maugendre, M.N., Haidoux, C., and Dreux, Claude

Published
2014
Full Text
View/download PDF

24. Familial cavernous malformations in a large French kindred: mapping of the gene to the CCM1 locus on chromosome 7q.

Author

Notelet, L., Chapon, F., Khoury, S., Vahedi, K., Chodkiewicz, J. P., Courtheoux, P., Iba-Zizen, M. T., Cabanis, E. A., Lechevalier, B., Tournier-Lasserve, E., and Houtteville, J. P.

Abstract

Objectives: To characterise clinically a large French family affected with cerebral cavernomas and to check for linkage of this condition to chromosome 7.Methods: A family, originating from Normandy and in which five members had undergone surgery for cavernomas, was extended. All members older than 18 were studied clinically and by neuroimaging. Genetic linkage analysis was conducted using 11 polymorphic microsatellite markers located between D7S502 and D7S479.Results: The family included three generations. Among the 25 members investigated, 11 had an abnormal cerebral MRI, eight of them being symptomatic, and 12 were asymptomatic with a normal MRI. The status of the two remaining members could not be established on the basis of clinical and MRI data. The family reported shares some striking features with other previously linked families--namely, a high clinical penetrance and the presence of multiple lesions within most of the affected members. A lod score of 4.04 was obtained with marker D7S657 with no recombinant. Significant lod scores were also obtained with D7S524 (Zmax=3.32 at 0=0.00) and D7S630 (Zmax=3.44 at 0=0.00). These results establish linkage of the condition found in this family to chromosome 7. Haplotype analysis strongly suggests that the gene is telomeric to D7S802 and centromeric to D7S479.Conclusions: These data confirm linkage of cerebral cavernous malformations to chromosome 7 in a non-Hispanic family. [ABSTRACT FROM AUTHOR]

Published
1997

25. Therapeutic effect of mitoxantrone combined with methylprednisolone in multiple sclerosis: a randomised multicentre study of active disease using MRI and clinical criteria.

Author

Edan, G, Miller, D, Clanet, M, Confavreux, C, Lyon-Caen, O, Lubetzki, C, Brochet, B, Berry, I, Rolland, Y, Froment, J C, Cabanis, E, Iba-Zizen, M T, Gandon, J M, Lai, H M, Moseley, I, and Sabouraud, O

Subjects
MULTIPLE sclerosis diagnosis, AMENORRHEA, BALDNESS, IMMUNOMODULATORS, COMBINATION drug therapy, COMPARATIVE studies, LEUCOPENIA, LONGITUDINAL method, MAGNETIC resonance imaging, RESEARCH methodology, MEDICAL cooperation, MULTIPLE sclerosis, RESEARCH, EVALUATION research, RANDOMIZED controlled trials, MITOXANTRONE, METHYLPREDNISOLONE
Abstract

Objective: To evaluate the efficiency of mitoxantrone in multiple sclerosis.Methods: Forty two patients with confirmed multiple sclerosis, selected as having a very active disease on clinical and MRI criteria were randomised to receive either mitoxantrone (20 mg intravenously (IV) monthly) and methylprednisolone (1 g iv monthly) or methylprednisolone alone over six months. In the steroid alone group five patients dropped out due to severe exacerbation.Results: Blinded analysis of MRI data showed significantly more patients with no new enhancing lesions in the mitoxantrone group compared with the steroid alone group, (90% v 31%, P < 0.001). In the mitoxantrone group there was a month by month decrease almost to zero in the number of new enhancing lesions, and in the total number of enhancing lesions, whereas both remained high in the steroid alone group. The differences were significant for both indices at all months from 1-6. Unblinded clinical assessments showed a significant improvement in change in EDSS at months 2-6 in the mitoxantrone group, with a final mean improvement of more than one point (-1.1 v + 0.3; P < 0.001). There was a significant reduction in the number of relapses (7 v 31; P < 0.01), and an increase in the number of patients free of exacerbation (14 v 7; P < 0.05).Conclusion: In this selected group of patients with multiple sclerosis with very active disease, mitoxantrone combined with methylprednisolone was effective in improving both clinical and MRI indices of disease activity over a period of six months whereas methylprednisolone alone was not. Further double blinded long term studies are needed to properly evaluate the effect of mitoxantrone on progression in disability. [ABSTRACT FROM AUTHOR]

Published
1997

26. Location of the human posterior eye field with functional magnetic resonance imaging.

Author

Müri, R M, Iba-Zizen, M T, Derosier, C, Cabanis, E A, and Pierrot-Deseilligny, C

Abstract

The frontal eye field and parietal eye field are known to be involved during visually guided saccades. As the location of the human parietal eye field is not yet well known, functional MRI was used during such a saccade task to better localise this field. Besides activity in visual areas of the occipital cortex, bilateral activity was seen in the precentral sulcus, corresponding to the frontal eye field, and in the deep region of the intraparietal sulcus. It is suggested that this intraparietal area, bordering areas 39 and 40 of Brodmann, corresponds to the human parietal eye field. [ABSTRACT FROM AUTHOR]

Published
1996

31. Tomographic measurement of cerebral blood flow by the Ga-labelled-microsphere and continuous-CO-inhalation methods.

Author

Steinling, M., Baron, J., Maziere, B., Lasjaunias, P., Loc'h, C., Cabanis, E., and Guillon, B.

Abstract

The measurement of cerebral blood flow (CBF) by continuous CO inhalation has only been validated previously by indirect experimental protocols. In the present study using baboons, these measurements were compared directly with those obtained by injection of Ga-labelled serum-albumin microspheres in the left cardiac ventricle. Using a modified labelling technique, no elution of Ga occurred in vivo. Both methods provided similar regional CBF values, which could be described by a significant linear correlation ( $$CBF_{CO_2 }$$ =0.82 CBF+5.7; P<0.001). The validity of the labelled-microsphere-injection method was verified. The feasibility of stable in vivo labelling of Ga to serum-albumin microspheres provides a reference method for organ blood-flow measurements using positron-emission tomography. [ABSTRACT FROM AUTHOR]

Published
1985
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results