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High-quality scientific research papers need the support of correct and rigorous statistical methods. However, many papers in transfusion medicine research have problems with the improper use of statistical methods. This paper starts from the transfusion medicine related papers published in China in recent years, summarizes and analyzes common problems in the use of statistics from the aspects of research data type description, statistical method selection, statistical result interpretation and statistical content writing, and discusses possible solutions to provide certain references for the writing of research papers in transfusion medicine. more...

[Objective] To investigate the role of ASPN in the development of keloid and the underlying mechanisms. [Methods] Immunofluorescence staining was used to assess the expression levels of ASPN in keloid of keloid patients and normal scar. WB and qRT-PCR were used to assess the activity of TGF-β pathway and expression levels of α-SMA、Collagen Ⅰ/Ⅲ, COMP and POSTN in fibroblasts with overexpression of ASPN, ASPN-treated fibroblasts and Keloid fibroblasts with ASPN knockdown. Moreover, wound healing was observed in C57BL/6J mice treated with or without ASPN at 0 d, 3 d, 7 d, and 14 d after wound. The expression levels of α-SMA、Collagen Ⅰ/Ⅲ and TGF-β in the wounded skin were assessed by immunofluorescence staining 14 days after wound. [Results] ASPN was highly expressed in keloid fibroblasts. The expression levels of α-SMA、Collagen Ⅰ/Ⅲ、COMP and POSTN were significantly increased, and the TGF-β signaling pathway was activated in fibroblasts after either overexpression of or stimulation with ASPN (P more...

In recent years, the Chinese education and training market has experienced significant growth, but the excessive academic pressure on students and the disorderly expansion of the training industry have led to the implementation of the “double reduction” policy. This article analyzes the impact of the “double reduction” policy on the Chinese education and training market, and explores the reasons for the sharp decline in market size and the transformation of business models. Research has found that after policy implementation, the market size sharply shrinks, and many training institutions face pressure to close or reduce their scale. Large training institutions are also facing challenges and need to re-examine their business layout, close some branch campuses, and lay off employees to reduce costs. In terms of business model transformation, the “double reduction” policy has prompted educational institutions to undergo profound transformation. Online education is restricted, and institutions must re plan their online business development blueprint, adjust course schedules, optimize course content, and explore diversified business models. Blended learning mode has become an important exploration direction for educational institutions, emphasizing the provision of high-quality educational services and valuing the cultivation of students’ thinking ability, innovation ability, and comprehensive quality. Looking ahead, although the “double reduction” policy has brought short-term impacts to the education and training market, in the long run, it has positive and far-reaching significance for the Chinese education and training market. The market will continue to explore and innovate, moving towards a more scientific, diversified, and sustainable development path. more...

A convenient aerobic oxidative hydroxylation of 3-substituted oxindoles under mild reaction conditions is described herein. This process was accomplished by the activation of molecular oxygen in the air in the presence of a photocatalyst under the irradiation of visible light. The desired product was delivered in up to 89% yield without the addition of base or stoichiometric oxidant. more...

In this paper, the removal of 2,4,6-trichlorophenol (2,4,6-TCP) by synthesized Ni/Fe nanoparticles were investigated. At the same time, the factors, such as the dosage of Ni/Fe, Ni content in Ni/Fe nanoparticles, sulfate ion, HA, coexisting substances in water which affected the removal of 2,4,6-TCP by synthesized Ni/Fe nanoparticles were also investigated. Under the experimental conditions, the removal efficiency of 2,4,6-TCP by Ni/Fe nanoparticles in water was about 72% for 2 h. The dosage of Ni/Fe, Ni content in Ni/Fe nanoparticles, and Fe3+ all promoted the dechlorination reaction of 2,4,6-TCP by Ni/Fe nanoparticles. Sulfate, oxalic acid and citric acid played an inhibitory role on the removal of 2,4,6-TCP by Ni/Fe nanoparticles in water. Fe2+ had no obvious affect to the removal of 2,4,6-TCP by Ni/Fe nanoparticles in water. In addition, low initial HA concentration was favorable for the removal of 2,4,6-TCP by Ni/Fe nanoparticles, while high concentrations of HA played an inhibitory role. more...