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1. Detection of HHV-5 HHV-6a HHV-6b and HHV-7 in the urine: potential use as a non-invasive diagnostic tool for immune profiling

Author

Govind, Shelia, Lang, Pierre Olivier, Bürkle, Alexander, Moreno-Villanueva, María, Franceschi, Claudio, Capri, Miriam, Bernard, Jurgen, Weinberger, Birgit, Grubeck-Loebenstein, Beatrix, Fiegl, Simone, Gonos, Efstathios S., Sikora, Ewa, Jansen, Eugène, Dollé, Martijn E. T., Grune, Tilman, Breusing, Nicolle, and Aspinall, Richard

Published
2024
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2. Machine learning for precision diagnostics of autoimmunity

Author

Kruta, Jan, Carapito, Raphael, Trendelenburg, Marten, Martin, Thierry, Rizzi, Marta, Voll, Reinhard E., Cavalli, Andrea, Natali, Eriberto, Meier, Patrick, Stawiski, Marc, Mosbacher, Johannes, Mollet, Annette, Santoro, Aurelia, Capri, Miriam, Giampieri, Enrico, Schkommodau, Erik, and Miho, Enkelejda

Published
2024
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3. Associations of circulating GDF15 with combined cognitive frailty and depression in older adults of the MARK-AGE study

Author

Kochlik, Bastian, Herpich, Catrin, Moreno-Villanueva, María, Klaus, Susanne, Müller-Werdan, Ursula, Weinberger, Birgit, Fiegl, Simone, Toussaint, Olivier, Debacq-Chainiaux, Florence, Schön, Christiane, Bernhard, Jürgen, Breusing, Nicolle, Gonos, Efstathios S., Franceschi, Claudio, Capri, Miriam, Sikora, Ewa, Hervonen, Antti, Hurme, Mikko, Slagboom, P. Eline, Dollé, Martijn E. T., Jansen, Eugene, Grune, Tilman, Bürkle, Alexander, and Norman, Kristina

Published
2024
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4. Development and validation of cardiometabolic risk predictive models based on LDL oxidation and candidate geromarkers from the MARK-AGE data

Author

Valeanu, Andrei, Margina, Denisa, Weber, Daniela, Stuetz, Wolfgang, Moreno-Villanueva, María, Dollé, Martijn E.T., Jansen, Eugène HJM, Gonos, Efstathios S., Bernhardt, Jürgen, Grubeck-Loebenstein, Beatrix, Weinberger, Birgit, Fiegl, Simone, Sikora, Ewa, Mosieniak, Grazyna, Toussaint, Olivier, Debacq-Chainiaux, Florence, Capri, Miriam, Garagnani, Paolo, Pirazzini, Chiara, Bacalini, Maria Giulia, Hervonen, Antti, Slagboom, P. Eline, Talbot, Duncan, Breusing, Nicolle, Frank, Jan, Bürkle, Alexander, Franceschi, Claudio, Grune, Tilman, and Gradinaru, Daniela

Published
2024
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5. The Onset of Type 2 Diabetes: Proposal for a Multi-Scale Model

Author

Castiglione, Filippo, Tieri, Paolo, De Graaf, Albert, Franceschi, Claudio, Liò, Pietro, Van Ommen, Ben, Mazzà, Claudia, Tuchel, Alexander, Bernaschi, Massimo, Samson, Clare, Colombo, Teresa, Castellani, Gastone C, Capri, Miriam, Garagnani, Paolo, Salvioli, Stefano, Nguyen, Viet Anh, Bobeldijk-Pastorova, Ivana, Krishnan, Shaji, Cappozzo, Aurelio, Sacchetti, Massimo, Morettini, Micaela, and Ernst, Marc

Subjects
Medicine, Computer applications to medicine. Medical informatics, R858-859.7
Abstract

BackgroundType 2 diabetes mellitus (T2D) is a common age-related disease, and is a major health concern, particularly in developed countries where the population is aging, including Europe. The multi-scale immune system simulator for the onset of type 2 diabetes (MISSION-T2D) is a European Union-funded project that aims to develop and validate an integrated, multilevel, and patient-specific model, incorporating genetic, metabolic, and nutritional data for the simulation and prediction of metabolic and inflammatory processes in the onset and progression of T2D. The project will ultimately provide a tool for diagnosis and clinical decision making that can estimate the risk of developing T2D and predict its progression in response to possible therapies. Recent data showed that T2D and its complications, specifically in the heart, kidney, retina, and feet, should be considered a systemic disease that is sustained by a pervasive, metabolically-driven state of inflammation. Accordingly, there is an urgent need (1) to understand the complex mechanisms underpinning the onset of this disease, and (2) to identify early patient-specific diagnostic parameters and related inflammatory indicators. ObjectiveWe aim to accomplish this mission by setting up a multi-scale model to study the systemic interactions of the biological mechanisms involved in response to a variety of nutritional and metabolic stimuli and stressors. MethodsSpecifically, we will be studying the biological mechanisms of immunological/inflammatory processes, energy intake/expenditure ratio, and cell cycle rate. The overall architecture of the model will exploit an already established immune system simulator as well as several discrete and continuous mathematical methods for modeling of the processes critically involved in the onset and progression of T2D. We aim to validate the predictions of our models using actual biological and clinical data. ResultsThis study was initiated in March 2013 and is expected to be completed by February 2016. ConclusionsMISSION-T2D aims to pave the way for translating validated multilevel immune-metabolic models into the clinical setting of T2D. This approach will eventually generate predictive biomarkers for this disease from the integration of clinical data with metabolic, nutritional, immune/inflammatory, genetic, and gut microbiota profiles. Eventually, it should prove possible to translate these into cost-effective and mobile-based diagnostic tools.

Published
2013
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6. Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort

Author

Schoissengeier, Vanessa, Maqboul, Lina, Weber, Daniela, Grune, Tilman, Bürkle, Alexander, Moreno-Villaneuva, Maria, Franceschi, Claudio, Capri, Miriam, Bernhard, Jürgen, Toussaint, Olivier, Debacq-Chainiaux, Florence, Weinberger, Birgit, Gonos, Efstathios S., Sikora, Ewa, Dollé, Martijn, Jansen, Eugène, Slagboom, P. Eline, Hervonnen, Antti, Hurme, Mikko, Breusing, Nicolle, Frank, Jan, Bulmer, Andrew C., and Wagner, Karl-Heinz

Published
2024
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7. Biomarkers of aging in frailty and age-associated disorders: State of the art and future perspective

Author

Salvioli, Stefano, Basile, Maria Sofia, Bencivenga, Leonardo, Carrino, Sara, Conte, Maria, Damanti, Sarah, De Lorenzo, Rebecca, Fiorenzato, Eleonora, Gialluisi, Alessandro, Ingannato, Assunta, Antonini, Angelo, Baldini, Nicola, Capri, Miriam, Cenci, Simone, Iacoviello, Licia, Nacmias, Benedetta, Olivieri, Fabiola, Rengo, Giuseppe, Querini, Patrizia Rovere, and Lattanzio, Fabrizia

Published
2023
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8. Circulating cell-free DNA in health and disease — the relationship to health behaviours, ageing phenotypes and metabolomics

Author

Kananen, Laura, Hurme, Mikko, Bürkle, Alexander, Moreno-Villanueva, Maria, Bernhardt, Jürgen, Debacq-Chainiaux, Florence, Grubeck-Loebenstein, Beatrix, Malavolta, Marco, Basso, Andrea, Piacenza, Francesco, Collino, Sebastiano, Gonos, Efstathios S., Sikora, Ewa, Gradinaru, Daniela, Jansen, Eugene H. J. M., Dollé, Martijn E. T., Salmon, Michel, Stuetz, Wolfgang, Weber, Daniela, Grune, Tilman, Breusing, Nicolle, Simm, Andreas, Capri, Miriam, Franceschi, Claudio, Slagboom, Eline, Talbot, Duncan, Libert, Claude, Raitanen, Jani, Koskinen, Seppo, Härkänen, Tommi, Stenholm, Sari, Ala-Korpela, Mika, Lehtimäki, Terho, Raitakari, Olli T., Ukkola, Olavi, Kähönen, Mika, Jylhä, Marja, and Jylhävä, Juulia

Published
2023
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12. Association Between TTV Viremia, Chronic Inflammation, and Ischemic Heart Disease Risk: Insights From MARK-AGE and Report-Age Projects.

Author

Giacconi, Robertina, Piacenza, Francesco, Maggi, Fabrizio, Bürkle, Alexander, Moreno-Villanueva, María, Mancinelli, Lucia, Spezia, Pietro Giorgio, Novazzi, Federica, Ferrante, Francesca Drago, Minosse, Claudia, Grossi, Paolo Antonio, Mancini, Nicasio, Cecati, Monia, Dollé, Martijn E T, Jansen, Eugène, Grune, Tilman, Gonos, Efstathios S, Franceschi, Claudio, Capri, Miriam, and Weinberger, Birgit

Subjects
MYOCARDIAL ischemia, CORONARY disease, OLDER people, DNA methylation, COPPER
Abstract

The implication of Torquetenovirus (TTV) in ischemic heart disease (IHD) has not been thoroughly explored. This study investigated the association between TTV viremia, pro-inflammatory cytokines, and IHD risk in an aging population. This cross-sectional study included 900 non-IHD subjects and 86 individuals with IHD (aged 55–75 years) selected from the MARK-AGE project. Results were verified in another independent Report-Age cohort, including 94 inpatients with chronic IHD and 111 inpatients with non-IHD (aged 65–96 years). Multivariable logistic regression in the MARK-AGE cohort revealed that male sex, TTV viremia ≥4log, Cu/Zn ratio, diabetes, hypertension, and smoking were significant IHD predictors. Notably, TTV viremia ≥4log independently increased the IHD risk (odds ratio [OR]: 2.51, 95% confidence interval [CI]: 1.42–4.43), confirmed in the Report-Age cohort (OR: 4.90, 95% CI: 2.32–10.39). In a RASIG subgroup, individuals with TTV viremia ≥4 log, both with and without IHD, exhibited increased plasma pro-inflammatory cytokine levels (IFN-γ, IL-1β, IL-6, IL-10, IL-12p70, TNF-α) compared to those with TTV viremia <4 log. No significant difference in cytokine production was observed between IHD patients and non-IHD with TTV viremia ≥4 log. A positive correlation between TTV viremia and DNA methylation estimator of leukocyte telomere length was observed in Report-Age patients. Additionally, IHD Report-Age patients with TTV viremia ≥4 log displayed higher NLR and SIRI index than those with TTV viremia <4 log. In conclusion, a high TTV viremia is associated with an elevated IHD risk in the older population, potentially arising from an augmented pro-inflammatory response and immunosenescence. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Do low molecular weight antioxidants contribute to the Protection against oxidative damage? The interrelation between oxidative stress and low molecular weight antioxidants based on data from the MARK-AGE study

Author

Pinchuk, Ilya, Kohen, Ron, Stuetz, Wolfgang, Weber, Daniela, Franceschi, Claudio, Capri, Miriam, Hurme, Mikko, Grubeck-Loebenstein, Beatrix, Schön, Christiane, Bernhardt, Jürgen, Debacq-Chainiaux, Florence, Dollé, Martijn E.T., Jansen, Eugène H.J.M., Gonos, Efstathios S., Sikora, Ewa, Breusing, Nicolle, Gradinaru, Daniela, Moreno-Villanueva, María, Bürkle, Alexander, Grune, Tilman, and Lichtenberg, Dov

Published
2021
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15. Ageing affects subtelomeric DNA methylation in blood cells from a large European population enrolled in the MARK-AGE study

Author

Bacalini, Maria Giulia, Reale, Anna, Malavolta, Marco, Ciccarone, Fabio, Moreno-Villanueva, María, Dollé, Martijn E. T., Jansen, Eugène, Grune, Tilman, Gonos, Efstathios S., Schön, Christiane, Bernhardt, Jürgen, Grubeck-Loebenstein, Beatrix, Sikora, Ewa, Toussaint, Olivier, Debacq-Chainiaux, Florence, Capri, Miriam, Hervonen, Antti, Hurme, Mikko, Slagboom, P. Eline, Breusing, Nicolle, Aversano, Valentina, Tagliatesta, Stefano, Franceschi, Claudio, Blasco, Maria A., Bürkle, Alexander, Caiafa, Paola, and Zampieri, Michele

Published
2021
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16. Physical activity and cardiometabolic risk factors in sprint and jump-trained masters athletes, young athletes and non-physically active men.

Author

Rittweger, Jörn, Sies, Wolfram, Capri, Miriam, and Pesta, Dominik

Subjects
PHYSICAL activity, SPRINTING, LIPID metabolism, C-reactive protein, GLUCOSE metabolism
Abstract

Assessing physical activity and cardiometabolic risk in masters athletes as an example of very high physical activity at old age. Forty-three men were studied in full factorial design, either as sprint or jump-trained masters athletes (MA, n=10, age 60–75 years), as young sprint or jump-trained athletes (YA, n=10, age 20–35 years), older control participants (OC, n=11, age 60–75 years) or as young control participants (AC, n=12, age 20–35 years). We performed bio-electrical impedance analysis and assessed serum markers of lipids and glucose metabolism and C-reactive protein, structured training hours, and habitual activity via mobile actimetry. Body fat was greater in OC than in MA (23.9 [SD 4.2] % vs. 14.0 [SD 5.7] %, p<0.001), and also greater than in YA and YC (both p<0.001). Weekly training hours were comparable between MA and YA (7.9 [SD3.3] hours vs. 11.1 [SD 4.8] hours, p=0.69). Habitual walking distance was greater in MA than in OC (7,387 [SD 4,923] m/day vs. 4,110 [SD 1,772] m/day, p=0.039), and so was habitual running distance (667 [SD690] m/day vs. 132 [427] m/day, p<0.001). HOMA-index was greater in OC than in MA (2.07 [SD 1.39] vs. 0.80 [SD 0.41], p=0.0039), and so was C-reactive protein (1.35 [SD 1.74] mg/l vs. 0.58 [SD 0.27] mg/ml, p=0.018), whereas serum lipids showed only moderate or no effect (all p between 0.036 and 0.07). Improved body composition and physical activity levels in MA are associated with lower cardiometabolic risk, which seems more pronounced for insulin sensitivity and inflammaging than for lipid metabolism. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Circulating CXCL9, monocyte percentage, albumin, and C-reactive protein as a potential, non-invasive, molecular signature of carotid artery disease in 65+ patients with multimorbidity: a pilot study in Age.It.

Author

Capri, Miriam, Fronterrè, Sara, Collura, Salvatore, Giampieri, Enrico, Carrino, Sara, Feroldi, Francesca Maria, Ciurca, Erika, Conte, Maria, Olivieri, Fabiola, Ullo, Ines, Pini, Rodolfo, Vacirca, Andrea, Astolfi, Annalisa, Vasuri, Francesco, La Manna, Gaetano, Pasquinelli, Gianandrea, and Gargiulo, Mauro

Subjects
CAROTID artery diseases, CAROTID artery stenosis, ASYMPTOMATIC patients, RECEIVER operating characteristic curves, VASCULAR surgery
Abstract

Background: Carotid endarterectomy (CEA) for the prevention of upcoming vascular and cerebral events is necessary in patients with high-grade stenosis (=70%). In the framework of the Italian National project Age.It, a pilot study was proposed aiming at the discovery of amolecular signature with predictive potential of carotid stenosis comparing 65+ asymptomatic and symptomatic inpatients. Methods: A total of 42 inpatients have been enrolled, including 26 men and 16 women, with a mean age of 74 ± 6 years. Sixteen symptomatic and 26 asymptomatic inpatients with =70% carotid stenosis underwent CEA, according to the recommendations of the European Society for Vascular Surgery and the Society for Vascular Surgeons. Plaque biopsies and peripheral blood samples from the same individuals were obtained. Hematobiochemical analyses were conducted on all inpatients, and plasma cytokines/molecules, such as microRNAs (miRs), IL-6, sIL-6Ralpha, sgp130, myostatin (GDF8), follistatin, activin A, CXCL9, FGF21, and fibronectin, were measured using the ELISA standard technique. MiR profiles were obtained in the discovery phase including four symptomatic and four asymptomatic inpatients (both plasma and plaque samples), testing 734 miRs. MiRs emerging from the profiling comparison were validated through RT-qPCR analysis in the total cohort. Results and conclusion: The two groups of inpatients differ in the expression levels of blood c-miRs-126-5p and -1271-5p (but not in their plaques), which are more expressed in symptomatic subjects. Three cytokines were significant between the two groups: IL-6, GDF8, and CXCL9. Using receiver operating characteristic (ROC) analysis with a machine learning-based approach, the most significant blood molecular signature encompasses albumin, C-reactive protein (CRP), the percentage of monocytes, and CXCL9, allowing for the distinction of the two groups (AUC = 0.83, 95% c.i. [0.85, 0.81], p = 0.0028). The potential of the molecular signature will be tested in a second cohort of monitored patients, allowing the application of a predictive model and the final evaluation of cost/benefit for an assessable screening test. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Distinct profile of CD34+ cells and plasma-derived extracellular vesicles from triple-negative patients with Myelofibrosis reveals potential markers of aggressive disease

Author

Forte, Dorian, Barone, Martina, Morsiani, Cristina, Simonetti, Giorgia, Fabbri, Francesco, Bruno, Samantha, Bandini, Erika, Sollazzo, Daria, Collura, Salvatore, Deregibus, Maria Chiara, Auteri, Giuseppe, Ottaviani, Emanuela, Vianelli, Nicola, Camussi, Giovanni, Franceschi, Claudio, Capri, Miriam, Palandri, Francesca, Cavo, Michele, and Catani, Lucia

Published
2021
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22. Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study

Author

Santoro, Aurelia, Guidarelli, Giulia, Ostan, Rita, Giampieri, Enrico, Fabbri, Cristina, Bertarelli, Claudia, Nicoletti, Claudio, Kadi, Fawzi, de Groot, Lisette C. P. G. M., Feskens, Edith, Berendsen, Agnes, Brzozowska, Anna, Januszko, Olga, Kozlowska, Katarzyna, Fairweather-Tait, Susan, Jennings, Amy, Meunier, Nathalie, Caumon, Elodie, Napoli, Alessandro, Mercatelli, Daniele, Battista, Giuseppe, Capri, Miriam, Franceschi, Claudio, and Bazzocchi, Alberto

Published
2019
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29. Heterogeneity and Differentiation of the Human Arterial Tree: Focus on microRNA Expression in Vascular Disease.

Author

Ciavarella, Carmen, Motta, Ilenia, Capri, Miriam, Gargiulo, Mauro, and Pasquinelli, Gianandrea

Subjects
GENE expression, VASCULAR diseases, FRAIL elderly, MICRORNA, HETEROGENEITY
Abstract

Human arteries show structural and functional peculiarities according to the nutrient and oxygen needs of a specific vascular district. This architectural heterogeneity is reflected in the pathological setting of cardiovascular diseases (CVDs). Indeed, the responsiveness to cardiovascular risk factors, and the morphological and molecular patterns are discriminating factors among CVDs affecting different vascular beds. MicroRNAs (miRNAs) are endogenous regulators of gene expression and fine-tuners of vascular cell differentiation; thus, these non-coding RNAs can modulate arterial heterogeneity. The identification of an artery-specific miRNA signature would be promising in the therapy of CVDs, especially in patients who are frail and elderly. In the present review, we will provide a concise description of the arterial tree heterogeneity on a structural and cellular basis, mainly in the pathological context. Secondly, we will address the miRNA potential as crucial mediators of arterial heterogeneity, focusing on the abdominal aorta and femoral artery, with the final goal of strengthening the search for more targeted therapies in CVDs and stratification approaches in patients who are frail and elderly. [ABSTRACT FROM AUTHOR]

Published
2024
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30. The expression pattern of GDF15 in human brain changes during aging and in Alzheimer’s disease

Author

Chiariello, Antonio, Valente, Sabrina, Pasquinelli, Gianandrea, Baracca, Alessandra, Sgarbi, Gianluca, Solaini, Giancarlo, Medici, Valentina, Fantini, Valentina, Poloni, Tino Emanuele, Tognocchi, Monica, Arcaro, Marina, Galimberti, Daniela, Franceschi, Claudio, Capri, Miriam, Salvioli, Stefano, Conte, Maria, Chiariello, Antonio, Valente, Sabrina, Pasquinelli, Gianandrea, Baracca, Alessandra, Sgarbi, Gianluca, Solaini, Giancarlo, Medici, Valentina, Fantini, Valentina, Poloni, Tino Emanuele, Tognocchi, Monica, Arcaro, Marina, Galimberti, Daniela, Franceschi, Claudio, Capri, Miriam, Salvioli, Stefano, and Conte, Maria

Subjects
Aging, GDF15, inflammation, Cognitive Neuroscience, mitochondrial dysfunction, Alzheimer’s disease
Abstract

IntroductionGrowth Differentiation Factor 15 (GDF15) is a mitochondrial-stress-responsive molecule whose expression strongly increases with aging and age-related diseases. However, its role in neurodegenerative diseases, including Alzheimer’s disease (AD), is still debated.MethodsWe have characterized the expression of GDF15 in brain samples from AD patients and non-demented subjects (controls) of different ages.ResultsAlthough no difference in CSF levels of GDF15 was found between AD patients and controls, GDF15 was expressed in different brain areas and seems to be predominantly localized in neurons. The ratio between its mature and precursor form was higher in the frontal cortex of AD patients compared to age-matched controls (p p GDF15 and IL-6 mRNA levels was observed. Finally, when GDF15 was silenced in vitro in dermal fibroblasts, a decrease in OXPHOS complexes transcript levels and an increase in IL-6 levels were observed.DiscussionAlthough GDF15 seems not to be a reliable CSF marker for AD, it is highly expressed in aging and AD brains, likely as a part of stress response aimed at counteracting mitochondrial dysfunction and neuroinflammation.

Published
2023
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31. Regulatory T cells from patients with end-stage organ disease can be isolated, expanded and cryopreserved according good manufacturing practice improving their function

Author

Ulbar, Francesca, Montemurro, Tiziana, Jofra, Tatiana, Capri, Miriam, Comai, Giorgia, Bertuzzo, Valentina, Lavazza, Cristiana, Mandelli, Alessandra, Viganò, Mariele, Budelli, Silvia, Bacalini, Maria Giulia, Pirazzini, Chiara, Garagnani, Paolo, Giudice, Valeria, Sollazzo, Daria, Curti, Antonio, Arpinati, Mario, La Manna, Gaetano, Cescon, Matteo, Pinna, Antonio Daniele, Franceschi, Claudio, Battaglia, Manuela, Giordano, Rosaria, Catani, Lucia, and Lemoli, Roberto Massimo

Published
2019
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34. MARK-AGE population: From the human model to new insights

Author

Capri, Miriam, Moreno-Villanueva, María, Cevenini, Elisa, Pini, Elisa, Scurti, Maria, Borelli, Vincenzo, Palmas, Maria Giustina, Zoli, Marco, Schön, Christiane, Siepelmeyer, Anne, Bernhardt, Jürgen, Fiegl, Simone, Zondag, Gerben, de Craen, Anton J.M., Hervonen, Antti, Hurme, Mikko, Sikora, Ewa, Gonos, Efstathios S., Voutetakis, Konstantinos, Toussaint, Olivier, Debacq-Chainiaux, Florence, Grubeck-Loebenstein, Beatrix, Bürkle, Alexander, and Franceschi, Claudio

Published
2015
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35. MARK-AGE biomarkers of ageing

Author

Bürkle, Alexander, Moreno-Villanueva, María, Bernhard, Jürgen, Blasco, María, Zondag, Gerben, Hoeijmakers, Jan H.J., Toussaint, Olivier, Grubeck-Loebenstein, Beatrix, Mocchegiani, Eugenio, Collino, Sebastiano, Gonos, Efstathios S., Sikora, Ewa, Gradinaru, Daniela, Dollé, Martijn, Salmon, Michel, Kristensen, Peter, Griffiths, Helen R., Libert, Claude, Grune, Tilman, Breusing, Nicolle, Simm, Andreas, Franceschi, Claudio, Capri, Miriam, Talbot, Duncan, Caiafa, Paola, Friguet, Bertrand, Slagboom, P. Eline, Hervonen, Antti, Hurme, Mikko, and Aspinall, Richard

Published
2015
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40. Lifelong maintenance of composition, function and cellular/subcellular distribution of proteasomes in human liver

Author

Bellavista, Elena, Martucci, Morena, Vasuri, Francesco, Santoro, Aurelia, Mishto, Michele, Kloss, Alexander, Capizzi, Elisa, Degiovanni, Alessio, Lanzarini, Catia, Remondini, Daniel, Dazzi, Alessandro, Pellegrini, Sara, Cescon, Matteo, Capri, Miriam, Salvioli, Stefano, D’Errico-Grigioni, Antonia, Dahlmann, Burkhardt, Grazi, Gian Luca, and Franceschi, Claudio

Published
2014
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42. Combating inflammaging through a Mediterranean whole diet approach: The NU-AGE project's conceptual framework and design

Author

Fabbri, Cristina, Bertarelli, Claudia, Izzi, Massimo, Mazzocchi, Mario, Chardigny, Jean Michel, Morio, Beatrice, Rossi, Daniele, Notarfonso, Maurizio, O’Toole, Paul W., Cashman, Kevin, Carding, Simon R., Nicoletti, Claudio, Jacobs, Dirk, Xipsiti, Maria, Fernandez, Laura, Wills, Josephine, Irz, Xavier, Kuosmanen, Natalia, Gonos, Efstathios S., Voutetakis, Konstantinos, Salmon, Michael, Toussaint, Olivier, Traill, Bruce W., Nocella, Giuseppe, Caracciolo, Barbara, Xu, Weili, Mikko Ikonen, Tuure, Tuula, Brummer, Robert, Kadi, Fawzi, Breton, Sylvie, Triomphe, Marie, Magario, Guido, Villani, Filippo, Pancrazio, Annibale, Teufner, Brigitte, Stocker, Josef, Echevarría, Francisco Javier, Iglesias, Jose Ramón, Smrž, František, Krejcirova, Lucie, Koytsomitropoulou, Efthimia, Georgakidis, Konstantinos, Yornuk, Rezan, Ucar, Cihan, Van Ommen, Ben, Bouwman, Jildau, Collino, Sebastiano, Jankovics, Clara, Losó, Adrienn, de Vos, Willem, Fuentes, Susana, Commelin, Eric, Santoro, Aurelia, Pini, Elisa, Scurti, Maria, Palmas, Giustina, Berendsen, Agnes, Brzozowska, Anna, Pietruszka, Barbara, Szczecinska, Anna, Cano, Noël, Meunier, Nathalie, de Groot, C.P.G.M., Feskens, Edith, Fairweather-Tait, Susan, Salvioli, Stefano, Capri, Miriam, Brigidi, Patrizia, and Franceschi, Claudio

Published
2014
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46. Association of Torquetenovirus Viremia with Physical Frailty and Cognitive Impairment in Three Independent European Cohorts.

Author

Giacconi, Robertina, Laffon, Blanca, Costa, Solange, Teixeira-Gomes, Armanda, Maggi, Fabrizio, Macera, Lisa, Spezia, Pietro Giorgio, Piacenza, Francesco, Bürkle, Alexander, Moreno-Villanueva, María, Bonassi, Stefano, Valdiglesias, Vanessa, Teixeira, Joao Paulo, Dollé, Martijn E.T., Rietman, M. Liset, Jansen, Eugène, Grune, Tilman, Gonos, Efstathios S., Franceschi, Claudio, and Capri, Miriam

Subjects
FRAILTY, COGNITION disorders, VIREMIA, OLDER people, PORTUGUESE people
Abstract

Introduction: Immunosenescence and inflammaging have been implicated in the pathophysiology of frailty. Torquetenovirus (TTV), a single-stranded DNA anellovirus, the major component of the human blood virome, shows an increased replication rate with advancing age. An elevated TTV viremia has been associated with an impaired immune function and an increased risk of mortality in the older population. The objective of this study was to analyze the relation between TTV viremia, physical frailty, and cognitive impairment. Methods: TTV viremia was measured in 1,131 nonfrail, 45 physically frail, and 113 cognitively impaired older adults recruited in the MARK-AGE study (overall mean age 64.7 ± 5.9 years), and then the results were checked in two other independent cohorts from Spain and Portugal, including 126 frail, 252 prefrail, and 141 nonfrail individuals (overall mean age: 77.5 ± 8.3 years). Results: TTV viremia ≥4log was associated with physical frailty (OR: 4.69; 95% CI: 2.06–10.67, p < 0.0001) and cognitive impairment (OR: 3.49, 95% CI: 2.14–5.69, p < 0.0001) in the MARK-AGE population. The association between TTV DNA load and frailty status was confirmed in the Spanish cohort, while a slight association with cognitive impairment was observed (OR: 1.33; 95% CI: 1.000–1.773), only in the unadjusted model. No association between TTV load and frailty or cognitive impairment was found in the Portuguese sample, although a negative association between TTV viremia and MMSE score was observed in Spanish and Portuguese females. Conclusions: These findings demonstrate an association between TTV viremia and physical frailty, while the association with cognitive impairment was observed only in the younger population from the MARK-AGE study. Further research is necessary to clarify TTV's clinical relevance in the onset and progression of frailty and cognitive decline in older individuals. [ABSTRACT FROM AUTHOR]

Published
2023
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47. Uncovering the Relationship between Selenium Status, Age, Health, and Dietary Habits: Insights from a Large Population Study including Nonagenarian Offspring from the MARK-AGE Project.

Author

Giacconi, Robertina, Piacenza, Francesco, Aversano, Valentina, Zampieri, Michele, Bürkle, Alexander, Villanueva, María Moreno, Dollé, Martijn E. T., Jansen, Eugène, Grune, Tilman, Gonos, Efstathios S., Franceschi, Claudio, Capri, Miriam, Weinberger, Birgit, Sikora, Ewa, Toussaint, Olivier, Debacq-Chainiaux, Florence, Stuetz, Wolfgang, Slagboom, Pieternella Eline, Bernhardt, Jürgen, and Fernández-Sánchez, Maria Luisa

Abstract

An inadequate selenium (Se) status can accelerate the aging process, increasing the vulnerability to age-related diseases. The study aimed to investigate plasma Se and Se species in a large population, including 2200 older adults from the general population (RASIG), 514 nonagenarian offspring (GO), and 293 GO Spouses (SGO). Plasma Se levels in women exhibit an inverted U-shaped pattern, increasing with age until the post-menopausal period and then declining. Conversely, men exhibit a linear decline in plasma Se levels with age. Subjects from Finland had the highest plasma Se values, while those from Poland had the lowest ones. Plasma Se was influenced by fish and vitamin consumption, but there were no significant differences between RASIG, GO, and SGO. Plasma Se was positively associated with albumin, HDL, total cholesterol, fibrinogen, and triglycerides and negatively associated with homocysteine. Fractionation analysis showed that Se distribution among plasma selenoproteins is affected by age, glucometabolic and inflammatory factors, and being GO or SGO. These findings show that sex-specific, nutritional, and inflammatory factors play a crucial role in the regulation of Se plasma levels throughout the aging process and that the shared environment of GO and SGO plays a role in their distinctive Se fractionation. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Circulating miR-122-5p, miR-92a-3p, and miR-18a-5p as Potential Biomarkers in Human Liver Transplantation Follow-Up.

Author

Morsiani, Cristina, Collura, Salvatore, Sevini, Federica, Ciurca, Erika, Bertuzzo, Valentina Rosa, Franceschi, Claudio, Grazi, Gian Luca, Cescon, Matteo, and Capri, Miriam

Subjects
LIVER transplantation, BIOMARKERS, LIVER biopsy, PATIENT monitoring, MICRORNA
Abstract

The requirement of blood-circulating sensitive biomarkers for monitoring liver transplant (LT) is currently a necessary step aiming at the reduction of standard invasive protocols, such as liver biopsy. In this respect, the main objective of this study is to assess circulating microRNA (c-miR) changes in recipients' blood before and after LT and to correlate their blood levels with gold standard biomarkers and with outcomes such as rejection or complications after graft. An miR profile was initially performed; then, the most deregulated miRs were validated by RT-qPCR in 14 recipients pre- and post-LT and compared to a control group of 24 nontransplanted healthy subjects. MiR-122-5p, miR-92a-3p, miR-18a-5p, and miR-30c-5p, identified in the validation phase, were also analyzed considering an additional 19 serum samples collected from LT recipients and focusing on different follow-up (FU) times. The results showed significant, FU-related changes in c-miRs. In particular, miR-122-5p, miR-92a-3p, and miR-18a-5p revealed the same trend after transplantation and an increase in their level was found in patients with complications, independently from FU times. Conversely, the variations in the standard haemato-biochemical parameters for liver function assessment were not significant in the same FU period, confirming the importance of c-miRs as potential noninvasive biomarkers for monitoring patients' outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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