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Learners who learn from OER often cannot have their learning assessed or receive a credential. Open credentials offer a potential solution to this problem, combining badges or micro-credentials with competence frameworks and digital seals. This study identified the current situation of open credentials in post-secondary education in Europe, the main themes of the discourse, and the points of agreement and divergence surrounding them. The data comprised a corpus of transcriptions from 12 expert interviews and a focus group. Qualitative text analysis identified the principal themes. Findings included the following: (a) few assessments are available as open content; (b) linking OER and credentials requires detailed and expensive work on learning outcomes and assessment; (c) the aggregation of open credentials to create higher-level qualifications is a widely accepted ambition; (d) the European Union's infrastructure to support open credentials is appropriate and effective and can foster trust; (e) the outstanding challenges are organisational and practical, not technological; (f) assessment and content provisions should belong to separate organisational functions; and finally, (g) funding and support for open credentials in professional accreditation are essential for further progress.

Background Study: Several meta-analysis studies have investigated the effects of mobile learning on learning performance. However, limited attention has been paid to pedagogy in mobile learning, making quantitative evidence of the effects of pedagogical approaches on learning performance in mobile learning scarce. Filling this gap can therefore help stakeholders understand which mobile pedagogical approaches might work or not under which learning conditions, hence achieving better learning experience and performance. Objectives: To address this gap, this study conducted a meta-analysis and research synthesis of the effects of integrated pedagogical approaches on students' learning performance in mobile learning. Additionally, this study analysed the field of education, level of education, learning setting, sample size, and mobile device as moderating variables of the effect of pedagogical approaches. Methods: The software Comprehensive Meta-Analysis V.3 was used for this meta-analysis, where Hedges' g was calculated for the effect sizes. Specifically, 70 quantitative studies (N = 5575 participants) were coded and analysed. Results: The results indicate that pedagogical approaches in mobile learning have a large effect on students' learning performance (g = 0.93, p < 0.001). The most effective pedagogical approach was project-based learning (huge effect), while collaborative learning, situated learning and game-based learning had large effects. Finally, cognitive theory of multimedia learning and inquiry-based learning had medium effects. The results also indicate that the effect is moderated by the field of education, the level of education, the learning setting, the sample size, and the mobile device. Finally, it is found that study quality might influence the overall effect size. Conclusions: The findings of this study can be beneficial to both researchers and practitioners as they highlight and discuss which pedagogical approaches could be more effective in mobile learning under specific conditions. Further research, on the other hand, should focus on covering additional moderators of learning performance like mobile device type and screen size which is one of the limitations of this study.

In this article, ambassadors of the International Council for Open and Distance Education (ICDE) Open Educational Resources (OER) Advocacy Committee (OERAC) provide a snapshot of regional and global Open Educational Resources (OER)initiatives. This committee has been active since 2017 with membership renewed biannually. The ambassadors work to further OER awareness and understanding, to increase global recognition of OER, and provide policy support for the acceptance and application of OER. This overview highlights national and regional initiatives associated with the UNESCO OER recommendation and the five action areas that include: building capacity and leveraging OER; developing supporting policies; ensuring equity and effectiveness; encouraging sustainable OER model development; and, promoting and facilitating international collaboration. In addition, monitoring and evaluation of the action areas are suggested to be prioritized. This overview is not exhaustive, and much work remains to implement the OER Recommendation at scale, maximize its implementation, connect these recommendations to the United Nation's Sustainable Development Goals (SDGs), along with the futures of education with a new social contract for education, individuals, and the planet.

This paper reports the results of a narrative inquiry study on exchange programs, intercultural awareness, and professional development in eight former participants of the Fulbright Foreign Language Teaching Assistant--FLTA--program. This study used written narratives to collect data from eight participants of the FLTA scholarship program who belonged to the cohort 2017-2018. The results of this study showed that after being a FLTA, participants improved their English language skills; they became more aware of their teaching practices by implementing and adapting different teaching methodologies, they experienced cross-cultural interaction, and understood better cultural differences which really fostered their personal and professional development as English language teachers in their home countries.

The emergence of open educational resources (OER) represents one of the most significant educational developments in the 21st century. Given their capacity to be freely adapted, re-used, and shared in different contexts, OER expand the options for educators. This paper reports on an initial study concerning such choices in which educators' personalities are investigated in relation to the OER adoption. Choosing open approaches has been shown to correlate with personal attitudes and several studies have highlighted the potential and need for investigating how personality might affect OER adoption. To address this gap, this study investigates the impact of educators' personality differences in relation to OER adoption. The analysis focuses specifically on the perception towards OER and the intention to use OER using the Five-Factor Model (FFM) to identify educators' personalities. Following a mixed methods approach, data collected from university educators using questionnaires (57 respondents) and interviews (15 respondents) are discussed in a two-stage hierarchical regression analysis. Demographic variables (age and gender) do not show any significant relationship. Findings reveal that while the explored five personality dimensions do not have an impact on the educator attitudes towards OER, they seem to have a significant impact on their intention to use OER. Specifically, only three personality dimensions -- namely, extraversion, agreeableness, and openness -- have a significant impact on the intention to use OER. This shows that 'open attitude' (mixing extraversion, and agreeableness, and openness) may be a fundamental prerequisite for educators to engage in open teaching practices, including the use of OER.

In terms of scale, shock, and disenfranchisement, the disruption to formal education arising from COVID-19 has been unprecedented. Anecdotally, responses from teachers and educators around the world range from heightened caution to being inspired by distance education as the "new normal." Of all the challenges, face-to-face and formal teaching have been most heavily affected. Despite some education systems demonstrating resilience, a major challenge is sustaining quality and inclusiveness in formal education suddenly delivered at a distance. In probing these issues, this article profiles international perspectives on the role of open education in responding to the impact on formal school and higher education caused by the COVID-19 pandemic. We proceed by highlighting and analysing practices and case studies from 13 countries representing all global regions, identifying and discussing the challenges and opportunities that have presented themselves. Reports cover the period from the beginning of 2020 until 11 March 2021, the first anniversary of the COVID-19 outbreak as declared by the World Health Organization. In our comparative study, we identify seven key aspects of which three (missing infrastructure and sharing OER, open education and access to OER, and urgent need for professional development and training for teachers) are directly related to open education at a distance. After comparing examples of existing practice, we make recommendations and offer insights into how open education strategies can lead to interventions that are effective and innovative--to improve formal education at a distance in schools and universities in the future.

Abstract The projected winter changes of the North Atlantic eddy-driven jet (EDJ) under climate change conditions have been extensively analysed. Previous studies have reported a squeezed and elongated EDJ. However, other changes present large uncertainties, specifically those related to the intensity and latitude. Here, the projections of the EDJ in a multimodel ensemble of CMIP6 are scrutinised by using a multiparametric description of the EDJ. The multimodel mean projects non-stationary responses of the EDJ latitude through the winter, characterised by a poleward shift in early winter and equator migration in late winter. These intraseasonal shifts (rather than a genuine narrowing) explain the previously established squeezing of the EDJ and are linked to the future changes in different drivers: the 200 hPa meridional temperature gradient and Atlantic warming hole in early winter, and the stratospheric vortex in late winter. Model biases also influence EDJ projections, contributing to the poleward shift in early winter.

Abstract The Andean domesticated common beans (Phaseolus vulgaris) are significant sources of phenolic compounds associated with health benefits. However, the regulation of biosynthesis of these compounds during bean seed development remains unclear. To elucidate the gene expression patterns involved in the regulation of the flavonoid pathway, we conducted a transcriptome analysis of two contrasting Chilean varieties, Negro Argel (black bean) and Coscorron (white bean), at three developmental stages associated with seed color change, as well as different flavonoid compound accumulations. Our study reveals that phenolic compound synthesis initiates during seed filling, although it exhibits desynchronization between both varieties. We identified 10,153 Differentially Expressed Genes (DEGs) across all comparisons. The KEGG pathway ‘Flavonoid biosynthesis’ showed enrichment of induced DEGs in Negro Argel (PV172), consistent with the accumulation of delphinidin, petunidin, and malvidin hexosides in their seeds, while catechin glucoside, procyanidin and kaempferol derivatives were predominantly detected in Coscorrón (PV24). Furthermore, while the flavonoid pathway was active in both varieties, our results suggest that enzymes involved in the final steps, such as ANS and UGT, were crucial, inducing anthocyanin formation in Negro Argel. Additionally, during active anthocyanin biosynthesis, the accumulation of reserve proteins or those related to seed protection and germination was induced. These findings provide valuable insights and serve as a guide for plant breeding aimed at enhancing the health and nutritional properties of common beans.

Abstract The relative conservation of the influenza hemagglutinin (HA) stem compared to that of the immunodominant HA head makes the HA stem an attractive target for broadly protective influenza vaccines. Here we report the first-in-human, dose-escalation, open-label trial (NCT04579250) evaluating an unadjuvanted group 2 stabilized stem ferritin nanoparticle vaccine based on the H10 A/Jiangxi-Donghu/346/2013 influenza HA, H10ssF, in healthy adults. Participants received a single 20 mcg dose (n = 3) or two 60 mcg doses 16 weeks apart (n = 22). Vaccination with H10ssF was safe and well tolerated with only mild systemic and local reactogenicity reported. No serious adverse events occurred. Vaccination significantly increased homologous H10 HA stem binding and neutralizing antibodies at 2 weeks after both first and second vaccinations, and these responses remained above baseline at 40 weeks. Heterologous H3 and H7 binding antibodies also significantly increased after each vaccination and remained elevated throughout the study. These data indicate that the group 2 HA stem nanoparticle vaccine is safe and induces stem-directed binding and neutralizing antibodies.

Hydrogen (H2) is a highly efficient and clean energy source with the potential for renewable energy. The production of H2 from biological routes such as biophotolysis, photofermentation, dark fermentation, and bioelectrochemical production is characterized as a renewable alternative to current production, which is mainly based on energy-intensive electrochemical and thermochemical processes and responsible for the emission of high amounts of environmentally harmful compounds. Dark fermentation is the most efficient and cost-effective method for producing biohydrogen, making it a key research focus. This article offers a comprehensive overview of the dark fermentation process with the aim of enhancing hydrogen productivity and yields. Aspects related to the main substrates used, the inoculum sources and their pretreatment, and physical-chemical parameters of the process are covered. Furthermore, this manuscript addresses topics such as process integration, genetic and metabolic engineering of fermentative microorganisms, and the main types of bioreactors aimed at greater yields and productivity of biohydrogen to enable its production through dark fermentation on a larger scale.

Introduction: Preclinical and clinical evidence has elucidated that cannabis based medical formulations (CBMFs) may display anxiolytic, anti-depressive, and neuro-protective properties. CBMFs are often considered as novel therapeutic anxiolytic agents that can be prescribed as pharmacotherapy for symptomatic domains in anxiety disorders. Our aim was to explore effectiveness and tolerability of enriched cannabidiol (CBD) oil extract formulations in adults with anxiety symptoms in an outpatient mental health program in Colombia during the COIVD – 19 pandemic. Methods: We conducted an observational, retrospective, real world evidence (RWE) case-series at Zerenia Clinic in Bogotá, Colombia between June 2021 and December 2022. Our convenience sample consisted of people searching for CBMFs for the treatment of anxiety symptoms. A cohort of 24 adults was prescribed with enriched CBD in the form of non-sterile oral liquids suspended in sesame seed oil extracts unspecified anxiety disorder (UAD) and followed throughout the first year of treatment. Primary outcome measures established were the anxiety subscale in the hospital anxiety and depression scale (HADS – A), and the clinical global impression scale with regards to severity (CGI – S) at baseline, 6-month, and 12-month during follow-up. Secondary outcome measures established were HADS depression subscale (HADS – D) and the Epworth Sleepiness Scale (ESS) respectively. Results: After 6 months of treatment with sublingually administered enriched CBD oil extracts in a median dosage of 100mg, more than half (54.17%) of the sample continued to report significant anxiety symptoms. After 12 months, only 37.50% persisted with significant anxiety symptoms with a median dose of 120mgs of enriched CBD oil extracts. Similar subjective improvements were reported with regards to sleep disturbances (SDs) as a secondary outcome. At baseline, less than half (46,83%) of the sample reported significant daytime sleepiness. After 6-months of enriched CBD oil extract treatment, less than one third(29,17%) continued to report SDs. At end point, a high proportion of the sample (87.50%) were considered to have normal daytime sleepiness. No significant adverse–drug reactions or deaths were reported during the 12-month follow-up. Conclusions: Further research should determine the long-term efficacy, safety and appropriate dosages of enriched CBD oil extracts in treating specific anxiety disorders rather than broad and unspecified anxiety symptoms. The state of the art of MCBFs for anxiety disorders should be warranted and solidified through randomized controlled trials. The next stage for cannabis research should be focused in performing head-to-head trials comparing enriched CBD extracts or capsules versus first-line treatments proven to be effective in anxiety disorders.

Abstract Background Eclampsia and pre-eclampsia rank as the third leading causes of maternal death in Ecuador, following pre-existing chronic diseases and postpartum haemorrhage, as reported by the Ecuadorian National Institute of Statistics and Census (INEC). In contrast, HELLP (Haemolysis, Elevated Liver enzymes, Low Platelet count) syndrome remains underexplored epidemiologically, not only in Latin America but globally. This study marks the first population-based investigation into HELLP syndrome incidence and mortality in Ecuador, examining geographical variations, altitude influences and ethnic backgrounds. Methods Conducted as a retrospective population-based cohort study from 2015 to 2017, this research delves into the incidence, risk factors and maternal mortality associated with HELLP syndrome in Ecuador. Utilising data from INEC and the Ecuadorian Ministry of Health, we identified HELLP syndrome cases through ICD-10 (International Classification of Diseases, tenth revision) coding in hospitalised individuals. Logistic regression analysis was employed to explore association, whilst geospatial statistical analysis focused on cantons to identify significant spatial clusters. Primary outcome measures include HELLP syndrome incidence and maternal mortality, supplying crucial insights into the syndrome’s impact on maternal health in Ecuador. Results The incidence of HELLP syndrome is 0.76 (0.69–0.84)/ 1000 deliveries. Afro-Ecuadorian communities have a higher risk (Odds Ratio (OR) = 2.18 (1.03–4.63)) compared to Indigenous Ecuadorian communities. Living at mid-level or high altitude is a significant risk factor OR of 2.79 (2.19–3.55) and an OR 3.61 (2.58–5.03), respectively. Being an older mother was also identified as a risk factor. Women living more than 20 km from the obstetric unit have an OR of 2.55 (2.05–3.18). Moreover, we found that cantons with higher crude HELLP syndrome incidence also have lower numbers of physicians (R = 0.503, p-value

Patients with substance use disorders may view healthcare professionals as capable of supporting them through their suffering and experience. Although numerous studies have focused on the roles, approaches, and attitudes of healthcare professionals, there is a lack of information on the nursing perspective. This study aims to explore the experiences and nursing approaches towards patients with psychoactive substance dependence admitted to an Italian acute hospital ward. A qualitative phenomenological study was conducted. Data were collected using semi-structured face-to-face interviews. The interviews were transcribed, read thoroughly, and analysed. Fifteen nurses were interviewed. Six main themes were extracted: (1) origin context, (2) participants’ personal thoughts, (3) type of approach provided, (4) school education received on the topic, (5) effectiveness of rehabilitative therapy, and (6) methods that can improve nursing care. The findings suggest that most respondents experience stigma and discrimination when providing care to these patients. In response to the results obtained, models have been suggested, such as Jean Watson’s Human Caring Theory, which shows how practising a holistic approach based on empathy and active listening can improve the relationship between nurses and patients. Furthermore, to eliminate stereotypes, it would be appropriate to act on the university education of nurses. This study was not registered.

Abstract Obesity, a global health crisis, disrupts multiple systemic processes, contributing to a cascade of metabolic dysfunctions by promoting the pathological expansion of visceral adipose tissue (VAT). This expansion is characterized by impaired differentiation of pre-adipocytes and an increase in senescent cells, leading to a pro-inflammatory state and exacerbated oxidative stress. Particularly, the senescence-associated secretory phenotype (SASP) and adipose tissue hypoxia further impair cellular function, promoting chronic disease development. This review delves into the potential of autophagy modulation and the therapeutic application of senolytics and senomorphics as novel strategies to mitigate adipose tissue senescence. By exploring the intricate mechanisms underlying adipocyte dysfunction and the emerging role of natural compounds in senescence modulation, we underscore the promising horizon of senotherapeutics in restoring adipose health. This approach not only offers a pathway to combat the metabolic complications of obesity, but also opens new avenues for enhancing life quality and managing the global burden of obesity-related conditions. Our analysis aims to bridge the gap between current scientific progress and clinical application, offering new perspectives on preventing and treating obesity-induced adipose dysfunction.

Abstract Objective Obesity represents a significant global health challenge characterized by chronic low-grade inflammation and metabolic dysregulation. The hypothalamus, a key regulator of energy homeostasis, is particularly susceptible to obesity’s deleterious effects. This study investigated the role of the immunoproteasome, a specialized proteasomal complex implicated in inflammation and cellular homeostasis, during metabolic diseases. Methods The levels of the immunoproteasome β5i subunit were analyzed by immunostaining, western blotting, and proteasome activity assay in mice fed with either a high-fat diet (HFD) or a regular diet (CHOW). We also characterized the impact of autophagy inhibition on the levels of the immunoproteasome β5i subunit and the activation of the AKT pathway. Finally, through confocal microscopy, we analyzed the contribution of β5i subunit inhibition on mitochondrial function by flow cytometry and mitophagy assay. Results Using an HFD-fed obese mouse model, we found increased immunoproteasome levels in hypothalamic POMC neurons. Furthermore, we observed that palmitic acid (PA), a major component of saturated fats found in HFD, increased the levels of the β5i subunit of the immunoproteasome in hypothalamic neuronal cells. Notably, the increase in immunoproteasome expression was associated with decreased autophagy, a critical cellular process in maintaining homeostasis and suppressing inflammation. Functionally, PA disrupted the insulin-glucose axis, leading to reduced AKT phosphorylation and increased intracellular glucose levels in response to insulin due to the upregulation of the immunoproteasome. Mechanistically, we identified that the protein PTEN, a key regulator of insulin signaling, was reduced in an immunoproteasome-dependent manner. To further investigate the potential therapeutic implications of these findings, we used ONX-0914, a specific immunoproteasome inhibitor. We demonstrated that this inhibitor prevents PA-induced insulin-glucose axis imbalance. Given the interplay between mitochondrial dysfunction and metabolic disturbances, we explored the impact of ONX-0914 on mitochondrial function. Notably, ONX-0914 preserved mitochondrial membrane potential and attenuated mitochondrial ROS production in the presence of PA. Moreover, we found that ONX-0914 reduced mitophagy in the presence of PA. Conclusions Our findings strongly support the pathogenic involvement of the immunoproteasome in hypothalamic neurons in the context of HFD-induced obesity and metabolic disturbances. Targeting the immunoproteasome highlights a promising therapeutic strategy to mitigate the detrimental effects of obesity on the insulin-glucose axis and cellular homeostasis. This study provides valuable insights into the mechanisms driving obesity-related metabolic diseases and offers potential avenues for developing novel therapeutic interventions.

Literate programming and cloud-operated open literate educational resources (COOLERs) have been catching the attention of the education community in recent years. This set of learning materials mainly comprises digital notebook-like documents, which are stored, backed, and delivered from cloud services and eventually displayed in students' web browsers. As we demonstrate in this article, the advent of cloud architectures and the COVID-19 pandemic (which forced worldwide long-term distant academic environments) fortuitously teamed up with this learning and methodological trend by easing its use and fostering its adoption. With more detail, we have quantitatively measured the impact that the COOLER paradigm has had on the teaching realm by analyzing five years of logged data gathered by its current major player in the ecosystem: MyBinder. Among other results, we show how this growth in the production and delivery of notebooks made an important leap during the second SARS-CoV-2 wave (July-September 2020). However, the general usage trend seems to have strongly decreased after the end of the most recent seventh wave (September 2022), coinciding with the official end of the global health crisis and all the lockdown episodes. From these examined data, we conclude that COOLER and recent massive online learning scenarios have been very intimately linked. This fact may represent a flaw in the adoption of these exciting and useful learning materials.

Despite the recognition of the benefits that can be achieved through the use of Open Educational Resources (OER) and, more broadly, Open Educational Practices (OEP), there has been little research on the competences that are needed to enable educators to utilise such practices. To contribute to closing this gap, this paper presents a framework of the competences that educators in higher education should develop in order to effectively engage in OEP. The framework development was based on an in-depth analysis of a set of existing successful open teaching practices, which allowed to identify the underlying competences needed to engage in each one of them. The competence framework consists of one transversal attitude (that of being open to constructively engaging in OEP) and two competence categories (those relating to OER and those relating to open pedagogies). These two categories include a total of eight competences, described in detail through the corresponding knowledge and skills. The paper closes with a reflection on how to facilitate the attainment of these competences, that could become a key part of existing capacity building actions for educators at all levels, and suggests some directions for possible future research.