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458 results on '"Brown, Matthew P."'

2. A genome-wide association analysis reveals new pathogenic pathways in gout

Author

Major, Tanya J., Takei, Riku, Matsuo, Hirotaka, Leask, Megan P., Sumpter, Nicholas A., Topless, Ruth K., Shirai, Yuya, Wang, Wei, Cadzow, Murray J., Phipps-Green, Amanda J., Li, Zhiqiang, Ji, Aichang, Merriman, Marilyn E., Morice, Emily, Kelley, Eric E., Wei, Wen-Hua, McCormick, Sally P. A., Bixley, Matthew J., Reynolds, Richard J., Saag, Kenneth G., Fadason, Tayaza, Golovina, Evgenia, O’Sullivan, Justin M., Stamp, Lisa K., Dalbeth, Nicola, Abhishek, Abhishek, Doherty, Michael, Roddy, Edward, Jacobsson, Lennart T. H., Kapetanovic, Meliha C., Melander, Olle, Andrés, Mariano, Pérez-Ruiz, Fernando, Torres, Rosa J., Radstake, Timothy, Jansen, Timothy L., Janssen, Matthijs, Joosten, Leo A. B., Liu, Ruiqi, Gaal, Orsolya I., Crişan, Tania O., Rednic, Simona, Kurreeman, Fina, Huizinga, Tom W. J., Toes, René, Lioté, Frédéric, Richette, Pascal, Bardin, Thomas, Ea, Hang Korng, Pascart, Tristan, McCarthy, Geraldine M., Helbert, Laura, Stibůrková, Blanka, Tausche, Anne-K., Uhlig, Till, Vitart, Véronique, Boutin, Thibaud S., Hayward, Caroline, Riches, Philip L., Ralston, Stuart H., Campbell, Archie, MacDonald, Thomas M., Nakayama, Akiyoshi, Takada, Tappei, Nakatochi, Masahiro, Shimizu, Seiko, Kawamura, Yusuke, Toyoda, Yu, Nakaoka, Hirofumi, Yamamoto, Ken, Matsuo, Keitaro, Shinomiya, Nariyoshi, Ichida, Kimiyoshi, Lee, Chaeyoung, Bradbury, Linda A., Brown, Matthew A., Robinson, Philip C., Buchanan, Russell R. C., Hill, Catherine L., Lester, Susan, Smith, Malcolm D., Rischmueller, Maureen, Choi, Hyon K., Stahl, Eli A., Miner, Jeff N., Solomon, Daniel H., Cui, Jing, Giacomini, Kathleen M., Brackman, Deanna J., Jorgenson, Eric M., Liu, Hongbo, Susztak, Katalin, Shringarpure, Suyash, So, Alexander, Okada, Yukinori, Li, Changgui, Shi, Yongyong, and Merriman, Tony R.

Published
2024
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4. Ancient Plasmodium genomes shed light on the history of human malaria

Author

Michel, Megan, Skourtanioti, Eirini, Pierini, Federica, Guevara, Evelyn K., Mötsch, Angela, Kocher, Arthur, Barquera, Rodrigo, Bianco, Raffaela A., Carlhoff, Selina, Coppola Bove, Lorenza, Freilich, Suzanne, Giffin, Karen, Hermes, Taylor, Hiß, Alina, Knolle, Florian, Nelson, Elizabeth A., Neumann, Gunnar U., Papac, Luka, Penske, Sandra, Rohrlach, Adam B., Salem, Nada, Semerau, Lena, Villalba-Mouco, Vanessa, Abadie, Isabelle, Aldenderfer, Mark, Beckett, Jessica F., Brown, Matthew, Campus, Franco G. R., Chenghwa, Tsang, Cruz Berrocal, María, Damašek, Ladislav, Duffett Carlson, Kellie Sara, Durand, Raphaël, Ernée, Michal, Fântăneanu, Cristinel, Frenzel, Hannah, García Atiénzar, Gabriel, Guillén, Sonia, Hsieh, Ellen, Karwowski, Maciej, Kelvin, David, Kelvin, Nikki, Khokhlov, Alexander, Kinaston, Rebecca L., Korolev, Arkadii, Krettek, Kim-Louise, Küßner, Mario, Lai, Luca, Look, Cory, Majander, Kerttu, Mandl, Kirsten, Mazzarello, Vittorio, McCormick, Michael, de Miguel Ibáñez, Patxuka, Murphy, Reg, Németh, Rita E., Nordqvist, Kerkko, Novotny, Friederike, Obenaus, Martin, Olmo-Enciso, Lauro, Onkamo, Päivi, Orschiedt, Jörg, Patrushev, Valerii, Peltola, Sanni, Romero, Alejandro, Rubino, Salvatore, Sajantila, Antti, Salazar-García, Domingo C., Serrano, Elena, Shaydullaev, Shapulat, Sias, Emanuela, Šlaus, Mario, Stančo, Ladislav, Swanston, Treena, Teschler-Nicola, Maria, Valentin, Frederique, Van de Vijver, Katrien, Varney, Tamara L., Vigil-Escalera Guirado, Alfonso, Waters, Christopher K., Weiss-Krejci, Estella, Winter, Eduard, Lamnidis, Thiseas C., Prüfer, Kay, Nägele, Kathrin, Spyrou, Maria, Schiffels, Stephan, Stockhammer, Philipp W., Haak, Wolfgang, Posth, Cosimo, Warinner, Christina, Bos, Kirsten I., Herbig, Alexander, and Krause, Johannes

Published
2024
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9. Large-scale analysis of whole genome sequencing data from formalin-fixed paraffin-embedded cancer specimens demonstrates preservation of clinical utility

Author

Basyuni, Shadi, Heskin, Laura, Degasperi, Andrea, Black, Daniella, Koh, Gene C. C., Chmelova, Lucia, Rinaldi, Giuseppe, Bell, Steven, Grybowicz, Louise, Elgar, Greg, Memari, Yasin, Robbe, Pauline, Kingsbury, Zoya, Caldas, Carlos, Abraham, Jean, Schuh, Anna, Jones, Louise, Tischkowitz, Marc, Brown, Matthew A., Davies, Helen R., and Nik-Zainal, Serena

Published
2024
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10. The development and internal pilot trial of a digital physical activity and emotional well-being intervention (Kidney BEAM) for people with chronic kidney disease

Author

Young, Hannah M. L., Castle, Ellen M., Briggs, Juliet, Walklin, Christy, Billany, Roseanne E., Asgari, Elham, Bhandari, Sunil, Bishop, Nicolette, Bramham, Kate, Burton, James O., Campbell, Jackie, Chilcot, Joseph, Cooper, Nicola, Deelchand, Vashist, Graham-Brown, Matthew P. M., Haggis, Lynda, Hamilton, Alexander, Jesky, Mark, Kalra, Philip A., Koufaki, Pelagia, Macdonald, Jamie, McCafferty, Kieran, Nixon, Andrew C., Noble, Helen, Saynor, Zoe L., Taal, Maarten W., Tollitt, James, Wheeler, David C., Wilkinson, Thomas J., and Greenwood, Sharlene A.

Published
2024
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17. Engineering Ethics as an Expert-Guided and Socially-Situated Activity

Author

Grohman, Magdalena G., Gans, Nicholas, Lee, Eun Ah, Tacca, Marco, and Brown, Matthew J.

Abstract

Engineering ethics education typically focuses on decisions by individual engineers and case studies of disasters. This does not reflect the everyday decisions that practicing engineers must make, and neglects the fact that most engineers work on teams rather than alone. The focus on safety and disaster prevention leaves little time for discussing pervasive social impacts of engineering and technology. Our research seeks to fill these gaps by determining how ethical decision making occurs in team settings, how it can be influenced by ethics-focused team members, and to what extent a social context influence consideration of social impacts. Over three years, we observed ethics discussions among teams of engineering students. First, we observed undergraduates during their Capstone Design project. We contrasted typical teams and teams with an additional team member trained and educated in engineering ethics. Second, we observed university research laboratory groups composed of undergraduate students, graduate students and postdocs in their spontaneous and regular conversations. Data analysis suggests that engineering students have a narrow understanding of engineering ethics, and that their explicit and implicit understanding can be in conflict. We also observed that an engineering expert can improve the breadth and depth of conversations. We also observe that engineering students rarely--if ever--discuss ethical or social implications of their work during routine activities. This also points to the benefits of facilitated discussions.

Published
2020

20. The NightLife study — the clinical and cost-effectiveness of thrice-weekly, extended, in-centre nocturnal haemodialysis versus daytime haemodialysis using a mixed methods approach: study protocol for a randomised controlled trial

Author

Hull, Katherine L., Bramham, Kate, Brookes, Cassandra L., Cluley, Victoria, Conefrey, Carmel, Cooper, Nicola J., Eborall, Helen, Fotheringham, James, Graham-Brown, Matthew P. M., Gray, Laura J., Mark, Patrick B., Mitra, Sandip, Murphy, Gavin J., Quann, Niamh, Rooshenas, Leila, Warren, Madeleine, and Burton, James O.

Published
2023
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21. Multi-campaign ship and aircraft observations of marine cloud condensation nuclei and droplet concentrations

Author

Sanchez, Kevin J., Painemal, David, Brown, Matthew D., Crosbie, Ewan C., Gallo, Francesca, Hair, Johnathan W., Hostetler, Chris A., Jordan, Carolyn E., Robinson, Claire E., Scarino, Amy Jo, Shingler, Taylor J., Shook, Michael A., Thornhill, Kenneth L., Wiggins, Elizabeth B., Winstead, Edward L., Ziemba, Luke D., Chambers, Scott, Williams, Alastair, Humphries, Ruhi S, Keywood, Melita D., Ward, Jason P., Cravigan, Luke, McRobert, Ian M., Flynn, Connor, Kulkarni, Gourihar R., Russell, Lynn M., Roberts, Gregory C., McFarquhar, Greg M., Nenes, Athanasios, Woods, Sarah F., Reid, Jeffery S., Small-Griswold, Jennifer, Brooks, Sarah, Kirschler, Simon, Voigt, Christianne, Wang, Jian, Delene, David J., Quinn, Patricia K., and Moore, Richard H.

Published
2023
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24. Evaluating the effect of a digital health intervention to enhance physical activity in people with chronic kidney disease (Kidney BEAM): a multicentre, randomised controlled trial in the UK

Author

Greenwood, Sharlene A, Young, Hannah M L, Briggs, Juliet, Castle, Ellen M, Walklin, Christy, Haggis, Lynda, Balkin, Caitlin, Asgari, Elham, Bhandari, Sunil, Burton, James O, Billany, Roseanne E, Bishop, Nicolette C, Bramham, Kate, Campbell, Jackie, Chilcot, Joseph, Cooper, Nicola J, Deelchand, Vashist, Graham-Brown, Matthew P M, Hamilton, Alexander, Jesky, Mark, Kalra, Philip A, Koufaki, Pelagia, McCafferty, Kieran, Nixon, Andrew C, Noble, Helen, Saynor, Zoe, Taal, Maarten W, Tollit, James, Wheeler, David C, Wilkinson, Thomas J, Worboys, Hannah, and Macdonald, Jamie H

Published
2024
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26. Investigating CS Teacher Licensure in Indiana

Author

Koressel, Jacob, Ottenbreit-Leftwich, Anne, Jantaraweragul, Katie, Jeon, Minji, Warner, Jayce, and Brown, Matthew

Abstract

This study aims to investigate the licensure status of computer science teachers in Indiana by examining teacher licensure data as it relates to school locale and school demographics across the state. Results indicate that there is no significant difference in the presence of teachers with CS-Related or Approved licenses across schools with various locale designations and demographic (ethnic and economic) compositions. It is a positive indication that there are no glaring disparities in access to well-prepared CS teachers across student groups. This also provides an opportunity to investigate additional factors that may shed light on future areas of focus.

Published
2022
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27. Early Childhood Development in the Aftermath of the 2016 Wildfires in Alberta, Canada

Author

Drolet, Julie L., McDonald-Harker, Caroline, Lalani, Nasreen, McGreer, Sarah, Brown, Matthew R. G., and Silverstone, Peter H.

Abstract

The 2016 wildfires in Alberta, Canada, created numerous challenges for families with children under five years of age, due to the limited postdisaster access to early childhood development (ECD) programs, resources, and supports. In the immediate aftermath of the wildfires, families struggled to balance recovery activities with childcare responsibilities, which adversely affected their overall recovery. In this article, we discuss three main challenges experienced by families with young children after the wildfires: inadequate access to childcare services, a lack of availability and funding for ECD programs and resources, and limited long-term recovery support for families. Because of their early developmental stage, young children are especially vulnerable to the adverse effects of a disaster and dependent on their adult caregivers, thus it is essential to understand the unique challenges families face after a disaster. Children's prolonged exposure to the stress of a disaster environment is compounded when parents have limited access to crucial programs, resources, and supports during the most crucial periods of rebuilding and recovery. The findings we report in this article provide insights into the critical role disaster and emergency preparedness and planning play in ECD service delivery and infrastructure, and into the need for recovery efforts to "build back better." We advise all levels of government to consider ECD and the provision of child care to be essential services during natural disasters, crises, and pandemics. We further advise them to make the financial investment needed to ensure sustainable recovery operations, including infrastructure, provision of ECD services, and hiring of educators who can deliver high-quality, affordable early learning and child care in postdisaster environments.

Published
2021
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28. Paradigms Lost and Gained: Stakeholder Experiences of Crisis Distance Learning during the COVID-19 Pandemic

Author

Epps, Alun, Brown, Matthew, Nijjar, Baldish, and Hyland, Lynda

Abstract

The physical distancing requirements designed to slow the contagion of COVID-19 instigated sweeping changes to the education sector. School closures in 193 countries brought significant disruption to education and to the lives of children, parents, and teachers. This study explored the experiences of school stakeholders during this period of crisis distance learning (DL). The perspectives of participants in six discrete focus groups of pupils, parents, and teachers at a private school in Dubai, United Arab Emirates, were subject to thematic analysis. Researchers identified three key themes, including 'a need for stakeholder support', 'curriculum delivery implications', and 'educational outcomes of crisis distance learning'. Conclusions and recommendations will be of interest to researchers, teachers, school leaders, and teacher education providers.

Published
2021
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29. Empowering English Teachers: Teacher Agency in Australia

Author

Brown, Matthew, McKnight, Lucinda, Yager, Karen, and O'Sullivan, Kerry-Ann

Abstract

This article presents an account of a panel on English teacher agency in Australia at the 2020 IFTE conference, held virtually as a result of the COVID-19 pandemic. The article introduces the way the panel chair set up the concerns of the panel, providing relevant background, theoretical framing, and introductions to the panellists and the key questions that panellists were invited to address. The three panellists then contribute written insights from their research and/or practice, and reflections on their participation and the discussions that ensued. Fundamentally, the article explores how teachers might navigate their work if what they hoped to teach is not what they are told to teach, and provides practical suggestions for claiming agency. This is a timely intervention, as teacher agency is increasingly being eroded through a variety of forces.

Published
2021

36. Clinical practice guideline exercise and lifestyle in chronic kidney disease

Author

Baker, Luke A., March, Daniel S., Wilkinson, Thomas J., Billany, Roseanne E., Bishop, Nicolette C., Castle, Ellen M., Chilcot, Joseph, Davies, Mark D., Graham-Brown, Matthew P. M., Greenwood, Sharlene A., Junglee, Naushad A., Kanavaki, Archontissa M., Lightfoot, Courtney J., Macdonald, Jamie H., Rossetti, Gabriella M. K., Smith, Alice C., and Burton, James O.

Published
2022
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37. Association of ambulatory blood pressure with coronary microvascular and cardiac dysfunction in asymptomatic type 2 diabetes

Author

Yeo, Jian L., Gulsin, Gaurav S., Brady, Emer M., Dattani, Abhishek, Bilak, Joanna M., Marsh, Anna-Marie, Sian, Manjit, Athithan, Lavanya, Parke, Kelly S., Wormleighton, Joanne, Graham-Brown, Matthew P. M., Singh, Anvesha, Arnold, J. Ranjit, Lawson, Claire, Davies, Melanie J., Xue, Hui, Kellman, Peter, and McCann, Gerry P.

Published
2022
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43. Non-destructive on-machine inspection of machining-induced deformed layers.

Author

Brown, Matthew, Crawforth, Pete, and Curtis, David

Subjects
SUSTAINABILITY, WORKPIECES, SURFACE topography, MATERIAL plasticity, X-ray diffraction, COOLANTS
Abstract

Complete inspection of workpiece surface integrity invariably involves a form of destructive testing to enable the assessment of microstructural defects such as machining-induced white layers and near-surface plastic deformation. The incumbent offline and destructive microscopy inspection process is incompatible with both a digital and sustainable manufacturing vision of zero waste, as such, a non-destructive technique which utilises a novel X-ray diffraction surface integrity inspection method (XRD-SIIM) has been developed. This approach has been designed to complement traditional machinability-type assessments of tool life and machined surface topography, establishing a new process flow for validation. In this paper, for the first time, non-destructive on-machine validation of workpiece microstructural surface integrity is demonstrated, via a comparative investigation into the effect of insert grade, cutting speed and coolant delivery method on the depth of the imparted plastic deformation depth. It is shown that XRD-SIIM allows repeatable, non-destructive determination of deformed layers within a typical machining centre enclosure, with comparable findings to the incumbent cross-sectional microscopy approach. The generation of surface integrity digital fingerprints of a machining operation facilitates rapid comparison between testing variables, with a transition to an objective quantifiable assessment rather than one which open to subjectivity. In turn, XRD-SIIM expedites the development and benchmarking of new operations, tooling, materials, or coolant. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Skeletal Muscle Texture Assessment Using Ultrasonography: Comparison with Magnetic Resonance Imaging in Chronic Kidney Disease.

Author

Wilkinson, Thomas J., Baker, Luke A., Watson, Emma L., Nikopoulou, Katerina, Karatzaferi, Christina, Graham-Brown, Matthew PM., Smith, Alice C., and Sakkas, Giorgos K.

Abstract

Skeletal muscle dysfunction is common in chronic kidney disease (CKD). Of interest is the concept of "muscle quality," of which measures include ultrasound-derived echo intensity (EI). Alternative parameters of muscle texture, for example, gray level of co-occurrence matrix (GCLM), are available and may circumvent limitations in EI. The validity of EI is limited in humans, particularly in chronic diseases. This study aimed to investigate the associations between ultrasound-derived parameters of muscle texture with MRI. Images of the thigh were acquired using a 3 Tesla MRI scanner. Quantification of muscle (contractile), fat (non-contractile), and miscellaneous (connective tissue, fascia) components were estimated. Anatomical rectus femoris cross-sectional area was measured using B-mode 2D ultrasonography. To assess muscle texture, first (i.e., EI)- and second (i.e., GLCM)-order statistical analyses were performed. Fourteen participants with CKD were included (age: 58.0 ± 11.9 years, 50% male, eGFR: 27.0 ± 7.4 ml/min/1.73m2, 55% Stage 4). Higher EI was associated with lower muscle % (quadriceps: β = −.568, p =.034; hamstrings: β = −.644, p =.010). Higher EI was associated with a higher fat % in the hamstrings (β = −.626, p =.017). A higher angular second moment from GLCM analysis was associated with greater muscle % (β =.570, p =.033) and lower fat % (β = −.534, p =.049). A higher inverse difference moment was associated with greater muscle % (β =.610, p =.021 and lower fat % (β = −.599, p =.024). This is the first study to investigate the associations between ultrasound-derived parameters of muscle texture with MRI. Our preliminary findings suggest ultrasound-derived texture analysis provides a novel indicator of reduced skeletal muscle % and thus increased intramuscular fat. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Improving self‐management behaviour through a digital lifestyle intervention: An internal pilot study.

Author

Lightfoot, Courtney J., Wilkinson, Thomas J., Vadaszy, Noemi, Graham‐Brown, Matthew P. M., Davies, Melanie J., Yates, Thomas, and Smith, Alice C.

Subjects
TREATMENT of chronic kidney failure, PATIENT education, SELF-management (Psychology), BEHAVIOR modification, HUMAN services programs, RESEARCH funding, MEDICAL care, EDUCATIONAL outcomes, DIGITAL health, STATISTICAL sampling, PILOT projects, BLIND experiment, INTERVIEWING, EVALUATION of human services programs, INTERNET, RANDOMIZED controlled trials, CHRONIC kidney failure, CONTROL groups, PRE-tests & post-tests, LONGITUDINAL method, THEMATIC analysis, HEALTH behavior, RESEARCH, RESEARCH methodology, COMPARATIVE studies, PATIENT satisfaction, PATIENT participation, BEHAVIOR therapy
Abstract

Background: Self‐management is a key component of successful chronic kidney disease (CKD) management. Here, we present the findings from the internal pilot of a multicentre randomised controlled trial (RCT) aimed to test the effect of a digital self‐management programme ('My Kidneys & Me' (MK&M)). Methods: Participants (aged ≥18 years and CKD stages 3‐4) were recruited from hospital kidney services across England. Study processes were completed virtually. Participants were randomised 2:1 to either intervention (MK&M) or control group. The first 60 participants recruited were included in a 10‐week internal pilot which assessed study feasibility and acceptability against pre‐specified progression criteria: 1) eligibility and recruitment, acceptability of 2) randomisation and 3) outcomes, 4) MK&M activation, and 5) retention and attrition rates. Semi‐structured interviews further explored views on trial participation. Results: Of the 60 participants recruited, 41 were randomised to MK&M and 19 to control. All participants completed baseline measures and 62% (n=37) completed post‐intervention outcome measures. All progression criteria met the minimum thresholds to proceed. Nine participants were interviewed. The themes identified were satisfaction with study recruitment processes (openness to participate, reading and agreeing to "terms and conditions"), acceptability of study design (remote study participation, acceptability of randomisation, completion of online assessment(s)), and methods to improve recruitment and retention (personalised approach, follow‐up communication). Conclusion: This internal pilot demonstrated the feasibility and acceptability of a virtually run RCT. Progression criteria thresholds to proceed to the definitive RCT were met. Areas for improvement were identified and protocol amendments were made to improve trial delivery. [ABSTRACT FROM AUTHOR]

Published
2024
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